44results about How to "To achieve the purpose of sustained and controlled release" patented technology

The invention discloses a cyclodextrin inclusion compound of 3,5-dyhydroxyl-4-isopropyl toluylene and a preparation method thereof. In the invention, by adopting cyclodextrin to wrapping a medicine, the solubility and the dissolution of the medicine are increased, the stability and the bioavailability of the medicine are improved, and the aim of slowly-controlled release of the medicine can be simultaneously achieved. The invention also provides the preparation method of the cyclodextrin inclusion compound of the 3,5-dyhydroxyl-4-isopropyl toluylene, which is simple in operation, safe and convenient, and high in production efficiency; and the prepared inclusion compound can be used as a slow-release and targeting preparation and provides a new dosage form for medicine production.

The invention discloses a high-specific surface silkworm excrement-porous carbon-MOFs composite material prepared through an impregnation method and a preparation method and application thereof. The preparation method comprises the steps that firstly, silkworm excrement and water are subjected to mixing swelling and then freeze-dried; secondly, the freeze-dried silkworm excrement is subjected to a carbonization chambering reaction in protection gas, and then cleaning, centrifuging and drying are conducted to obtain a silkworm excrement-based porous carbon material; thirdly, a metal salt solution and the material are stirred, mixed, centrifuged and dried, and high-dispersion metal oxides are formed on the surface of the silkworm excrement-based porous carbon material by introducing oxygen under the plasma modification conditions; fourthly, MOFs grow on the surface of the silkworm excrement-based carbon material by taking the high-dispersion metal oxides as precursors through a microwave radiation method; lastly, suction filtration and drying are conducted, and the high-specific surface silkworm excrement-porous carbon-MOFs composite material prepared through the impregnation method is obtained. The material can be applied to sustained or controlled release of pesticides. The composite carbon material obtained through the method has the high specific surface and carboxy groups and can achieve the high adsorption capacity and the good sustained or controlled release effect on the pesticides.

The invention discloses a melamine silkworm excrement composite carbon material, a preparation method and an application thereof. The method comprises the following steps: mixing and swelling silkworm excrement and water, then freeze-drying the mixture and then preparing the freeze-dried silkworm excrement into carbonized silkworm excrement under protective gas; adding water into melamine powder and the carbonized silkworm excrement, allowing the mixture to stand and then drying the mixture, introducing N2 to prepare a plasma modified melamine silkworm excrement composite carbon material; mixing the composite material crude product with ZnCl2, performing an activating and expanding reaction under protective gas, then cleaning, centrifuging and drying the reaction product to obtain the melamine silkworm excrement composite carbon material. The material can be applied to the field of sustained and controlled release of pesticides. The graft compounding is performed on the melamine and the silkworm excrement by utilizing plasma modification, the grafting composite reaction speed of the two materials is greatly improved, the obtained composite carbon material has a relatively high specific surface area and N-containing polar group, and the melamine silkworm excrement composite carbon material has relatively high adsorption capacity and good sustained and controlled release effects on the pesticide.

The invention relates to a method for improving the anti-aging performance of film-controlled sustained-release pellets coated with water dispersion, in particular to a method for improving the film-controlled slow-release pellets coated with water dispersion by adopting high-swellability pellet cores. A method for releasing the anti-aging properties of pellets, the core of which contains high expansibility auxiliary materials. The method can be used to prepare film-controlled slow-release micropills that can maintain stable release performance within the validity period of the drug without being limited by storage time. The invention also provides the use of the polymer swelling agent for improving the anti-aging performance of the film-controlled sustained-release pellets coated with the water dispersion. In addition, the invention provides a film-controlled sustained-release pellet coated with an anti-aging performance, and the pellet core is an expandable pellet core containing a polymer expander.

The invention discloses a preparation method of a latticed microporous film formed by macromolecule crosslinking. Dimethyl sulfoxide is used a solvent, polyvinyl alcohol is used as film forming agent, a thermoplastic polyurethane elastomer is used as a flexibilizer, and a formaldehyde solution is used as a crosslinking agent. The solvent is added into the film forming agent and the flexibilizer thermoplastic polyurethane elastomer for backflow dissolving, then the formaldehyde solution is added for crosslinking to obtain a film casting solution; the film casting solution is cooled, heated, taken out and naturally cooled to room temperature, standing is performed for removing bubbles, film wiping is performed on a glass plate, and the film is placed in a cold water coagulating bath to be coagulated. According to the microporous film, the large pore diameter is 5 micrometers, the small pore diameter is 0.5-2 micrometers, a communication pore structure is formed inside, micropores is distributed in a concentrated mode, the number of pores is large, and the pores are evenly distributed on the surface of the film. The elongation at break of the microporous film reaches 400%, and the strength of the microporous film reaches 1400 Kpa. The polyvinyl alcohol is crosslinked to the polyurethane to prepare the latticed microporous film, the high-strength toughness of the polyurethane is reserved, the latticed micropores are formed along with increasing of the adding amount of the polyvinyl alcohol, and medicine release can be effectively controlled.

The present invention discloses a galanthamine hydrobromide composition and its preparation method. It is characterized by that said composition includes sulfoacid cation exchange resin and galanthamine hydrobromide, and their weight ratio is 2:0.05-1. Said composition can be made into oral preparation and can attain the goal of slowly-controlled release.

The invention discloses a dopamine silkworm sand composite carbon material and preparation method and application thereof. The preparation method comprises the steps of mixing silkworm sand with water to make the mixture swell, then cooling and drying, preparing the cooled and dried silkworm sand into carbonized silkworm sand under protection gas, mixing dopamine hydrochloride powder and carbonized silkworm sand with water to regulate the solution pH level to be alkaline, keeping in static condition and drying, preparing plasma modified dopamine silkworm sand composite carbon material through O2, mixing the crude composite material with ZnCl2, conducting the activation and cavity expansion reaction, washing, centrifuging and drying to acquire the dopamine silkworm sand composite carbon material. The material can be used to pesticide controlled release. The material uses plasma modification to graft dopamine Hydrochloride with silkworm sand, and greatly enhances the grafting reaction speed of both materials. The acquired composite carbon material enjoys high specific surface area and N polar groups, and can exert a high absorption quantity and a good controlled releasing function to pesticides.

Disclosed is a surfacely modified hydrophobic Chitosan oligosaccharide polymer drug-loaded colloidal cluster, obtained by grafting chitosan with a average molecular weight of 1.5kD-51kD and aliphatic acid of C10-C22, comprising based on hydrophobic modified Chitosan oligosaccharide polimer colloidal clusters, modifying amidogens or hydroxy groups of Chitosan oligosaccharide molecules on polimer surface with bi-functional small organic moleculers, forming chemical bond bridges between molecules on the surfaces of polymer colloidal clusters,to improve the instability of polymer colloidal cluster diluted, and to imorove the original loose structure of polimer colloidal cluster surfece to form a fine and close net-shaped structure, to decrease a sudden release of drugs, and to control drugs with slow release. The drug-loaded colloidal cluster provided is a nano-carrier with excellent organelle targeting, is applicated in life science field and pharmacy field.

The invention discloses an alkaline oxide surface modifying silkworm excrement based hierarchical pore carbon material and a preparation method and application thereof. the preparation method includes: mixing silkworm excrement with ZnCl2 solution for swelling, and lyophilizing; enabling the silkworm excrement to be in activation chambering reaction in protection gas after lyophilizing; washing, centrifuging, and drying to obtain a silkworm excrement based hierarchical pore carbon material; stirring and mixing a metal salt solution with the material, centrifuging, drying, and feeding oxygen to prepare a plasma modified alkaline oxide surface modifying silkworm excrement based hierarchical pore carbon material. The material can be applied in the aspect of pesticide controlled-release. A protection gas condition is utilized to activate the silkworm excrement at high temperature, and alkaline oxide surface modifying is performed on the material through an impregnation method and a plasma modifying mode, so that the carbon material has large specific surface area and alkaline adsorption site and can have high adsorption capacity and good controlled-release effect on pesticide.

The invention discloses a naringin controlled release capsule and a preparation method thereof. Substances contained in the capsule are composed of one part of a quick release drug core and two parts of a slow release drug core; the quick release drug core is mainly prepared from naringin and a quick disintegration agent, and the slow release drug core is prepared from naringin and a hydrophilic gel slow release framework material; each part of the quick release drug core or the slow release drug core contains 1 / 3 the total mass of the naringin. The two types of drug cores are encapsulated according to the ratio of 1: 2, and the capsule is obtained. Compared with the prior art, the capsule is quick in effect onset, the blood concentration is maintained to be effective, stable and durable, and the side effect can be lowered; the production method is simple and applicable to large-scale industrial production.

The invention discloses high-specific-surface-area N-doped surface-modified silkworm excrement-based microporous carbon material and a preparation method and application thereof; silkworm excrement and water are mixed and swelled and then lyophilized, the lyophilized silkworm excrement is then prepared into carbonized silkworm excrement under a protective gas, the carbonized silkworm excrement is then mixed with KOH, mixture is subjected to activation and pore-enlarging reaction in the protective gas and is then washed, centrifuged and dried to obtain the high-specific-surface-area silkworm excrement-based microporous carbon material, and N2 atmosphere is then introduced into a plasma reactor to prepare the high-specific-surface-area N-doped surface-modified silkworm excrement-based microporous carbon material; the material is applicable to pesticide release control; silkworm excrement is carbonized and activated at high temperature in the protective gas, the material is subjected to N-doped surface modification by means of plasma modification, and the obtained carbon material has high specific surface area and controllable N-containing polar groups and has high adsorbing capacity and good release control effect for pesticides.

The invention discloses an oxygen-doped surface modification silkworm excrement based hierarchical pore carbon material and a preparation method and application thereof. The preparation method comprises the following steps: firstly carrying out freeze drying after mixed swelling of silkworm excrement and a ZnCl2 solution, then carrying out an excitation chambering reaction on the silkworm excrement after freeze drying in protective gas, then obtaining a silkworm excrement based hierarchical pore carbon material after cleaning, centrifuging and drying, and then introducing an oxygen gas atmosphere in a plasma reactor to prepare the oxygen-doped surface modification silkworm excrement based hierarchical pore carbon material; and the material can be applied to the aspect of pesticide controlled release. The condition of the protective gas is used for carrying out activating treatment on the silkworm excrement under high temperature, and then oxygen-doped surface modification is carried out on the material through a plastic modification manner, so that the obtained carbon material has relatively high specific surface area and controllable oxygen-containing polar groups and has relatively high adsorption capacity and relatively good controlled release effect for pesticides.

The invention discloses a high surface area melamine and silkworm dropping composite carbon material and a preparation method and application thereof. Under shielding gas, original silkworm dropping is prepared into carbonized silkworm dropping; melamine powder and the carbonized silkworm dropping are mixed, ZnCl2 solution is added to the mixture, and the mixture is placed on a high-speed mechanical ball mill to undergo oscillation activation grafting reaction to obtain melamine / ZnCl2 / silkworm dropping slurry, the slurry is dried to obtain a crude composite material; the crude composite material undergoes activation reaming reaction under the shielding gas and undergoes cleaning, centrifugation and drying to obtain the high surface area melamine and silkworm dropping composite carbon material. The material is applied to the aspect of sustained or controlled release of pesticides. High-speed mechanical oscillation is utilized to perform grafting composition on melamine and the silkworm dropping and perform activator ZnCl2 mixing and preliminary activation, the grafting composite reaction speed of the two materials and the dispersity of the activator on the surface of the silkworm dropping composite material are improved, and the obtained composite carbon material has high surface area, contains N-polarity groups, and has high pesticide adsorption capacity and good sustained or controlled release effects.

The invention discloses a graphene coated silkworm excrement porous carbon composite material and a preparation method and application thereof. The preparation method comprises the following steps: mixing and swelling silkworm excrements and ZnCl2 solution, and performing freeze drying; carrying out an activating and pore enlarging reaction on the freeze-dried silkworm excrements in protective gases; cleaning, centrifuging and drying, thereby obtaining a silkworm excrement based porous carbon material; mixing graphene oxide solution with the silkworm excrement based porous carbon material, and performing centrifugal drying, thereby obtaining a graphene oxide coated silkworm excrement based porous carbon material; and adding the material into a plasma reactor, and introducing into an H2 atmosphere, thereby obtaining the graphene coated silkworm excrement porous carbon composite material. The material can be applied to aspect of pesticide sustained release. The material disclosed by the invention has high specific surface area and a graphene coated core-shell structure, and can achieve high adsorption capacity and excellent sustained-release effects on pesticides.