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Oral liquid preparation of pidotimod

A liquid preparation, the technology of pidotimod, which is applied in the field of pharmaceuticals, can solve the problems of unstable product quality and difficulty in long-term stable storage, and achieve high stability, stable storage, and improved solubility

Active Publication Date: 2012-07-04
SUZHOU SIXTH PHARMA PLANT OF JIANGSU WUZHONG PHARMA GROUP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The technical problem to be solved by the present invention is the problem that the pidotimod oral liquid preparation in the prior art does not add any pH regulator, resulting in unstable product quality and difficult long-term stable storage. The reasonable ratio between the parts, so that the quality is stable, and the pidotimod oral liquid preparation is easy to store stably

Method used

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  • Oral liquid preparation of pidotimod
  • Oral liquid preparation of pidotimod
  • Oral liquid preparation of pidotimod

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Example 1 prescription:

[0030]

[0031] Get the purified water of preparation amount 20% and boil, add sucrose 470g thereinto, stir evenly; Add medicinal charcoal of 0.05% of the total volume of concentrated medicinal solution in the above-mentioned uniformly stirred solution and stir evenly, after boiling, plate frame (lining filter with canvas).

[0032] Take the purified water of 70% preparation amount, add edetate disodium 3g, trishydroxymethylaminomethane 96g, sodium chloride 4g, stevioside 12g, pidotimod 200g to it successively, stir while adding, Make the above substances fully dissolved.

[0033] Combine the two kinds of purified water after adding the above-mentioned substances, add 4g of the above-mentioned food essence to it, stir well, use 5% sodium hydroxide aqueous solution to fine-tune the pH value to 4.4-5.6, add purified water to 10000ml, and stir well After filling, the pidotimod oral liquid preparation with a specification of 10ml and 0.2g was...

Embodiment 2

[0035] prescription:

[0036]

[0037] Get the purified water of preparation amount 20% and boil, add sorbitol 446g thereinto, stir evenly; Add the medicinal charcoal of 0.05% of the total volume of thick dispensing liquid in the above-mentioned uniformly stirred solution and stir evenly, after boiling, plate frame ( Lined with canvas) filter press.

[0038] Take purified water with 70% preparation amount, add calcium sodium edetate 3g, trishydroxymethylaminomethane 100g, sodium chloride 6g, fructose syrup 24g, pidotimod 200g to it successively, stir while adding , so that the above-mentioned substances are fully dissolved.

[0039] Combine the two kinds of purified water after adding the above-mentioned substances, add 3g of the above-mentioned food essence to it, stir well, use 5% sodium hydroxide aqueous solution to fine-tune the pH value to 4.5-5.5, add purified water to 10000ml, and stir well After filling, the pidotimod oral liquid preparation with a specification o...

Embodiment 3

[0041] prescription:

[0042]

[0043]Take purified water with a preparation amount of 20% and boil it, add 520g of aspartame to it, and stir evenly; add medicinal charcoal with a total volume of 0.05% of the concentrated medicinal liquid to the above-mentioned uniformly stirred solution, and stir evenly, and then boil it. Frame (lined with canvas) filter press.

[0044] Take the purified water with 70% preparation amount, add 2.5g of disodium edetate, 0.5g of glycerin, 94g of trishydroxymethylaminomethane, 3g of sodium hydroxide, 6g of sodium chloride, 14g of natural concentrated grape juice, Domod 200g, stir while adding, so that the above-mentioned substances are fully dissolved.

[0045] Combine the two kinds of purified water after adding the above-mentioned substances, add 6g of the above-mentioned food essence to it, stir well, use 5% sodium hydroxide aqueous solution to fine-tune the pH value to 4.4-5.6, add purified water to 10000ml, and stir well After filling, ...

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PUM

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Abstract

The invention provides an oral liquid preparation of pidotimod, which can promote immunoreaction of a human body, effectively reduces times and degree of treating acute attack of bacteria or virus induced infection, shortens the course of the disease, can serve as an auxiliary medicine of antibiotic during acute infection and belongs to the field of medicines. The oral liquid preparation comprises the pidotimod, a chemical stabilizer, a pH regulator, a flavoring agent and the like, wherein trihytdroxy methyl-aminomethane serves as the pH regulator; and stability of the solution can be effectively improved through quantitative proportion and synergistic effect of each ingredient. The oral liquid preparation has stable quality, is convenient to store for a long time and is particularly suitable for old people or children to take.

Description

technical field [0001] The invention relates to an oral liquid preparation containing pidotimod, which belongs to the field of medicines. Background technique [0002] The immune response in the human body exists in the occurrence and development of many diseases, including specific immune response and non-specific immune response, which directly affects the health of the human body. Pidotimod is a safe and effective immune function enhancer, which can promote both specific immune response and non-specific immune response. Animal experiments and clinical experiments have shown that although pidotimod has no direct antibacterial and antiviral activity, it can significantly play a role in treating bacteria (pneumococcus, Escherichia coli, Pseudomonas aeruginosa, Proteus, etc.) ), fungus, virus (influenza virus, herpes simplex virus, myocarditis virus and Menge virus, etc.) It can effectively reduce the number and degree of acute attacks and shorten the course of the disease....

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/08A61K38/05A61K47/18A61K47/04A61P37/04
Inventor 王金陵汪志超阎政姚建林赵唯一冯志英臧建英
Owner SUZHOU SIXTH PHARMA PLANT OF JIANGSU WUZHONG PHARMA GROUP
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