78 results about "Membrane lipid metabolism" patented technology

A method is provided to produce biodiesel from algae using a two-stage, autotrophic and heterotrophic cultivations of chlorella for biodiesel production. This method includes a sequence of procedures: cultivating photoautotrophic algae, concentrating cells and then transferring them to a fermentor for heterotrophic cultivation. During the photoautotrophic cultivation stage, the culture is exposed to a light source, such as sunlight with carbon dioxide obtained from a carbon dioxide source or from air. antibacterial agents may be added to prevent contamination from undesired microorganisms. Organic carbons are added during heterotrophic cultivation stage. Fermentation conditions are optimized for maximizing lipid synthesis. High biomass is achieved to about 108 g / L with lipid content reaching about 52% of dry cell weight. After cultivation, biodiesel is made through extraction and transesterification of algae lipids.

The present invention describes compositions and methods for treating, preventing and improving the appearance of skin, particularly, treating, preventing, ameliorating, reducing and / or eliminating loss of subcutaneous fat in the skin, wherein the compositions include natural plant constituents that stimulate lipid synthesis. The plant extracts are preferably derived from Rhinacanthus nasutus, Humulus scandens, Sesbania grandiflora, Amorphophallus campanulatu, Pouzolzia pentandra, and Piper betel, and any combinations thereof . The compositions are preferably applied to the skin, or are delivered by directed means, to a site in need thereof.

The present invention describes compositions and methods for treating, preventing and improving the appearance of skin, particularly, treating, preventing, ameliorating, reducing and / or eliminating loss of subcutaneous fat in the skin, wherein the compositions include natural plant constituents that stimulate lipid synthesis. The plant extracts are preferably derived from Rhinacanthus nasutus, Humulus scandens, Sesbania grandiflora, Amorphophallus campanulatu, Pouzolzia pentandra, and Piper betel, and any combinations thereof. The compositions are preferably applied to the skin, or are delivered by directed means, to a site in need thereof.

The present invention relates to formulations of ingredients that are useful for improving the appearance, texture and / or moisture of skin. In particular, the formulations of the present invention stimulate collagen, elastin, and lipid synthesis and / or inhibit or minimize the loss of collagen, elastin, and lipids in the skin. Additionally, the formulations of the present invention inhibit matrix metalloproteases, such as MMP-1, MMP-9, collagenase, or elastase.

Cosmetic compositions comprising a metal-complexed peptide fraction of stressed yeast extracts and / or a calcium influx inhibitor are disclosed, as well as methods of using such compositions to impart exfoliating, anti-aging, anti-lipid, anti-inflammatory, and / or lightening benefits to the skin; and / or lightening benefits to the hair. These compositions are believed to have modulatory activity against at least one biochemical pathway implicated in skin aging, inflammation, lipid synthesis, and melanin production.

The present invention relates to formulations of ingredients that are useful for improving the appearance, texture and / or moisture of skin. In particular, the formulations of the present invention stimulate collagen, elastin, and lipid synthesis and / or inhibit or minimize the loss of collagen, elastin, and lipids in the skin. Additionally, the formulations of the present invention inhibit matrix metalloproteases, such as MMP-1, MMP-9, collagenase, or elastase.

The present invention is related to a composition comprising a serine as an active ingredient for treating or preventing fatty liver diseases. The inventive compound significantly inhibits the SREBP-1 transcription activity involved in lipid synthesis and reduced the fatty liver formation through various in vitro test and in vivo test therefore it can be useful in the prevention and treatment of the fatty liver diseases as a medicament or health functional food.

There is a topical composition having carnitine creatinate and a cosmetically acceptable vehicle. There is also provided a method for improving the aesthetic appearance of skin. There is also provided a method for inhibiting the induced lipid synthesis in skin. There is also provided a method for inhibiting the formation of cellulite in skin.

Heterocyclic modulators of lipid synthesis are provided as well as pharmaceutically acceptable salts thereof; pharmaceutical compositions comprising such compounds; and methods of treating conditions characterized by disregulation of a fatty acid synthase pathway by the administration of such compounds and combinations of such compounds and other therapeutic agents.

Compounds that are fatty acid synthesis modulators are provided. The compounds may be used to treat disorders characterized by disregulation of the fatty acid synthase function by modulating the function and / or the fatty acid synthase pathway. Methods are provided for treating such disorders including viral infections, such as hepatits C infection, cancer and metabolic disorders.

The invention discloses an application of soluble dietary fibers in kelp in preparation of lipid-lowering and weight-losing medicines and functional foods. The soluble dietary fibers are extracted from the waste kelp residues, after feeding for 3 weeks, the weight of obese mice is remarkably reduced compared with that of a negative control group; after 6 weeks of experiment period, the lipid-lowering effect is obvious; the epididymis fat and the liver of a mouse are subjected to histopathological section, the soluble dietary fibers in the section dyed by HE can obviously reduce the size of thefat, and the fat lesion of the liver of the mouse is relieved. By detecting mRNA expression of related factors related to lipid metabolism in fat and liver and mRNA expression of common inflammatoryfactors in obesity, the soluble dietary fibers can down-regulate expression of lipid synthesis genes and pro-inflammatory factors and up-regulate expression of lipid metabolism genes. The soluble dietary fiber disclosed by the invention is high in safety and low in price, and has a remarkable effect in the aspects of reducing fat and losing weight of OB obese mice.

The invention provides a CectGPDH2 gene and an application thereof in increase of fatty acid content. The nucleotide sequence of the CectGPDH2 gene is shown as SEQ NO.1. The gene comes from Chlorella ellipsoidea and encodes GPDH, wherein the GPDH participates in shuttle of the mitochondrion G3P (glycerol-3-phosphate), provides electrons for respiratory chains, is a key enzyme for G3P synthesis, is one of the key enzymes for connecting glucose metabolism with lipid metabolism and plays an important role in lipid synthesis and energy metabolism in plants. The total fatty acid content of seeds of Arabidopsis thaliana and rape genetically modified with the gene can be increased obviously, and the gene can be used for increasing the oil content of plant cells and the content of linoleic acid (C18:2) and eicosenoic acid (C20:1) in the plants and has good application prospect.

The invention provides an apple pectin dietary fiber beverage and a preparation method thereof. The beverage is particularly prepared from, by weight, 1-3 parts of apple pectin, 5-10 parts of blueberry juice, 2-6 parts of fructo-oligosaccharide, 0.1-0.3 part of honey, 0.02-0.05 part of citrus extract, 0.01-0.02 part of globe artichoke extract, 80-92 parts of water. Since the apple pectin and the blueberry juice serve as main materials of the apple pectin dietary fiber beverage, the problem of taste singleness of the apple pectin is solved, and the apple pectin and the blueberry juice are complementary in taste and jointly reduce blood fat. In addition, by addition of the fructo-oligosaccharide, intestinal peristalsis conditions can be improved, and lipid excretion is promoted. By the citrus extract and the globe artichoke extract, endogenous lipid synthesis is inhibited, blood fat reduction can be promoted in multiple approaches, and body detoxifying performance is improved.

The present invention provides compositions and methods for inhibiting protozoan growth comprising a synergistic combination of lipid synthesis inhibitors. In addition, the invention provides compositions and methods that are useful for the treatment of protozoan infections and the identification of potential new drugs for the treatment of protozoan infections.

The invention relates to the technical field of synthetic biology, in particular to an application of glycometabolism and lipid metabolism for improving synthetic yield of fatty acid derivatives by yarrowia. The expression of fatty alcohol and a glycometabolism path can achieve balance and coordination of lipid production and other related pathways to promote rational distribution of cellular metabolism and improve lipid synthesis efficiency. The application finds through experiments that when glycolysis and lipid product production pathways are synergistic, the effective pull-push effect canbe achieved, and the production of the lipid product can up-regulate the expression of the glycolysis, the glycolysis can synergistically further promote the expression of lipid products for gene synthesis, the overall metabolic flux can be greatly improved, and efficient production of the lipid products can be achieved. on the other hand, synergistic expression is also conducive to the realization of dynamic regulation, so that the production of the product can be adjusted in real time according to the different metabolic states of the cells, and further the production efficiency of a cell factory is optimized.

The invention discloses heterocyclic modulators of lipid synthesis for use against cancer and viral infections. According to the invention, also provided are heterocyclic modulators of lipid synthesis are provided as well as pharmaceutically acceptable salts thereof, pharmaceutical compositions comprising such compounds, and methods of treating conditions characterized by disregulation of a fatly acid synthase pathway by the administration of such compounds.

The invention provides a Cem GPDH (Glycerol-3-phosphate dehydrogenase) gene and an application of the Cem GPDH gene in the aspect of increase of cellular fatty acid content. A nucleotide sequence of the Cem GPDH gene is represented as SEQ ID NO: 1. The gene is derived from Chlorella ellipsoidea, and GPDH is coded. G3P (Glycerol-3-phosphate) synthesized through catalysis by GPDH is an important raw material for synthesis of TAG (triacylglycerol), the enzyme participates in mitochondria G3P shuttle, provides electrons for a respiratory chain, is a key enzyme for G3P synthesis, is one of key enzymes for connecting glycometabolism and lipid metabolism and has an important effect on lipid synthesis and energy metabolism in plants; and besides, the gene can remarkably increase the total fatty acid content of cells when utilized to convert yeast cells, plant cells and microalgae cells.

A use of a Lactobacillus reuteri GMNL-263 in decreasing blood lipid levels is disclosed. Lactobacillus reuteri GMNL-263 (accession No.: CCTCC M 209263) specifically inhibits gene expression related to pro-inflammatory factor and lipid synthesis and promotes gene expression related to cholesterol metabolism. Lactobacillus reuteri GMNL-263 is utilized to produce a composition for decreasing blood lipid levels, thereby achieving the aim of hyperlipidemia treatment.

The invention relates to application of a hibiscus sabdariffa-green tea composition in relieving diet-induced metabolic disorders, and particularly provides an aqueous extract and a composition with the same. The aqueous extract is the aqueous extract of the mixture of hibiscus sabdariffa flower and green tea or is the mixture of a hibiscus sabdariffa aqueous extract and a green tea aqueous extract. It is found that the hibiscus sabdariffa aqueous extract and the green tea aqueous extract can remarkably relieve weight increment of the body and epididymis fat of a mouse induced by high-fat and high-sugar diet, lower blood glucose and blood fat, improve mouse liver fat deposition and increase insulin sensitivity, while has no obvious influence on the food intake and water intake of the mouse. It is also found that the hibiscus sabdariffa-longjing tea composition extracting solution can lower fatty liver by increasing liver fatty acid oxidation and lowering lipid synthesis; in addition, insulin resistance can be lowered in the way of restraining mTORC1 / S6K.

Phototropin is a blue light receptor, which mediates a variety of blue-light elicited physiological processes in plants and algae. In higher plants these processes include phototropism, chloroplast movement and stomatal opening. In the green alga Chlamydomonas reinhardtii, phototropin plays a vital role in progression of the sexual life cycle and in the control of the eye spot size and light sensitivity Phototropin is also involved in blue-light mediated changes in the synthesis of chlorophylls, carotenoids, chlorophyll binding proteins. We compared the transcriptome of phototropin knock out (PHOT KO) mutant and wild-type parent to analyze differences in gene expression in high light grown cultures (500 μmol photons m−2 s−1). Our results indicate the up-regulation of genes involved in photosynthetic electron transport chain, carbon fixation pathway, starch, lipid, and cell cycle control genes. With respect to photosynthetic electron transport genes, genes encoding proteins of the cytochrome b6f and ATP synthase complex were up regulated potentially facilitating proton-coupled electron transfer. In addition genes involved in limiting steps in the Calvin cycle Ribulose-1,5-bisphosphate carboxylase / oxygenase (RuBisCO), Sidoheptulose 1,7 bisphosphatase (SBPase), Glyceraldehyde-3-phosphate dehydrogenase (3PGDH) and that mediate cell-cycle control (CDK) were also up regulated along with starch synthase and fatty acid biosynthesis genes involved in starch and lipid synthesis. In addition, transmission electron micrographs show increased accumulation of starch granules in PHOT mutant compared to wild type, which is consistent with the higher expression of starch synthase genes. Collectively, the altered patterns of gene expression in the PHOT mutants were associated with a two-fold increase in growth and biomass accumulation compared to wild type when grown in environmental photobioreactors (Phenometrics) that simulate a pond environment. In conclusion, our studies suggest that phototropin may be a master gene regulator that suppresses rapid cell growth and promotes gametogenesis and sexual recombination in wild type strains.

The invention relates to application of noremin in preparation of a drug for ameliorating liver injury caused by cholestasis and metabolic diseases, and belongs to the technical field of drug preparation. According to the application of the nometin in preparation of the drug for ameliorating the liver injury caused by the echolestasis and the metabolic diseases, the noremin can achieve an obviousamelioration effect on the liver injury by improving bile acid metabolism, anti-inflammatory and anti-oxidative stress, reducing lipid synthesis and the like.

The invention discloses composition with a blood lipid lowering effect. The composition is prepared from the following raw materials in parts by weight: 5-30 parts of herba cistanche, 1-20 parts of tartary buckwheat, 1-20 parts of green tea, 1-20 parts of lotus leaves and 0.2-15 parts of dark plum. The invention further discloses an application of the composition in preparation of medicines or health food with the blood lipid lowering effect. The composition is prepared from the herba cistanche, the tartary buckwheat, the green tea, the lotus leaves and the dark plum, all the five raw materials belong to traditional medicinal and edible materials, and are safe and secure to eat; the herba cistanche as the monarch drug, the tartary buckwheat, the green tea and the lotus leaves as the minister drugs and the dark plum as the adjuvant drug are complementary to one another, and accordingly, scientific compatibility of the monarch, the minister and the adjuvant is realized, effective components with the blood lipid lowering effect such as flavone, polyphenol, active polysaccharide, alkaloid and the like in the five raw materials are effectively enriched, and the synergistic blood lipid lowering effect is achieved by inhibiting exogenous lipid absorption, inhibiting endogenous lipid synthesis, promoting lipid transport and excretion and regulating lipid metabolism.

The present disclosure is directed to the treatment of diseases or conditions characterized by the buildup of fatty tissue, or hyperphagia, such as Prader-Willi syndrome, obesity, metabolic syndrome, type II diabetes, etc. A composition containing a monoclonal antibody directed against gastric inhibitory polypeptide is administered. This results in a reduced rate of weight gain, weight loss, and / or reduction in fatty tissue, and a marked decrease in lipid synthesis and accumulation.

Compounds that are fatty acid synthesis modulators are provided. The compounds may be used to treat disorders characterized by disregulation of the fatty acid synthase function by modulating the function and / or the fatty acid synthase pathway. Methods are provided for treating such disorders including viral infections, such as hepatitis C infection, cancer and metabolic disorders, such as non-alcoholic steatohepatitis (NASH).

The invention discloses a semen cassiae composition with an auxiliary effect of lowering blood lipid. The semen cassiae composition is prepared by carrying out mixed fermentation for two times on thefollowing raw materials in parts by weight: 20 to 50 parts of semen cassiae, 10 to 50 parts of fructus crataegi, 10 to 50 parts of soybean and 10 to 50 parts of rice. The two times of mixed fermentations refer to that the semen cassiae, the fructus crataegi and the soybean are inoculated into bacillus natto according to formula proportions for fermentation, wherein the inoculation amount of the bacillus natto is 8 to 16 percent; the rice and monascus are added into an obtained fermented product for secondary mixed fermentation, wherein the adding amount of the monascus, counted by the weight of the rice, is 5 to 15 percent; finally, the product is obtained. The active components in the semen cassiae composition disclosed by the invention have an obvious synergistic effect, so as to realizepositive and obvious effects of lowering blood lipid on the aspects of reducing endogenous lipid synthesis, promoting the transportation and excretion of the lipid, regulating lipid metabolism and the like; the semen cassiae composition is proved to be safe, non-toxic and harmless by a safety toxicological test.

The invention discloses applications of 18beta-glycyrrhetinic acid taken as a conditioning agent for reduce lipid synthesis and / or the conditioning agent for reducing very low density lipoprotein formation and secretion in drugs. A drug containing the 18beta-glycyrrhetinic acid with effective doses is disclosed; the 18beta-glycyrrhetinic acid can be taken as a conditioning agent of HNF4alpha and can lower the expression of APOB, MTP and PLA2G12B; and a method for inhibiting the expression of FASN, SCD-1 and ACAC[alpha] is also disclosed. The 18beta-glycyrrhetinic acid can inhibit the expression of lipid metabolism related genes, so that lipid synthesis and the formation and secretion of very low density lipoprotein can be inhibited, lipid content in the liver can be lowered, the fatty degree of the liver can be reduced, liver functions can be obviously improved, blood fat can be reduced, and the effects of preventing and / or treating diseases related to abnormal lipid metabolism can befinally achieved. In addition, as the 18beta-glycyrrhetinic acid is a natural substance, the 18beta-glycyrrhetinic acid is good in curative effect and small in toxic and side effect.

The present invention is related to a composition comprising a serine as an active ingredient for treating or preventing fatty liver diseases. The inventive compound significantly inhibits the SREBP-1 transcription activity involved in lipid synthesis and reduced the fatty liver formation through various in vitro test and in vivo test therefore it can be useful in the prevention and treatment of the fatty liver diseases as a medicament or health functional food.