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Ligustrum robustum (Roxb.) Blume total flavonoids, and preparation method and application thereof

A technology of privet privet and total flavonoids, which is applied in the preparation of alcohol extract of privet privet, total flavonoids of privet privet, preparation field, and can solve problems such as damage

Pending Publication Date: 2020-10-16
ZUNYI MEDICAL UNIVERSITY
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Moderate drinking can promote blood circulation, expel cold and dampness, reduce swelling and relieve pain, relax tendons and activate blood circulation, but long-term heavy drinking can cause alcohol poisoning and alcoholic liver damage
At present, there is no relevant research on the prevention and treatment of acute alcoholic liver injury with total flavonoids (LTF) of Ligustrum stouti

Method used

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  • Ligustrum robustum (Roxb.) Blume total flavonoids, and preparation method and application thereof
  • Ligustrum robustum (Roxb.) Blume total flavonoids, and preparation method and application thereof
  • Ligustrum robustum (Roxb.) Blume total flavonoids, and preparation method and application thereof

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Experimental program
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Embodiment Construction

[0041] The following is further described in detail through specific implementation methods:

[0042] 1 material

[0043] (1) Medicinal materials and reagents: Ligustrum robustum leaves (collected from Fenggang County, Zunyi, Guizhou Province, after identification, the original plant is Ligustrum robustum (Roxb.) Blume), Co60 irradiated experimental mice maintained Feed (Jiangsu Synergy Pharmaceutical Bioengineering Co., Ltd.), silibinin (batch number: 850610070, Tianjin Tasly Pharmaceutical Co., Ltd.), alanine aminotransferase and aspartate aminotransferase kits (batch number: 20191227, Nanjing Jiancheng Institute of Bioengineering), Sodium carboxymethylcellulose (batch number: 20130821, specification: 500g), 95% ethanol (analytical grade).

[0044] (2) Animals: 88 SPF-grade 8-week-old C57 / BL6J male mice, provided by Sibeifu (Beijing) Biotechnology Co., Ltd. [license number: SCXK (Beijing) 2019-0010], the animals were placed at room temperature ±2°C, relative humidity 50% t...

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Abstract

The invention discloses application of Ligustrum robustum (Roxb.) Blume total flavonoids in the technical field of preparation and application of traditional Chinese medicinal materials. LD50 of Ligustrum robustum (Roxb.) Blume total flavonoids is larger than 500 mg / kg, it is proved that the Ligustrum robustum (Roxb.) Blume total flavonoids are low in toxicity, toxicity of alcohol on gastrointestinal tracts and nerves of mice can be effectively improved, and the Ligustrum robustum (Roxb.) Blume total flavonoids have a certain pharmacodynamic effect and safety for preventing acute alcoholic liver injury mice.

Description

technical field [0001] The present invention relates to the technical field of preparation and application of traditional Chinese medicinal materials, in particular to total flavonoids of Ligustrum stomatitis, its preparation method and application, more specifically to the preparation method and application of alcohol extract of Ligustrum stomatitis and the total flavonoids of Ligustrum stomatitis, its preparation method and application . Background technique [0002] Various alcoholic beverages comprise white wine, red wine, beer and are subject to liking of people always. Moderate drinking can promote blood circulation, expel cold and dampness, reduce swelling and relieve pain, relax tendons and activate blood circulation, but long-term heavy drinking can cause alcoholism and alcoholic liver damage. Alcoholic liver injury is one of the common liver diseases in my country. Alcoholic liver injury can develop into alcoholic fatty liver, alcoholic hepatitis, alcoholic liver ...

Claims

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Application Information

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IPC IPC(8): A61K36/638A61P1/16A61P39/02A23L33/105
CPCA61K36/638A61P1/16A61P39/02A23L33/105A61K2236/333A61K2236/39A61K2236/55A23V2002/00A23V2200/32A23V2200/334A23V2250/21A23V2250/2116A23V2300/14
Inventor 张倩茹荆晶何芋岐谭道鹏秦琳杜艺玫王阳
Owner ZUNYI MEDICAL UNIVERSITY
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