The invention discloses edible mushroom buccal tablets and a preparation method thereof. The edible mushroom buccal tablets are prepared from the following raw materials in percentage by mass: 60-65% of edible mushroom powder, 10-15% of sprouted tephrosia vogelii powder, 5-8% of a honeysuckle flower extracting solution, 4-6% of a chrysanthemum extracting solution, 3-5% of a lemongrass extracting solution, 2-5% of starch, 2-5% of cane sugar and 0.1-0.3% of magnesium stearate, wherein the total percentage by mass of the components is 100%. The edible mushroom powder is prepared by mixing shiitake mushrooms, pleurotus nebrodensis, agrocybe cylindracea, bolete, hericium erinaceus, hypsizygus marmoreus and white funguses in the mass ratio of the shiitake mushrooms to the pleurotus nebrodensis to the agrocybe cylindracea to the bolete to the hericium erinaceus to the ypsizygus marmoreus and to the white funguses being 3 to 2 to 2 to 3 to 1 to 1 to 3, and then performing ultra-fine pulverization. The edible mushroom buccal tablets disclosed by the invention provide amino acids, vitamins, minerals and protein which are necessary for human bodies, can prevent multiple diseases, and have good effects of improving the immunity of the human bodies and improving the cardiorespiratory function; besides, the edible mushroom buccal tablets have the effects of reducing blood pressure, reducing noise, reducing internal heat and calming the mind and are foods having notable efficacies of health preservation and health care.