70results about How to "Little difference in loading" patented technology

The invention discloses a full automatic capsule stowing machine which comprises a capsule split-charging swivel table (5), an actuating mechanism and a controller (3). A plurality of stations are arranged on the capsule split-charging swivel table; and a charging device (2), a medicinal powder stowing gauging device (4), a capsule tightening device (41), a drawing mechanism (41), and a die cleaning plant (1) are respectively arranged on the corresponding stations. The capsule stowing machine has the characteristics of good leak tightness of the capsule split-charging swivel table, accurate medicinal powder stowing amount, high probability of the capsule manufactured on the machine, strong production capacity, and the realization of capsule tally function.

The invention relates to the field of pharmaceutical preparations, and particularly discloses a palbociclib pharmaceutical composition and a method for preparing the same. The palbociclib pharmaceutical composition comprises, by weight, 20%-30% of palbociclib, 30%-40% of pregelatinized starch, 20%-30% of lactitol, 3%-5% of starch sodium glycollate, 4%-6% of hydroxyethyl methyl celluloses, 3%-5% ofhydroxyethyl celluloses and 1%-3% of citric acid fatty glyceride. The palbociclib pharmaceutical composition and the method have the advantages that excellent dissolution effects can be realized by the palbociclib pharmaceutical composition, the contents of related substances can be obviously reduced, the stability can be obviously enhanced, and clinical medicines can be advantageously safely used and can be advantageously stored for a long term; the particle sizes of raw auxiliary materials are controlled, accordingly, the palbociclib pharmaceutical composition is good in mixing property andflowability as discovered via experiments, and capsules can be directly filled with the palbociclib pharmaceutical composition by means of mixing.

The invention discloses irbesartan capsules and a preparation method thereof. The irbesartan capsule mainly comprises irbesartan, pregelatinized starch, microcrystalline cellulose, croscarmellose sodium, hydroxypropyl methylcellulose and magnesium stearate. A boiling one-step granulation method is adopted, which means that mixing, granulation and drying steps are completed in one step in a closed container of a boiling one-step granulator. The prepared particles have uniform granularity, good fluidity, small difference of capsule capacity, good solubility, less steps than the conventional wet-process granulation process, few production equipment, low production cost, high efficiency and high yield.

The invention provides a preparation method of total glucosides of paeony capsules, which is characterized in that the total glucosides of paeony granules are prepared first, and the total glucosides of paeony granules are prepared from raw materials of total glucosides of paeony and medicinal auxiliary materials. The ratio of raw materials and pharmaceutical excipients is 1:0.001~1:25. Dry granulator granulation equipment is used to granulate the prepared materials in the dry granulator. By adjusting the extrusion force of the dry granulator, Extrusion frequency conversion, feeding frequency conversion, side sealing pressure to prepare suitable granules, setting parameters range: extrusion force 0 ~ 15kg, extrusion frequency conversion 20 ~ 50Hz, feeding frequency conversion 20 ~ 45, side sealing pressure 5 ~ 20kg, the prepared The good total glucosides of paeony granules can be put into capsules, and the total glucosides of paeony capsules prepared by the invention have the characteristics of small difference in filling capacity, good moisture absorption resistance and the like.

The invention discloses a cephalosporin medicinal composition, consisting of a compound I, a compound II and water of which the quantity is 1.0-2.8 percent of the weight of the medicinal composition, wherein the D90 granularity of the medicinal composition is 95-175 microns. The medicinal composition is good in stability, content uniformity and packaging uniformity, the quality of the antibacterial medicinal composition is effectively ensured, and the safety of medication is improved.

The invention which belongs to the traditional Chinese medicinal piece field concretely relates to an ultrafine traditional Chinese medicinal granule piece and a preparation process thereof. The invention which aims at present granulation processes and devices, small viscosity of traditional Chinese medicines, and the defects of irregular shape, easy moisture absorbing and bad fluidity of prepared granules provides a new production process which allows the ultrafine traditional Chinese medicinal granule piece with regular shape and good fluidity to be prepared from the small viscosity traditional Chinese medicines. The preparation process comprises the following steps: crushing the traditional Chinese medicines until the crushed traditional Chinese medicines can pass a 80-100 mesh sieve, processing according to a routine method, and crushing the traditional Chinese medicines to 400-1200 meshes; preparing a soft material; granulating by adopting a compression granulator; and drying the granules. The granule piece of the invention, which is prepared through crushing, processing and re-crushing, allows the traditional Chinese medicines to be uniformly and thoroughly processed, and the granule piece obtained through granulating and shaping the small viscosity traditional Chinese medicines by strong extruding force of the compression granulator has the advantages of regular shape, good visibility, small specific surface area, difficult moisture absorbing, and good fluidity, and can satisfy clinical medicine demands.

The invention belongs to the technical field of traditional Chinese medicines and particularly relates to application of a lung-tonifying and blood-activating capsule to the preparation of a drug for treating chronic bronchitis. The lung-tonifying and blood-activating capsule is prepared from a traditional Chinese medicine extract and an auxiliary material according to the ratio of 1:(0.05-0.2); and the traditional Chinese medicine extract is prepared from the following raw materials in part by weight: 50-100 parts of radix astragali, 50-100 parts of radix paeoniae rubra and 25-50 parts of fructus psoraleae. The lung-tonifying and blood-activating capsule provided by the invention can significantly reduce the contents of TNF and ET in chronic bronchitis model rat lung tissues and has a positive therapeutic effect on the chronic bronchitis. In addition, through electric field pretreatment on traditional Chinese medicine fine powder, the load difference of the hard capsule is significantly improved, so that the quality of the hard capsule is greatly improved.

The invention relates to a capsule containing a Hypericum perforatum extract. According to the invention, through changing of the addition sequence of adjuvants in preparation of the capsule, the capsule with good disintegration efficiency and good fluidity is prepared. A preparation method for the capsule comprises the following concrete steps: uniformly mixing the Hypericum perforatum extract with a lubricant; and then adding other components, carrying out uniform mixing and filling the capsule, wherein the other components are pharmaceutic adjuvants or a composition of other active medicines and pharmaceutic adjuvants.