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Nanocapsule for promoting blood circulation and preparation method thereof

A technology of capsules and Tongmai, which is applied in the field of Chinese patent medicine capsules and its preparation, can solve problems such as unqualified subpackage volume, difficult subpackage operation, and long disintegration time, so as to reduce water content and improve stability , Improve the effect of disintegration time

Inactive Publication Date: 2014-03-12
HAINAN HULUWA PHARMA GRP CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The disintegration time of the medicine prepared by this preparation method is long, the curative effect is not good, and the operation of dispensing is also very difficult, and it is easy to appear that the difference in dispensing volume is unqualified

Method used

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  • Nanocapsule for promoting blood circulation and preparation method thereof
  • Nanocapsule for promoting blood circulation and preparation method thereof
  • Nanocapsule for promoting blood circulation and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Danshen 500g Chuanxiong 500g

[0030] Pueraria 500g Dextrin 15g

[0031] Microcrystalline Cellulose 10g

[0032] 1) Pulverization: respectively pulverize Salvia miltiorrhiza, Chuanxiong, and Pueraria lobata through a 200-mesh sieve (the mesh size of the sieve is subject to the Taylor system), and sterilize to obtain nano-powder raw materials;

[0033] 2) Adhesive: Prepare 2% dextrin aqueous solution and put it in a spray tank for later use;

[0034] 3) Mixing and granulation: Pass the microcrystalline cellulose through a 100-mesh sieve, weigh 15g and the prescription amount of nano-powder raw material and put it into the feeder of the one-step granulator, turn on the fan and heat it, so that the material can be evenly heated in a fluidized state. Turn on the spray button, spray 2% dextrin aqueous solution, adjust the liquid inlet speed 27ml / min, atomization pressure 0.10-0.12MPa, inlet air temperature 80-85℃, material temperature 43-45℃, until the 2% dextrin aqueous s...

Embodiment 2

[0037] Danshen 800g Chuanxiong 800g

[0038] Pueraria 800g Dextrin 15g

[0039] Microcrystalline Cellulose 15g

[0040] (1) Pulverization: respectively pulverize salvia miltiorrhiza, chuanxiong, and kudzu root through a 200-mesh sieve, and sterilize to obtain nano-powder raw materials;

[0041] (2) Adhesive: Prepare 2% dextrin aqueous solution and put it in a spray tank for later use;

[0042] (3) Mixing and granulation: Pass the microcrystalline cellulose through a 100-mesh sieve, weigh 15g and the prescription amount of nano-powder raw material and put it into the feeder of the one-step granulator, turn on the fan and heat it, so that the material can be evenly heated in a fluidized state , turn on the spray button, spray 2% dextrin aqueous solution, adjust the liquid inlet speed 26ml / min, atomization pressure 0.10~0.12MPa, inlet air temperature 80~85℃, material temperature 45~47℃, until all the adhesive is sprayed , dried, cooled and discharged to obtain capsule granules...

Embodiment 3

[0045] Danshen 1000 Chuanxiong 1000

[0046] Pueraria 1000 Dextrin 10g

[0047] Microcrystalline Cellulose 20g

[0048] (1) Pulverization: respectively pulverize salvia miltiorrhiza, chuanxiong, and kudzu root through a 200-mesh sieve, and sterilize to obtain nano-powder raw materials;

[0049] (2) Adhesive: Prepare 2% dextrin aqueous solution and put it in a spray tank for later use;

[0050] (3) Mixing and granulation: Pass the microcrystalline cellulose through a 100-mesh sieve, weigh 20g and the prescription amount of nano-powder raw material and put it into the feeder of the one-step granulator, turn on the fan and heat it, so that the material can be evenly heated in a fluidized state , turn on the spray button, spray dextrin aqueous solution, adjust the liquid inlet speed 25-32ml / min, atomization pressure 0.10-0.12MPa, inlet air temperature 80-85℃, material temperature 43-47℃, until the dextrin aqueous solution is completely sprayed Put in, dry, cool down and dischar...

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Abstract

The invention discloses a nanocapsule for promoting blood circulation and a preparation method thereof. The nanocapsule for promoting blood circulation is prepared from the following ingredients in parts by weight: 500-1000 parts of danshen roots, 500-1000 parts of szechuan lovage rhizome, 500-1000 parts of kudzuvine roots, 10-20 parts of an adhesive and 10-20 parts of a disintegrating agent, wherein the danshen roots, the szechuan lovage rhizome and the kudzuvine roots are particles less than 200 meshes. According to the invention, the ultrafine traditional Chinese medicines, the using amount of which is one tenth of the medicine using amount of the original prescription, are adopted, so that valuable traditional Chinese medicine resources are saved greatly, and the planting environment of the traditional Chinese medicinal materials is effectively protected; cell disruption is performed on indissolvable effective constituents or effective constituents slightly soluble in water, so that the bioavailability of the nanocapsule can be improved obviously; the production technology is simple, the extraction process is not required, the investment of corresponding equipment and plants, inspection cost and labor intensity are reduced, and the time and resources are saved; the quality of the nanocapsule is not determined through workers' experience, so that the final quality is stable, the difference among batches is less, and the operability is high.

Description

technical field [0001] The invention belongs to the field of Chinese patent medicine capsules and the preparation thereof, in particular to a nanometer Tongmai capsule and a preparation method thereof. Background technique [0002] Tongmai Capsule is made from Tongpulse Agent which has been sold in the domestic market. It belongs to the 9th category of traditional Chinese medicine registration. It has the function of promoting blood circulation and Tongmai. Coronary heart disease, angina pectoris. It belongs to the category of "chest pain" in traditional Chinese medicine. [0003] At present, Tongmai has been marketed in the form of granules and oral liquid, both of which contain more sucrose (sugar content of Tongmai Granules is about 80%, sugar content of Tongmai Oral Liquid is about 30%), due to the high sugar content , which limits the use of some patients, such as obese patients, diabetic patients, etc., especially the latter, due to the relative or absolute lack of i...

Claims

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Application Information

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IPC IPC(8): A61K36/537A61K9/48A61K47/38A61K47/32A61K47/36A61P9/10A61P9/00A61P7/02
Inventor 刘全国陈克领林文君
Owner HAINAN HULUWA PHARMA GRP CO LTD
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