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Drugs for the prevention and treatment of alcoholic liver disease

A technology of alcoholic liver disease and medicament, which is applied in the fields of acute alcoholic liver injury and alcoholic liver fibrosis, prevention and treatment of alcoholic liver disease, and can solve the problems of curative effect blocking progress of alcoholic liver disease, so as to achieve prevention and treatment Symptoms of alcoholic liver fibrosis, no side effects, improvement of liver cell swelling and fatty degeneration

Active Publication Date: 2020-06-26
THE FIRST AFFILIATED HOSPITAL OF WENZHOU MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, so far there is no drug that has a particularly good curative effect and blocks the progression of alcoholic liver disease

Method used

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  • Drugs for the prevention and treatment of alcoholic liver disease
  • Drugs for the prevention and treatment of alcoholic liver disease
  • Drugs for the prevention and treatment of alcoholic liver disease

Examples

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preparation example Construction

[0056] Another object of the present invention is to provide a preparation method of a medicament for preventing and treating alcoholic liver disease, the preparation is a liquid medicament, and the preparation method comprises the following steps:

[0057] Step (1), preparing the Lactobacillus rhamnosus supernatant;

[0058] In step (2), vitamin E is added to the supernatant of Lactobacillus rhamnosus, preferably sodium tanshinone IIA sulfonate is also added.

[0059] In step (1), preparing the Lactobacillus rhamnosus supernatant comprises the following steps:

[0060] Step (1-1) activation: take 3% inoculum of Lactobacillus rhamnosus and inoculate it into MRS liquid medium (weigh 14.4g MRS broth powder and dissolve it in 300ml distilled water, store at 4°C after autoclaving), 37 Cultivate with shaking at ℃ for 20-30 hours, so that the strains in the liquid medium reach the set concentration;

[0061] Step (1-2) purification: take the bacterial solution and inoculate it in ...

Embodiment 1

[0074] The composition of the prescription is as follows: 1 mL of Lactobacillus rhamnosus supernatant and 100 mg of vitamin E.

[0075] Adopt following preparation method to obtain liquid medicament:

[0076] Step (1), preparing the Lactobacillus rhamnosus supernatant;

[0077]Activation: Take 3% inoculum of Lactobacillus rhamnosus and inoculate it into 5mL MRS liquid medium (weigh 14.4g MRS broth powder and dissolve it in 300ml distilled water, store at 4°C after autoclaving), shake and culture at 37°C for 24 hours , so that the strains in the liquid medium reach A600 of 1.380-1.400;

[0078] Purification: Inoculate 150 μL of bacterial liquid into MRS solid medium and incubate at 37°C for 24 hours;

[0079] Proliferation: Inoculate pale white circular flat single colonies with a diameter of 1.8-2mm into 4-6mL MRS liquid culture medium, culture at 37°C for 24 hours, and screen for highly active bacteria;

[0080] Extraction: Centrifuge the highly active bacterial solution a...

Embodiment 2

[0083] The composition of the prescription is as follows: 1 mL of supernatant of Lactobacillus rhamnosus, 100 mg of vitamin E and 50 mg of sodium tanshinone ⅡA sulfonate.

[0084] Adopt following preparation method to obtain liquid medicament:

[0085] Step (1), prepare Lactobacillus rhamnosus supernatant, method is the same as embodiment 1;

[0086] In step (2), 100 mg of vitamin E and 50 mg of sodium tanshinone IIA sulfonate are added to 1 mL of the supernatant of Lactobacillus rhamnosus to obtain a liquid medicine.

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Abstract

The invention discloses a medicament for preventing and treating alcoholic liver disease. The active ingredients of the medicament include supernatant of Lactobacillus rhamnosus and vitamin E, preferably added with sodium tanshinone IIA sulfonate. The present invention is based on modern pathological research, combined with the theory of traditional Chinese medicine, and verified by curative effect, the medicament restores the damage of the intestinal barrier caused by alcohol, improves the antioxidant capacity of the liver, improves liver cell swelling and fatty degeneration, and relieves fibrous intervals. Liver diseases, especially acute alcoholic liver injury and alcoholic liver fibrosis have obvious preventive and therapeutic effects.

Description

technical field [0001] The invention relates to the field of compound medicaments, in particular to medicaments for preventing and treating alcoholic liver disease, especially acute alcoholic liver injury and alcoholic liver fibrosis. Background technique [0002] Alcoholic liver disease refers to a series of alcohol-related liver diseases caused by prolonged or excessive alcohol intake, such as alcoholic fatty liver, alcoholic hepatitis, alcoholic liver fibrosis, alcoholic cirrhosis, and alcoholic liver cancer. The latest epidemiological survey found that with economic development and changes in lifestyle, alcohol dependence and alcohol abuse have become increasingly serious public health problems in today's world, and alcohol has become the leading cause of liver damage after hepatitis virus worldwide. the second leading cause of disease. Studies have shown that more than 90% of alcoholics suffer from fatty liver, of which 10% to 35% can develop into alcoholic hepatitis, ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K35/747A61P1/16C12P1/04C12R1/225A61K31/58A61K31/355
CPCA61K31/355A61K31/58A61K35/747C12P1/04C12N1/205C12R2001/225A61K2300/00
Inventor 陈永平陈达之萧云蕾许烂漫李骥卢明芹金晓芝
Owner THE FIRST AFFILIATED HOSPITAL OF WENZHOU MEDICAL UNIV
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