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New application of lobed kudzu vine flower micromolecules to regulation of alcohol-dependent behaviors

A technology of alcohol dependence and small molecules, applied in the field of biomedicine, can solve problems such as prominent side effects, poor drug metabolism, adverse effects on patients' spirit and body, and achieve the effect of treating alcohol dependence

Pending Publication Date: 2021-10-22
GANSU UNIV OF CHINESE MEDICINE
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the efficacy of these drugs has been affirmed in the long-term clinical application process, the side effects are also very prominent, such as possible drug abuse, adverse effects on the patient's spirit and body, and poor drug metabolism. Another very prominent side effect is that people who have successfully quit alcohol Patient relapses quickly

Method used

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  • New application of lobed kudzu vine flower micromolecules to regulation of alcohol-dependent behaviors
  • New application of lobed kudzu vine flower micromolecules to regulation of alcohol-dependent behaviors
  • New application of lobed kudzu vine flower micromolecules to regulation of alcohol-dependent behaviors

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Embodiment Construction

[0031] The present invention will be further described below in conjunction with the accompanying drawings and specific embodiments.

[0032] Application of kudzu flower small molecules for regulating alcohol dependence behavior:

[0033] 1. Main material

[0034] 1.1 Main reagents

[0035] Bromophenol blue dye (Sigma-alorich, MKCD9610), agar powder (Cali-Bio, CB300005), sucrose (Sigma-alorich, WXBC9911V), yeast extract (OXOID, 4255382-02), sterile enzyme-free water (Beijing Suo Laibao Technology Co., Ltd., 20201116).

[0036] 1.2 Experimental animals

[0037] Drosophila melanogaster w 1118 (5905) from the Bloomington Drosophila Resource Center. Set the Drosophila constant temperature light incubator: temperature 25±1°C, relative humidity 45-65%, 12h light / 12h dark, and raise the Drosophila in the incubator.

[0038] 1.3 Experimental drugs

[0039] Puerarin (Puerarin, Shanghai Yuanye Biotechnology Co., Ltd., LOT: SO2M91354875), daidzin (Daidzin, Shanghai Yuanye Biotech...

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Abstract

The invention discloses a novel application of lobed kudzu vine flower micromolecules to regulation of alcohol-dependent behaviors, provides a basis for the treatment of alcohol dependence by the lobed kudzu vine flower micromolecules, discloses an application of the lobed kudzu vine flower micromolecules in reducing relative drinking amount and alcohol preference in a withdrawal reaction period, discloses an application of the lobed kudzu vine flower micromolecules in reducing alcohol sensitivity and acute alcohol tolerance, and further discloses an application of the lobed kudzu vine flower micromolecules in improvement of long-term alcohol tolerance. It is determined that the lobed kudzu vine flower micromolecules can remarkably regulate the alcohol dependence behavior and have the protection effect on alcohol-caused body damage; it is determined that the lobed kudzu vine flower micromolecules play a role in treating alcohol dependence through 'multi-component, multi-channel and multi-target'; it is determined that puerarin, daidzein and daidzein have the effects of adjusting the alcohol dependence behavior and treating alcohol dependence.

Description

technical field [0001] The invention belongs to the biomedicine technology, and specifically relates to a new application of kudzu flower small molecules for regulating alcohol dependence behavior. Background technique [0002] In 2018, WHO released the Global Status Report on Alcoholand Health 2018. According to the report, nearly 3 million people died from drinking alcohol in 2016, accounting for 5.3% of the total global deaths; in 2016, the incidence of alcohol use disorder and alcohol dependence in the Chinese population has reached the world level. In China, 6% of men and 1 % of female residents died of alcohol-related diseases; alcohol dependence seriously damages the health of drinkers, such as gastric ulcer, liver cirrhosis, and irreversible disorders of the nervous system, etc. In recent years, there has also been a trend of drinking younger. Therefore, research on alcohol dependence has important medical and social value. [0003] Since the 20th century, alcohol ...

Claims

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Application Information

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IPC IPC(8): A61K31/352A61K31/7048A61K36/488A61P25/32
CPCA61K31/7048A61K31/352A61K36/488A61P25/32
Inventor 刘永琦和建政修明慧杨馥嘉
Owner GANSU UNIV OF CHINESE MEDICINE
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