30results about How to "High clinical promotion value" patented technology

The invention relates to a pathogenic bacterium liquid-based thin-layer smear detection kit and a detection method thereof. The detection kit comprises a preconditioning liquid, a liquefier, a diluent, a differential staining liquid and consumable items. The detection method of the detection kit comprises the following steps: adding the strongly alkaline preconditioning liquid and the liquefier into a detection sample to carry out a homogeneous treatment on the sample, adding the diluter, adopting a liquid-based centrifugal settling thin-layer preparation technology to obtain multiple uniformly-distributed pathogenic bacterium liquid-based thin-layer smears, carrying out differential staining, observing and calculating according the staining reaction, the morphology and the arrangement mode of the pathogenic bacteria, thus working out a detection result of multiple pathogenic bacteria in the sample. The invention establishes a fast and sensitive detection method based on the pathogenic bacterium liquid-based thin-layer smears, the whole process can be completed within one hour, and the detection method is simple, thereby achieving high clinical popularization values.

The invention belongs to the traditional Chinese pharmaceutics field, and relates to an application of traditional Chinese medicine radix scrophulariae to the preparation of a drug for preventing and curing cardiac hypertrophy, hypertrophic cardiomyopathy and chronic heart failure. The invention researches the effect of the cardiac hypertrophy and ventricle reconstruction model of a plurality of mice and rats on the traditional Chinese medicine radix scrophulariae. The experimental results show that the radix scrophulariae water or the alcohol abstracts has evident function for preventing the cardiac hypertrophy, the ventricular remodeling and the chronic heart failure caused by various reasons, the mechanism is obviously related with the excessive activation of the neuroendocrine system such as a suppressing renin-angiotensin-aldosterone system and is related with the functions of blood pressure reduction, heart beat slowing and hemodynamics improvement. The figwort can be used for preparing the drug for preventing the diseases of cardiac hypertrophy, hypertrophic cardiomyopathy and chronic heart failure and for reducing the possibility of the incidence rate of arrhythmia and the sudden death of patients with cardiac hypertrophy, hypertrophic cardiomyopathy and chronic heart failure.

The invention provides a polypeptide compound with a HER2 targeting function. The polypeptide compound with the HER2 targeting function is formed by connecting a HER2 affinity with a bifunctional chelating agent through a polypeptide sequence; the polypeptide sequence is Met-Val-Lys; the general structural formula of the polypeptide compound is shown in formula (I) as shown in specification, wherein R is a HER2 affinity molecule and X is a bifunctional chelator group. The invention also provides a radiolabelled complex targeting HER2 by taking the polypeptide compound as a ligand. The radiolabeled complex provided by the invention can be used as a radioactive diagnostic probe for evaluating the HER2 receptor of breast cancer, and the probe can reduce the concentration of the kidney under the condition of keeping the uptake of the tumor unchanged, so that the target-to-non-target ratio of the tumor is improved, and the radiation dose to the kidney is reduced. The invention also provides a preparation method of the polypeptide compound and the radiolabelled complex, and application of the polypeptide compound and the radiolabelled complex in preparation of a HER2 positive breast cancer radioactive diagnosis and treatment probe for humans or animals.

The invention discloses a DTC prognosis marker and application thereof, and a construction method of a DTC prognosis evaluation model, and belongs to the technical field of cancer prognosis evaluation. The prognosis condition of a DTC patient can be predicted by detecting the expression quantity of the glycolysis-related genes, so that the reagent for detecting the expression quantity of the glycolysis-related genes can be used for preparing a reagent or a kit for predicting DTC prognosis, and the glycolysis-related genes comprise ADM, CD44, MKI67 and TYMS. The invention also provides a method for screening the glycolysis-related gene, and a DTC prognosis evaluation system is constructed based on the glycolysis-related gene, so that prognosis risk layering of patients with differentiated thyroid cancer is realized, patients with high and low risks are obviously separated, and clinical results of differentiated thyroid cancer can be predicted. The method can guide individualized treatment and has high clinical application value.

The invention discloses an externally-applied traditional Chinese medicine for treating cancer tumor pain and ascites. The traditional Chinese medicine is prepared from pangolin scales, calculus bovis factitius, snow lotus herb, cordyceps sinensis, ganoderma lucidum, unibract fritillary bulbs, saffron, scorpions, centipedes, sea horse, venenum bufonis, herba dendrobii, zaocys dhumnade, rhizoma gastrodiae, Indian iphigenia bulbs, rhizoma paridis chinensis, herba rhodiolae, radix angelica sinensis, tortoise-shell glue, spreading hedyotis herb, cloves, radix achyranthis bidentatae, licorice roots and pitaya flowers. All the raw materials are subjected to water extraction, concentration, ethanol extraction, cold storage, drying, microwave treatment and smashing, and traditional Chinese medicine composition powder is obtained; the traditional Chinese medicine composition powder is further processed into externally-applied traditional Chinese medicine such as gel or patches or plasters used for treating the cancer tumor pain and ascites. According to the externally-applied traditional Chinese medicine, medication is safe, the efficacy is rapid to achieve, the method is simple and convenient, and the externally-applied traditional Chinese medicine is lasting, stable, definite in efficacy and free of toxic and side effects and has a great clinical popularization value.

The invention discloses an auxiliary circumcising device for penis root circumcision. A front pressing sheet, a back pressing sheet, a guide nail sheet and a thrusting assembly adopt semi-ring structures; the clamping ends of two clamping arms of pressurizing pilers sequentially pass through the thrusting assembly, the guide nail sheet and the back pressing sheet to be in threaded connection withthe front pressing sheet; the two clamping arms are connected with a guide rod assembly; the guide rod assembly comprises an outer pipe and a push rod which is movably arranged in the outer pipe; sliding grooves are symmetrically formed in the two sides of the outer pipe; the two sides of a push rod is hinged with the inner sides of the two clamping arms through movable assemblies correspondingly;each movable assembly comprises a connecting rod and a mounting sheet; one end of the mounting sheet is hinged with one end of the connecting rod, and the other end of the mounting sheet passes through the sliding grooves to be welded with the push rod; and a spring assembly is in sleeving connection with the push rod. The auxiliary circumcising device for penis root circumcision can overcome thedefects of the traditional penis root circumcision, can reduce the operation difficulty of the penis root circumcision and can realize the idealization effects of minimum scar and minimum influence on the penis function by a surgeon in the penile circumcision so as to finally fulfill the aims of accurately cutting and improving the treatment quality.

The invention belongs to the field of traditional Chinese medicine, and relates to a traditional Chinese medicine composition for treating primary hypertension and a preparation method thereof. The traditional Chinese medicine composition is prepared from, by weight, 25-30 parts of apocynum venetum, 20-28 parts of harlequin glorybower leaves and twigs, 16-23 parts of vitex, 15-20 parts of selfheal, 12-20 parts of herba artemisiae scopariae, 15-25 parts of uncaria, 13-20 parts of ligusticum wallichii, 10-17 parts of radix angelica sinensis, 5-15 parts of dendrobe, 8-17 parts of lycium barbarum, 6-10 parts of bighead atractylodes rhizomes, 10-17 parts of fructus crataegi and 8-15 parts of liquorice. The traditional Chinese medicine composition is reasonable in formula and high in synergistic effect, is significant in curative effect, stable in medicine effect and little in medicine side effect when the traditional Chinese medicine composition is used for treating the primary hypertension and has the significant clinical popularization value.

A Chinese medicine in the form of pill for making eye muscle stronger, nourishing liver, preventing the retrograde lesion of eye, improving vision, etc is prepared from 36 Chinese-medicinal materials including pilose asiabell root, rehmannia root, Chinese angelica root, yam, etc.

The invention belongs to the field of traditional Chinese medicine and particularly relates to traditional Chinese medicine liniment for treating stage 2 and stage 3 bedsores in clinical nursing. The traditional Chinese medicine liniment is prepared by yellow angledtwig magnoliavine root stem and leaf, herba violae acuminatae, all-grass of Nippon Cinquefoil, serrate clubmoss herb, serrate rabdosia herb, radix lithospermi, radix polygoni cuspidati and Chinese ilex leaf according to a certain weight proportion. The traditional Chinese medicine liniment has effects of promoting blood circulation to remove blood stasis, clearing away heat and toxic materials, relieving swelling and pain, resisting bacteria and diminishing inflammation and eliminating necrotic tissues and promoting granulation, can firmly adhere to an affected part, can isolate bacterial and benefit wound surface cleaning through self-dissolution, can directly reach lesions through absorption by skin soft tissues, can produce relatively advantaged medicine concentration locally, does not stick to the skin, and is easy to remove, free of secondary damage, good in breathability, convenient to use and worthy of clinical popularization.

The invention discloses a pharmaceutical composition used for treating cancer pain for an anesthesia department. The pharmaceutical composition comprises the following raw materials in parts by weight: 10-20 parts of silktree flower, 15-25 parts of longestapex beautyberry leaves, 4-10 parts of perilla leaf, 6-12 parts of Zanthoxylum nitidum, 4-8 parts of aspongopus, 5-15 parts of levisticum, 4-8 parts of Strychnos ignatii, 10-20 parts of pseudo-ginseng, 8-12 parts of semen hyoscyami, 7-13 parts of scentedros wood, 4-6 parts of borax, and 1-5 parts of pillworm. The pharmaceutical composition has the advantages of proper compatibility of the raw materials, accords with compatibility between monarch and ministerial drug by science of Chinese pharmacology and modern pharmacology, has efficacy for clearing heat and detoxifying, activating blood circulation to dissipate blood stasis, rectifying qi and relieving pain, and removing toxicity for detumescence, can effectively alleviate ache, has advantages of good curative effect, no side effect, no drug dependence, and low drug usage cost, can directly reach the focus position, enhances cancer treatment effect, reduces discomfortableness of the patients during a treatment process, increases the patient immunity, and has great clinical popularization value.

The invention discloses an application of a traditional Chinese medicine composition in preparation of medicine for treating infantile asthma, and belongs to the technical field of traditional Chinese medicine. The traditional Chinese medicine composition is prepared from gentiana sarcorrhiza, radix ophiopogonis, perilla frutescens, gardenia jasminoides, polygonum cuspidatum, fructus citri, winged yam rhizome, dried tangerine or orange peel, herba menthae, radix peucedani and liquorice. According to the traditional Chinese medicine composition, the medicinal materials and dose achieve scientific compatibility, and the effects of moistening the lung and descending qi, freeing the lung and relieving asthma, preventing phlegm from forming and stopping coughing, regulating qi to smooth the middle and the like are achieved; the traditional Chinese medicine composition has the obvious treatment advantages of being fast to take effect, good in curative effect and the like when being used for treatment of infantile asthma clinically.

The invention belongs to the field of a traditional Chinese medicine, and relates to a traditional Chinese medicine composition for treating essential hypertension. The traditional Chinese medicine composition is mainly prepared from the following raw materials in parts by weight: 18-26 parts of spatholobus stem, 22-30 parts of bluish dogbane, 20-24 parts of clerodendron leaf, 16-22 parts of prunella spike, 12-18 parts of virgate wormwood herb, 14-24 parts of uncaria stem and thorn, 18-22 parts of Szechuan lovage rhizome, 16-22 parts of notoginseng, 8-16 parts of dendrobium, 8-18 parts of mulberry leaf, 4-10 parts of rhizoma atractylodis and 4-10 parts of licorice. The traditional Chinese medicine composition has a reasonable medicament composition and good synergism, and is used for treating essential hypertension; the traditional Chinese medicine composition has the advantages of substantial curative effect, stable drug effect, few medicament side-effect, and substantial clinic popularization value.

The invention particularly relates to traditional Chinese medicine plastic for treating phase-I and phase-II pressure sores and a preparation method of the traditional Chinese medicine plastic and belongs to the field of traditional Chinese medicine. The traditional Chinese medicine plastic is prepared from 1%-30% of traditional Chinese medicine sugarless paste, 0.5%-5% of polyvinyl alcohol 2488, 0.5%-10% of water-soluble chitosan, 3%-10% of glycerinum, 0.5%-1.5% of polysorbate-80, 0.5%-1.5% of borneol and water. The traditional Chinese medicine clear paste is prepared from roots of Chinese barberry, Chinese mahonia leaves, Root or stem of Creeping Mallotus, radix zanthoxyli, cottonrose hibiscus leaves and radix angelicae. The plastic has the effects of promoting blood circulation to remove blood stasis, clearing away heat and toxic materials, relieving swelling and pain, resisting bacteria, diminishing inflammation and improving wound surface microcirculation disturbance and durable pain, skin channels can be dredged, toxin and necrotic tissue are removed, bruises are eliminated, and new flesh is generated by itself. The effect on the phase-I and phase-II pressure sores is remarkable, specificity is high, use is convenient, and high clinical popularization value is achieved.

The invention discloses an ointment for treating rotavirus enteritis. The ointment is prepared from the following raw material medicines: 10-15g of agastache rugosus, 12-18g of rhizoma atractylodis, 10-15g of pericarpium citri reticulatae, 10-15g of fructus amomi, 28-32g of poria cocos, 12-18g of cortex magnoliae officinalis, 12-18g of pericarpium arecae, 22-26g of rice sprouts, 28-32g of coix seeds and 12-18 g of myrobalan pulp. The invention also provides a preparation method of the ointment. The ointment disclosed by the invention is applied to the Shenque acupoint, the spleen acupoint andthe stomach acupoint after being heated, so that the ointment plays a role in treatment through direct subcutaneous absorption and indirect stimulation to stimulate meridian Qi of the acupoints. Aftertreatment, abdominal pain, diarrhea, nausea, vomiting, inappetence, abdominal distension, tiredness, fatigue and the like of a sick child are obviously superior to those of oral montmorillonite powder, and are obviously superior to those of a Dingguier navel patch in the aspects of comprehensive curative effect, syndrome curative effect, RV negative conversion rate and the like. The ointment is remarkable in curative effect, convenient to use, good in safety, low in price, simple in medicine and high in clinical popularization value.

The invention discloses an intra-operative retina fixer which is used for complicated vitreous body resection operation and made of gold materials. The intra-operative retina fixer is characterized inthat the fixer is in a shape of a fine needle, a needle body is cylindrical, needle end portions are provided with convex arc-shaped surfaces, one needle end is provided with a flat head needle nose,accounts for 1 / 5 of the length of the fine needle and is gradually and oppositely reduced to a sheet along an axis of the needle body, a elliptical hole is reserved from the middle of the sheet to the end center, a ring is formed at the edge, and an end ring is gradually thickened. According to requirements of operated patients, the intra-operative needle body is folded into any shape, a retina is accurately and locally pressed, so that stripped proliferative membranes can reversely exert, a front proliferative membrane and a rear proliferative membrane of the retina are completely stripped,and the retina at a drawn position is protected. The intra-operative retina fixer is convenient to use and completely taken out after post-operation, residue and wound are omitted, the shortcomings ofpast perfluorocarbon liquid are fundamentally overcome, the intra-operative retina fixer can be repeatedly disinfected and used, so that operation safety and stripping efficiency are greatly improved, financial burden of a patient is greatly relieved, and the intra-operative retina fixer has high clinical popularization values.

The invention discloses an auxiliary circumcision device for circumcision at the root of the penis. The front pressing piece, the rear pressing piece, the guide nail piece and the thrust assembly all adopt a semi-ring structure. The ends pass through the thrust assembly, the guide nail piece, the rear pressure piece and the front pressure piece in turn; the two clamping arms are connected by a guide rod assembly, which includes an outer tube and a push rod that is movably installed in the outer tube. There is a chute in lateral symmetry, and the two sides of the push rod are respectively hinged with the inner sides of the two clamping arms through the movable assembly. The movable assembly includes a connecting rod and a mounting piece. The push rod is welded, and the spring assembly is sleeved on the push rod. The present invention can overcome the disadvantages of traditional penile root circumcision surgery, reduce the difficulty of penile root circumcision surgery, realize the idealized effect of "minimum scar + minimum impact on penile function" in penile circumcision surgery, and finally achieve precise excision and improve medical treatment. purpose of quality.

The invention belongs to the field of traditional Chinese medicines, and discloses a traditional Chinese medicine coating agent for treating pressure sore caused by qi-stagnation and blood stasis. The traditional Chinese medicine is prepared from Chinese medicine clear paste, polyvinyl alcohol (17-88), hydroxypropyl cellulose (EF), glycerol, sorbic acid, talcum powder and water. The traditional Chinese medicine clear paste is prepared from panax notoginseng, radix zanthoxyli, radix saposhnikoviae, rheum officinale, centella, garden balsam stem and folium rhododendri daurici according to a certain weight distribution ratio. The traditional Chinese medicine coating agent has the effects of promoting blood circulation to remove blood stasis, clearing heat to remove toxicity, reducing swelling and relieving pain, and resisting bacterium and removing inflammation, and can promote blood circulation of a wound surface to relieve an ischemia and hypoxia state of the wound surface, promote blocked and damaged nerves to be smooth to make qi and blood smooth, and repair and dredge damaged capillaries and microcirculation to enable the capillaries and the microcirculation to supply blood and nutrients timely, so that the purpose of recovery through rapid healing of the wound surface in an antiphlogistic manner is realized. The traditional Chinese medicine coating agent is high in specificity when being used for treating pressure sore caused by qi-stagnation and blood stasis, and is obvious in effect.

The invention discloses a medicine for treating pains of knee osteoarthritis and a preparation method thereof. The medicine is prepared from the following raw materials in parts by weight: 10-20 parts of dragon blood, 8-14 parts of ligusticum wallichii, 8-16 parts of abrus cantoniensis hance, 20-30 parts of radix achyranthis bidentatae, 10-20 parts of aster auriculatus franch, 10-20 parts of teasel, 2-6 parts of turtle shell, 10-20 parts of lycopodium clavatum, 2-6 parts of gekko subpalmatus, 5-9 parts of curcuma zedoary, 10-15 parts of zaocys dhumnade, and 8-12 parts of radix clematidis. The medicine has the effects of promoting blood circulation, dredging meridians, diminishing swelling and removing toxicity, can be used for treating pains of tendons and bones, wind-cold-dampness arthralgia and callousness, promoting blood circulation to remove stasis, relieving pain, dispelling wind and drying dampness, has excellent anti-inflammation and pain-relieving effects, has the advantages of remarkable curative effect, good medicine absorption and quick action by taking blood circulation promoting, blood stasis removing, channel and meridian dredging as a treatment principle, and can be used for eliminating muscle spasm, improving local blood circulation and tissue nutrition, quickly relieving or eliminating pains of patients and increasing the range of joint movement. The medicine has a great clinical popularization value.

The invention relates to a medical facility, and discloses an internal medicine examination bed. A protective pad is laid on a bed body, the protective pad is composed of a plurality of layers of isolation films stacked in sequence, a film uncovering recovery assembly is arranged on the outside of the bed body, the film uncovering recovery assembly includes a recovery box and a film uncovering mechanism, and a box opening is formed in the upper end of the recovery box; the film uncovering mechanism includes a support seat, a swing arm, a suction cup, a reset device, and a vent valve; the filmuncovering mechanism can adsorb a corner of the isolation film on the uppermost layer and gradually lift up, gradually uncover, and finally strip off the isolation film, and finally the separated isolation film falls into the recovery box. According to the internal medicine examination bed, a delicate structural design and scientific protection mechanism are adopted, in clinical use, each patientcan use a separate layer of isolation film, the uncovering and recovery of the isolation film is completed with the help of the film uncovering recovery assembly, the possibility of cross-infection caused by the internal medicine examination bed is greatly decreased, using is convenient and quick, the medical efficiency is guaranteed, the production cost of the internal medicine examination bed islow, and the internal medicine examination bed has great clinical promotion value.

The invention belongs to the field of traditional Chinese medicines, and relates to a traditional Chinese medicine smeared film for post-operation wound healing and a preparation method thereof. The traditional Chinese medicine smeared film is prepared from 1 to 30 percent of traditional Chinese medicine clear paste, 1 to 5 percent of polyvinyl butyral, 0.3 to 0.8 percent of dibutyl phthalate, 0.5 to 2.5 percent of chitosan, 3 to 10 percent of glycerin, 0.5 to 1.5 percent of laurocapram, 15 to 40 percent of ethyl alcohol and the balance of water, wherein the traditional Chinese medicine clear paste is prepared from barberry root, lindera glauca leaf, syzygium buxifolium, Chinese gall, creeping mallotus root or leaf, fineleaf schizonepeta herb, pseudo-ginseng leaf and kadsura longipedunculata, has the effects of clearing heat, promoting diuresis, activating blood, promoting tissue regeneration, and relieving swelling and pain, can promote wound healing, and also has an anti-bacterial effect and an analgesic effect. The smeared film can be adhered to a wounded part, bacteria are isolated, a wounded surface can be cleaned favorably by self-dissolution, generated tissue fluid is adsorbed, the smeared film cannot be adhered to the skin and is easy to tear off, the secondary injury is avoided, and the smeared film is high in air permeability, convenient to use and greater in clinical popularization value.

The invention relates to a gene chip, and discloses an integrated detection gene chip of an mtDNA mutation site related to Leber genetic optic neuropathy, as well as the preparation and the application thereof. A specific oligonucleotide detecting probe of the mtDNA mutational site related to the Leber genetic optic neuropathy and a specific oligonucleotide detecting probe of a mononucleotide polymorphyism site mtDNA 11719G>A are fixed on the carrier surface lattice of the gene chip. The gene chip has the advantages of time saving, low cost, simple operation and the like, has 32 mutation sites related to the Leber genetic optic neuropathy in a specific detecting clinical sample only through one-time PCR amplification and one-time crossing reaction, and is suitable for the gene diagnosis of the Leber genetic optic neuropathy.

The present invention provides a polypeptide compound with HER2 targeting function, which is composed of a HER2 affinity body and a bifunctional chelating agent connected through a polypeptide sequence; the polypeptide sequence is Met-Val-Lys; the polypeptide compound has a general structure The formula is shown in the following formula (I), wherein, R is a HER2 affinity body molecule, and X is a bifunctional chelating agent group. The present invention also provides a HER2-targeted radiolabeled complex using the polypeptide compound as a ligand. The radiolabeled complexes of the present invention can be used as radioactive diagnostic probes for the evaluation of HER2 receptors in breast cancer. The probes can reduce kidney accumulation while keeping tumor uptake unchanged, thereby improving tumor target and HER2 receptors. Non-target ratio, while reducing the radiation dose to the kidney. The present invention also provides the preparation method of the polypeptide compound and radiolabeled complex, and its application in the preparation of HER2-positive breast cancer radiodiagnostic and therapeutic probes for humans or animals.

The invention belongs to the field of traditional Chinese medicines, and in particular relates to a medicinal preparation containing folium artemisiae argyi for treating habitual abortion and a preparation method of the medicinal preparation. The medicinal preparation is prepared from the following raw materials in parts by weight: 10-22 parts of folium artemisiae argyi, 10-20 parts of corn stigma, 8-20 parts of ramie root, 8-16 parts of bamboo shavings, 8-14 parts of radix scutellariae, 6-18 parts of Chinese yam, 6-14 parts of the fruits of Chinese wolfberry, 8-14 parts of radix angelica sinensis, 6-14 parts of cortex lycii radicis, 4-14 parts of fructus amomi, 6-12 parts of fructus aurantii, and 4-10 parts of licorice root. The medicinal preparation has the curative effects for habitual abortion, and is rapid in taking effect, good in curative effects, and free of toxic and side effects when used for treating habitual abortion, and a production technology is simple, and easy for popularization and application.

An application of pepperweed seed in preparing the medicines for preventing and treating myocardial hypertrophy and / or ventricular hypertrophy, and in turn preventing heart failure, arrhythmia and sudden death is disclosed.