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44results about How to "To achieve the purpose of sustained and controlled release" patented technology
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Chitosan coating medicine slow release microsphere and preparation method thereof
InactiveCN101618021AGood biocompatibilityLow toxicityHydroxy compound active ingredientsDigestive systemChitosan coatingAlcohol
The invention discloses a chitosan coating medicine slow release microsphere and a preparation method thereof. The chitosan coating medicine slow release microsphere comprises a condensate capsule shell of chitosan and glutaric dialdehyde, core medicine resveratrol, oxidative resveratrol, pterostilbene or white cedar alcohol, wherein the core medicine resveratrol, the oxidative resveratrol, the pterostilbene or the white cedar alcohol are coated into the capsule shell. The preparation method is simple and easy, the preparation cost is low, the microsphere envelop rate is 10-50 percent, the microsphere is round and has good dispersivity, the stability of the original medicine is increased, and the chitosan coating medicine slow release microsphere realizes the function of medicine slow control and release and can be conveniently matched with other medicines. The chitosan coating medicine slow release microsphere is suitable for preparing a slow release formulation of medical resveratrol, oxidative resveratrol, pterostilbene and white cedar alcohol.
Owner:HEBEI UNIVERSITY OF SCIENCE AND TECHNOLOGY
Sustained/controlled release microsphere of biological extract Genipin cross-linked chitosan coated stilbene compound and preparation method thereof
InactiveCN102240268ALow toxicityUniform qualityAntimycoticsHydroxy compound active ingredientsCross-linkMicrosphere
The invention discloses a sustained / controlled release microsphere of a chitosan coated stilbene compound using a biological extract Genipin as a cross-linking agent and a preparation method thereof. In the microsphere, a cross-linked condensation compound layer of the chitosan and the Genipin serves as a capsule shell and is used for coating a medicament 3,5-dihydroxyl-4-isopropyl stilbene, resveratrol, pterostilbene, oxidized resveratrol or piceatannol; the medicament stability of the product is improved; the sustained / controlled release of the medicament is realized; and the released Genipin after in vivo metabolism of the capsule shell has the characteristics of biocompatibility, no cytotoxicity and the like. The invention is applicable to the sustained / controlled release microspheresof Genipin cross-linked chitosan coated 3,5-dihydroxyl-4-isopropyl stilbene, resveratrol, pterostilbene, oxidized resveratrol, piceatannol and other stilbene compounds and a preparation method thereof. The preparation method is low in requirements on the control condition and easy to operate. In the microspheres, the quality is uniform; the grain size is 0.1 to 100 mu m; the surface of the microsphere has a multiporous structure; and the entrapment rate of the capsule shell to the medicament is 30 to 90 percent.
Owner:HEBEI UNIVERSITY OF SCIENCE AND TECHNOLOGY
Production method of spraying sulfoacid resin type sustained and controlled-release fertilizer
InactiveCN102417426ASimple production processReduce manufacturing costFertiliser formsFertilizer mixturesControl releasePolyvinyl alcohol
The invention discloses a production method of a spraying sulfoacid resin type sustained and controlled release fertilizer, comprising the following steps: 1, putting a granular fertilizer in a granulation device for preheating; 2, putting urea in a fusion device for fusing, when urea is completely fused, adding sulphur powder, polyvinyl alcohol and cinnamic acid ester in the fused urea, uniformly stirring, then filtering to obtain a fused urea resin sulphur liquid with uniform quality, allowing the preheated granular fertilizer to form a material curtain in the granulation device, and uniformly spraying the fused urea resin sulphur liquid on the surfaces of the fertilizer particles; 3, carrying out cooling on the sprayed fertilizer in a cooling device; and 4, adding a conditioner in the particle cooling device. The prepared fertilizer disclosed herein can achieve the sustained and controlled-release purpose of the fertilizer, and can thoroughly solve the problem of secondary pollution to soil from the traditional coated sustained and controlled-release fertilizers. In addition, the production method has the advantages of simple process and low production cost, and can be used forforming large scale production.
Owner:河北凯龙肥料有限公司
Galanthamine hydrobromide compound as well as preparation method and medicine compositions thereof
ActiveCN104177368AHigh chemical purityImprove stabilityNervous disorderOrganic chemistryPharmaceutical drugCombinatorial chemistry
The invention discloses a galanthamine hydrobromide compound as well as a preparation method and medicine compositions thereof. The galanthamine hydrobromide compound disclosed by the invention has the advantages of high chemical purity and good stability, wherein the maximum content of single impurity is below 0.1%; and the stability to light and heat is particularly good. The medicine compositions of the galanthamine hydrobromide compound, prepared by adopting special auxiliary materials, have the following more obvious advantages of being good in stability, easy to implement and remarkable in economic benefit, meeting the clinical needs, reducing the production cost and realizing the industrialization.
Owner:天津梅花生物医药科技有限公司
High-specific-surface-area N-doped surface-modified silkworm excrement-based microporous carbon material and preparation method and application thereof
ActiveCN106311143ALarge specific surface areaControllable N-containing polar groupsBiocideOther chemical processesShielding gasBiological activation
The invention discloses high-specific-surface-area N-doped surface-modified silkworm excrement-based microporous carbon material and a preparation method and application thereof; silkworm excrement and water are mixed and swelled and then lyophilized, the lyophilized silkworm excrement is then prepared into carbonized silkworm excrement under a protective gas, the carbonized silkworm excrement is then mixed with KOH, mixture is subjected to activation and pore-enlarging reaction in the protective gas and is then washed, centrifuged and dried to obtain the high-specific-surface-area silkworm excrement-based microporous carbon material, and N2 atmosphere is then introduced into a plasma reactor to prepare the high-specific-surface-area N-doped surface-modified silkworm excrement-based microporous carbon material; the material is applicable to pesticide release control; silkworm excrement is carbonized and activated at high temperature in the protective gas, the material is subjected to N-doped surface modification by means of plasma modification, and the obtained carbon material has high specific surface area and controllable N-containing polar groups and has high adsorbing capacity and good release control effect for pesticides.
Owner:GUANGXI UNIV
Silkworm excrement porous carbon MOFs composite material with high specific surface and preparation method and application thereof
ActiveCN106423071AEfficient modificationModified environmental protectionBiocideOther chemical processesMicrowave radiometryControlled release
The invention discloses a silkworm excrement porous carbon MOFs composite material with a high specific surface and a preparation method and application thereof. First, silkworm excrement and a ZnCl2 solution are mixed and swelled and then frozen and dried; then the frozen and dried silkworm excrement is subjected to an active pore expanding reaction, cleaned, centrifuged and dried to obtain a silkworm excrement-based multi-stage pore carbon material; next, a metal salt solution and the material are stirred and mixed and then centrifuged and dried; under the condition of plasma modification, oxygen is injected to form a high-dispersion metal oxide on the surface of the silkworm excrement-based multi-stage pore carbon material, then through a microwave irradiation method, MOFs are grown on the surface of the silkworm excrement-based carbon material with the high-dispersion metal oxide being a precursor, and finally the silkworm excrement porous carbon MOFs composite material with the high specific surface is obtained after suction filtration and drying. The material can be applied to pesticide slow controlled release. The obtained composite carbon material has the high specific surface and carboxyl groups, and can achieve the effects of high adsorption capacity and good slow controlled release.
Owner:GUANGXI UNIV
High-specific-surface-area basic oxide surface-modified silkworm faeces-based microporous carbon material and preparation method and application thereof
ActiveCN106179229AHigh adsorption capacityIncreased generation reaction speedOther chemical processesAlkali metal oxides/hydroxidesPesticideChemistry
The invention discloses a high-specific-surface-area basic oxide surface-modified silkworm faeces-based microporous carbon material and a preparation method and application thereof. The preparation method comprises the following steps: mixing and swelling silkworm faeces and water to obtain a mixture, performing freeze drying on the mixture, and preparing carbonized silkworm faeces from the freeze-dried silkworm faeces under protection gas; mixing the carbonized silkworm faeces with KOH, performing activating and reaming reaction in the protection gas, and then performing cleaning, centrifugation and drying to obtain a high-specific-surface-area silkworm faeces-based microporous carbon material; stirring and mixing a metal salt solution with the material, performing centrifugation and drying, and feeding oxygen to prepare a plasma modified basic oxide surface-modified silkworm faeces-based microporous carbon material. The material is applied to the aspect of controlled release of pesticides. According to the preparation method, the silkworm faeces can be carbonized and activated at high temperature under the condition of the protection gas, and basic oxide surface modification is carried out by a soaking method and a plasma modification mode, so that the obtained carbon material is higher in specific surface area and alkaline adsorption site, and has higher adsorption capacity for the pesticides and a better controlled release effect of the pesticides.
Owner:GUANGXI UNIV
Controlled-release early-strength composite material, preparation method and application thereof in cement-based material
ActiveCN114685090ASolve the problem of direct dissolution in waterImprove early strengthSolid waste managementInorganic saltsControlled release
The invention belongs to the technical field of building material additives, and particularly discloses a sustained-release early-strength composite material and a preparation method thereof. A method combining an anti-solvent method and a sol-gel method is designed, the problem that inorganic salt is directly dissolved when meeting water is solved through chemical coating, and the inorganic salt is coated with a porous nano packaging material, so that the purpose of sustained and controlled release is achieved, and the sustained and controlled release early strength composite material is obtained. When the early-strength composite material is applied to a cement-based material which is a cement liquid phase environment, the early-strength composite material can release inorganic salt in a cement hydration acceleration period along with the improvement of the alkalinity of the cement liquid phase, the hydration process is regulated and controlled in an ion form, the formation of hydration products is promoted, the early strength of the cement-based material is improved, and the purpose of early strength is achieved. The sustained and controlled release characteristic of the early-strength composite material ensures that the released inorganic salt does not adsorb or wrap a workability adjusting product, so that the workability and durability of a cement-based material are not influenced.
Owner:BOTE NEW MATERIALS TAIZHOU JIANGYAN CO LTD +2
Graphene silkworm excrement microporous carbon core-shell composite material as well as preparation and application thereof
ActiveCN106622122AEfficient modificationModified environmental protectionBiocideOther chemical processesControlled releaseMetallurgy
The invention discloses a graphene silkworm excrement microporous carbon core-shell composite material as well as a preparation and an application thereof. Silkworm excrement and water are mixed and swelled, freeze drying is carried out, and after freeze-drying, the silkworm excrement is prepared into carbonized silkworm excrement with shielding gas; the carbonized silkworm excrement and KOH are mixed, activation and hole enlarging reaction is carried out with shielding gas, an oxidized graphene solution and a silkworm excrement based microporous carbon material are mixed, and centrifugation and drying are carried out in order to obtain an oxidized graphene silkworm excrement microporous carbon core-shell composite material; the material is placed in a plasma reactor, H2 atmosphere is introduced, and the graphene silkworm excrement microporous carbon core-shell composite material is prepared. The material can be applied to the aspect of sustained and controlled release of pesticide. The material has a high specific surface area and a core-shell structure covered by graphene, and has high adsorption capacity and good sustained and controlled release effects for pesticide.
Owner:GUANGXI UNIV
N-doping surface modification silkworm excrement-based multi-stage hole carbon material and preparation method and application thereof
ActiveCN106477547AAchieve slow and controlled releaseControl adsorption capacityBiocideCarbon preparation/purificationControlled releaseFreeze-drying
The invention discloses an N-doping surface modification silkworm excrement-based multi-stage hole carbon material and a preparation method and application thereof. Firstly, silkworm excrement and ZnCl2 solution are subjected to mixed swelling; then, freeze drying is performed; the silkworm excrement subjected to freeze drying is subjected to activation hole expansion reaction in protection gas; next, cleaning, centrifugation and drying are performed to obtain a silkworm excrement-based microporous carbon material; next, N2 gas is introduced for preparing the N-doping surface modification silkworm excrement-based multi-stage hole carbon material in a plasma reactor; the material can be applied to the aspect of pesticide slow and controlled release. The protection gas condition is used for performing activation treatment at high temperature; then, by using a plasma modification mode, the material is subjected to N-doping surface modification, the obtained carbon material has high specific surface area and controllable N polar groups; high adsorption volume and good slow and controlled release effects are achieved.
Owner:GUANGXI UNIV
Slow-release traditional Chinese medicine package for coarse salt hot compress and preparation method thereof
InactiveCN108272929AIncrease usageTo achieve the purpose of sustained and controlled releaseAntipyreticAnalgesicsAngelica Sinensis RootTherapeutic effect
The invention discloses a slow-release traditional Chinese medicine package for coarse salt hot compress and a preparation method thereof. The slow-release traditional Chinese medicine package comprises folium artemisiae argyi, flowers carthami, angelica sinensis, lycopodium clavatum, rhizoma acori graminei, mastic, dandelion and beta cyclodextrin. In the components of the slow-release traditionalChinese medicine package, the folium artemisiae argyi and the lycopodium clavatum have therapeutic effects of eliminating cold to stop pain, relaxing tendons and activating collaterals; the flowers carthami, the angelica sinensis and the rhizoma acori graminei have the effects of activating blood, removing stasis, nourishing the blood and promoting blood circulation; the mastic and the dandelioncan achieve obvious therapeutic effects of clearing away heat and toxic materials, diminishing inflammation and relieving pain; the beta cyclodextrin can form an inclusion complex together with guestmolecules matched with the size of a cavity, so as to improve the stability of the guest modules; and when the beta cyclodextrin and the traditional Chinese medicines are mixed, effective components in the traditional Chinese medicines can be adsorbed, so that in a heating process, the slow release cycle of the medicines is greatly prolonged to fulfill the aim of slow and controlled release of themedicines to achieve a long-acting medicine effect, and the number of times of use of the slow-release traditional Chinese medicine package is effectively increased.
Owner:可孚医疗科技股份有限公司
Silkworm excrement porous carbon MOFs composite material, preparation method thereof and application
ActiveCN106614552AEfficient modificationModified environmental protectionBiocideOther chemical processesCarboxyl radicalPorous carbon
The invention discloses a silkworm excrement porous carbon MOFs composite material, a preparation method thereof and an application. The preparation method includes steps of freeze-drying silkworm excrement with ZnCl2 solution after being mixed and swelled; and then performing activated chambering reaction on the freeze-dried silkworm excrement in a protection gas; and then cleaning, centrifuging and drying the silkworm excrement; and acquiring the silkworm excrement based porous carbon material; centrifuging and drying metal salt solution with material after being stirred and mixed; under the plasma modification condition, charging oxygen to the surface of the silkworm excrement based porous carbon material and forming a high-dispersing metal oxide; through a hydrothermal synthesis method, applying the high-dispersing metal oxide as a precursor; growing the MOFs on the surface of the silkworm excrement based carbon material; at last, filtering and drying the MOFs and acquiring the silkworm excrement porous carbon MOFs composite material. The composite carbon material is high in specific surface area and carboxyl radical, and has high absorption capacity and good controlled release effects for pesticide.
Owner:GUANGXI UNIV
Cyclodextrin inclusion compound of 3,5-dyhydroxyl-4-isopropyl toluylene and preparation method thereof
InactiveCN101721713BEasy to operateOperational securityAntimycoticsHydroxy compound active ingredientsControlled releaseSolubility
The invention discloses a cyclodextrin inclusion compound of 3,5-dyhydroxyl-4-isopropyl toluylene and a preparation method thereof. In the invention, by adopting cyclodextrin to wrapping a medicine, the solubility and the dissolution of the medicine are increased, the stability and the bioavailability of the medicine are improved, and the aim of slowly-controlled release of the medicine can be simultaneously achieved. The invention also provides the preparation method of the cyclodextrin inclusion compound of the 3,5-dyhydroxyl-4-isopropyl toluylene, which is simple in operation, safe and convenient, and high in production efficiency; and the prepared inclusion compound can be used as a slow-release and targeting preparation and provides a new dosage form for medicine production.
Owner:HEBEI UNIVERSITY OF SCIENCE AND TECHNOLOGY
High-specific-area O-doped surface-modified silkworm-excrement-based microporous carbon material as well as preparation method and application thereof
ActiveCN106417278AImprove adsorption capacityQuick responseBiocideOther chemical processesFreeze-dryingShielding gas
The invention discloses a high-specific-area O-doped surface-modified silkworm-excrement-based microporous carbon material as well as a preparation method and an application thereof. Firstly, silkworm excrement and water are mixed, swelled and freeze-dried, and carbonized silkworm excrement is prepared from the freeze-dried silkworm excrement in the protective gas; the carbonized silkworm excrement and KOH are mixed and subjected to an activation pore enlargement reaction in the protective gas, a high-specific-area silkworm-excrement-based microporous carbon material is obtained after washing, centrifugation and drying, and the high-specific-area O-doped surface-modified silkworm-excrement-based microporous carbon material is prepared in a plasma reactor in the oxygen atmosphere and can be applied to sustained or controlled release of pesticides. The silkworm excrement is carbonized and activated under the protective gas condition at the high temperature, O-doped surface modification is performed on the material in the plasma modification manner, and the obtained carbon material has the higher specific surface area and controllable O-containing polar groups and can have the higher adsorption capacity and the better sustained or controlled release effect on the pesticides.
Owner:GUANGXI UNIV
A kind of high specific surface impregnation method silkworm sand porous carbon mofs composite material and its preparation method and application
ActiveCN106362700BEfficient modificationModified environmental protectionOther chemical processesAlkali metal oxides/hydroxidesCarboxyl radicalPorous carbon
The invention discloses a high-specific surface silkworm excrement-porous carbon-MOFs composite material prepared through an impregnation method and a preparation method and application thereof. The preparation method comprises the steps that firstly, silkworm excrement and water are subjected to mixing swelling and then freeze-dried; secondly, the freeze-dried silkworm excrement is subjected to a carbonization chambering reaction in protection gas, and then cleaning, centrifuging and drying are conducted to obtain a silkworm excrement-based porous carbon material; thirdly, a metal salt solution and the material are stirred, mixed, centrifuged and dried, and high-dispersion metal oxides are formed on the surface of the silkworm excrement-based porous carbon material by introducing oxygen under the plasma modification conditions; fourthly, MOFs grow on the surface of the silkworm excrement-based carbon material by taking the high-dispersion metal oxides as precursors through a microwave radiation method; lastly, suction filtration and drying are conducted, and the high-specific surface silkworm excrement-porous carbon-MOFs composite material prepared through the impregnation method is obtained. The material can be applied to sustained or controlled release of pesticides. The composite carbon material obtained through the method has the high specific surface and carboxy groups and can achieve the high adsorption capacity and the good sustained or controlled release effect on the pesticides.
Owner:GUANGXI UNIV
A kind of melamine silkworm excrement composite carbon material and its preparation method and application
ActiveCN106423070BEfficient modificationModified environmental protectionBiocideOther chemical processesFreeze-dryingCarbonization
The invention discloses a melamine silkworm excrement composite carbon material, a preparation method and an application thereof. The method comprises the following steps: mixing and swelling silkworm excrement and water, then freeze-drying the mixture and then preparing the freeze-dried silkworm excrement into carbonized silkworm excrement under protective gas; adding water into melamine powder and the carbonized silkworm excrement, allowing the mixture to stand and then drying the mixture, introducing N2 to prepare a plasma modified melamine silkworm excrement composite carbon material; mixing the composite material crude product with ZnCl2, performing an activating and expanding reaction under protective gas, then cleaning, centrifuging and drying the reaction product to obtain the melamine silkworm excrement composite carbon material. The material can be applied to the field of sustained and controlled release of pesticides. The graft compounding is performed on the melamine and the silkworm excrement by utilizing plasma modification, the grafting composite reaction speed of the two materials is greatly improved, the obtained composite carbon material has a relatively high specific surface area and N-containing polar group, and the melamine silkworm excrement composite carbon material has relatively high adsorption capacity and good sustained and controlled release effects on the pesticide.
Owner:GUANGXI UNIV
Method for improving the anti-aging performance of film-controlled sustained-release pellets coated with aqueous dispersion
ActiveCN103006569BCompensation for permeability changesEliminates the effects of over-tighteningPharmaceutical non-active ingredientsGranular deliveryControl releasePresent method
The invention relates to a method for improving the anti-aging performance of film-controlled sustained-release pellets coated with water dispersion, in particular to a method for improving the film-controlled slow-release pellets coated with water dispersion by adopting high-swellability pellet cores. A method for releasing the anti-aging properties of pellets, the core of which contains high expansibility auxiliary materials. The method can be used to prepare film-controlled slow-release micropills that can maintain stable release performance within the validity period of the drug without being limited by storage time. The invention also provides the use of the polymer swelling agent for improving the anti-aging performance of the film-controlled sustained-release pellets coated with the water dispersion. In addition, the invention provides a film-controlled sustained-release pellet coated with an anti-aging performance, and the pellet core is an expandable pellet core containing a polymer expander.
Owner:北京天衡药物研究院有限公司
A kind of preparation method of grid-like microporous membrane formed by polymer cross-linking
InactiveCN105854623BHigh strengthImprove toughnessMembranesSemi-permeable membranesPolyvinyl alcoholSolvent
Owner:CHANGCHUN UNIV OF TECH
Galanthamine hydrobromide composition and its preparing method
ActiveCN100500156CAchieve sustained releaseTo achieve the purpose of sustained and controlled releaseNervous disorderSolution deliveryControlled releaseIon-exchange resin
Owner:SHANGHAI MODERN PHARMA ENG INVESTIGATION CENT
A kind of dopamine silkworm sand composite carbon material and its preparation method and application
ActiveCN106417279BEfficient modificationModified environmental protectionBiocideAnimal repellantsControlled releaseHigh absorption
The invention discloses a dopamine silkworm sand composite carbon material and preparation method and application thereof. The preparation method comprises the steps of mixing silkworm sand with water to make the mixture swell, then cooling and drying, preparing the cooled and dried silkworm sand into carbonized silkworm sand under protection gas, mixing dopamine hydrochloride powder and carbonized silkworm sand with water to regulate the solution pH level to be alkaline, keeping in static condition and drying, preparing plasma modified dopamine silkworm sand composite carbon material through O2, mixing the crude composite material with ZnCl2, conducting the activation and cavity expansion reaction, washing, centrifuging and drying to acquire the dopamine silkworm sand composite carbon material. The material can be used to pesticide controlled release. The material uses plasma modification to graft dopamine Hydrochloride with silkworm sand, and greatly enhances the grafting reaction speed of both materials. The acquired composite carbon material enjoys high specific surface area and N polar groups, and can exert a high absorption quantity and a good controlled releasing function to pesticides.
Owner:GUANGXI UNIV
Surface-modified hydrophobically modified drug-carried chitosan polymer micelle and method for preparing same
InactiveCN100417417CGood curative effectImprove instabilityPowder deliveryPharmaceutical non-active ingredientsPolymeric surfaceNanocarriers
Disclosed is a surfacely modified hydrophobic Chitosan oligosaccharide polymer drug-loaded colloidal cluster, obtained by grafting chitosan with a average molecular weight of 1.5kD-51kD and aliphatic acid of C10-C22, comprising based on hydrophobic modified Chitosan oligosaccharide polimer colloidal clusters, modifying amidogens or hydroxy groups of Chitosan oligosaccharide molecules on polimer surface with bi-functional small organic moleculers, forming chemical bond bridges between molecules on the surfaces of polymer colloidal clusters,to improve the instability of polymer colloidal cluster diluted, and to imorove the original loose structure of polimer colloidal cluster surfece to form a fine and close net-shaped structure, to decrease a sudden release of drugs, and to control drugs with slow release. The drug-loaded colloidal cluster provided is a nano-carrier with excellent organelle targeting, is applicated in life science field and pharmacy field.
Owner:ZHEJIANG UNIV
A kind of alkaline oxide surface modified silkworm excrement based hierarchical porous carbon material and its preparation method and application
ActiveCN106311141BEfficient modificationModified environmental protectionBiocideOther chemical processesControl releaseShielding gas
The invention discloses an alkaline oxide surface modifying silkworm excrement based hierarchical pore carbon material and a preparation method and application thereof. the preparation method includes: mixing silkworm excrement with ZnCl2 solution for swelling, and lyophilizing; enabling the silkworm excrement to be in activation chambering reaction in protection gas after lyophilizing; washing, centrifuging, and drying to obtain a silkworm excrement based hierarchical pore carbon material; stirring and mixing a metal salt solution with the material, centrifuging, drying, and feeding oxygen to prepare a plasma modified alkaline oxide surface modifying silkworm excrement based hierarchical pore carbon material. The material can be applied in the aspect of pesticide controlled-release. A protection gas condition is utilized to activate the silkworm excrement at high temperature, and alkaline oxide surface modifying is performed on the material through an impregnation method and a plasma modifying mode, so that the carbon material has large specific surface area and alkaline adsorption site and can have high adsorption capacity and good controlled-release effect on pesticide.
Owner:GUANGXI UNIV
A kind of naringin controlled-release capsule and its preparation method
ActiveCN105560207BQuick releaseTo achieve the purpose of sustained and controlled releaseOrganic active ingredientsPharmaceutical non-active ingredientsNaringinSide effect
The invention discloses a naringin controlled release capsule and a preparation method thereof. Substances contained in the capsule are composed of one part of a quick release drug core and two parts of a slow release drug core; the quick release drug core is mainly prepared from naringin and a quick disintegration agent, and the slow release drug core is prepared from naringin and a hydrophilic gel slow release framework material; each part of the quick release drug core or the slow release drug core contains 1 / 3 the total mass of the naringin. The two types of drug cores are encapsulated according to the ratio of 1: 2, and the capsule is obtained. Compared with the prior art, the capsule is quick in effect onset, the blood concentration is maintained to be effective, stable and durable, and the side effect can be lowered; the production method is simple and applicable to large-scale industrial production.
Owner:广州中天康顺生物医药有限公司
Sustained/controlled release microsphere of biological extract Genipin cross-linked chitosan coated stilbene compound and preparation method thereof
The invention discloses a sustained / controlled release microsphere of a chitosan coated stilbene compound using a biological extract Genipin as a cross-linking agent and a preparation method thereof. In the microsphere, a cross-linked condensation compound layer of the chitosan and the Genipin serves as a capsule shell and is used for coating a medicament 3,5-dihydroxyl-4-isopropyl stilbene, resveratrol, pterostilbene, oxidized resveratrol or piceatannol; the medicament stability of the product is improved; the sustained / controlled release of the medicament is realized; and the released Genipin after in vivo metabolism of the capsule shell has the characteristics of biocompatibility, no cytotoxicity and the like. The invention is applicable to the sustained / controlled release microspheresof Genipin cross-linked chitosan coated 3,5-dihydroxyl-4-isopropyl stilbene, resveratrol, pterostilbene, oxidized resveratrol, piceatannol and other stilbene compounds and a preparation method thereof. The preparation method is low in requirements on the control condition and easy to operate. In the microspheres, the quality is uniform; the grain size is 0.1 to 100 mu m; the surface of the microsphere has a multiporous structure; and the entrapment rate of the capsule shell to the medicament is 30 to 90 percent.
Owner:HEBEI UNIVERSITY OF SCIENCE AND TECHNOLOGY
A high specific surface n-doped surface-modified silkworm sand-based microporous carbon material and its preparation method and application
ActiveCN106311143BEfficient modificationModified environmental protectionBiocideOther chemical processesShielding gasBiological activation
The invention discloses high-specific-surface-area N-doped surface-modified silkworm excrement-based microporous carbon material and a preparation method and application thereof; silkworm excrement and water are mixed and swelled and then lyophilized, the lyophilized silkworm excrement is then prepared into carbonized silkworm excrement under a protective gas, the carbonized silkworm excrement is then mixed with KOH, mixture is subjected to activation and pore-enlarging reaction in the protective gas and is then washed, centrifuged and dried to obtain the high-specific-surface-area silkworm excrement-based microporous carbon material, and N2 atmosphere is then introduced into a plasma reactor to prepare the high-specific-surface-area N-doped surface-modified silkworm excrement-based microporous carbon material; the material is applicable to pesticide release control; silkworm excrement is carbonized and activated at high temperature in the protective gas, the material is subjected to N-doped surface modification by means of plasma modification, and the obtained carbon material has high specific surface area and controllable N-containing polar groups and has high adsorbing capacity and good release control effect for pesticides.
Owner:GUANGXI UNIV
A kind of O-doped surface-modified silkworm excrement-based hierarchical porous carbon material and its preparation method and application
ActiveCN106390926BEfficient modificationModified environmental protectionBiocideOther chemical processesFreeze-dryingShielding gas
Owner:GUANGXI UNIV
Preparation method of latticed microporous film formed by macromolecule crosslinking
InactiveCN105854623AHigh strengthImprove toughnessMembranesSemi-permeable membranesSolventGlass sheet
The invention discloses a preparation method of a latticed microporous film formed by macromolecule crosslinking. Dimethyl sulfoxide is used a solvent, polyvinyl alcohol is used as film forming agent, a thermoplastic polyurethane elastomer is used as a flexibilizer, and a formaldehyde solution is used as a crosslinking agent. The solvent is added into the film forming agent and the flexibilizer thermoplastic polyurethane elastomer for backflow dissolving, then the formaldehyde solution is added for crosslinking to obtain a film casting solution; the film casting solution is cooled, heated, taken out and naturally cooled to room temperature, standing is performed for removing bubbles, film wiping is performed on a glass plate, and the film is placed in a cold water coagulating bath to be coagulated. According to the microporous film, the large pore diameter is 5 micrometers, the small pore diameter is 0.5-2 micrometers, a communication pore structure is formed inside, micropores is distributed in a concentrated mode, the number of pores is large, and the pores are evenly distributed on the surface of the film. The elongation at break of the microporous film reaches 400%, and the strength of the microporous film reaches 1400 Kpa. The polyvinyl alcohol is crosslinked to the polyurethane to prepare the latticed microporous film, the high-strength toughness of the polyurethane is reserved, the latticed micropores are formed along with increasing of the adding amount of the polyvinyl alcohol, and medicine release can be effectively controlled.
Owner:CHANGCHUN UNIV OF TECH
A kind of high specific surface melamine silkworm sand composite carbon material and its preparation method and application
ActiveCN106179236BImprove grafting reaction speedShort reaction timeOther chemical processesAlkali metal oxides/hydroxidesDispersityShielding gas
The invention discloses a high surface area melamine and silkworm dropping composite carbon material and a preparation method and application thereof. Under shielding gas, original silkworm dropping is prepared into carbonized silkworm dropping; melamine powder and the carbonized silkworm dropping are mixed, ZnCl2 solution is added to the mixture, and the mixture is placed on a high-speed mechanical ball mill to undergo oscillation activation grafting reaction to obtain melamine / ZnCl2 / silkworm dropping slurry, the slurry is dried to obtain a crude composite material; the crude composite material undergoes activation reaming reaction under the shielding gas and undergoes cleaning, centrifugation and drying to obtain the high surface area melamine and silkworm dropping composite carbon material. The material is applied to the aspect of sustained or controlled release of pesticides. High-speed mechanical oscillation is utilized to perform grafting composition on melamine and the silkworm dropping and perform activator ZnCl2 mixing and preliminary activation, the grafting composite reaction speed of the two materials and the dispersity of the activator on the surface of the silkworm dropping composite material are improved, and the obtained composite carbon material has high surface area, contains N-polarity groups, and has high pesticide adsorption capacity and good sustained or controlled release effects.
Owner:GUANGXI UNIV
Dopamine-silkworm excrement composite carbon material high in specific surface area and preparation method and application thereof
ActiveCN106390934AImprove grafting reaction speedShort reaction timeBiocideOther chemical processesDispersityAbsorption capacity
The invention discloses a dopamine-silkworm excrement composite carbon material high in specific surface area and a preparation method and application thereof. The preparation method includes: preparing raw silkworm excrement into carbonized silkworm excrement under protective gas; mixing dopamine hydrochloride powder with the carbonized silkworm excrement, adding a ZnCl2 solution, placing into a high-speed mechanical ball mill to perform oscillation activation grafting reaction to obtain dopamine / ZnCl2 / silkworm excrement slurry, and drying the slurry to obtain a crude composite material; performing activation pore-expanding reaction on the crude composite material under protective gas, cleaning, centrifuging, and drying to obtain the dopamine-silkworm excrement composite carbon material high in specific surface area. The preparation method has the advantages that high-speed mechanical oscillation is used to perform grafting compositing on the dopamine hydrochloride and the silkworm excrement and mix the composited dopamine hydrochloride and silkworm excrement with activating agent ZnCl2 to perform primary activation, the grafting composting reaction speed of the two materials are increased greatly, the dispersity of the activating agent on the surface of the silkworm excrement composite material is increased greatly, and the obtained composite carbon material is high in specific surface area, contains N polar groups, and is high in pesticide absorption capacity and good in sustained-release effect.
Owner:GUANGXI UNIV
A kind of graphene-coated silkworm sand porous carbon composite material and its preparation method and application
ActiveCN106417277BEfficient modificationModified environmental protectionBiocideAnimal repellantsPorous carbonFreeze-drying
Owner:GUANGXI UNIV
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