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A kind of preparation method of grid-like microporous membrane formed by polymer cross-linking

A grid-like, high-molecular technology, applied in chemical instruments and methods, membrane technology, semi-permeable membrane separation, etc., can solve the problems of undiscovered, slow-controlled release of membrane materials, etc., to achieve uniform distribution and concentrated distribution of micropores , the effect of a large number of pores

Inactive Publication Date: 2018-05-22
CHANGCHUN UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The film prepared by polyvinyl alcohol has good water solubility, but the film prepared by polyvinyl alcohol has no microporosity and cannot be used as a slow controlled release film material in the biomedical field.
[0006] At present, there is no high-strength microporous membrane prepared by crosslinking polyvinyl alcohol on polyurethane, that is, the microporous membrane can effectively control the release of drugs.

Method used

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  • A kind of preparation method of grid-like microporous membrane formed by polymer cross-linking
  • A kind of preparation method of grid-like microporous membrane formed by polymer cross-linking

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Example 1 A method for preparing a mesh-like microporous membrane formed by polymer crosslinking, the steps and conditions are as follows:

[0016] (1) The ratio of solvent (mL), film forming agent (g), toughening agent (g) and crosslinking agent (mL) is 100:1:12.5:3, and the mass and volume of the corresponding material are: solvent 20 mL of dimethyl sulfoxide, 0.20 g of polyvinyl alcohol, 2.5 g of thermoplastic polyurethane elastomer as the toughening agent, and 0.6 mL of formaldehyde solution with a mass concentration of 40% as the crosslinking agent;

[0017] (2) According to the proportion, first add the film-forming agent polyvinyl alcohol into a 100mL three-necked flask, add the solvent dimethyl sulfoxide, reflux at 40°C until completely dissolved, add thermoplastic polyurethane elastomer, reflux at 65°C until completely dissolved, and add formaldehyde The solution was refluxed for 30 minutes to obtain a uniform casting solution;

[0018] (3) Cool down the unifo...

Embodiment 2

[0029] Example 2 A preparation method of a grid-shaped high-strength microporous membrane formed by polymer crosslinking, the steps and conditions are as follows:

[0030] (1) The ratio of solvent (mL), film forming agent (g), toughening agent (g) and crosslinking agent (mL) is 100:0.75:10:2.5, and the mass and volume of the corresponding material are: solvent 20 mL of dimethyl sulfoxide, 0.15 g of polyvinyl alcohol, 2.0 g of thermoplastic polyurethane elastomer as the toughening agent, and 0.5 mL of formaldehyde solution with a mass concentration of 40% as the crosslinking agent;

[0031] (2) According to the proportion, first add the film-forming agent polyvinyl alcohol into a 100mL three-necked flask, add the solvent dimethyl sulfoxide, reflux at 40°C until completely dissolved, add thermoplastic polyurethane elastomer, reflux at 65°C until completely dissolved, and add formaldehyde The solution was refluxed for 30 minutes to obtain a uniform casting solution;

[0032] (3)...

Embodiment 3

[0034] Example 3 A method for preparing a mesh-like microporous membrane formed by polymer crosslinking, the steps and conditions are as follows:

[0035] (1) The ratio of solvent (mL), film forming agent (g), toughening agent (g) and crosslinking agent (mL) is 100:1.25:14:3.5, and the mass and volume of the corresponding material are: solvent 20 mL of dimethyl sulfoxide, 0.25 g of polyvinyl alcohol, 2.8 g of thermoplastic polyurethane elastomer as the toughening agent, and 0.7 mL of formaldehyde solution with a mass concentration of 40% as the crosslinking agent;

[0036](2) According to the proportion, first add the film-forming agent polyvinyl alcohol into a 100mL three-necked flask, add the solvent dimethyl sulfoxide, reflux at 40°C until completely dissolved, add thermoplastic polyurethane elastomer, reflux at 65°C until completely dissolved, and add formaldehyde The solution was refluxed for 30 minutes to obtain a uniform casting solution;

[0037] (3) Cool down the uni...

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Abstract

The invention discloses a preparation method of a latticed microporous film formed by macromolecule crosslinking. Dimethyl sulfoxide is used a solvent, polyvinyl alcohol is used as film forming agent, a thermoplastic polyurethane elastomer is used as a flexibilizer, and a formaldehyde solution is used as a crosslinking agent. The solvent is added into the film forming agent and the flexibilizer thermoplastic polyurethane elastomer for backflow dissolving, then the formaldehyde solution is added for crosslinking to obtain a film casting solution; the film casting solution is cooled, heated, taken out and naturally cooled to room temperature, standing is performed for removing bubbles, film wiping is performed on a glass plate, and the film is placed in a cold water coagulating bath to be coagulated. According to the microporous film, the large pore diameter is 5 micrometers, the small pore diameter is 0.5-2 micrometers, a communication pore structure is formed inside, micropores is distributed in a concentrated mode, the number of pores is large, and the pores are evenly distributed on the surface of the film. The elongation at break of the microporous film reaches 400%, and the strength of the microporous film reaches 1400 Kpa. The polyvinyl alcohol is crosslinked to the polyurethane to prepare the latticed microporous film, the high-strength toughness of the polyurethane is reserved, the latticed micropores are formed along with increasing of the adding amount of the polyvinyl alcohol, and medicine release can be effectively controlled.

Description

technical field [0001] The invention belongs to the technical field of organic macromolecular materials, and in particular relates to a method for preparing a grid-like high-strength microporous membrane formed by cross-linking macromolecules. Background technique [0002] At present, slow controlled release membrane materials are research hotspots in the field of biomedicine and biomedical engineering. Polymer materials are an indispensable part of the delivery and penetration of drugs and growth factors in the membrane sustained and controlled release drug delivery system. Polymer materials are used as drug carriers or embedded drug frameworks in the sustained release system, which can control the local The release of drugs or growth factors prolongs the local action time of drugs and maintains the stability of the structure and biological activity of drugs or growth factors [1] . [0003] Polyurethane material is a medical polymer material confirmed by the medical commu...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B01D67/00B01D69/02B01D71/38B01D71/58
CPCB01D67/0002B01D69/02B01D71/38B01D71/58B01D2323/30
Inventor 程桂茹张龙王辰刘媛媛
Owner CHANGCHUN UNIV OF TECH
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