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Galanthamine hydrobromide composition and its preparing method

A technology of galantamine hydrobromide and a composition, which is applied in directions such as drug combination, active ingredients of heterocyclic compounds, pill delivery, etc., can solve the problems of inconvenience of patients, short action time of preparations, etc., and achieve the effect of convenience for patients

Active Publication Date: 2009-06-17
SHANGHAI MODERN PHARMA ENG INVESTIGATION CENT
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] However, the above-mentioned preparations are all non-sustained and controlled-release preparations, and the preparations have a short action time, and often need to be taken 3 to 4 times a day, which brings great inconvenience to patients.

Method used

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  • Galanthamine hydrobromide composition and its preparing method
  • Galanthamine hydrobromide composition and its preparing method
  • Galanthamine hydrobromide composition and its preparing method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] Suspend 5 g of 200-mesh sulfonic acid cation exchange resin in 100 ml of deionized water, add 2.5 g of galantamine hydrobromide, heat and stir at 60°C for 2 hours, filter, and dry to obtain galantamine hydrobromide Sustained release composition.

Embodiment 2

[0040] Suspend 20 g of 200-mesh sulfonic acid cation exchange resin in 60 ml of deionized water, add 0.5 g of galantamine hydrobromide, heat and stir at 60°C for 2 hours, filter, and dry to obtain galantamine hydrobromide Sustained release composition.

Embodiment 3

[0042] Add 5 g of the product of Example 1 into 100 ml of a cyclohexane solution containing 0.5 g of ethyl cellulose, heat and stir to reflux temperature, keep it warm for 1 hour, cool to 20 ° C, filter, and dry to obtain hydrogen cellulose coated with ethyl cellulose. Galantamine Bromate Sustained Release Preparation. Components and parts by weight are as follows:

[0043] Sulfonic acid cation exchange resin 5g, galantamine hydrobromide 2.5g, ethyl cellulose 0.5g.

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Abstract

The present invention discloses a galanthamine hydrobromide composition and its preparation method. It is characterized by that said composition includes sulfoacid cation exchange resin and galanthamine hydrobromide, and their weight ratio is 2:0.05-1. Said composition can be made into oral preparation and can attain the goal of slowly-controlled release.

Description

technical field [0001] The invention relates to a composition containing Reminyl (galantamine hydrobromide), an extract of daffodil flower bulbs, in particular to a galantamine hydrobromide oral (sustained) controlled-release composition. Background technique [0002] Senile dementia-Alzheimer's disease (Alzheimer's disease, AD) is one of the diseases with a higher incidence rate among the elderly. It is a disease that affects patients' daily life and work. This disease not only brings great pain to patients, but also brings great economic and nursing burdens to family members and society. [0003] It is now known that the content of acetylcholine in the brain is closely related to memory, and the amount of acetylcholine in the brain of elderly or dementia patients decreases. [0004] Supplementing choline drugs can improve their memory and thinking ability. However, direct administration of choline or lecithin does not increase acetylcholine in the brain, so acetylcholine...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/55A61K9/10A61K9/20A61K47/34A61P25/28
Inventor 贺芬侯惠民陈昂
Owner SHANGHAI MODERN PHARMA ENG INVESTIGATION CENT
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