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Irbesartan capsules and preparation method thereof

A technology of irbesartan and capsules, applied in the field of medicine, can solve the problems of low efficiency, many equipment and personnel configuration, complicated preparation process and the like

Active Publication Date: 2012-10-03
YANGTZE RIVER PHARM GRP GUANGZHOU HAIRUI PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Tablets and capsules are currently on the market, and the preparation process is traditional wet granulation process. The preparation process is relatively complicated, and the equipment, material consumption, and staffing are large, and there are disadvantages such as high cost, low efficiency, and low yield.

Method used

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  • Irbesartan capsules and preparation method thereof
  • Irbesartan capsules and preparation method thereof
  • Irbesartan capsules and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] The preparation method of embodiment 1 irbesartan capsule

[0027] Irbesartan capsules mainly contain the following components:

[0028]

[0029] The preparation method is as follows:

[0030] a. take the hypromellose of prescription quantity, be dissolved in appropriate amount of purified water, make 3% hypromellose aqueous solution, standby as adhesive;

[0031] b. Pass irbesartan through a No. 5 sieve, pregelatinized starch, microcrystalline cellulose, croscarmellose sodium and magnesium stearate through a No. 6 sieve respectively, and set aside;

[0032] c. Put the sieved irbesartan, pregelatinized starch, microcrystalline cellulose, and croscarmellose sodium in a boiling one-step granulator, set the inlet air temperature to 50°C, and The frequency conversion is 25.00Hz, the air outlet temperature is 50°C, mix evenly, and then spray the adhesive through the spray gun above the boiling one-step granulator, the spray speed is 20.0r / min, the spray gun atomization ...

Embodiment 2

[0037] The preparation method of embodiment 2 irbesartan capsules

[0038] Irbesartan capsules mainly contain the following components:

[0039]

[0040] The preparation method is as follows:

[0041] a. take by weighing the hypromellose of prescription quantity, be dissolved in appropriate amount of purified water, make 5% hypromellose aqueous solution, standby as adhesive;

[0042] b. Pass irbesartan through a No. 4 sieve, pregelatinized starch, microcrystalline cellulose, croscarmellose sodium and magnesium stearate through a No. 5 sieve respectively, and set aside;

[0043] c. Put the sieved irbesartan, pregelatinized starch, microcrystalline cellulose, and croscarmellose sodium in a boiling one-step granulator, set the inlet air temperature to 50°C, and The frequency conversion is 25Hz, the outlet air temperature is 50°C, mix evenly, and then spray the adhesive through the spray gun above the boiling one-step granulator, the injection speed is 25.0r / min, the spray gu...

Embodiment 3

[0048] The preparation method of embodiment 3 irbesartan capsules

[0049] Irbesartan capsules mainly contain the following components:

[0050]

[0051] The preparation method is as follows:

[0052] a. take the hypromellose of prescription quantity, be dissolved in appropriate amount of purified water, make 4% hypromellose aqueous solution, standby as adhesive;

[0053] b. Pass irbesartan through a No. 5 sieve, pregelatinized starch, microcrystalline cellulose, croscarmellose sodium and magnesium stearate through a No. 5 sieve, and set aside;

[0054] c. Put the sieved irbesartan, pregelatinized starch, microcrystalline cellulose, and croscarmellose sodium in a boiling one-step granulator, set the inlet air temperature to 55°C, and The frequency conversion is 25Hz, the outlet air temperature is 50°C, mix evenly, and then spray the adhesive through the spray gun above the boiling one-step granulator, the injection speed is 30.0r / min, the spray gun pressure is 0.25Mpa, an...

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Abstract

The invention discloses irbesartan capsules and a preparation method thereof. The irbesartan capsule mainly comprises irbesartan, pregelatinized starch, microcrystalline cellulose, croscarmellose sodium, hydroxypropyl methylcellulose and magnesium stearate. A boiling one-step granulation method is adopted, which means that mixing, granulation and drying steps are completed in one step in a closed container of a boiling one-step granulator. The prepared particles have uniform granularity, good fluidity, small difference of capsule capacity, good solubility, less steps than the conventional wet-process granulation process, few production equipment, low production cost, high efficiency and high yield.

Description

technical field [0001] The invention belongs to the field of medicine. Specifically, the invention relates to an irbesartan capsule for treating mild and moderate hypertension and a preparation method thereof. Background technique [0002] According to the latest estimates, there are 1.2 billion people with high blood pressure worldwide. About one-third of adults in the United States, or about 80 million people, have high blood pressure. In my country, the number of hypertensive patients has exceeded 300 million, and there is a trend of younger age. [0003] Irbesartan is a recently developed sartan drug, which has good clinical curative effect, especially for patients with mild and moderate hypertension, has definite antihypertensive effect, few adverse reactions and good tolerance. [0004] Tablets and capsules are currently on the market, and the preparation process is traditional wet granulation process. The preparation process is relatively complicated, and the equipm...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/48A61K31/4184A61K47/38A61P9/12
Inventor 李继仁
Owner YANGTZE RIVER PHARM GRP GUANGZHOU HAIRUI PHARM CO LTD
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