The invention belongs to the technical field of heat exchange, and discloses a high-efficient anti-scale heat exchanger and an industrial waste heat recovery system. The high-efficient anti-scale heatexchanger comprises a box body, a first stage water collector, one or more second stage water collectors, a first stage water separator, two stage water separators and coils; a water inlet and a water outlet are formed in the box body, the first stage water collector is arranged in the box body, one ends of the second stage water collectors are closed, the other ends of the second stage water collectors are in communication with the first stage water collector, the first stage water separator is arranged in the box body, each two stage water separator is arranged opposite to one two stage water collector, one ends of the two stage water separators are closed and the other ends of the two stage water separators are in communication with the first stage water separator, the coils are in spiral structures, one ends of the coils are in communication with the second stage water collectors, and the other ends of the coils are in communication with the opposite second stage water separators.Through the coils with spiral structures, a heat exchange area in unit volume is effectively increased, and the heat exchange efficiency is improved. In addition, the coils expand and contract slightly due to change of the medium temperature inside and outside tubes, scale formed on the outer surfaces of the coils falls off by itself, and accumulation of the scale is effectively avoided.