30results about How to "Strong free radical scavenging activity" patented technology

The invention discloses a Chinese mahonia extracting solution as well as a preparation method and an application thereof. The Chinese mahonia extracting solution prepared by water extraction has good free radical scavenging activity and the effect of inhibiting peroxidation of lipoxygenase and lipid, and due to the characteristics, the Chinese mahonia extracting solution has the effects of scavenging excessive free radicals accumulated in bodies, preventing formation of lipofuscin, protecting cell membranes, maintaining the normal metabolism of cells and prolonging organism senescence; when being applied to cosmetics, the Chinese mahonia extracting solution has remarkable effects of improving facial laxity and reducing generation of wrinkles and black spots.

A class of N-benzylaniline derivatives with free radical scavenging effect and their medicinal use, the structure conforms to the general formula (I) wherein: R is -Cl, -Br, -F, -C(CH 3 ) 3 or-CF 3 , X is ‑O‑ or ‑NH‑. The drugs have good effects of reducing nerve damage after stroke and promoting functional recovery, and can be used for preparing drugs for treating stroke damage and ischemic nerve function loss caused by it.

The invention relates to microorganism derived antioxidant, in particular to a hydroxyl-anthraquinone derivative with antioxidant activity and application thereof. A structural formula of the hydroxyl-anthraquinone derivative is shown as a formula I, and the hydroxyl-anthraquinone derivative is prepared from talaromyces fungus Talaromyces islandicus by fermentation. According to experiments, the hydroxyl-anthraquinone derivative which is a compound has high activity in scavenging of radicals DPPH (1,1-diphenyl-2-trinitrophenylhydrazine) and ABTS (2,2'-azine-bis-(3-ethylbenzothiazoline-6-sulfonic acid)) and can be applied to preparation of antioxidation related drugs, food additives, cosmetic additives or the like.

The invention relates to a rosmarinic acid-containing thromboplastin time measuring reagent. The rosmarinic acid-containing thromboplastin time measuring reagent is composed of a Tris-HCl buffer containing 25 U / ml of human thrombin, 2% of bovine serum albumin, 1.5 mM of rosmarinic acid, 0.05% of sodium azide, 3.5% of methionine, 1.5% of PEG, 3% of mannitol, 2.5% of maltose and 10 mM of calcium chloride, wherein percentage is mass-volume ratio, and a pH value is 7.4. A preparation method of the reagent comprises the following steps: preparing the buffer with the pH value being 7.4 and Tris concentration being 50 mM, adding BSA with final concentration being 2%, 1.5mM of rosmarinic acid with final concentration being 2%, triazacyclononane with final concentration being 0.05%, methionine with final concentration being 3.5%, PEG with final concentration being 1.5%, mannitol with final concentration being 3%, maltose with final concentration being 2.5%, and 10mM of calcium chloride in the buffer, wherein, besides calcium chloride, the unit of the materials is mass-volume fraction; filtering a mixed liquor with a 0.22-micrometer filter membrane, and adding a human thrombin freeze-drying preparation in a filtrate so that the concentration of human thrombin in a final filtrate is 25 U / ml, and obtaining a TT reagent. According to the invention, rosmarinic acid is taken as a stabilizing agent, so that antioxidation performance and stabilization performance of the thromboplastin time measuring reagent can be obviously increased.

The invention discloses new application of a graphdiyne nano-material serving as a free radical scavenger and a radiation protective agent, and belongs to the technical fields of nano-materials, freeradical scavenging and radiation protection. The graphdiyne nano-material provided by the invention has a large conjugated pi bond structure, and also has a diyne bond structure with high reaction activity; because of the unique structures, the graphdiyne nano-material has good electron absorption capacity, so that free radicals can be effectively scavenged and can serve as the free radical scavenger. The graphdiyne has good free radical scavenging activity, can powerfully scavenge a large amount of ROS (Reactive Oxygen Species) produced by a body because of the induction of high-energy ray ina radiotherapy process, and the damage to normal tissues by the ROS is reduced, so that a radiation protecting effect is achieved. According to the new application of the graphdiyne nano-material serving as the free radical scavenger and the radiation protective agent, the graphdiyne nano-material is applied to free radical scavenging for the first time, and a new opportunity is provided for developing a new free radical scavenger for oxidation resistance.

The invention discloses a Kunlun chrysanthemum chalcone compound as well as a preparation method and application thereof. A structural formula of the compound is as shown in a formula (I). Alpha,3,2'-trihydroxy-4'-O-beta-D-glucopyranose chalcone separated from Kunlun chrysanthemum is a compound which is obtained from a natural resource for the first time; the compound has high oxidative activity and very high radical-scavenging activity, and can be used as a representative anti-oxidative active ingredient and a natural radical-scavenging agent in the Kunlun chrysanthemum. The formula (I) is as shown in the specification.

The invention provides a method for simultaneously separating and purifying four flavonoid components from Meconopsis whole-leaf flowers. The invention also provides a method for simultaneously separating and purifying two known flavonoid components. The present invention successfully separates and purifies four kinds of flavonoids from Meconopsis whole leaf by HSCCC method, and the separation speed is fast, which lays a foundation for the research on the material basis of Meconopsis whole leaf. It has been found through research that the above-mentioned isolated known compounds or new compounds have good free radical scavenging activities, and can be used as anti-oxidation drugs or health products.

The invention discloses a novel whitening toner, which mainly consists of such functional ingredients as cherry blossom, undaria pinnatifida, calluna vulgaris and the whitening toner. In accordance with important factors affecting skin color, such as tyrosinase activity, ultraviolet rays, radicals, skin moisten and the like, the whitening product which is pure natural, comprehensive in function, safe and efficient is developed. The whitening toner disclosed by the invention can overcome shortcomings in the prior art; the whitening toner is simple in preparation method, low in cost and applicable to popularization in a large scale; and the whitening toner, when used for a long time, has a whitening effect, and the whitening toner is suitable for various people.

The invention relates to a new coumarin active content, i.e. pigeon pea lactone extracted and separated from cajan leaves, an extraction and separation method and an application thereof. The structure of the compound is shown as a figure 1. The invention adopts the technical scheme that agricultural waste of cajan leaves is used as raw material which is extracted by a solvent; the extracting solution is concentrated and dispersed in water; an ultrasonic oscillation flocculation technology, a bubble column extraction technology and a column chromatography separation technology in positive-phase silica gel are adopted and combined with a low-temperature crystallization and recrystallization technology to obtain the content with the purity higher than 95 percent; and the anti-oxidation activity and the action of the chemical content on cardiovascular diseases are detected by a DPPH model, a beta-renieratene-linoleic acid model, an in-texture SOD enzyme model, a platelet aggregation modelinduced by ADP in corpora and an aorta systole model induced by phenylephrine. Results show that the active content has favorable free radical scavenging activity, anti-oxidation activity in corpora and in vitro, platelet aggregation restraining action in corpora and a certain hemangiectasis action. Meanwhile, the preparation method of the pigeon pea lactone in the invention is easy and practicaland can obtain a product with high purity high yield and high added value in a short period which is suitable for industrialized production and application, can be further developed and researched into a new antioxidant as an additive for medicines, foods and cosmetics.