52results about How to "Long period of action" patented technology

The present invention relates to an intranasal pharmaceutical dosage form comprising a dosing unit comprising naloxone or a pharmaceutically acceptable salt thereof in an amount of equivalent to ≧0.5 mg naloxone HCl dissolved in an application fluid of a volume of ≦250 μl. Furthermore, the present invention relates to such an intranasal pharmaceutical dosage form for use in the treatment of opioid overdosing and / or at least one symptom thereof.

The invention discloses a method for treating persistent halogenated hydrocarbons in soil by a slow-release compound remediation agent. The method includes steps: pre-ploughing contaminated soil, directly spreading a certain quantity of the slow-release compound remediation agent into ploughed soil, harrowing to well mix, watering to keep certain moisture content, and covering the soil surface with a protecting layer to realize anaerobic reduction dehalogenation reaction, wherein spreading quantity of the remediation agent is 0.05-1.5% of the dry weight of the contaminated soil, the soil ploughing depth is 25-40cm, the soil moisture content is adjusted to 50-80% of maximum field moisture capacity after spreading of the remediation agent, and remediation treatment time is 30-350d. The remediation method takes advantages of great adsorption performance of black charcoal, efficient chemical reducibility of nano zero-valence metal and dissimilatory iron reduction dehalogenation performanceof functional microorganisms to achieve physical, chemical and biological synergistic remediation effects on persistent halogenated hydrocarbon contaminated soil and has advantages of long action period, structural stability, low cost, environmental friendliness and the like.

The invention discloses a microbial trapping agent and application thereof. An active component of the trapping agent is bacillus amyloliquefaciens YN2010-KC (CGMCC No. 5722) fermentation liquor in which the living bacteria count is larger than or equal to 3*10<9>cfu / ml. The trapping agent can induce trypetid, vinegar fly and vegetable leafminer to eat due to a particular smell emitted thereby and catch both female and male flies, is long in action period and low in cost, does not contain any chemical toxic agents, does not kill and wound any other non-target living beings and belongs to an environment-friendly biological trapping agent. Euaresta aequalis is trapped: the quantity of the Euaresta aequalis is increased by 18.81 to 23.71% compared with that of the control, and the quantity of female flies trapped by the trapping agent is increased by 37.78% to 30 times compared with that of the control. Tetradacus citri is trapped: the quantity of the Tetradacus citri is increased by 64.43% compared with that of the control, and the quantity of female flies trapped by the trapping agent is increased by 33.25 times. The vegetable leafminer is trapped: the female fly rate accounts for 55 to 60%.

The invention discloses a biodegradable composite coating material for a slow-release fertilizer. The biodegradable composite coating material is characterized in that firstly, neutral sodium hydroxide-hydroxylamine hydrochloride-isopropyl alcohol mixed liquid is prepared; secondly, active hydroxyl in sodium alga acid and ethyl chloroacetate react, and the sodium alga acid is modified; thirdly, the modified sodium alga acid, cellulose and octenyl succinic anhydride react; finally, the reactant and acrylic emulsion are compounded, and bentonite is filled to prepare the biodegradable composite coating material for the slow-release fertilizer. According to the composite coating material, the sodium alga acid, the cellulose and the acrylic emulsion serving as a main body of the material are nontoxic, the biodegradable material is low in cost and simple in preparation method, industrial production of the materials is easily achieved, and production and application of the material are environmentally friendly.

The invention provides an immune-enhancing antineoplastic collagen composition as well as a preparation method and an application thereof. The composition is characterized by consisting of antineoplastic factors, collagen, polysaccharide substances and active factors. The composition is applicable to, but not limited in, cells for treating breast cancer, colorectal cancer, ovarian cancer, pancreatic cancer, prostatic cancer, bladder cancer, melanoma, lung cancer, stomach cancer, liver cancer, head and neck squamous cell carcinoma, carcinoma of uterine cervix, renal cell carcinoma, thyroid cancer, acute myeloid leukemia, myeloma, esophageal squamous cancer, lymphoma and the like.

The invention discloses an oral sustained-release preparation of hydroxypiperidone. The sustained-release preparation comprises the following components: hydroxypiperidone or a pharmaceutically acceptable salt thereof, one or more pharmaceutically acceptable excipients, and at least one polymer with a sustained-release effect. According to the invention, the medicinal high-molecular material is selected as the sustained-release material, and an in-vitro release test result shows that the provided sustained-release hydroxypiperidone tablet gradually releases drugs within 8-24 hours, so that the peak-valley phenomenon of drug absorption is reduced, the blood concentration required by treatment is maintained, compared with a common tablet, the oral sustained-release preparation of the hydroxypiperidone has the advantages that purposes of reduction of the administration times, lasting effect and convenience in administration can be achieved, and the sustained-release preparation is beneficial to treatment of diseases.

An active body is provided that includes at least one active mass block made of monobasic or polybasic high-energy materials such as a nitrocellulose mixture, for example, comprising approximately 60 percent nitroglycerin and 40 percent diethylene glycol dinitrate, which is provided with structures both on a surface and on an interior. In addition, the inner structures can be filled with an active mass substance. The ignition is triggered by a pyrotechnical primer composition, which initiates the active body, preferably from the inside.

The invention discloses a drugcoated balloon controllable in drug metabolism and a preparation method of the drugcoated balloon, and relates to the technical field of drugcoated balloons. The drugcoated balloon is prepared through the steps of mixing a drug acceptor protein inhibitor with drugs, water and ethanol to obtain medicinal liquid, spraying the medicinal liquid onto the surface of the balloon back and forth through ultrasonic spraying equipment, and performing drying so as to obtain the drugcoated balloon. The drug acceptor protein inhibitor can also be replaced with a drug metabolismisoenzyme inhibitor, an inducer or a mixture of the drug acceptor protein inhibitor and a drug metabolism isoenzyme inhibitor for preparing the medicinal liquid, and through adjusting the addition quantity of the drug acceptor protein inhibitor and the compounding ratio of the drug acceptor protein inhibitor to drugs further, the drug metabolism period of the drugcoated balloon can be adjusted and controlled. The invention provides the drugcoated balloon controllable in drug metabolism and a simple and efficient preparation method of the drugcoated balloon controllable in drug metabolism, andthe prepared drugcoated balloon has the functions that metabolism can be effectively controllable without destroying the structure of an intima, at the initial stage of using the drugcoated balloon,drug metabolism can be generated to achieve the effect of drug treatment, and the effect period of the drugs can be prolonged through adjusting the formula.

A cowshed feces deodorant comprises bacillus licheniformis, bacillus subtilis, dried yeast, lactic acid bacteria and photosynthetic bacteria and is prepared from, by weight, 47% of a complex bacterialagent and 53% of corn flour serving as a carrier by proportional mixing for feces deodorization. The complex bacterial agent is prepared by mixing, by weight, 15% of bacillus licheniformis, 21% of bacillus subtilis, 17% of lactic acid bacteria, 27-32% of dried yeast and 12-18% of photosynthetic bacteria, wherein the effective viable count of bacillus licheniformis, bacillus subtilis and photosynthetic bacteria is larger than 200 million per gram. The optimal proportions of dried yeast and photosynthetic bacteria in the complex bacterial agent are 32% and 15% respectively. The bacillus licheniformis can be bacillus cereus, bacillus latersprorus and bacillus megatherium; the photosynthetic bacteria can be rhodopseudomonas palustris and rhodopseudomonas sulfidophila.

The invention provides an environment-friendly microbial composite paraffin remover and inhibitor for an oil well. The environment-friendly microbial composite paraffin remover and inhibitor comprises15-20 parts of a paraffin-philic mixed bacteria solution, 15-60 parts of a strain nutrient solution, 5-9 parts of a first surfactant, 5-9 parts of a second surfactant and 2-4 parts of a mutual solvent; wherein the paraffin-philic mixed bacteria solution is a mixed solution of pseudomonas aeruginosa, bacillus subtilis and micrococcus terreus fermentation liquor; the strain nutrient solution comprises the following components by weight: 20-35 parts of sweet potato powder, 1-5 parts of liquid paraffin, 1-4 parts of vinasse, 1-3 parts of agar, 1-2 parts of sodium chloride, 1-2 parts of ammonium chloride, 2-7 parts of potassium dihydrogen phosphate, 1-2 parts of calcium chloride, 1-2 parts of sodium sulfate and 90-100 parts of water; the first surfactant is a fluorocarbon surfactant FC-3B or oleamide betaine FDCH-1; the second surfactant is polyoxyethylene octylphenol ether-10 or SP80; and the mutual solvent is n-octyl alcohol or ethylene glycol monobutyl ether. The composite paraffin remover and inhibitor effectively solves the technical defects of paraffin removal and inhibition by the existing chemical method and microbiological method, and has the advantages of economy, environmental protection, high paraffin dissolving speed in thickened oil, strong anti-scouring capability, long action period and the like.

The invention discloses a composite biological stimulant for delaying senescence and death of leaves in middle and late growth stages of peanuts, and belongs to the technical field of agricultural biotechnology. According to the compound biological stimulant for delaying senescence and death of leaves in middle and late growth stages of peanuts, a plant growth regulator melatonin is used in combination with Fe2O3 nanoparticles or ZnO nanoparticles, so that the action period of the growth regulator can be prolonged, and senescence and death of peanuts can be effectively prevented and controlled.

The invention discloses a solid slow-release scale inhibitor and a preparation method thereof, and belongs to the technical field of oilfield auxiliary agents. A purpose of the invention is to solve the problems of a certain corrosivity to wellbore, short action period, high cost and the like of the scale inhibitor. According to the method, a quadripolymer is subjected to blending modification with organic attapulgite to obtain a solid slow-release scale inhibitor capable of effectively inhibiting formation and deposition of wellbore scale in an oil extraction process, greatly reducing the regular scale removal period of a wellbore, reducing the oil extraction cost and ensuring the safe and stable operation of an oil well. According to the invention, organic nano-clay is applied to the solid slow-release scale inhibitor, so that the stability and the mechanical strength of the solid slow-release scale inhibitor can be effectively improved, and the action period of the solid slow-release scale inhibitor is effectively prolonged.

The invention discloses a sustained-release composite remediation agent for treating persistent halogenated hydrocarbon in groundwater and a preparation method thereof. The preparation method comprises the following steps: 1) preparing bacterial liquid saturated black carbon; 2) preparing a colloidal solution A containing locust bean gum and an organic carbon source; 3) preparing a colloidal suspension B containing locust bean gum, an organic carbon source, a nano-scale zero-valent metal and the bacterial liquid saturated black carbon; 4) carrying out a crosslinking reaction for 2-6h; and 5) carrying out a delayed crosslinking reaction for 2-6h to obtain a sustained-release composite remediation agent for treating persistent halogenated hydrocarbon in groundwater. The sustained-release composite remediation agent prepared by the method provided by the invention can utilize the good adsorption performance of black carbon, the high-efficiency chemical reducibility of the nano-scale zero-valent metal and the dissimilation iron reduction dehalogenation capability of functional microorganisms to achieve the physical, chemical and biological synergistic remediation effect of persistent halogenated hydrocarbon polluted groundwater, and has the advantages of long action period, stable structure, low cost, environmental friendliness and the like.

The invention belongs to the technical field of tertiary oil recovery and particularly relates to a method for extracting oil in single well steam stimulation by combining microorganisms and CO2 in the heavy oil well. The method comprises the following steps: (1) screening test oil wells; (2) screening microorganisms and nutrients thereof; (3) injecting the microorganisms and the nutrients thereof into the stratum of the test oil well; (4) injecting liquid CO2; (5) shutting the test oil well down; (6) opening the test oil well for production. The method disclosed by the invention has the advantage of wide application range and is simple in process implementation; oil well sand production and sleeve damage situations are avoided and the oil well utilization rate is high; the thickened oil viscosity can be greatly reduced, the oil-water interfacial tension is reduced, the stratum energy can be effectively replenished, the characteristics of long action period, remarkable enhanced production effect of oil, and the like are achieved, and therefore, the method is an economic and effective method for increasing the yield of the heavy oil well and can be widely applied to a single well steam stimulation technology of the heavy oil well.

The invention relates to the technical field of curing technologies and asphaltene inhibition in thickened oil development, in particular to a solid asphaltene inhibitor as well as a preparation method and application thereof. The solid asphaltene inhibitor comprises 35-60% of an ethylene-vinyl acetate copolymer, 6-20% of xylene and 20-60% of span 80. The preparation method comprises the followingsteps: evenly mixing the ethylene-vinyl acetate copolymer and xylene with the mass 6 times that of the ethylene-vinyl acetate copolymer, and carrying out a melt cementing reaction at the temperatureof 100-110 DEG C; adding span 80, uniformly mixing, and continuously heating to volatilize part of xylene until the viscosity of the mixture is not increased any more and the content of xylene in themixture is 15-30%; and extruding the mixed mixture into a mold for molding to obtain a product. The solid asphaltene inhibitor is loaded into a drug carrier, is directly fed or fed through a drug feeding pipe, has the use temperature of 30-90 DEG C, the pressure of 0.1-30 MPa, the effective concentration of 0.8-1.2%, a good slow release effect, a long action period, a small dosage and low cost, has an excellent asphaltene deposition inhibition effect, has pour point depressing and paraffin control effects, and reduces the oilfield exploitation cost to a great extent.

The invention discloses extinguishment liquor used for preventing and extinguishing coal spontaneous combustion fire hazards. Water is used as a solvent, and the extinguishment liquor comprises, by weight percentage, 20%-26% of a surface active agent, 6%-12% of sodium alkyl sulfonate, 9%-15% of melamine compounded phosphate ester, 9%-15% of ammonium chloride and potassium carbonate compounded diammonium hydrogen phosphate, 1%-4% of carboxymethylcellulose or xanthan gum, 2%-5% of urea or sodium xylene sulfonate, 5%-8% of magnesium chloride, 7%-12% of sodium bicarbonate and the balance water, and the total amount is 100%. By means of the extinguishment liquor used for coal spontaneous combustion, the coal spontaneous combustion fire hazards can be quickly and effectively extinguished, quickcooling for removing heat in a high temperature zone is achieved, after-combustion is avoided, and the extinguishment liquor used for coal spontaneous combustion is efficienct, quick, environment-friendly, low in cost and easy and convenient to operate.

The invention belongs to the technical field of tropical crop pest control, and particularly relates to an application of a Delphinium brunonianum Royle or a Delphinium brunonianum Royle extract in control of Dysmicoccus neobrevipes of sisal hemp. According to the invention, the researcher finds that the Delphinium brunonianum Royle extract has an efficient poisoning effect on the Dysmicoccus neobrevipes; the Delphinium brunonianum Royle extract belongs to a plant source component, can effectively prevent the generation of drug resistance of the Dysmicoccus neobrevipes of sisal hemp, and is non-toxic and harmless to human and livestock, environment-friendly and relatively long in action period. According to the invention, a green and safe choice is provided for the development of botanicalpesticides for preventing and controlling the Dysmicoccus neobrevipes of sisal hemp.

The invention discloses a carbonized bamboo board mattress and belongs to the field of furniture. The carbonized bamboo board mattress comprises a mattress support framework equipped with a base plate and a panel respectively at two side surfaces thereof; a cavity forms between the base plate and the panel and is provided with external Chinese herbal medicines beneficial for human body; the panel is made of carbonized bamboo board and provided with a plurality of apertures. Compared with a prior art, the apertures on the panel of the invention enable efficacy of Chinese herbal medicines to extend above the mattress without obstruction and effect on a human body, so the effects are direct and obvious. Besides, a purpose of average effect of the external Chinese herbal medicines during an action period is realized; and efficacy of drug absorbed by the carbonized bamboo board radiates slowly, so an effect period of the external Chinese herbal medicines is prolonged. In addition, the carbonized bamboo board can improve integral environment of a bedroom.

The invention discloses a 28-homobrassinolide microcapsule suspending agent, which is prepared from the following ingredients in percentage by mass: 0.0001 to 60 percent of 28-homobrassinolide, 0.1 to 5 percent of wetting agents, 0.1 to 8 percent of dispersing agents, 1 to 6 percent of anti-freezing agents, 0.1 to 3 percent of thickening agents, 0.1 to 3 percent of antifoaming agents, 3 to 5 percent of capsule wall materials, 0.1 to 10 percent of pH conditioning agents and the balance of water. The microcapsule suspending agent is helpful for stabilizing the 28-homobrassinolide in a preparation and exerting the drug effect of the 28-homobrassinolide.

The invention provides a gel type annulus protection liquid and a preparation method thereof. The gel type annulus protection liquid is composed of a corrosion inhibitor, an organic phosphonic acid scale inhibitor, a non-oxidizing bactericide, a deoxidant, a hydrophobic association polymer, a cross-linking agent and the like, can be injected into a system at a time according to field requirements,and can also be injected into the system in a slug mode according to concentration decreasing, and the effect of effectively preventing leakage of protection liquid caused by failure of a packer is achieved. In addition, due to the association effect, the hydrophobic association polymer in the system can form an intermolecular association space network structure, gel formed after further crosslinking between molecules has a certain drainage function and can play a certain role in plugging casing breaking formation water immersed into an annulus, and the action period of the annulus protectionliquid is prolonged. The system is simple in on-site injection process, obvious in application effect and free of pollution to the environment.

The invention belongs to the technical field of uranium-polluted underground water remediation, and discloses a pH-responsive nano-iron-based sustained-release material, a preparation method and application, and the preparation method of the pH-responsive nano-iron-based sustained-release material comprises the following steps: preparing a nano-iron-based material; preparing a cross-linked chitosan solution with pH response; the cross-linked chitosan wraps the nano iron-based material; and carrying out solid-liquid separation, washing and drying on the obtained precipitate to obtain the pH response type nano-iron-based slow-release material for repairing the uranium-polluted underground water of the acid-process in-situ leaching mine. The prepared nano slow-release material can slowly release the nano iron-based material under the acidic condition, and the released nano iron-based material can improve the pH of acidic uranium polluted underground water on one hand and fix uranium in the underground water through adsorption and chemical reduction effects on the other hand. The nano sustained-release material is small in particle size (20-100nm) and good in migration and diffusion performance, and has the advantages of long action period, stable structure, low cost, environmental friendliness and the like.

The invention discloses a solid slow-release scale inhibitor and a preparation method thereof, and belongs to the technical field of oilfield auxiliary agents. A purpose of the invention is to solve the problems of a certain corrosivity to wellbore, short action period, high cost and the like of the scale inhibitor. According to the method, a quadripolymer is subjected to blending modification with organic attapulgite to obtain a solid slow-release scale inhibitor capable of effectively inhibiting formation and deposition of wellbore scale in an oil extraction process, greatly reducing the regular scale removal period of a wellbore, reducing the oil extraction cost and ensuring the safe and stable operation of an oil well. According to the invention, organic nano-clay is applied to the solid slow-release scale inhibitor, so that the stability and the mechanical strength of the solid slow-release scale inhibitor can be effectively improved, and the action period of the solid slow-release scale inhibitor is effectively prolonged.

The invention discloses slow-release fertilizer granules which consist of chemical slow-release agents and organic fertilizers in a weight ratio of (3-6):(15-30), wherein the chemical slow-release agents consist of the following raw materials in parts by weight: 2-6 parts of calcium superphosphate, 1.3-1.4 parts of polyvinyl alcohol, 2-4 parts of humic acid, 2-3 parts of diammonium phosphate, 0.5-1 part of carbendazol and 1-2 parts of EDTA (Ethylene Diamine Tetraacetic Acid) helated zinc. As the chemical fertilizers with slow-release effects are combined with the organic fertilizers to form a mixed fertilizer, the slow-release fertilizer granules are high in fertilizer efficiency absorption rate, long in action period and applicable to growth cycles of crops, the yield of crops can be increased by 30%, and the yield and the benefits of the crops can be increased.

The invention provides an immune-enhancing antineoplastic collagen composition as well as a preparation method and an application thereof. The composition is characterized by consisting of antineoplastic factors, collagen, polysaccharide substances and active factors. The composition is applicable to, but not limited in, cells for treating breast cancer, colorectal cancer, ovarian cancer, pancreatic cancer, prostatic cancer, bladder cancer, melanoma, lung cancer, stomach cancer, liver cancer, head and neck squamous cell carcinoma, carcinoma of uterine cervix, renal cell carcinoma, thyroid cancer, acute myeloid leukemia, myeloma, esophageal squamous cancer, lymphoma and the like.

The invention discloses a method for treating persistent halogenated hydrocarbons in soil by a slow-release compound remediation agent. The method includes steps: pre-ploughing contaminated soil, directly spreading a certain quantity of the slow-release compound remediation agent into ploughed soil, harrowing to well mix, watering to keep certain moisture content, and covering the soil surface with a protecting layer to realize anaerobic reduction dehalogenation reaction, wherein spreading quantity of the remediation agent is 0.05-1.5% of the dry weight of the contaminated soil, the soil ploughing depth is 25-40cm, the soil moisture content is adjusted to 50-80% of maximum field moisture capacity after spreading of the remediation agent, and remediation treatment time is 30-350d. The remediation method takes advantages of great adsorption performance of black charcoal, efficient chemical reducibility of nano zero-valence metal and dissimilatory iron reduction dehalogenation performanceof functional microorganisms to achieve physical, chemical and biological synergistic remediation effects on persistent halogenated hydrocarbon contaminated soil and has advantages of long action period, structural stability, low cost, environmental friendliness and the like.

The invention provides an immunoenhanced composition, a preparation method and application. The composition is characterized by comprising collagens which are free of immunogenicity and can be degraded in vivo, polysaccharide substances and loose particles of active factors. The immunoenhanced composition applied to vaccination can intensity the immunoreactions of an antigen, and reduce side effects of inflammation, granuloma and abscess in the immunoreactions.

The invention belongs to the field of high-speed rail train cleaning and protection, and relates to a high-speed rail train shell protective liquid. Raw materials include, by weight, 2 to 5 parts of sodium chloride, 1 to 3 parts of calcium laurate, 1 to 4 parts of sodium pyrrolidone carboxylate, 15 to 25 parts of epoxy silicon dioxide nanoparticle hydrosol, 2 to 3 parts of 2,4-dihydroxy benzophenone, 10 to 15 parts of glycerol and 20 to 25 parts of deionized water. The protective liquid can still be firmly adsorbed on the surface of a shell of the high-speed rail train when the high-speed railtrain runs at a high speed, forms an anti-pollution superfine micro-nano structure, and can effectively suppress adsorption and adhesion of pollutants on the surface of the shell of the high-speed rail train; the high-speed rail train can be cleaned more easily, the cleaning time is shortened, the use amount of a cleaning agent is reduced, and the protective liquid has the advantages of being efficient in protection, long in action period, convenient to use and low in cost and has remarkable market prospects.

The invention relates to aqueous solution pharmaceutical compositions comprising at least one non-ionic tonicity agent, at least one buffer and an active ingredient, wherein said active ingredient is a compound of formula I, wherein R1-R9 are defined herein; processes for preparing these compositions and their use in medicine, especially their use in the treatment of ocular diseases.

The invention discloses a sustained-release composite remediation agent for treating persistent halogenated hydrocarbon in groundwater and a preparation method thereof. The preparation method comprises the following steps: 1) preparing bacterial liquid saturated black carbon; 2) preparing a colloidal solution A containing locust bean gum and an organic carbon source; 3) preparing a colloidal suspension B containing locust bean gum, an organic carbon source, a nano-scale zero-valent metal and the bacterial liquid saturated black carbon; 4) carrying out a crosslinking reaction for 2-6h; and 5) carrying out a delayed crosslinking reaction for 2-6h to obtain a sustained-release composite remediation agent for treating persistent halogenated hydrocarbon in groundwater. The sustained-release composite remediation agent prepared by the method provided by the invention can utilize the good adsorption performance of black carbon, the high-efficiency chemical reducibility of the nano-scale zero-valent metal and the dissimilation iron reduction dehalogenation capability of functional microorganisms to achieve the physical, chemical and biological synergistic remediation effect of persistent halogenated hydrocarbon polluted groundwater, and has the advantages of long action period, stable structure, low cost, environmental friendliness and the like.