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Novel use of extractive from sapan wood

A technology of extract and hematoxylin, which can be used in medical preparations containing active ingredients, drug combinations, cardiovascular system diseases, etc., and can solve problems such as unreported and rare hematoxylin

Inactive Publication Date: 2005-01-05
TSINGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The records of Sappanol as a cerebrovascular drug are relatively rare, especially the application of Sappanol or Sappanol extract in the preparation of drugs for the treatment of cerebral ischemia, increased cerebral peroxides, etc.

Method used

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  • Novel use of extractive from sapan wood
  • Novel use of extractive from sapan wood
  • Novel use of extractive from sapan wood

Examples

Experimental program
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Effect test

preparation example Construction

[0018] The preparation process of the hematoxylin extract provided by the invention is as follows: firstly, 80% ethanol with 5 to 15 times the weight of the medicinal material is reflux extracted, the extract is concentrated under normal pressure or reduced pressure, and dried to obtain the hematoxylin extract.

[0019] The components of the hematoxylin extract were determined by high performance liquid chromatography at a wavelength of 446nm. 16 h 12 o 5 ) content is between 1.5% and 10.0%.

[0020] In the application of medicaments, the Sappanwood extract is prepared into medicaments by conventional preparation process either alone or in a compound. The medicament can be various dosage forms that can be used clinically.

[0021] The following examples and drug efficacy experiment data confirm the preparation and application of the Sapphire extract of the present invention, and the following examples should not be regarded as limiting the present invention.

Embodiment 1

[0023] Get 0.5 kg of hematoxylin and extract with 30% ethanol refluxing which is 4 times its weight. The extract was filtered, concentrated under reduced pressure, recovered ethanol, and dried to obtain hematoxylin extract.

[0024] The brazilian hematoxylin components of the sappan wood extract were determined by high performance liquid chromatography, and the brazilian hematoxylin content in the extract was about 8.22%.

Embodiment 2

[0026] Get 0.5 kg of hematoxylin and use 10 times of the weight of the material to extract with reflux of 80% ethanol. Concentrate the extract to recover ethanol, add water to dilute to the crude drug concentration of 0.5g / ml, put it on the column, use polyamide as the exchange column, and elute with 6 times column volume of water and 6 times column volume of 80% ethanol respectively, and a part of it is washed after collection. dehydration. The collected eluate was concentrated under reduced pressure at a temperature of 60° C., and dried under normal pressure to obtain a hematoxylin extract. The brazilian hematoxylin components of the sappan wood extract were determined by high performance liquid chromatography, and the brazilian hematoxylin content in the extract was about 9.84%.

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Abstract

An application of the sapan wood extract (brasileiin, C16H12O5) in preparing medicine for treating cerebral ischemia and cerebral function ariation caused by excessing peroxide in brain tissue is disclosed.

Description

technical field [0001] The invention relates to a traditional Chinese medicine extract containing multiple active ingredients prepared from sumac wood, a preparation method and its new application in medicine, belonging to the technical field of traditional Chinese medicine. Background technique [0002] Sumac is the dried heartwood of the leguminous plant Caesalpinia sappan L. Distributed in my country's Guangxi, Guangdong, Taiwan, Guizhou, Yunnan, Sichuan and other places. Available all year round. Remove the skin and sapwood, take the heartwood and dry it in the sun. Contains brasilin, brasilein and other ingredients. "Compendium of Materia Medica" records: Sumu has the effect of "breaking blood, draining pus and relieving pain". Indications for the treatment of women's blood-qi and abdominal pain, relieving carbuncle, swelling, and blood stasis." "Dictionary of Chinese Medicine-Volume 1" records: Sappan has the effects of "promoting blood and removing blood stasis, r...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61P9/10
Inventor 邢东明赵玉男王如峰王伟杜力军丁怡
Owner TSINGHUA UNIV
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