46results about How to "Low related substances" patented technology

The present invention discloses a display device and a manufacturing method thereof by which a manufacturing process can be simplified. Further, the present invention discloses technique for manufacturing a pattern such as a wiring into a desired shape with good controllability. A method for forming a pattern for constituting the display device according to the present invention comprises the steps of forming a first region and a second region; discharging a composition containing a pattern formation material to a region across the second region and the first region; and flowing a part of the composition discharged to the first region into the second region; wherein wettability with respect to the composition of the first region is lower than that of the second composition.

This invention concerns a method for absorbing acrylic acid, characterized by supplying an acrylic acid-containing reaction gas component obtained by the reaction of catalytic gas phase oxidation to an acrylic acid absorption column and advancing a high boiling inert hydrophobic organic liquid into counter-flow contact with said reaction gas in said acrylic acid absorption column with the mass flow rate of the organic liquid fixed in the range of 0.2-7.0 times the mass flow rate of the acrylic acid in the reaction gas thereby absorbing acrylic acid in said organic liquid and obtaining an acrylic acid-containing solution including a low boiling substance in the range of 0.7-7.5 wt % based on the weight of bottom liquid of absorption column.

A medical rubber closure according to the present invention includes a disc-shaped flange portion and a leg portion formed to be continuous to a lower surface side of the flange portion, and a region at the lower surface side of the flange portion and the leg portion are made of a nitrile based rubber, a region at a top surface side of the flange portion is made of a butyl based rubber, and the leg portion is laminated with a coating layer made of a fluorine based resin film.

The invention relates to a method and device for controlling an internal combustion engine comprising an inlet pipe leading to a cylinder input where a gas input valve is placed. Said engine also comprises a drive for the gas input valve which makes it possible to adjust a gas input valve lift for at least two values. The engine also comprises an injection valve for metering fuel and a spark plug which controls the crankshaft angle of air-fuel mixture ignition. Said internal combustion engine is controlled in a following manner: a fuel is metered at least once during the intake stroke of a cylinder when the valve lift (VL) passes from one value to the other and at least one final injection is carried out in a dosing manner only when the valve lift (VL) is really carried out.

The present invention discloses a display device and a manufacturing method thereof by which a manufacturing process can be simplified. Further, the present invention discloses technique for manufacturing a pattern such as a wiring into a desired shape with good controllability. A method for forming a pattern for constituting the display device according to the present invention comprises the steps of forming a first region and a second region; discharging a composition containing a pattern formation material to a region across the second region and the first region; and flowing a part of the composition discharged to the first region into the second region; wherein wettability with respect to the composition of the first region is lower than that of the second composition.

An injection of trace elements for providing external nutrients is prepared through depositing in water, cold storage, ultrasonic treating, ultrafiltration, adding filtered sorbitol in dark condition and N2 atmosphere, pouring in containers, sterilizing and lamp examining.

A freeze-dried powder injection of clindamycin hydrochloride for treating various infectious diseases, tonsillitis, tympanitis, acute bronchitis, pneumonia, etc is prepared from clindamycin hydrochloride through ultrafiltration, mixing with filtered mannitol in dark condition and N2 atmosphere, pouring in containers, freeze drying, and sealing.

The invention relates to a method and device for controlling an internal combustion engine comprising an inlet pipe leading to a cylinder input where a gas input valve is placed. Said engine also comprises a drive for the gas input valve which makes it possible to adjust a gas input valve lift for at least two values. The engine also comprises an injection valve for metering fuel and a spark plug which controls the crankshaft angle of air-fuel mixture ignition. Said internal combustion engine is controlled in a following manner: a fuel is metered at least once during the intake stroke of a cylinder when the valve lift (VL) passes from one value to the other and at least one final injection is carried out in a dosing manner only when the valve lift (VL) is really carried out.

A freeze-dried powder injection of VC for preventing and treating scurvy, acute and chronic infectious diseases, purpura, Keshan disease, etc is prepared from VC, sodium hydrogen sulfate, and disodium versenate through ultrasonic treating, adding CO2 saturated water for injection in dark condition and N2 atmosphere, regulating pH value and temp, etc.

The invention belongs to the technical field of medicines, and particularly relates to cefoperazone sodium and tazobactam sodium pharmaceutical composition for injection and a preparation method of the cefoperazone sodium and tazobactam sodium pharmaceutical composition. The pharmaceutical composition is a freeze-dried powder preparation. The mass ratio of cefoperazone sodium to tazobactam sodium in the pharmaceutical composition is 4:1. The preparation method comprises the steps as follows: firstly, tazobactam is refined; then, tazobactam sodium is prepared from refined tazobactam and sodium bicarbonate; finally, cefoperazone sodium and prepared tazobactam sodium are uniformly mixed for preparation of freeze-dried powder. Compared with like products sold in the market, the pharmaceutical composition has the advantages of good solubility, light color, few related substances, small polymer content and low adverse reaction rate; besides, effective constituents in the pharmaceutical composition are stable, and when the pharmaceutical composition is preserved for a long term, few effective constituents are degraded, the content of impurities is low, the quality performance of products is relatively good, and the medication safety of patients is guaranteed accordingly.

The invention provides a process for refining bendazac lysine and analogs thereof, belonging to the technical field of chemical drug preparation. The process comprises the steps of adopting bendazac or bendazac analogs and L-lysine or L-histidine as raw materials; reacting the raw and salifying the materials in an aqueous solution of a polar aprotic solvent so as to obtain a crude product; and then recrystallizing the crude product in an aqueous solution of a polar protic solvent, wherein the polar aprotic solvent preferably selected from acetonitrile while the polar protic solvent is preferably selected from ethanol. The bendazac lysine and the analogs thereof which are finally prepared by using the invention are both white crystalline powders with yield of more than 80% and content of 99.6-101%, wherein the content of 3-hydroxyl-1-benzyl indazole is lower than 0.1%; or even no 3-hydroxyl-1-benzyl indazole is detected; and the total content of impurities does not exceed 0.2%. The refining process provided by the invention has the advantages of simple method, mild condition, short reaction time, low product cost, high purity and high yield, is beneficial for large-scale production and can be also can be used for refining commercial bendazac lysine raw materials.

A gingko-dipyridamole injection for treating cerebral thrombus, cerebrovascular spasm, cerebral insufficiency, ischemic heart disease, ischemic retinosis, etc is prepared from gingko leaves through breaking, reflux extracting in alcohol, concentrating, filtering, resin adsorption, alcohol eluting to obtain liquid extract, mixing with dipyridamole in dark condition, filling N2, pouring in containers, sterilizing, lamp examining, and packing.

The invention relates to an oral preparation containing amisulpride. The amisulpride which is active medicine is prepared into cyclodextrin inclusion compound, is sieved, is uniformly mixed with pharmaceutically acceptable auxiliary materials, and is granulated by a wet method or a dry method, obtained granules are squashed to form tablets, filled into capsules to form a capsule preparation or is directly separately packaged to obtain a granule preparation. The water solubility and the stability of the oral preparation containing the amisulpride can be strengthened, bitter taste of the amisulpride is covered, medication compliances of patients are improved, and bioavailability of the oral preparation is improved to a great extent.

The invention relates to bicontinuous microemulsions and to the use thereof as a fuel, combustion or heating fluid. Said fuels permit an increased efficiency of internal combustion systems and heating installations of any type and, simultaneously, a minimized emission of pollutants, associated with combustion, to be obtained.

The invention relates to the technical field of the pharmacy, and especially relates to a preparation method of a compound paracetamol and amantadine hydrochloride capsule. The method is characterized in that smaller amounts of components comprising dextrin, calculus bovis factitious, chlorphenamine maleate and caffeine in a prescription are uniformly mixed to obtain mixed powder I, and larger amounts of compounds comprising viregyt hydrochloride and paracetamol in the prescription are uniformly mixed with the mixed powder I to realize uniform mixing and the uniformity of the content of the chlorphenamine maleate in the whole capsule. Double-tapered rotary vacuum drying is adopted, the physical and chemical properties of a material are not changed after the drying of the material, and the content of relevant substances in a finally finished product is low.

The invention relates to the technical field of medicines and discloses a mezlocillin sodium and sulbactam sodium compound drug composition for injection. The mezlocillin sodium and sulbactam sodium compound drug composition comprises mezlocillin sodium, sulbactam sodium and sodium benzoate. The mezlocillin sodium and sulbactam sodium compound drug composition realizes higher product performance by less auxiliary materials, has the advantages of being good in solubility, shallow in color, uniform in main drug mixing, low in related substance, low in polymer content, low in incidence rate of adverse reactions and the like and ensures that patients are safer in the clinical use, and the treatment effect is more reliable.

The invention discloses an edaravone A-type crystal and a preparation method thereof. The X-ray diffraction pattern of the crystal is basically shown in the figure 1. According to the crystal and the method thereof, related substance of the product can be effectively reduced, the purity is improved, and the reaction yield is increased. The crystal has strengthened stability, and is suitable for storing particularly in high-temperature high-humidity conditions. The crystal has excellent solubility due to its better chemical property and stable crystal distribution. When medicine is prepared, satisfactory dosage accuracy can be achieved, so as to improve the safety of the product and reduce the patient's risk. Therefore, the crystal provided by the invention is suitable for preparing stable medicinal preparation.