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99 results about "Brain tissue injury" patented technology

Double-layer titanium mesh for cranioplasty

The invention relates to a double-layer titanium mesh for cranioplasty, which is characterized by comprising an inner-layer titanium mesh and an outer-layer titanium mesh, wherein the outer-layer titanium mesh coincides with the defective edge on the outer surface of the cranial bone; the curvature of the outer-layer titanium mesh conforms to the appearance of the head; the gap between the inner-layer titanium mesh and the outer-layer titanium mesh is filled with autologous bone granules or artificial bone granules; the outer-layer titanium mesh comprises a scalp contact surface and fixed-end grooves; the curvature of the outer-layer titanium mesh conforms to the outer surface of the skull; the edge of the outer-layer titanium mesh coincides with the defective edge on the outer surface of the cranial bone; the outer-layer titanium mesh is fixed on the defective position on the outer surface by screws, so that the outer surface of the cranial bone can be closed; and the outer-layer titanium mesh is provided with holes. The titanium mesh can simultaneously repair the inner surface and the outer surface of the cranial bone, thereby realizing full anatomical and functional recovery and avoiding the brain tissue damage caused by inner surface defects.
Owner:中国人民解放军第四军医大学唐都医院

Preparation process of high-purity NMN based on enzymatic method

The invention relates to the technical field of NMN preparation and discloses a preparation process of high-purity NMN based on an enzymatic method. The preparation process comprises the following steps: (1) raw material pretreatment: performing microfiltration and nanofiltration on nicotinamide ribose at first, and collecting concentrated crude product solution; (2) a production process: enablingthe crude product solution to react under the catalysis of nicotinamide ribokinase or recombinant cells containing the nicotinamide ribokinase to generate beta-nicotinamide mononucleotide; and (3) apurification process: adjusting the pH value of the produced beta-nicotinamide mononucleotide solution to 3-7, sampling the beta-nicotinamide mononucleotide solution on a reversed-phase high-performance liquid chromatography preparation column, and carrying out gradient elution and purification to obtain the purified beta-nicotinamide mononucleotide solution. The preparation process of the high-purity NMN based on the enzyme method ensures the productivity of the nicotinamide mononucleotide, improves the purity of the product, and can make the nicotinamide mononucleotide more obvious in the effect of relieving and improving the injury of ischemic heart and brain tissues. The nicotinamide mononucleotide can better improve oxidation-related degenerative diseases and body dysfunction.
Owner:比瑞博生物科技(北京)有限公司

Visible cerebral ventricle and subdural external drainage system

The invention discloses a visible cerebral ventricle and subdural external drainage system. The visible cerebral ventricle and subdural external drainage system comprises a visible cerebral ventricle puncture system and a drainage system. The visible cerebral ventricle puncture system comprises a visible puncture guiding core, and LED light sources and a miniature camera are coaxially arranged at the intracranial end of the visible puncture guiding core. The wall of a puncture sheath is see-through, and millimeter scales are arranged on the outer wall of the puncture sheath. The visible cerebral ventricle and subdural external drainage system has the remarkable advantages that as the miniature camera can be connected to one end of the visible puncture guiding core, and a monitor is connected to the other end of the visible puncture guiding core, cerebral puncture is completely performed in a direct-viewing mode, precision is improved, and it is avoided that due to operation based on a rule of thumb, the cerebral tissue is damaged, or cerebral hemorrhage occurs. As miniature vanes (fixing clamps) are arranged at the position distant from the cerebral ventricle by 10 cm-15 cm and used for fixing a drainage tube at the incised skin, the defect that a drainage tube used for the current clinic is simply bound and fixed through threads is overcome.
Owner:葛建伟

Ischemic cerebrovascular disease treatment composition, medicament, preparation method and application

The invention belongs to the pharmaceutical technical field, and discloses an ischemic cerebrovascular disease treatment composition, a medicament, a preparation method and application, the ischemic cerebrovascular disease treatment composition comprises ginsenoside Rg1 and astragaloside, and the weight ratio of ginsenoside Rg1 to astragaloside is 5:4. The animal pharmacodynamics experiments prove that the ischemic cerebrovascular disease treatment composition can inhibit the cerebral ischemia reperfusion injury of brain tissue, has the anti-cerebral ischemia-reperfusion injury enhancement effect by the astragaloside and ginsenoside Rg1 compatibility, also can improve energy metabolism disorders of the cerebral ischemia reperfusion injured brain tissue, anti-oxidative stress damage functions and the like, and ultimately achieves the purposes of enhancing the efficacy and reducing the toxic and side effects.
Owner:HUNAN UNIV OF CHINESE MEDICINE

Application of salvianolic acid A and derivatives thereof to prevention and treatment of high-altitude sickness

The invention relates to the field of medicine, in particular to application of salvianolic acid A and derivatives to prevention and / or treatment of high-altitude sickness. The application of the salvianolic acid A involves protection of cardiovascular diseases, cerebrovascular endothelial cells and ischemic brain tissues, prevention and / or treatment of cerebral thrombosis, improvement on neurological function symptoms after cerebral ischemia, prevention and / or treatment of diabetes mellitus and complications, inhibition of brain tissue neuron damage or death, prevention and / or treatment of cerebral thrombosis, drugs for treating ischemic penumbra and multi-drug resistance of tumors, prevention and treatment of HIV encephalopathy and the like. Application of the salvianolic acid A and the derivatives thereof to prevention and / or treatment to the high-altitude sickness has not been reported.
Owner:SHINEWAY PHARMA GRP LTD

Calcium silicate nano hollow microsphere modified thermosensitive hydrogel and preparation method and application thereof

The invention provides calcium silicate nano hollow microsphere modified thermosensitive hydrogel and a preparation method and application thereof. The preparation method includes: preparing calcium silicate nano hollow microspheres, dispersing the microspheres in the complex solution of carboxymethyl chitosan and beta-sodium glycerophosphate, and processing at 30-70 DEG C. The preparation methodhas the advantages that the method is simple and low in cost, the reaction conditions of the method can be achieved easily, and the raw materials used by the method are cheap and easy to obtain; the prepared thermosensitive hydrogel is safe, low in cytotoxicity, good in biocompatibility and good in low-temperature flowability, the hydrogel can fast turn into gel at 37 DEG C, the surface of the gelis loose and porous, and the gel is large in specific surface and capable of benefiting neural stem cell adsorption; the calcium silicate nano hollow microspheres are evenly dispersed in the thermosensitive hydrogel, and the thermosensitive hydrogel can promote neural stem cell differentiation; when the thermosensitive hydrogel is applied to brain tissue damage repairing, neural stem cell adsorption can be promoted effectively, the neural stem cells can be effectively promoted to differentiate into neurons and neuroglia, and the thermosensitive hydrogel is promising in clinical application prospect.
Owner:SHANDONG UNIV

Isoliquiritigenin and application thereof to treatment of acute lung and liver and brain tissue damage

PendingCN109846864ADelay progressionImprove brain injuryAntibacterial agentsNervous disorderDiseaseCase fatality rate
The invention provides an application of isoliquiritigenin to medicines for treatment of lung and liver damage diseases caused by septicopyemia, and an application of the isoliquiritigenin to medicines for treatment of brain tissue injury diseases caused by wounds. The medicines are favorable for delaying of progress deterioration of state of an illness, the case-fatality rate and the illness anddisability rate are notably reduced, and the quality of life is improved. The medicines are high in treatment maneuverability and low in cost, and the diagnosis and treatment cost for patients and medical institutions can be notably reduced.
Owner:THE FIRST AFFILIATED HOSPITAL OF WENZHOU MEDICAL UNIV
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