Decoquinate liposome and preparation method and application thereof
A technology of decoquinate and liposomes, which is applied in the field of medicine, can solve the problems of poor inhibition of malaria parasites, etc., and achieve simple and feasible preparation methods, poor repeatability, and good anti-malarial effects
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Embodiment 1
[0064] The present embodiment provides a kind of decoquinate liposome, and its preparation method comprises the following steps:
[0065] (1) Accurately weigh 20mg decoquinate, 80mg soybean lecithin, 15mL absolute ethanol and 285mL water;
[0066] (2) Place the above-mentioned decoquinate and soybean lecithin in absolute ethanol, heat in a boiling water bath for 10 minutes to dissolve, and use it as the organic phase;
[0067] (3) Magnetically stir the water phase at a stirring speed of 500rpm. Slowly inject the organic phase obtained in step (2) into the water phase with a pipette. The volume ratio of the organic phase to the water phase is 1:19. Continue stirring for 2 min after injecting into the aqueous phase to obtain the decoquinate liposomes.
Embodiment 2
[0069] The present embodiment provides a kind of decoquinate liposome, and its preparation method comprises the following steps:
[0070] (1) Accurately weigh 20mg decoquinate, 40mg soybean lecithin, 10mg cholesterol, 30mL absolute ethanol and 270mL water;
[0071] (2) Place the above-mentioned decoquinate, soybean lecithin and cholesterol in absolute ethanol, heat in a boiling water bath for 10 minutes to dissolve, and use it as the organic phase;
[0072] (3) Water is used as the water phase, magnetically agitated the water phase, and the stirring speed is 1000rpm, and the organic phase obtained in step (2) is slowly injected into the water phase with a pipette, and the volume ratio of the organic phase to the water phase is 1: 9. Continue stirring for 5 min after all the organic phase is injected into the water phase to obtain the decoquinate liposomes.
Embodiment 3
[0074] The present embodiment provides a kind of decoquinate liposome, and its preparation method comprises the following steps:
[0075] (1) Accurately weigh 40mg decoquinate, 80mg soybean lecithin, 130mg polyethylene glycol 15-hydroxystearate, 30mL absolute ethanol and 270mL water;
[0076] (2) Place the above-mentioned decoquinate and soybean lecithin in absolute ethanol, heat in a boiling water bath for 10 minutes to dissolve, and use it as the organic phase;
[0077] (3) Water is used as the water phase. Add polyethylene glycol 15-hydroxystearate into the water, magnetically stir the water phase at a stirring speed of 200 rpm, and slowly inject the organic phase obtained in step (2) into the water phase with a pipette , the volume ratio of the organic phase to the aqueous phase is 1:9, and after all the organic phases are injected into the aqueous phase, continue to stir for 5 minutes to obtain the decoquinate liposomes.
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