58results about How to "Has development value" patented technology

The invention relates to a substituted cinnamic acid nitrogen-containing derivative which has a structure of formula (I) and cytotoxic activity and the medical salts and solvates, and the invention further relates to a preparation method of the compounds with the formula (I), a pharmaceutical composition and a medical usage. The compound of the invention has stronger activity to inhibit the growth of the tumor cells of human esophageal cancer (Eca-109) and poorly differentiated gastric adenocarcinoma (BGC 823), which can be expected to be used as an antitumor drug.

The invention provides an entire-gene cDNA clone of modified measles virus, which is obtained from the substitution and transformation of main surface antigen genes (H gene) of main existing epidemic strains (genotype of H1 and representative strain of China93-7) in China to the full-length cDNA clones of measles virus strain CC-47. The invention adopts the RNA virus reverse genetic technique to carry out the rescue of modified CC-47 virus on the cDNA level so as to obtain modified infective virus, thus providing great convenience for the research on the replication, the proliferation and the package of novel virus stains. In addition, the novel produced infective virus has the hemagglutinin antigen of an epidemic strain and has more suitable application value of the hoplivac.

The invention relates to a method for constructing a salt-cavern gas storage base. The method comprises the following steps that 1, an L-shaped horizontal well is drilled from the ground, wherein theL-shaped horizontal well comprises a vertical well segment, an inclined well segment communicated with the vertical well segment and a horizontal well segment communicated with the inclined well segment, and the horizontal well segment of the L-shaped horizontal well is located in the middle of a salt layer; 2, an upper casing pipe column is disposed on the vertical well segment and the inclined well segment, a fixing structure for fixed connection and sealing is adopted between the upper casing pipe column and a stratum, and a combined pipe string is placed in the horizontal well segment; 3,a flushing pipe column is placed into the combined pipe string, water is sprayed to the surrounding salt wall through a mesh hole of a screen pipe in order to impact the salt wall to form melting chambers, jetting nozzles are located from far to near, each screen pipe sub-segment is adopted for melting the salt layer, finally a series of the melting chambers are formed, and thus the salt-cavern gas storage base is obtained. According to the method for constructing the salt-cavern gas storage base, the construction speed is high, the capacity is large, and the comprehensive cost is low.

The invention provides an application of a traditional Chinese medicine composition in preparing a liver-protecting medicine. The traditional Chinese medicine composition is mainly prepared from the following bulk pharmaceutical chemicals in parts by weight: 50 parts of the root of kudzu vine, 20-40 parts of turnjujube, 35-55 parts of chrysanthemums, 22-32 parts of ginseng, 24-36 parts of rhizoma atractylodis macrocephalae, 20-30 parts of codonopsis pilosula, 28-42 parts of Chinese dates, 12-28 parts of plantain herbs, 25-35 parts of pseudo-ginseng, 15-25 parts of mangnolia officinalis, 12-24 parts of astragalus membranaceus, 15-25 parts of the root of red-rooted salvia, 2-12 parts of schisandra chinensis, 4-16 parts of wolfberry, and 2-18 parts of liquorice. Compared with the prior art, the traditional Chinese medicine composition has the advantages of low cost, simple technology, and no toxic or side effect, can effectively protect liver, and has a certain development value.

The invention discloses a bacillus licheniformis fibrinolytic enzyme produced by the method: bacillus licheniformis ZJUEL31410 CGMCC 1397 is fermented and cultured to get fermented liquid, then separation and purification are carried out to the fermented liquid to get the bacillus licheniformis fibrinolytic enzyme. The invention firstly discovers that the bacillus licheniformis ZJUEL31410 CGMCC 1397 can be used for producing fibrinolytic enzyme. The bacillus licheniformis fibrinolytic enzyme products produced by the invention take cheap agricultural by-products of soybean pulp, expanded soybeans and bran as raw materials, thereby being nontoxic. Besides, a liquid fermentation method is adopted in the production, resulting in short technique process, low cost, high industrial production efficiency and high activity of enzyme, thereby being with development value.

The invention relates to a super rich selenium yeast and the application thereof. The super rich selenium yeast is characterized in that the selenium-super rich yeast is selenium-super rich yeast separated from selenium mines in Enshi small reservoirs. The taxonomy name of the yeast is Wikerhamomyces anomala and the name is XS-1. On 15th, November, 2013, the yeast is preserved in the general microbiology center of China General Microbiological Culture Collection Center and the preservation number is CGMCC nO.8475. The super rich selenium yeast can be applied to the preparation for selenium-rich yeast.

The invention discloses vibrio natriegens and application thereof and belongs to the field of microorganisms. The provided vibrio natriegens SK42.001 grows rapidly, carries natural plasmids, can express exogenous genes, and has the development value and the application potential to serve as a novel model organism. Meanwhile, the strain contains a gene capable of encoding algin lyase and a gene capable of encoding oligo-algin lyase and can also be used for producing and preparing related products of algin oligosaccharides.

The invention provides a detoxifying and beauty treatment electuary, which is prepared from the following components in percentage by weight: 25 to 40 percent of lily, 20 to 30 percent of kudzuvine root, 10 to 20 percent of fern root, 5 to 15 percent of cinnamomvine and 1 to 10 percent of honeysuckle flower. A method for preparing the detoxifying and beauty treatment electuary comprises the following steps of: cleaning, slicing, crushing, washing, filtering, separating, extracting, adding cane sugar in an amount which is 10 to 20 percent based on the total weight of the components, mixing, spraying, drying, packaging and warehousing. The detoxifying and beauty treatment electuary is mainly used for relaxing bowels and detoxifying and treating facial erythra and oral and tongue ulcers which are caused by heart-fire flaming, faucitis, facial colored patches and detoxifying for pregnant women.

The invention provides new application of danshinolic acid C, and particularly, the danshinolic acid C can be used for preparing a drug for protecting the ischemic brain tissue damage. The danshinolicacid C has a good effect of resisting the ischemic brain tissue damage, the effect is obvious, and the danshinolic acid C has development and utilization values.

The invention provides an application of a traditional Chinese medicine compound in preparing of lipid-lowering drugs. The traditional Chinese medicine compound mainly comprises the raw materials including, by weight, 50 parts of purslane, 25-45 parts of ginseng, 30-50 parts of notoginseng, 20-30 parts of Szechuan lovage rhizomes, 20-30 parts of gingko leaves, 25-35 parts of leeches, 25-35 parts of rhodiola, 15-25 parts of dalbergia odorifera, 20-30 parts of astragalus, 25-35 parts of cooked rehmannia, 10-20 parts of salvia, 10-20 parts of red peony roots, 5-15 parts of schisandra and 5-15 parts of fructus lycii. Compared with the prior art, the traditional Chinese medicine compound has no toxic and side effects, can effectively lower blood fat and has certain development value.

The invention provides a traditional Chinese medicine composition with a function of dispelling effect of alcohol and a preparation method thereof. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 50 parts of the root of kudzu vine, 20-40 parts of turnjujube, 35-55 parts of chrysanthemum flowers, 22-32 parts of ginseng, 24-36 parts of rhizoma atractylodis macrocephalae, 20-30 parts of codonopsis pilosula, 28-42 parts of Chinese dates, 12-28 parts of plantain herb, 25-35 parts of pseudo-ginseng, 15-25 parts of mangnolia officinalis, 12-24 parts of astragalus membranaceus, 15-25 parts of the root of red-rooted salvia, 2-12 parts of schisandra chinensis, 4-16 parts of wolfberry, and 2-18 parts of liquorice. The invention further provides a preparation method and an application of the traditional Chinese medicine composition. Compared with the prior art, the traditional Chinese medicine composition is low in cost, simple in technology, and free of toxic or side effect to the body, and can effectively dispel the effect of alcohol, and thus having a certain development value.

The invention provides a detoxifying formula which comprises the following components in percentage by weight: 25-35% of wild buckwheat, 25-35% of lotus root and 35-45% of the root of kudzu vine. The preparation method comprises the following steps of: cleaning after combination; slicing; crushing; water-washing; filtering; separating; extracting; homogenizing; concentrating; spraying and drying; automatically metering; packaging; and putting in storage. Meanwhile, the invention further provides detoxifying milk powder which comprises 79-97% of milk products, wherein the milk powder is prepared by the steps of: adding 3-21% of the milk products; mixing and stirring; then, adding 12% of sugar of the mixture; homogenizing, heating, sterilizing, concentrating, spraying and drying; automatically metering; and packaging products. The raw materials of the detoxifying milk powder and formula are extracted and synthesized by affinal drug and diet traditional Chinese medicines issued by the ministry of health, so that the milk powder is free from any toxic and side effects, is a scientific and technological milk product expected by massive consumers for many years, is an innovative healthy milk product which can replace medicines, and has development value.

The invention discloses a lung-tonifying capsule for treating lung-distension caused by qi deficiency of the lung and the kidney and a preparation method thereof. The lung-tonifying capsule is prepared from astragalus, dangshen, largehead atractylodes rhizome fried with earth, morinda root processed with salt-water, malaytea scurfpea fruit processed with salt-water, cistanche, dried orange peel, prepared pinellia tuber, fried perilla fruit, glehnia root, fructus schisandrae sphenanthera processed with vinegar, honey-fried licorice root and silica. The lung-tonifying capsule has a good treatment effect on chronic obstructive pulmonary disease in a stable phase; compared with a single western medicine group, the lung-tonifying capsule has obvious advantages in the aspects of improvement of clinical symptoms and pulmonary functions; and the lung-tonifying capsule, a traditional Chinese medicine preparation, has substantial curative effects and no toxic and side effects and endows patients with more options for medicines.

The invention relates to a method for detecting the roundness and the sphericity of an inner sphere of an outer ring of a knuckle bearing. The method comprises the following steps that (1), different sections of the inner sphere of the outer ring of the knuckle bearing are selected; (2), two pairs of measurement sensors which are perpendicular to each other and are located on the same plane are adopted to measure the diameter of each section for many times; (3), the diameter data obtained by measuring the same section for many times are averaged, the measurement values and the average value are compared and analyzed, and the roundness of the sections of the inner sphere of the outer ring is judged according to the error; (4), according to the diameter data of the different sections, a radian is calculated, an average value is obtained, the radian values and the average value are compared and analyzed, and the sphericity of the inner sphere of the outer ring is judged according to the error; (5), the percent of pass of the knuckle bearing is determined; (6), the error is analyzed. The method for detecting the roundness and the sphericity of the inner sphere of the outer ring of the knuckle bearing has the advantages that non-contact measurement is achieved, and the surface of the knuckle bearing is not damaged; the application range is wide, operation is easy, and the safety is high; the detection precision and efficiency are high, and development value is achieved.

The invention provides a compound preparation for treating gastric ulcer. The compound preparation is prepared from the following raw materials in parts by weight: 0.02 part of omeprazole, 0.2 to 0.6 part of aluminium sulphate, 10 to 20 parts of cyclodextrin, 20 to 30 parts of curcuma zedoary, 5 to 15 parts of salvia miltiorrhizae, 5 to 20 parts of thunberg fritillary bulb, 15 to 25 parts of hedyotis diffusa, and 50 to 100 parts of skeleton material. Compared with the prior art, the compound preparation for treating the gastric ulcer provided by the invention has no toxic or side effect, has a comprehensive treatment effect and can effectively treat the gastric ulcer; one-time medicament application of a plurality of medicaments is realized; the effect is remarkable; the compound preparation for treating the gastric ulcer has a certain development value.

The invention discloses an anti-tumor polypeptide and a preparation method and application thereof. The polypeptide is completely matched with the 7-19th amino acid residues of a segment of glutamyltranspeptidase (gamma-GGT) protein; the amino acid sequence is VLGLLAVVLVLVI and is named VI-13. In order to improve the solubleness, the sequence is reconstructed into VLGLRLAVRVLRVLRVI and is named VI-17. The polypeptide is obtained through a solid-phase synthesis method. An in vitro and in vivo pharmacodynamic experiment result shows that growth of human hepatocellular carcinoma cell line Hep3B can be significantly inhibited and the anti-tumor polypeptide has potential anti-tumor drug development value.

The invention provides an extracting and separating method of total flavones of wisteria flowers.The method comprises the following steps that 1, fresh wisteria flowers are taken and dried at 70 DEG C, and the dried wisteria flowers are smashed and sieved with a 60-mesh sieve; 2, the sieved material is subjected to heating reflux at 70 DEG C with ethanol with the volume fraction of 90%, extract is dried, and the ethanol extract is obtained; 3, water is added to the ethanol extract for dispersion, the dispersed ethanol extract is extracted sequentially through petroleum ether and ethyl acetate, ethyl acetate layers are merged, solvent is removed, and an ethyl acetate extract is obtained; 4, the ethyl acetate extract is taken and separated through a D101 macroporous adsorption resin column, elution is conducted with ethanol with the volume fraction of 30% to remove impurities, ethanol with the volume fraction of 80% serves as an eluent for elution, eluant obtained in the elution process conducted with ethanol of 80% is collected, vacuum concentration and drying are conducted, and the total flavone extract of the wisteria flowers is obtained.The method is simple in technology, high in extraction rate, good in repeatability, stable and feasible.

The invention belongs to the technical field of volcano region information identification, discloses a method and a system for identifying a high-temperature hydrothermal geothermal field in a volcanoregion, and provides a quantitative index for judging whether the high-temperature hydrothermal geothermal field in the volcano region is suitable for hydrothermal power generation or not. The quantitative index is less involved in the existinggeothermal field exploration and identification research, and has certain innovativeness. Firstly, which geothermal field type is preliminarily judged fromearth surface thermal display, then the geothermal field type to which the geothermal field type belongs is further quantitatively judged and an underground exploration range is delineated through gravity and magnetic anomaly and a geodetic heat flow value, then fault development condition identification is carried out, and quantitative analysis of reservoir stratum lithology and quantitative analysis of resistivity measured by magnetotelluric are combined; and a corresponding type of geothermal field range suitable for hydrothermal power generation is finally delineated. Multi-parameter combined judgment, quantitative analysis and qualitative analysis are combined, and whether the geothermal field is suitable for hydrothermal power generation or not is judged as accurately as possible.

The invention provides an infant intestines protection internal heat clearing milk mate which comprises the following components in percentage by weight: 10-30% of pawpaw, 15-25% of sophora flower buds, 15-25% of hovenia trichocarpa and 30-55% of kudzu vine roots. The infant intestines protection internal heat clearing milk mate is prepared by steps of blending, cleaning, slicing, crushing, waterwashing, filtration, separation, filtration, precipitation, sand extraction, concentration, squeezing, low temperature drying, automatic metering, packaging and warehouse preservation. The milk mate has the beneficial effects of main functions of relaxing bowl and removing toxin, and has remarkable dietary therapy effects on chronic stasis, dysentery, diarrhea and internal heat clearing, and protection functions as well.

The invention relates to a super rich selenium yeast and the application thereof. The super rich selenium yeast is characterized in that the selenium-super rich yeast is selenium-super rich yeast separated from selenium mines in Enshi small reservoirs. The taxonomy name of the yeast is Wikerhamomyces anomala and the name is XS-1. On 15th, November, 2013, the yeast is preserved in the general microbiology center of China General Microbiological Culture Collection Center and the preservation number is CGMCC nO.8475. The super rich selenium yeast can be applied to the preparation for selenium-rich yeast.

The invention relates to a method for making a suaeda salsa beverage through an ultrasonic wave assisted enzyme method, and relates to a beverage. Ultrasonic waves and a dynamic counter current circulation are combined, so that the extraction rate of polyphenol in suaeda salsa is greatly increased, and the effect of yielding twice the result with half the effort is achieved; the ultrasonic wave assisting, the aqueous enzymatic method extraction and an ultrafiltration technology are combined, so that the water-soluble functional ingredients in the suaeda salsa are greatly reserved; and comparedwith the extraction rate by a conventional extraction method, the extraction rate of polyphenols substances in the suaeda salsa is increased by 30-70%, so that the suaeda salsa beverage is rich in anti-oxidant ingredients including polyphenols and the like in the suaeda salsa, and has trace elements and rich amino acids required by human bodies, the pursuit of people for double efficacy of beingnutrient and health-care can be met, and the suaeda salsa beverage is adapted to the high-rhythm living of present people.

The invention discloses a mulberry resveratrol synthetase, a coding gene, a recombinant vector and an application thereof. The amino acid sequence of resveratrol synthase from mulberry trees is shownin SEQ ID NO.1, and the gene sequence is shown in SEQ ID NO.1. The invention clones a resveratrol synthase gene (MaRS) of mulberry tree, which is a novel gene, and the gene length is 1176bp. This geneis the key gene of resveratrol biosynthesis in mulberry trees. The MaRS gene can be transformed into resveratrol using p-coumaric acid as substrate. Therefore, the gene can biosynthesize resveratrolby microbial fermentation, and has the development value in medicine, health food and cosmetics.

The invention discloses a bacillus licheniformis fibrinolytic enzyme produced by the method: bacillus licheniformis ZJUEL31410 CGMCC 1397 is fermented and cultured to get fermented liquid, then separation and purification are carried out to the fermented liquid to get the bacillus licheniformis fibrinolytic enzyme. The invention firstly discovers that the bacillus licheniformis ZJUEL31410 CGMCC 1397 can be used for producing fibrinolytic enzyme. The bacillus licheniformis fibrinolytic enzyme products produced by the invention take cheap agricultural by-products of soybean pulp, expanded soybeans and bran as raw materials, thereby being nontoxic. Besides, a liquid fermentation method is adopted in the production, resulting in short technique process, low cost, high industrial production efficiency and high activity of enzyme, thereby being with development value.

The invention provides an extraction and separation method of total sterol in pumpkin vines. The extraction and separation method comprises the following operation steps: (1) taking fresh pumpkin vines to be dried at 70 DEG C, crushing and filtering with a 60-mesh sieve; (2) using ethanol with the mass concentration of 90% for heating reflux at 70 DEG C, and drying an extract to obtain an ethanol extract; (3) adding water to disperse the ethanol extract, extracting with petroleum ether for several times, combining petroleum ether layers, and removing a solvent to obtain a petroleum ether extract; (4) applying the petroleum ether extract to a silica gel column for separation, eluting with methylene chloride and methanol in a volume ratio of 100:1 to remove impurities, using methylene chloride and methanol in the volume ratio of 10:1 as an eluent for elution, collecting eluate, decompressing, concentrating and drying the eluate to obtain the extract of total sterol in the pumpkin vines. The extraction and separation method provided by the invention is simple in process, high in extraction rate, excellent in reproducibility, stable and feasible.

The invention discloses a Duyun Maojian teabag formula. The Duyun Maojian teabag formula comprises 1.5-6 parts of Duyun Maojian tea, 0.5-6 parts of Pu'er tea, 0.25-2.5 parts of Dendrobium officinale,0.05-2.25 parts of sweet osmanthus, and 0.01-2.25 parts of lotus leaf. The Duyun Maojian teabag formula has the pure aroma of the brewing tea, the taste is sweet, the soup color is dark red, the mouthfeel is good, the requirements of the teabag are met, and the Duyun Maojian teabag formula has a certain market and development value. The raw material resource is wide, and the Duyun Maojian teabag formula is capable of enriching the tea line in southern Fujian, improving the utilization rate of summer and autumn tea, increasing the sales volume of Duyun Maojian tea, and opening up another saleschannel.

The invention provides a preparation method of a compound preparation for treating high blood pressure.The preparation method comprises the following steps that 1, cyclodextrin is taken and ground into paste by adding water, curcumin is taken and ultrasonically dissolved by adding a sufficient amount of ethyl alcohol, the obtained solution is dropwise added into the cyclodextrin paste, grinding is performed while the solution is dropwise added and continuously performed after dropwise adding is finished, drying is performed, and a curcumin inclusion complex is obtained; 2, milkvetch roots, radix achyranthis bidentatae, buckwheat, spica prunellae and flowers of common tulip are weighed in proportion and extracted by adding ethyl alcohol to obtain alcohol extracting residues and an extracting solution, and the extracting solution is concentrated to obtain an alcohol extracting solution for standby application; 3, the alcohol extracting residues are removed, extraction is performed by adding pure water, and an extracting solution is concentrated to obtain a water extracting solution for standby application; 4, a framework material is dissolved, the alcohol extracting solution and the water extracting solution are added into the dissolved framework material, and high-speed dispersing, concentrating and drying are performed to obtain a compound; 5, the curcumin inclusion complex and the compound are mixed to be uniform, and then the compound preparation is obtained.Compared with the prior art, the preparation method has the advantages that the technology is simple, one-time use of multiple drugs is achieved, and the effect is significant.

The invention discloses vanillin ester condensed 1,3-butanediol and a preparation method thereof. The preparation method comprises the following steps of: preparing vanillin ester; and preparing the vanillin ester condensed 1,3-butanediol. Compared with the conventional essences, the vanillin ester condensed 1,3-butanediol has the advantages that: the aroma of the vanillin ester condensed 1,3-butanediol is evaluated and analyzed by aroma evaluating experts, is pure powder aroma and thick, the aroma of 2-methoxy-4-(4-methyl-1,3-dioxane-2-yl)-phenylacetate and 2-methoxy-4-(4-methyl-1,3-dioxane-2-yl)-2-methyl phenylpropionate is the best, fresh, green, and durable, the aroma can be kept for 48-72 hours generally, and the 2-methoxy-4-(4-methyl-1,3-dioxane-2-yl)phenyl acetate and the 2-methoxy-4-(4-methyl-1,3-dioxane-2-yl)phenyl2-methylpropionate have development value and can be widely applied to various daily use chemical essences. In addition, the preparation method is simple, high in yield and easy to operate, has high practicability and can generate good economic benefit and social benefit.

The invention discloses a reservoir water production rate calculation method based on an apparent oil layer resistivity curve. The method comprises the following steps of firstly, carrying out reservoir classification by utilizing a conventional logging curve; then constructing an apparent oil layer resistivity model on the basis of reservoir classification, and calculating an apparent oil layer resistivity curve; and finally, comparing the apparent oil layer resistivity curve with the deep detection resistivity curve, qualitatively judging the reservoir fluid property, and quantitatively calculating the water production rate of the reservoir according to the logarithm normalization difference value of the apparent oil layer resistivity curve and the deep detection resistivity curve. According to the method, the fluid property of the reservoir is simply and accurately judged, the water production rate of the reservoir is accurately calculated, a reference basis can be provided for development of a water flooded layer, and a guidance basis is provided for adjustment of middle and later development schemes of an oil field.