The invention discloses a box girder unbonded prestressing and steel plate-concrete combination reinforcing design method. The method comprises the following steps that firstly, a combination reinforcing structure is determined, specifically, the reinforced box girder unbonded prestressing and steel plate-concrete combination reinforcing structure is determined, the combination reinforcing structure comprises a steel jacket case composed of a bottom steel plate, two longitudinal side steel plates and two end blocking steel plates, and a plurality of unbonded prestressed rebars are arranged in the steel jacket case; secondly, box girder structural parameters are determined before reinforcement; and thirdly, structural parameters of the combination reinforcing structure are determined, specifically, the parameters are initialized, the theoretical maximum thickness of the reinforcing steel plates is calculated, the thickness of the reinforcing steel plates and the thickness of concrete are determined, and the height of the longitudinal side steel plates and the width of the bottom steel plate are determined. The method is simple in step, reasonable in design, convenient to implement and good in application effect, the structural parameters of the bridge combination reinforcing structure can be determined easily, conveniently and rapidly, and the designed bridge combination reinforcing structure is economical, practical and good in reinforcing effect.