The invention relates to a flexible thin film photovoltaic reel-to-reel CSD spraying and coating device, and solves the problem that a coating solution is easy to run off from two sides on the surface of a stainless steel substrate coiled material which is flatly conveyed, and the coating is not uniform. The device comprises an unwinding shaft, a winding shaft and a plurality of conveying rollers. A film coating coiled material output by the unwinding shaft sequentially passes through the conveying rollers and then is wound on the winding shaft, a film coating section is arranged behind the unwinding shaft, a film coating solution spraying nozzle is arranged above the front end of the film coating section, and a plurality of side supports for lifting the side edges of the film coating coiled material upwards are arranged on the two sides of the film coating section. A plurality of pressing wheels are arranged on the inner sides of the side supports. According to the film coating coiled material, a lifting maintaining structure with the low middle and the two high sides is formed in the coating section, it is ensured that when a film coating solution is maintained to be deposited on the surface of the film coating coiled material, the liquid level height of the solution is consistent, meanwhile, reverse backflow cannot be formed on the two sides of a coating film, the uniformity of transverse coating of the film coating coiled material is ensured, and the continuity of longitudinal film coating is achieved; and the industrial production requirement of roll-to-roll CSD spray film coating can be met.