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Ligustrum robustum C and application of its composition in preparation of medicine for treating hyperlipidemia and reducing fat

A technology for hyperlipidemia and privetide, which is applied in the directions of drug combination, application, food science, etc., can solve the problems such as no reports on the pharmacological effect of sterolone C.

Inactive Publication Date: 2017-12-19
施普生科技发展(北京)有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] So far, there is no report of the pharmacological effects of privetin C on the treatment of hyperlipidemia and weight loss

Method used

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  • Ligustrum robustum C and application of its composition in preparation of medicine for treating hyperlipidemia and reducing fat
  • Ligustrum robustum C and application of its composition in preparation of medicine for treating hyperlipidemia and reducing fat
  • Ligustrum robustum C and application of its composition in preparation of medicine for treating hyperlipidemia and reducing fat

Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0020] The preparation of stout privetin C

[0021] Extract 80% ethanol from the old leaves of privet privet, and recover under reduced pressure to obtain the extract; the extract is suspended and distributed with 10 times deionized water to remove the water-soluble components, and the fat-soluble components are evaporated in a water bath at 60°C to obtain the extract; the extract is dissolved in silicon by ethanol Mix the sample with algae earth, first elute with petroleum ether to remove low-polarity impurities, then elute with ethyl acetate, recover ethyl acetate under reduced pressure to obtain the extract; the extract is adsorbed by silica gel, dichloromethane:methanol (10 : 1) elution to obtain the crude privet C stout, repeated crystallization to obtain the pure privet C stout, the HPLC purity detection reaches 98%.

experiment example 2

[0023] Study on Evaluation of Antihyperlipidemic Activity of Liguestrin C

[0024] 1. Experimental materials

[0025] Animals, feed and feeding conditions

[0026] 60 golden hamsters, 7-8 weeks old, weighing 90-100 g, were purchased from Beijing Weitong Lihua Experimental Animal Technology Co., Ltd., production license: SCXK (Beijing) 2012-0001. Golden hamster conventional feed and high-fat feed (0.2% cholesterol, 15% lard, 84.8% basic feed) were provided by Beijing Huafukang Biotechnology Co., Ltd., production license: SCXK (Beijing) 2014-0008. The golden hamsters were reared in an SPF-grade environment with a temperature of 20-25°C and a humidity of 40%-70%, 10 hamsters / cage, given regular feed or high-fat feed, and free access to water.

[0027] Drugs and Reagents

[0028] Ligustin C: It is prepared by Example 1 of the embodiment, and its purity is up to 98% by HPLC.

[0029] Fenofibrate (Lipingzhi), 200mg / capsule, produced by French Liboforni Pharmaceutical Company, pr...

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Abstract

The invention discloses a preparation method of ligustrum robustum C and an application thereof. The invention firstly discloses a structure (in a graph 1) of the ligustrum robustum C. The invention discloses a method for preparing the ligustrum robustum C, which comprises the following steps: performing steps of extraction, separating and purifying of plants such as ligustrum robustum, or performing chemical synthesis of the materials. Through a lot of animal experiments, the ligustrum robustum C and its composition can effectively reduce lipid content in animal blood and liver of a hyperlipidemia model, and can be used for preparing medicines and health products for treating hyperlipidemia and reducing fat.

Description

technical field [0001] The present invention relates to stout privetin C{(2E)-3,7-dimethyl-2,6-octadiene-1-yl3-O-(6-deoxy α-L-mannopyranosyl)- 4-O-[(2E)-3-(4-Hydroxyphenyl)-2-acryloyl]-β-D-glucopyranoside; (2E)-3,7-Dimethyl-2,6-octadien- 1-yl3-O-(6-deoxy-α-L-mannopyranosyl)-4-O-[(2E)-3-(4-hydroxyphenyl)-2-propenoyl]-β-D-glucop yranoside} The new pharmacological use, especially relates to the use of privetin C in the preparation of medicines for treating hyperlipidemia and weight loss, and belongs to the field of pharmacological uses of privetin C. Background technique [0002] With the rapid development of economy and the change of people's lifestyle, cardiovascular and cerebrovascular diseases have become the number one killer of people's health. According to the latest statistics released by the World Health Organization (WHO), among the 56.4 million deaths worldwide in 2015, the number of deaths caused by cardiovascular and cerebrovascular diseases reached 15 million, a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7032A61P3/06A61P3/04A23L33/125
CPCA23L33/125A23V2002/00A61K31/7032A23V2200/3262A23V2200/332A23V2250/60
Inventor 杨润梅潘瑞乐赵宁高南南常琪
Owner 施普生科技发展(北京)有限公司
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