Novel application of rendan mini-pill traditional Chinese medicine composition in alleviation of hangover or treatment of alcoholic liver injury
A technology for alcoholic liver injury and a composition, which is applied in the fields of medical technology and health care products, can solve the problems such as the limited effect of reversing alcoholic liver injury and restoring liver function, and achieves reducing body weight and liver index, preventing or treating alcoholic liver disease. Effects of damage, prolongation of alcohol tolerance time
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
Method used
Image
Examples
Embodiment 1
[0032] Example 1 Anti-drunk and hangover experiment
[0033]Sixteen healthy C57 mice were randomly divided into a drunk model group and a Longhuren Dan prevention group, with 8 mice in each group. The model group was administered with normal saline, and the Longhurendan prevention group was administered with 250mg / kg dose, followed by 56% vol of Niulanshan Erguotou (previously determined by pre-experiment for drunken mice) at a dose of 15ml / kg. Observe and record the tolerance time (from sobriety to the time when the righting reflex disappears) of the mice drunkenness, and calculate the drunkenness rate.
[0034] The results are shown in Table 1 below. Compared with the drunken model group, after pretreatment with Longhurendan, the degree of drunkenness of the mice was significantly improved, and the drunkenness tolerance time of the mice was significantly prolonged (P<0.01). It shows that Longhuren Dan has a certain anti-drunk and anti-alcoholic effect on drunk mice.
[003...
Embodiment 2
[0038] Example 2 Alcoholic liver injury experiment in mice
[0039] 1. Modeling
[0040] 36 healthy male C57 mice were randomly divided into 6 groups: blank group, model group, Longhurendan low-dose group (20mg / kg), Longhurendan medium-dose group (40mg / kg), Longhurendan High dose group (80mg / kg) and silybin group (70mg / kg). 3:00-5:00pm every day, the corresponding drugs were given by gavage, and the blank group and the model group were given CMC-Na. After 30 minutes of administration on the 11th day, the blank group was gavaged with 9 mg / kg maltodextrin solution, and the other groups were given 5 mg / kg ethanol solution. After 9 hours, the mice were anesthetized, and the serum and liver tissue were collected for subsequent testing. The specific experimental procedures are as follows: figure 1 shown.
[0041] Table 2 Grouping and administration
[0042]
[0043] 2. Effects of mouse model body weight and liver weight
[0044] The results of mouse model body weight and li...
PUM
Abstract
Description
Claims
Application Information
- R&D Engineer
- R&D Manager
- IP Professional
- Industry Leading Data Capabilities
- Powerful AI technology
- Patent DNA Extraction
Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.
© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com