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32results about How to "Does not cause toxic side effects" patented technology

Use of interferon alpha-1b for preparing medicine for preventing and treating upper respiratory tract inflammation

The present invention relates to an application of recombinant human interferon alpha Ib in preparation of medicine for preventing and curing viral infection of upper respiratory tract and reducing or eliminating one or several side effects related to applied other interferon. Said invention also relates to a recombinant human interferon alpha Ib spray used for above-mentioned application, in the aqueous solution whose total volume is 1000 ml it includes interferon alpha Ib with therapeutic effective dose; 2.5-27.0g of sodium chloride; 5-50mM of phosphoric acid buffer solution, its pH value is 5.7-8.0; 0.01-2g of benzalkonium chloride and 5-20g of human serum albumin.
Owner:BEIJING TRI PRIME GENE PHARMA CO LTD +1

Chinese medicament for treating kidney failure

The invention relates to a Chinese medicament for treating kidney failure, and belongs to the technical field of Chinese medicaments. The medicament for treating chronic kidney failure comprises the following active ingredients in part by weight: 10 to 20 parts of astragalus, 4 to 9 parts of heterophylly falsestarwort root, 5 to 15 parts of Indian buead, 4 to 10 parts of large-headed atractylodes rhizome, 8 to 15 parts of Chinese caterpillar fungus, 8 to 15 parts of twotooth achyranthes root, 15 to 20 parts of prepared common monkshood daughter root and 10 to 20 parts of rhubarb. The medicament for treating the kidney failure can improve the microcirculation of the kidney effectively, promote blood circulation and remove blood stasis, increase flow of renal blood and improve human immunity, has no toxic or side effect for long-term administration, does not cause medicinal tolerance, and has low cost and obvious curative effect on the kidney failure.
Owner:张天良

Application of multienzyme compound to prevention and treatment of fungus infection

The invention provides a multienzyme compound capable of preventing and treating fungus infection. The multienzyme compound of the invention can be used in daily prevention of fungus infection, and can kill fungi selectively without generation of toxic or side effects, or drug resistance. The multienzyme compound of the invention can treat fungus infection individually. Because the multienzyme compound can digest fungus cell walls, when cooperated with other antifungal medicaments to treat fungus infection, the multienzyme compound of the invention can promote penetration of other medicaments, enhance treatment effects of other medicaments effectively, reduce dosage and application amount, lower toxic and side effects, and reduce generation probability of drug resistance. In addition, the multienzyme compound of the invention can be selectively added with antifungal medicaments to improve treatment effects.
Owner:上海杜伊特医疗器械有限公司 +2

Medicament for treating AIDS and its preparing method

Disclosed is a medicament for treating AIDS, wherein the active constituents include Fucoidan-Glycocalyx polymeric compound, which is a protein polysaccharide containing sulfate groups extracted from Chinese herbal sea apron. The preparing process consists of steps of choosing materials, soaking and cleaning, disintegrating, water extracting, low concentration alcohol depositing, high concentration depositing, purifying to obtain the end product.
Owner:张石泉

Application of alpha-oxoglutarate to improving heat production capability of fat animals and reducing body fat content

The invention discloses application of alpha-oxoglutarate to improving the heat production capability of fat animals and reducing the body fat content. The invention provides new application of alpha-oxoglutarate, alpha-oxoglutarate can obviously improve whole heat production of high fat diet animal bodies and heat production of brown fat, can prominently improve expression of brown fat heat producing marker genes UCP1, PRDM16, PGC1alpha, Cidea and Elovl3, and meanwhile, can reduce the overall body fat content of the high fat diet animal bodies and the fat weight of different parts. In addition, alpha-oxoglutarate does not contain any substance harmful to animals or human body, the adding amount is less, and alpha-oxoglutarate can be directly added into animal drinking water, fodder, foodor drugs, has the advantages of safety, effectiveness and no toxic and side effects, has the wide application prospect at the aspect of improving heat production of the high fat diet animals and reducing the body fat content, and explores a new means for treating obesity and related diseases.
Owner:SOUTH CHINA AGRI UNIV

Traditional Chinese medicine composition and gels for treating gynecologic inflammation and preparation method thereof

InactiveCN105998974ARelieve itchingSolve abnormal leucorrheaAntibacterial agentsAntimycoticsDiseaseRhizome
The invention relates to the field of medicine for treating gynecologic inflammation and discloses a traditional Chinese medicine composition for treating gynecologic inflammation. The traditional Chinese medicine composition comprises 20-40 parts of cortex phellodendri, 20-40 parts of radix scutellariae, 20-40 parts of radix sophorae flavescentis, 10-20 parts of fructus kochiae, 10-20 parts of cortex dictamni, 10-20 parts of sevenlobed yam rhizomes, 10-20 parts of rhizoma smilacis glabrae and 10-20 parts of pericarpium granati. The invention further discloses gels prepared from the traditional Chinese medicine composition, 2-5 parts of methylcellulose, 2-5 parts of agar and 8-12 parts of arabic gum. The gels prepared from the traditional Chinese medicine composition can effectively inhibit trichomonas, mycotic, bacterial and mixed gynecological vagina inflammatory diseases of females and is high in pertinency and good in effect.
Owner:深圳市纯原上品生物科技有限公司

Method for improving quality of radix scutellariae with sodium hyposulfite

ActiveCN103975786AIncrease contentFully tap the potential of secondary metabolismHorticulture methodsSodium sulfiteMaterial quality
The invention discloses a method for improving the quality of radix scutellariae with sodium hyposulfite and relates to the technical field of radix scutellariae. The method comprises the steps of radix scutellariae fresh root extracting-washing-drying in shade for 1-2 days under the temperature of 20-25 DEG C-active oxygen carrier spraying-standing for 3-10 days under the temperature of 20-25 DEG C-drying. An active oxygen carrier is the sodium hyposulfite. The concentration of the sodium hyposulfite is 0.4 mumol / L-40 mmol / L. The processing time cycle is 3-15 days. Temperature is 10-35 DEG C. According to the method, traditional Chinese medicinal materials are planted in the zone most suitable for plants to grow in or in a main producing zone, various measures can be taken to improve yield, according to the essence of radix scutellariae quality forming, after medicine collecting, secondary metabolism of fresh medicine materials is subjected to human intervention, so that medicine material quality is greatly improved, and accordingly high quality and high yield are achieved. The secondary metabolism level of radix scutellariae is improved to the maximum degree, and the quality of all produced medicine materials reaches or exceeds the quality of famous-region drugs.
Owner:孟祥才

Decoquinate liposome and preparation method and application thereof

The invention relates to a decoquinate liposome and a preparation method and application thereof. The preparation raw materials of the decoquinate liposome comprise the following components in parts by weight of 1 part of decoquinate and 2-20 parts of lecithin. The liposome is good in stability, shows favorable malaria resisting effects in and out of animal bodies, can be used for quickly relieving symptoms of malaria particularly subtertian malaria, and is high in safety. The preparation method is simple and feasible, and the decoquinate liposome has mass production potential.
Owner:BLUE ELEGANT BIOTECH CO LTD

Kartogenin cartilage delivery material based on epsilon-polylysine as well as preparation method and kit thereof

The invention discloses a Kartogenin cartilage delivery material based on epsilon-polylysine and a preparation method thereof material. The cartilage delivery material is prepared by connecting Kartogenin molecules and epsilon-polylysine through covalent bonds. According to the cartilage delivery material, the residence time of KGN in an articular cavity can be prolonged, and the solubility of theKGN is improved; meanwhile, the material has cartilage permeability and cell membrane permeability, permeates into cartilage tissues and stem cells and cartilage cells in the cartilage tissues in anintegral material form, and is degraded under the action of intracellular enzymes to release the KGN, so that the bioavailability of the KGN is improved; and the tissue and cell compatibility is excellent, and the toxic and side effects cannot be caused. The invention also discloses a kit, freeze-dried powder of the Kartogenin cartilage delivery material is used as a component A, a biocompatible solvent is used as a component B, the use process is very simple, and the component A and the component B can be directly subjected to articular cavity injection administration after being mixed and dissolved.
Owner:SHANGHAI SIXTH PEOPLES HOSPITAL

Traditional Chinese medicine foot soaping liquid for treating diabetes

The invention relates to the field of traditional Chinese medicine, in particular to a traditional Chinese medicine foot soaping liquid for treating diabetes, and solves the problems that the traditional method for treating diabetes by orally taking drugs and injecting insulin has serious toxic side effect and bad curative effect and easily causes complicating disease and drug resistance. The liquid is composed of 14 drugs including leech, muskiness, chicken-bone herb, pericarpium zanthoxyli, red paeonia, mugwort leaf, radix aconiti, Guilu Erxian Jiao, prepared rhizome of rehmannia, Dioscorea opposita, cortex moutan, ginseng, polygonatum and the like. The drugs are soaked and then concentrated under normal pressure and concentrated under vacuum by a traditional Chinese medicine vacuum extracting machine set for extracting liquid medicines, and then the liquid medicine is made into a drug for external use preferably by a plenty of Chinese herbal medicines and by a special modern processing method in accordance with theory of traditional Chinese medicine. The drug is used in a foot soaking manner and a footherapy manner for treatment, and the drug has the functions, for human body, of soothing the liver and controlling breathing, promoting the production of body fluid to quench thirst, recovering glucose metabolism, balancing blood sugar, decreasing blood fat, promoting insulin secretion and keeping the blood sugar stable for a long time, and can enhance the immunity of the organism and avoid all defects of traditional oral drugs.
Owner:杨朝晖

Antibacterial varicosity polytetrafluoroethylene face implant material and preparation technology thereof

The invention discloses an antibacterial varicosity polytetrafluoroethylene face implant material and a preparation technology thereof. A base layer of the material consists of medical varicosity polytetrafluoroethylene, and an antibacterial function is prepared through the steps of performing surface modification on the base layer material and performing grafting with a macromolecule antibacterial agent. A specific preparation technology lies in that active site grafted acrylic is produced on the surface of the base layer material through activation pretreatment, then through a reaction of carboxyl functional groups of acrylic and with amino, a macromolecule type antibacterial agent is grafted, and antibacterial properties are given to the material. The antibacterial varicosity polytetrafluoroethylene face implant material disclosed by the invention is simple in technology and efficient, the prepared varicosity polytetrafluoroethylene face implant material has the characteristics of being good in bacteriostasis effects, safe and free from toxic and side effects, and can be widely applied to a face plastic surgery operation.
Owner:SHANDONG BRANDEN MEDICAL DEVICE

Application of Oleic Acid in Promoting Animal Mammary Gland Development

The invention discloses application of oleic acid in animal mammary gland development promotion and provides new application of the oleic acid. Cell experiments and animal experiments prove that the oleic acid can effectively promote the proliferation of pig primary mammary gland epithelial cells and mouse mammary gland epithelial cells HC11 and can increase the number of in-vivo mouse mammary gland duct branches and TEB to promote animal mammary gland development. The application has the advantages that the oleic acid is rich in source, free of substances harmful to animals and human being, safe and easy to obtain; in addition, the adding amount of the oleic acid in the application is low, and the oleic acid serving as the nutrition regulation substance can be directly added into animal feed, food or drugs and is safe, effective, free of toxic and side effects and promising in popularization and application prospect in the animal mammary gland development promotion.
Owner:SOUTH CHINA AGRI UNIV

Application of α-ketoglutarate in improving animal reproductive function damage caused by high-fat diet

ActiveCN107412216BImprove estrus cycle disorderImprove reproductive function damageOrganic active ingredientsAccessory food factorsPhysiologyFollicle
The invention discloses an application of alpha-ketoglutaric acid to improvement of animal reproduction function deficit caused by high fat diet, and provides a novel application of the alpha-ketoglutaric acid. Abnormity of animal estrus cycle, ovarian morphology and functions and sex hormone secretion caused by high fat diet can be remarkably improved by the alpha-ketoglutaric acid, animal reproduction function deficit caused by high fat diet is further improved, and particularly, estrus cycle disorder, corpus luteum number depletion, theca cell thickness increase, follicle-stimulating hormone content reduction and luteinizing hormone content rise caused by high fat diet are improved by the alpha-ketoglutaric acid, so that animal reproduction function deficit caused by high fat diet can be remarkably improved. Moreover, the alpha-ketoglutaric acid is free from substances harmful to animals or human bodies, adding quantity is small, and the alpha-ketoglutaric acid can be directly added into animal drinking water, feed, food or drugs, has the advantages of safety, effectiveness, no toxic and side effects and the like and has a good popularization and application prospect in improvement of animal reproduction function deficit caused by high fat diet.
Owner:SOUTH CHINA AGRI UNIV

Application of chenodeoxycholic acid in improving intestinal barrier function damage in animals

The invention discloses an application of chenodeoxycholic acid in improving intestinal barrier function damage in animals. The present study found that chenodeoxycholic acid can regulate the adverseeffects in improvement of intestinal barrier function damage in animals, reverses decrease of lipopolysaccharide (LPS)-induced intestinal epithelial cell trans epithellal electric resistance (TEER) and tight junction protein expression, can also significantly improve the decrease of high-fat diet or LPS-induced mice intestinal tight junction protein expression, decrease of goblet cell quantity, and increase of intestinal permeability, improves the intestinal barrier function damage of animals, provides a reference and technical theoretical basis for improving the intestinal health and production performance of animals, is a technique for improving high-fat diet or LPS-induced animal intestinal barrier function damage through nutrition regulation and control means, has great significance for animal production and human health, has the advantages of convenient use, safety, effectiveness, and no toxic side effects, and has broad application prospects.
Owner:SOUTH CHINA AGRI UNIV

Traditional Chinese medicine foot soaping liquid for treating diabetes

The invention relates to the field of traditional Chinese medicine, in particular to a traditional Chinese medicine foot soaping liquid for treating diabetes, and solves the problems that the traditional method for treating diabetes by orally taking drugs and injecting insulin has serious toxic side effect and bad curative effect and easily causes complicating disease and drug resistance. The liquid is composed of 14 drugs including leech, muskiness, chicken-bone herb, pericarpium zanthoxyli, red paeonia, mugwort leaf, radix aconiti, Guilu Erxian Jiao, prepared rhizome of rehmannia, Dioscoreaopposita, cortex moutan, ginseng, polygonatum and the like. The drugs are soaked and then concentrated under normal pressure and concentrated under vacuum by a traditional Chinese medicine vacuum extracting machine set for extracting liquid medicines, and then the liquid medicine is made into a drug for external use preferably by a plenty of Chinese herbal medicines and by a special modern processing method in accordance with theory of traditional Chinese medicine. The drug is used in a foot soaking manner and a footherapy manner for treatment, and the drug has the functions, for human body, of soothing the liver and controlling breathing, promoting the production of body fluid to quench thirst, recovering glucose metabolism, balancing blood sugar, decreasing blood fat, promoting insulin secretion and keeping the blood sugar stable for a long time, and can enhance the immunity of the organism and avoid all defects of traditional oral drugs.
Owner:杨朝晖

Application of fructose as vaccine adjuvant

The invention relates to the field of biological medicines, and particularly discloses an application of fructose as a vaccine adjuvant. The feed added with the fructose has the advantage that the death rate of an experimental animal is remarkably reduced in comparison with a feed which is not added with alanine through adding or no adding the fructose in the vaccine, so that the fructose is proved to be capable of improving the immunity effect of the vaccine and can be used as the vaccine adjuvant.
Owner:SUN YAT SEN UNIV

The Method of Using Hydrogen Peroxide to Improve the Quality of Fangfeng Medicinal Materials

ActiveCN103977048BFully tap the potential of secondary metabolismHigh content of parsnip actibutinPlant ingredientsSecondary metaboliteOxygen
The invention discloses a method for using hydrogen peroxide to improve the quality of windproof medicinal materials, and relates to the technical field of windproof medicinal materials. Place at 20-25°C for 3-10 days → dry; the active oxygen is hydrogen peroxide, and the concentration of hydrogen peroxide is 0.2μmol / L-50mmol / L, the treatment time period is 3-15 days; the temperature is 10-35°C. During the cultivation process of Fangfeng, any high-yield measures can be adopted to tap the high-yield potential. Through the treatment of fresh medicinal materials, the present invention maximizes the level of secondary metabolism and the quality of medicinal materials, so that the quality of cultivated Fangfeng medicinal materials can reach or exceed the quality of wild authentic medicinal materials. . Both output and quality are realized; the invention is easy to operate and easy to popularize.
Owner:孟祥才

Novel application of DHA as feed additive in regulation and control of muscle fiber types

The invention discloses novel application of DHA as a feed additive in regulation and control of muscle fiber types. According to the novel application of DHA as a feed additive, DHA is added in high-fat diet to increase mRNA m6A demethylase FTO protein expression in skeletal muscle tissue of a mouse, so the total mRNA m6A modification level in the skeletal muscle of the mouse is reduced. Under the condition of the high-fat diet, the quantity of mitochondria in the skeletal muscle of the mouse is increased, the oxidative phosphorylation gene expression of the skeletal muscle of the mouse is promoted, the glycolysis gene expression is reduced, conversion from the muscle fiber type of the skeletal muscle to slow muscle fiber is promoted, and the exercise tolerance of the mouse is improved. The addition amount of DHA in the high-fat diet is 500 mg / kg of body weight / day. DHA promotes expression of m6A demethylase FTO in a C2C12 cell line and reduces the level of m6A. DHA does not contain substances harmful to animals or human bodies, is small in addition amount, can be directly added into an animal feed, food or drugs, has the advantages of being safe, effective, free of toxic and side effects and the like, and has good popularization and application prospects in the application as the feed additive to improve the quality of animal meat.
Owner:ZHEJIANG UNIV

Feed additive for necrotic enteritis of livestock and poultry, livestock and poultry feed and preparation method

ActiveCN113647512AImprove necrotic enteritis injuryImprove developmentFood processingAnimal feeding stuffAvian necrotic enteritisEnteritides
The invention discloses a feed additive for necrotic enteritis of livestock and poultry. The invention provides new application of round-leaf grape pomace, cardamom, radix aucklandiae, bagasse, radix sophorae flavescentis and synanthrin. The invention also provides a preparation method of the livestock and poultry feed and the feed additive. Animal feeding tests prove that the feed additive not only can reduce the death rate of broilers with necrotic enteritis and intestinal lesions of the broilers with necrotic enteritis and effectively improve the necrotic enteritis of the broilers, but also can increase the average daily feed intake and the final body weight, reduce the content of dextran in serum of the broilers with necrotic enteritis and increase the content of IGF-I and EGF in the serum of the broilers with necrotic enteritis. Therefore, growth performance of the animals is further promoted, and the feed additive has a good popularization and application prospect in the aspects of promoting the growth performance and intestinal development of the broilers with necrotic enteritis.
Owner:广州骊加生物科技有限公司

The method of using sodium dithionite to improve the quality of Fangfeng medicinal materials

ActiveCN103977047BFully tap the potential of secondary metabolismHigh content of parsnip actibutinPlant ingredientsSecondary metaboliteSodium sulfite
The invention discloses a method for improving the quality of a wind-proof medicinal material by using sodium dithionite, which relates to the technical field of wind-proof medicinal materials. The preparation method is as follows: fresh root of a wind-proof root→cleaning→drying in the shade at 20-25°C for 1-2 days→spraying activity Oxygen carrier → place at 20-25°C for 3-10 days → dry; the active oxygen carrier is sodium dithionite, and the concentration of sodium dithionite is 0.1μmol / L-50mmol / L, and the treatment time period is 3 ~15 days; temperature 10‑35°C. During the cultivation process of Fangfeng, any high-yield measures can be adopted to tap the high-yield potential. Through the treatment of fresh medicinal materials, the present invention maximizes the level of secondary metabolism and the quality of medicinal materials, so that the quality of cultivated Fangfeng medicinal materials can reach or exceed the quality of wild authentic medicinal materials. . Both output and quality are realized; the invention is easy to operate and easy to popularize.
Owner:孟祥才

A compound composition of citral and carvacrol and its application

The invention discloses a compound composition of citral and carvacrol and its application. The combination of citral and carvacrol can inhibit the growth of Clostridium spp, can effectively control the number of Clostridium spp. in the intestinal tract of poultry, and can not only reduce the mortality of broiler chickens with necrotizing enteritis, the score of necrotizing enteritis lesions and the production of caecal contents. The number of Clostridium perfringens can also promote the growth performance of broilers with necrotizing enteritis, increase the average daily feed intake and final body weight, and promote the growth of broilers with necrotizing enteritis. It can be used to prevent necrotizing enteritis caused by Clostridium perfringens infection Enteritis and has a good application prospect.
Owner:广州微特加生物工程有限公司

A kind of feed additive for livestock and poultry necrotizing enteritis, livestock and poultry feed and preparation method

ActiveCN113647512BImprove necrotic enteritis injuryImprove growth performanceFood processingAnimal feeding stuffInulinAvian necrotic enteritis
The invention discloses a feed additive for necrotizing enteritis of livestock and poultry, provides new uses of muscadine pomace, cardamom, woodsy, bagasse, Sophora flavescens and inulin, and also provides a livestock and poultry The preparation method of feed and feed additive; it is confirmed by animal feeding experiments that the feed additive of the present invention can not only reduce the mortality of broiler chickens with necrotizing enteritis and intestinal lesions of necrotizing enteritis, effectively improve the necrotizing enteritis of chickens, but also improve the average daily feed intake It can reduce the dextran content in serum of necrotizing enteritis broilers, increase the content of IGF-I and EGF in serum, and promote the development of animal intestines, thereby promoting the growth performance of animals. It has a good prospect of promotion and application in tract development.
Owner:广州骊加生物科技有限公司

Application of alanine as vaccine adjuvant

The invention relates to the field of biological medicines, and particularly discloses application of alanine serving as a vaccine adjuvant. According to the application of alanine, the alanine is added or not added into a vaccine to discover that the death rate an experimental animal is significantly reduced after the alanine is added in comparison with that without the alanine, which shows that the alanine can be used for improving the immune effect of the vaccine and can be used as an immunologic adjuvant of the vaccine.
Owner:SUN YAT SEN UNIV

Methylprednisolone delivery material based on epsilon-polylysine, preparation method of methylprednisolone delivery material, and kit

The invention discloses a methylprednisolone delivery material based on epsilon-polylysine, a preparation method of the methylprednisolone delivery material, and a kit. The methylprednisolone deliverymaterial can prolong the residence time of methylprednisolone in an articular cavity and prolong the half-life period of methylprednisolone, has cartilage permeability and cell membrane permeability,can permeate into cartilage tissue and stem cells and cartilage cells in the cartilage tissue in the form of an integral material. The methylprednisolone delivery material degrades under the action of intracellular enzymes to release methylprednisolone, so that the bioavailability of the methylprednisolone is improved. The methylprednisolone delivery material provided by the invention has excellent tissue and cell compatibility, does not cause toxic or side effects, and has good biodegradability, and degradation products do not have toxicity. Besides, the material is simple to prepare, the using process is very simple, and articular cavity injection administration can be directly performed.
Owner:SHANGHAI SIXTH PEOPLES HOSPITAL
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