102results about How to "Low acid concentration" patented technology

Provided herein are methods of treating or ameliorating hypercholemia or a cholestatic liver disease by administering to an individual in need thereof a therapeutically effective amount of an Apical Sodium-dependent Bile Acid Transporter Inhibitor (ASBTI) or a pharmaceutically acceptable salt thereof. Also provided are methods for treating or ameliorating a liver disease, decreasing the levels of serum bile acids or hepatic bile acids, treating or ameliorating pruritis, reducing liver enzymes, or reducing bilirubin comprising administering to an individual in need thereof a therapeutically effective amount of ASBTI or a pharmaceutically acceptable salt thereof.

Tranexamic acid formulated in an oral dosage form with at least one agent that decreases tranexamic acid release in the stomach. Such formulations minimize nausea, vomiting, and other adverse gastric effects that may accompany tranexamic acid therapy, for example, to treat heavy menstrual bleeding. One embodiment is an extended release formulation with waxes, polymers, etc. that prevent a bolus release of tranexamic acid in the stomach. An alternative embodiment is a delayed release formulation with polymers that prevent release of tranexamic acid in the acid environment of the stomach and delay its release until the formulation reaches the less acid environment of the intestines. Such formulations enhance patient compliance with therapy because adverse effects of tranexamic acid therapy are reduced.

Tranexamic acid formulated in an oral dosage form with at least one agent that decreases tranexamic acid release in the stomach. Such formulations minimize nausea, vomiting, and other adverse gastric effects that may accompany tranexamic acid therapy, for example, to treat heavy menstrual bleeding. One embodiment is an extended release formulation with waxes, polymers, etc. that prevent a bolus release of tranexamic acid in the stomach. An alternative embodiment is a delayed release formulation with polymers that prevent release of tranexamic acid in the acid environment of the stomach and delay its release until the formulation reaches the less acid environment of the intestines. Such formulations enhance patient compliance with therapy because adverse effects of tranexamic acid therapy are reduced.

Provided herein are methods of treating or ameliorating primary sclerosing cholangitis and inflammatory bowel disease by administering to an individual in need thereof a therapeutically effective amount of an Apical Sodium-dependent Bile Acid Transporter Inhibitor (ASBTI) or a pharmaceutically acceptable salt thereof. Also provided are methods for treating or ameliorating primary sclerosing cholangitis comprising administering to an individual in need thereof a therapeutically effective amount of ASBTI or a pharmaceutically acceptable salt thereof.

Disclosed are modified release oral tranexamic acid formulations and methods of treatment therewith.

Disclosed are delayed release oral tranexamic acid formulations and methods of treatment therewith.

Disclosed are modified release oral tranexamic acid formulations and methods of treatment therewith.

Disclosed are modified release oral tranexamic acid formulations and methods of treatment therewith.

Improved systems and methods for reducing costs and increasing yields of cellulosic ethanol are disclosed herein, along with plants genetically transformed for increased biomass, expression of lignocellulolytic enzyme polypeptides, and / or simplification of harvesting and downstream processing. Methods for processing biomass from these transgenic plants that involve less severe and / or less expensive pre-treatment protocols than are typically employed are also disclosed.

The present invention discloses an ultrasonic cleaning tank comprising an ultrasonic transducer and a stainless steel reservoir; the reservoir wall thickness is between 1to 3 mm and the internal surface of the reservoir is blasted with grits; the internal surface of the reservoir with certain harshness is sprayed with a polytetrafluoroethylene layer and the polytetrafluoroethylene layer thickness is between 0.1 to 0.4 mm; the processing method is that the internal surface of the stainless steel reservoir is blasted with grits to make the surface harsh; after the internal surface is cleaned, at least twice polytetrafluoroethylene static sprayings are implemented on the internal surface of the reservoir; the coating of the cleaning tank surface is dense and the coating is closely combined with the reservoir to prevent the reservoir from being corroded by strong acid and have excellent abrasion resistant function; the ultrasonic conduction rate is high and the acid concentration of the cleaning liquid can be reduced which reduces the environmental pollution and effectively prolongs the service life of the cleaning device.

The invention belongs to the field of high polymer materials and particularly discloses cornstalk nanocellulose whiskers and a preparation method and application thereof. The molecular chain structural formula of the cornstalk nanocellulose whiskers is shown as in the described formula (1), wherein n is a natural number less than 200, and the molecular weight of cornstalk nanocellulose is 10000-30000. The preparation method of the cornstalk nanocellulose whiskers is simple, and high-temperature high-pressure hydrolysis pretreatment is adopted for full fibering; compared with acid or alkaline pretreatment in other nanocellulose preparation methods, the pretreatment method has the advantages that chemicals in the pretreatment process are saved, difficulty in treatment of waste fluid in the pretreatment process is lowered, and further acid concentration of subsequent acid hydrolysis cellulose can be lowered.

The invention provides a foam plug diversion and acidification technology. The method is that: a high permeable layer is temporality blocked by injecting foam plug and utilizing the diversion ability of the foamed fluid, then the acid liquid is converted to a low permeable layer and then the uniform acidification with different permeability is realized and thus, the acid-soluble blockage of the reservoir is effectively solved; at the same time, the high carrying capacity of the foamed fluid and the expansion of the nitrogen can back-drain the acidified solid particles and the residual acid, which can decrease the secondary injury. The invention is especially suitable for solving the acid-soluble injury of the heterogeneous stratum.

Disclosed are modified release oral tranexamic acid formulations and methods of treatment therewith.

Disclosed are modified release oral tranexamic acid formulations and methods of treatment therewith.

The invention relates to an aluminum alloy hard anodized film and a process method thereof. After degreasing and degreasing, the surface of the aluminum alloy workpiece is shot peened with clean stainless steel shot, and then hard anodized in an electrolyte with low sulfuric acid concentration, and hard anodized with low current density and then high current density The hard oxide film is obtained after treatment, the thickness of the oxide film is 340-374 μm, and the hardness is high, the film layer is dense, and it is beneficial to environmental protection and cost reduction.

The invention is intended to metabolize acetic acid and to lower acetic acid concentration in a medium at the time of xylose assimilation and ethanol fermentation by a yeast strain having xylose-metabolizing ability. The method for producing ethanol comprises a step of culturing recombinant yeast strains resulting from introduction of a xylose isomerase gene and an acetaldehyde dehydrogenase gene into a medium containing xylose, so as to perform ethanol fermentation.

The invention relates to a method for preparation of a compound amino acid liquid from cottonseed meal. The method includes: firstly carrying out mechanical crushing and cooking pretreatment on cottonseed meal, then inoculating Aspergillus niger, Aspergillus oryzae and Saccharomyces cerevisiae, and conducting culture under an aerobic condition for 15-20h to form a first level enzymolysis system, then inoculating Bacillus subtilis and bacillus licheniformis respectively to further conduct aerobic culture for 18-32h so as to form a fermentation broth, then adding edible grade concentrated hydrochloric acid into the fermentation broth to perform acid hydrolysis, and carrying out filtration and acidity adjustment settlement in order at the end of the hydrolysis to obtain the compound amino acid liquid, then refining the compound amino acid liquid by a complexing affinity extraction technology, mixing the extraction residual water phase generated in the refining process with the compound amino acid liquid to prepare light soy sauce, and taking the raffinate oil phase as an extraction agent for cycle use in refining of next batch compound amino acid liquid. The method provided by the invention not only effectively improves the raw material utilization rate, reduces the production cost, avoids generation of toxic by-products, but also increases the additional value of the product.

Disclosed are modified release oral tranexamic acid formulations and methods of treatment therewith.

The invention discloses a horizontal type pressure leaching kettle comprising a kettle body, a first feed port, oxygen inlets, a second feed port and a discharge port, wherein the kettle body is provided with a first end and a second end, and a leaching space is defined in the kettle body; the first feed port is arranged at the part, adjacent to the first end, of the top of the kettle body; the oxygen inlets are arranged at the bottom and lateral part of the kettle body; the second feed port is arranged at the part, adjacent to the second end, of the top of the kettle body; and the discharge port is arranged at the second end. In addition, the invention further provides a leaching method using the horizontal type pressure leaching kettle. The horizontal type pressure leaching kettle can be used for conducting zinc sulfide concentrate leaching reaction in the pressure kettle, and simultaneously realizing reduction of acid concentration and iron content of the discharged leachate.

A food composition and pharmaceutical composition with strains of lactic acid bacteria for reducing blood uric acid concentration are provided, comprising at least one or two isolated lactic acid bacteria strains selected from the following two: TSF331 (Lactobacillus fermentum) and TSR332 (Lactobacillus reuteri).

The invention belongs to the field of chemical industry, and in particular, relates to a dilute nitric acid production process. The process includes the following steps: after ammonia evaporation andheating, adjusting the flow quantity, allowing gas ammonia to enter an ammonia-air mixer and uniformly mixing the gas ammonia with compressed air; allowing the ammonia-air mixture after mixing to enter an oxidation furnace, carrying out catalytic oxidation reaction on a platinum mesh surface, oxidizing ammonia into nitric oxide, recycling waste heat from process gas leaving the catalyst through awaste heat boiler and tail gas respectively, and then condensing by a low-pressure quick cooler, after separation of dilute acid, mixing the process gas with air from a bleaching tower, and then allowing the mixed gas to enter an oxidation nitrogen compressor; further increasing the temperature of gas through the compressed process gas; recycling waste heat of the compressed process gas, cooling,and then allowing the cooled process gas to enter an absorption tower; and carrying out a reaction of oxide of nitrogen in the absorption tower after absorption with water to generate nitric acid. Theprocess has the advantages of high nitrogen oxide absorption rate, low ammonia consumption, high acid concentration and low tail gas emission concentration, and can reach the standard without furthertreatment.

The invention provides a two-stage curing vanadium extraction method of stone coal vanadium ores. The two-stage curing vanadium extraction method comprises the following steps: (1) firstly, breaking and grinding the stone coal vanadium ores, and then adding water and concentrated sulfuric acid to the obtained ore powder and mixing evenly to obtain a mixture, wherein the mass of the concentrated sulfuric acid added accounts for 10%-15% of the mass of the stone coal vanadium ores; (2) curing the mixture, next, leaching the obtained mixture by use of water, and performing liquid-solid separation to obtain a vanadium-containing leaching solution and leaching slag; (3) adding concentrated sulfuric acid to the leaching slag and mixing evenly, next, curing, leaching the obtained mixture by use of water, and performing liquid-solid separation to obtain a vanadium-containing leaching solution and leaching slag, wherein the mass of the concentrated sulfuric acid added accounts for 10%-15% of the mass of the stone coal vanadium ores; and (4) blending the vanadium-containing leaching solution of the step (2) and the vanadium-containing leaching solution of the step (3). The two-stage curing vanadium extraction method of the stone coal vanadium ores has the advantages that side reactions in curing are effectively inhibited and the vanadium leaching rate is greatly increased. A two-stage low-acid curing method is adopted, the acid concentration is relatively low, and the curing process is clean and environment-friendly; and as a result, the two-stage low-acid curing method has a great industrial application prospect.

The invention discloses a low-cost and environment-friendly method for preparing epoxidized silicone rubber. The method comprises the following steps: taking 1-10 parts of high vinyl silicone rubber,100 parts of an organic peroxy acid poor solvent and 0.5-12 parts of an epoxidation reagent; mixing the high vinyl silicone rubber with the organic peroxy acid poor solvent; after complete dissolution, adding the epoxidation reagent for reaction to obtain epoxidized silicone rubber solution; storing the obtained solution at low temperature to separate out a deoxidation product of the epoxidation reagent and an unreacted epoxidation reagent, then precipitating epoxidized silicone rubber; and performing washing and drying to obtain the epoxidized silicone rubber. The preparation method is more scientific and reasonable, the produced epoxidized silicone rubber has the molecular weight of original high vinyl silicone rubber and is free of gel, the performance of the epoxidized silicone rubberis more stable, the strength of the epoxidized silicone rubber is higher, meanwhile, the production cost is reduced, and the method is more suitable for mass production.

A method for processing a fruit, such as a cranberry, includes cutting open a fruit and partially removing a highly concentrated juice fraction from the fruit when pressed while maintained within a sub-freezing temperature range. The skin of the frozen fruit is penetrated by being sliced or punctured facilitating juice extraction and subsequently infusion, such as by vacuum. Before extraction, the sliced fruit is uniformly tempered to a temperature below 32° F., more specifically to between 26° F. and 32° F. To extract juice, the fruit is pressed, removing from about 40% to 65% by weight of the liquid, yielding a concentrated fruit juice, with significantly enhanced brix, acid, and color, and a partially dehydrated fruit piece, with significantly reduced brix, acid, and color, and still within the given sub-freezing temperature range. The fruit piece may then be infused, such as under vacuum while being rotated, with a variety of ingredients.

The invention discloses a low-energy-consumption preparation method for synthesizing high-purity folic acid. The method comprises adding 2,4,5-triamino-6-hydroxypyrimidine sulfate, p-aminobenzamide glutamic acid, trichloroacetone, sodium acetate and sodium pyrosulfite into water, performing docking reaction, adjusting pH by adding solid sodium acetate before the reaction is started and separately adding a sodium hydroxide solution during reaction and after the reaction is finished, and filtering; performing acid-washing and filtering in hydrochloric acid solution; adding a magnesium oxide solution into water for reaction, adding active carbon for decoloring, and filtering; adjusting pH value by using hydrochloric acid, cooling and filtering; and washing with purified water and filtering, drying the filter cake, so as to obtain the final product. By using the method for producing folic acid, energy consumption is reduced, also yield and product purity are improved, and also cost is substantially saved.

A method for processing a fruit, such as a cranberry, includes cutting open a fruit and partially removing a highly concentrated juice fraction from the fruit when pressed while maintained within a sub-freezing temperature range. The frozen fruit is cut open by being sliced or punctured facilitating juice extraction and subsequently infusion, such as by vacuum. Before extraction, the sliced fruit is uniformly tempered to a temperature below 32° F., more specifically to between 26° F. and 32° F. To extract juice, the fruit is pressed, removing from about 40% to 65% by weight of the liquid, yielding a concentrated fruit juice, with significantly enhanced brix, acid, and color, and a partially dehydrated fruit piece, with significantly reduced brix, acid, and color, and still within the given sub-freezing temperature range. The fruit piece may then be infused, such as under vacuum while being rotated, with a variety of ingredients.

This invention relates to a process for producing garden furniture from locust wood, including a one process step in which the locust wood is treated, the locust wood being steamed such that a color change of the locust wood from a yellowish to the brownish shade takes place.