Dry granulation method for cold and cough relieving capsules

Abstract

The invention discloses a dry granulation method for cold and cough relieving capsules. The method comprises the following steps of: adjusting process parameters of a dry granulation machine: the hydraulic system pressure is 13-14 MPa, the main engine speed regulation is less than or equal to 21 Hz, the horizontal feeding frequency is 12-18 Hz, and the vertical feeding frequency is 9-15 Hz; crushing and passing through a 20-mesh sieve; weighing spray powder and menthol clathrate and mixing by using an equivalent incremental method; then mixing for 10 minutes and discharging; granulating by using the dry granulation machine; and drying particles at 95+ / -5 DEG C for 30 minutes, then cooling to be blow 40 DEG C and discharging. During mixing, the obtained dry particles and magnesium stearate are mixed for 10 minutes to obtain finished particles. The particles prepared by the invention have uniform particle size, superior fluidity, hard and weight particles, small granulation error, higher content of active ingredients in the medicament, shortened working hour, reduced energy consumption, reduced cost and high production efficiency.

Description

Technical field [0001] The present invention is the field of pharmaceutical preparation technology, which involves a granular method of a cold cough capsule. [0002] Background technique [0003] Cold cough capsules are by Chaihu 250g, Gegen 250g, Pen Placciper 125g, bitter almond 125g, Forsythia 187.5g, Scutellaria baicalensis 187.5g, Artemisia annua 187.5g, Shanyin flower 187.5g, mint brain 0.375g, β — cyclopa essence 3.75 3.75 3.75G, magnesium magnesium magnesium 2.325g, the above nine flavors, except for mint brain, the remaining 8 -flavors such as Bupleurum plus 8 times fry for 4 hours for the first time, and add 6 times to decoction for 4 hours for the second time., Combine decoction, filtering, filtrate to decompress to the relative density of 1.10 ~ 1.15 (60 ~ 70 ℃).Take 80%of the extract for spraying to spray powder and spray it.Mint brain is composed of 10%(W / V) ethanol solution, and β -cycloid saturated solution is used to wrap (β -cyclic paste saturated solution syst...

AI Technical Summary

Problems solved by technology

[0004] Its existing granulation method is boiling granulation, and boiling granulation has to go through a humid heat process, and this process may lead to a decrease in the content of medicinal ingredients in the finished product; the process is cumbersome, the production cycle is long, the product quality is unstable, and the production cost bigger problem

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