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31results about How to "Achieve low toxicity" patented technology

Method for efficiently carrying CRISPR/Cas9 through functionalized graphene oxide for gene editing

The invention discloses a method for efficiently carrying CRISPR / Cas9 through functionalized graphene oxide for gene editing. An NGO-PEG-PEI / Cas9 / sgRNA complex is obtained by the following steps: covalently modifying aminated PEG and aminated PEI onto graphene oxide to obtain NGO-PEG-PEI; then assembling Cas9 protein and sgRNA into a Cas9 / sgRNA complex under a room-temperature condition; and mixing NGO-PEG-PEI with the Cas9 / sgRNA complex under a room-temperature condition. The editing of target gene can be realized by mixing the complex with the target gene. The functionalized GO has the characteristics of good biocompatibility and high carrying efficiency, can efficiently carry the Cas9 / sgRNA complex into cells for performing corresponding functions, and has the effect of keeping the Cas9 / sgRNA complex free of enzymatic degradation and high in stability.
Owner:SOUTH CHINA NORMAL UNIVERSITY

Insecticidal and disease-preventing suspended seed coating agent

The invention discloses an insecticidal and disease-preventing suspended seed coating agent which is mainly characterized in that effective active components are fludioxonil and an effective component B, wherein a weight ratio of fludioxonil to the effective component B is 1:60-60:1. The composition is prepared into the suspended seed coating agent. The suspended seed coating agent provided by the invention has the advantages of good film-forming performance, uniform coating, high suspension rate, good safety, low toxicity, and the like. The suspended seed coating agent can be widely applied in seed treatments of crops such as wheat, corn, paddy rice, peanut, cotton, and the like. The seed coating agent has a sustained-release effect, such that pesticide dose is reduced. The seed coating agent is safe to human and animals, has no phytotoxicity, and has good environmental compatibility.
Owner:陕西亿田丰作物科技有限公司

Multifunctional cationic polymer gene vector, and preparation method and application thereof

InactiveCN103396557AHas a targeted effectEnhanced proton buffering capacityGenetic material ingredientsPharmaceutical non-active ingredientsCytotoxicityPlasmid dna
The invention relates to a multifunctional cationic polymer gene vector and a preparation method and application thereof. A multifunctional cationic polymer is synthesized by oxidizing low molecular weight chitosan used as a framework material with potassium periodate and subjecting the oxidized low molecular weight chitosan and polyethyleneimine coupled with a sartan-class drug to reduction and ammonification. To overcome technical problems, the invention provides the novel cationic polymer with targeting performance of the acceptor of the tumor cell AT1, multiple proton buffering capability and adjuvant therapy effects on tumors and provides a preparation method with the advantages of mild conditions, low cost, applicability and reliability for the cationic polymer. A compound formed by the cationic polymer provided by the invention and plasmid DNA has the advantages of low cytotoxicity, good targeting performance, high transfection efficiency, substantial in-vitro antineoplastic effects, etc.; the polymer can be used for preparation of a non-virus gene transfer system capable of simultaneously transferring a gene drug and a chemical drug for cooperated treatment of a tumor.
Owner:CHINA PHARM UNIV

Chlorpyrifos-containing insect disinfestation composition

The invention discloses a chlorpyrifos-containing insect disinfestation composition, which is mainly characterized by comprising an effective active component chlorpyrifos and an effective component B, wherein the effective component B is selected from thiamethoxam, clothianidin and thiacloprid, a weight ratio of the chlorpyrifos to the effective component B is 20:1-1:5, and the composition can be prepared into a microcapsule suspension and a microcapsule suspension-suspending agent. The composition can be provided for prevention and control of a plurality of insect pests, has characteristics of significant synergy effect and prevention and control spectrum expanding, provides high activities for pests on grassy crops, tea trees, vegetables, cotton and fruit trees, and further has advantages of slow release, pesticide amount reduction, safety on human and animals, no pesticide injury, good environment compatibility, strong preparation adhesion, rain erosion resistance, long lasting period and the like.
Owner:SHAANXI MEIBANG PHARMA GRP CO LTD

Preparation and application of gene and chemotherapeutic drug co-delivery anti-tumor nanoparticle of target SR-BI (Scavenger Receptor-BI)

The invention relates to preparation and application of a gene and chemotherapeutic drug co-delivery anti-tumor nanoparticle of a target SR-BI (Scavenger Receptor-BI). The nanoparticle is a recombinant high density lipoprotein drug-loaded nanoparticle, comprises phospholipid, cholesterol, cholesteryl ester, apolipoprotein, cation lipid, a chemotherapeutic drug, a gene drug and the like, and is prepared by a film dispersion method. The invention aims at preparing the bionic tumor target drug-loaded nanoparticle, the preparation condition is mild, and the cost is low. The invention further provides the application of the gene and chemotherapeutic drug co-delivery anti-tumor nanoparticle. The gene and chemotherapeutic drug co-delivery anti-tumor nanoparticle has the advantages of spherical structure, good encapsulation efficiency, low cytotoxicity, good targeting, high safety, significant in-vitro anti-tumor effect and the like.
Owner:CHINA PHARM UNIV

High-efficiency environment-friendly pesticide complex composition

The invention discloses a high-efficiency environment-friendly pesticide complex composition with a preparation form of microcapsule suspension preparation or microcapsule suspension-suspension preparation. The composition comprises, by weight, 0.5-6% of avermectin, 3-40% of spirodiclofen, and balance of auxiliary agents and a filling material. With the pesticide provided by the invention, various mite infestations can be controlled. The pesticide has the advantages of environment friendliness, sustained release, long effect duration, enhanced adhesion force, enhanced penetration, and no phytotoxicity.
Owner:张秋芳

Organic paint removing agent, preparation method and application in removing paint layer at surface of special equipment

The invention discloses an organic paint removing agent and a preparation method. The paint removing agent is prepared by dichloromethane, formic acid, phenol, Span 80, lauryl sodium sulfate, organic glass powder and a surface modifying agent in percentage by weight. The preparation method comprises the following steps: mixing the dichloromethane and the formic acid; after the phenol is heated to 45-55 DEG C till being melted, adding mixing liquid; then adding the Span 80 and the lauryl sodium sulfate into the mixed liquid to stir; adding the organic glass powder and dissolving the organic glass powder to the mixed liquid; adding the surface modifying agent into one second of mixed liquid and then heating the mixture to 35-65 DEG C together till the mixture is completely melted; then adding one second of residual mixed liquid. The organic paint removing agent has the characteristics of low poison, no corrosion, rapid paint removal and less environmental pollution and can be widely applied to remove the paint layer at the surface of special equipment.
Owner:NANJING BOILER & PRESSURE VESSEL SUPERVISION & INSPECTION INST

Pesticidal suspended seed coating capable of preventing diseases

InactiveCN103283766AGood effectIt has the effect of one spray and two defensesBiocideFungicidesDiseaseRelease - action
The invention discloses a pesticidal suspended seed coating capable of preventing diseases. The seed coating is mainly characterized in that the effective active components are difenoconazole and an effective component B, wherein the weight ratio of the difenoconazole to the effective component B is 1:80-80:1, and the composition is prepared into a suspended seed coating. The invention has the advantages of favorable film formation property, uniform coating, high suspension percentage, high safety, low toxicity and the like, and can be widely used for seed treatment of wheat, corns, paddy rice, peanuts, cotton and other crops. The invention has a slow-release action, reduces the pesticide consumption, is safe for human and livestock, does not have chemical injury, and has favorable environmental compatibility.
Owner:陕西亿田丰作物科技有限公司

Pesticide composition containing sedaxane

The invention discloses a pesticide composition containing sedaxane. Effective active ingredients of the composition consist of sedaxane, tebuconazole and an effective ingredient C, wherein the effective ingredient C is thiamethoxam or imidacloprid, the weight ratio of sedaxane to tebuconazole to the effective ingredient C is (1-80): (1-80): (1-80), and the composition is made into a suspended seed coating. The composition disclosed by the invention can be used for preventing and treating a variety of underground pests and harmful bacteria and has an obvious synergistic effect, the control spectrum is enlarged, and the composition has relatively high activity to pests and harmful bacteria on wheat, vegetables, cotton, peanuts, watermelon and rice; the pests consist of aphids, midge, root-knot nematodes, wireworms, grubs, cutworms, thrips, mole crickets, athetis lepigone and borers, and diseases consist of sheath blight, bakanae disease, gummy stem blight, rust disease, stripe rust, root rot, head blight, powdery mildew, anthracnose, head smut and full rot. The composition has a sustained-release effect, the dosage of pesticides is reduced, and the composition is safe to human and livestock, is free from damage caused by chemicals and is good in environmental compatibility.
Owner:SHAANXI MEIBANG PHARMA GRP CO LTD

High-efficient pesticide combination containing chlorpyrifos

The invention discloses a high-efficient pesticide combination containing chlorpyrifos. The combination is mainly characterized by comprising active ingredients A and chlorpyrifos, wherein the active ingredients A are selected from thiamethoxam and thiacloprid, the weight ratio of the active ingredients A to the chlorpyrifos is (1:1)-(1:15), and the combination can be prepared into suspoemulsion, a microcapsule suspending agent and microcapsule suspension. The combination provided by the invention can be used for preventing and treating various insect pests, has an obvious synergistic effect, expands a preventing and treating spectrum, has high activity on the insect pests on cereal crops, ornamental plants, tea trees, vegetables, cottons and fruit trees, has a slow release function, reduces the using amount of the pesticide, is safe to human and livestock, is free of chemical injury, and has good environment compatibility; the preparation has enhanced binding performance, is resistant to rain wash, has long residual activity and the like.
Owner:陕西亿田丰作物科技有限公司

Prochloraz-containing pesticide composition

The invention discloses a prochloraz-containing pesticide composition. The composition is mainly characterized in that the effective active components are prochloraz and an effective component B, wherein the effective ingredient B is selected from thiamethoxam or clothianidin or thiacloprid; the weight ratio of the prochloraz to the effective component B is 1:100-50:1; and the composition is prepared into a suspended seed coating. The composition disclosed by the invention can prevent and treat many soil pests and germs, has an obvious synergistic action, widens the prevention and treatment spectrum, and has higher activity for pests and germs on wheat, vegetables, cotton, peanuts, cucumbers and paddy rice; and the diseases of paddy rice and vegetables comprise bakanae disease of rice, rice blast, sclerotinia rot of rape, anthracnose of rape, gray mold of cucumber and anthracnose of cucumber. The composition has a slow-release action, reduces the pesticide consumption, is safe for human and livestock, does not have chemical injury, and has favorable environmental compatibility.
Owner:陕西亿田丰作物科技有限公司

Sheath tube for preventing rat and termite biting, and production method thereof

The invention provides a sheath tube for preventing rat and termite biting. The sheath tube comprises, by weight, 100 parts of resin, 0.5-8 parts of a stabilizer, 1-15 parts of a rat-proof tougheningagent, 0.5-5 parts of an anti-ant lubricant, 0.5-10 parts of an anti-ant additive, 0.5-10 parts of an anti-mouse additive and 0.5-5 parts of a paint; the resin is PVC resin; the stabilizer is at leastone of a calcium-zinc stabilizer, a rare earth stabilizer and an organotin stabilizer; the anti-mouse toughening agent is an ethylene-vinyl acetate copolymer; the anti-ant lubricant is at least one of orange essential oil and camphor oil; the anti-ant additive is at least one of chili powder, garlic powder, prickly heat powder, borax, mint leaves and white resin; and the anti-mouse additive is atleast one of tulip, incense and camphor balls. The invention also provides a production method of the tube. The service life of the sheath tube is prolonged, so the hidden safety troubles of a gas pipe are reduced, the service life of an optical fiber is prolonged, and the maintenance cost is reduced.
Owner:KANGTAI PLASTIC SCI & TECH GRP

Microcapsual granule for preventing and controlling diseases and pests of peanuts

The invention discloses a microcapsual granule for preventing and controlling diseases and pests of peanuts. Effective components of the microcapsual granule are composed of abamectin and bifenthrin which are in weight ratio of 1:1, and the effective components account for 3% of the total weight of the microcapsual granule. Pharmacodynamic tests prove that the microcapsual granule has the positivecharacteristics such as strong complementarity, obvious synergistic effect, enlarged prevention and control spectrum, application amount reduction, prolonged pesticide application period, high crop safety, environment pollution reduction and strong environmental compatibility.
Owner:JIANGSU HUIFENG BIO AGRI CO LTD

Pesticide composition containing carboxin

The invention discloses a pesticide composition containing carboxin. The composition is mainly characterized in that effective active constituents of the composition comprise carboxin and effective component B, the effective component B is selected from the group consisting of thiamethoxam, thiacloprid, imidacloprid and clothianidin, a weight ratio of carboxin to the effective component B is 1: 80 to 40: 1, and a suspended seed coating agent is prepared from the composition. The composition provided by the invention can be used for preventing and treating a variety of soil pests and pathogens, produces an obvious synergistic effect, has an expanded prevention and treatment spectrum and shows high activity to pests and pathogens on wheat, corn, sorghum and cotton, wherein wheat, corn, sorghum and cotton diseases include corn head smut, wheat smut, wheat rust, millet smut, loose kernel smut of sorghum, head smut, damping-off of cotton and cotton verticillium wilt; furthermore, the composition has a sustained release effect, reduces the dosage of a pesticide, is safe to people and livestock, produces no phytotoxicity and has good environmental compatibility.
Owner:陕西亿田丰作物科技有限公司

Portable pesticide atomization machine

ActiveCN105494292ARealize the precision of prevention and controlAchieve low toxicityInsect catchers and killersGas cylinderSpray nozzle
The invention discloses a portable pesticide atomization machine. The machine comprises a gas source bin, a spray barrel, a spray nozzle and a pesticide tank and further comprises a gas cylinder, electromagnetic valves and a pressure valve; the spray nozzle is an atomizing nozzle; the gas cylinder is communicated with the gas source bin, the spray barrel and the pesticide tank through pipelines respectively, the gas flow electromagnetic valve is arranged on the pipeline through which the gas cylinder is connected with the spray barrel, the pressure valve is arranged on the pipeline through which the gas cylinder is connected with the pesticide tank, and a pressure gauge is installed at the outlet end of the gas cylinder; the gas source bin is connected with a power source; the gas flow electromagnetic valve, the pressure gauge, the pressure valve and the liquid pesticide electromagnetic valve are connected with a controller. The atomization machine is a portable normal temperature aerosol sprayer based on gas flow blasting secondary atomization and used for pest control, by means of the machine, precision, low-toxicity and high-work-efficiency operation of pest control can be achieved, the diameter of each droplet is small, the droplet deposition rate on the leaf surface is high, pesticide application amount is reduced, and popularization is easy to conduct.
Owner:SHANDONG AGRICULTURAL UNIVERSITY

Pesticide composition with carboxin

The invention discloses a pesticide composition with carboxin. The pesticide composition is mainly characterized by comprising the carboxin and an effective ingredient B; the carboxin is an effective active ingredient, the effective ingredient B is selectively thiamethoxam, thiacloprid, imidacloprid and clothianidin, a weight ratio of the carboxin to the effective ingredient B is 1:80-40:1, and the pesticide composition can be prepared to obtain a suspending seed coating agent. The pesticide composition has the advantages that diversified underground insects and germs can be prevented and treated by the pesticide composition, obvious synergistic effects can be realized, prevention and treatment spectra can be expanded, and the pesticide composition is high in activity for injurious insects and germs on wheat, corns, sorghum and cotton; diseases of the wheat, the corns, the sorghum and the cotton include corn head smut, bunt smut, wheat rust, rice smut, sorghum loose smut, head smut, cotton rhizoctonia and cotton verticillium wilt; relief effects can be realized by the pesticide composition, the use of pesticides can be reduced, and the pesticide composition is safe for human and animals, free of pesticide hazards and good in environmental compatibility.
Owner:陕西亿田丰作物科技有限公司

Pesticide composition containing triticonazole

The invention discloses a pesticide composition containing triticonazole. The composition is mainly characterized in that effective active components contain the triticonazole and an effective component B; the effective component B is selected from thiamethoxam, thiacloprid, imidacloprid and clothianidin, wherein the weight ratio of the triticonazole to the effective component B ranges from (1:90) to (30:1); the composition is prepared into a suspended seed coating. The composition disclosed by the invention can prevent and treat various underground insects and bacteria and has the obvious synergistic effect; an insecticidal spectrum is enlarged; the pesticide composition has high activity to the insects and the bacteria on wheat, corns, cotton, cucumbers and paddy rice; and diseases of the corns, the paddy rice and the cotton contain corn head smut, wheat smut, wheat powdery mildew, wheat tilletia and wheat net blotch. The pesticide composition has the slow release effect; the dosage of pesticides can be reduced; the pesticide composition is safe to people and livestock, has no phytotoxicity and is good in environmental compatibility.
Owner:陕西亿田丰作物科技有限公司

Preparation method of flame-retardant high-performance flexible explosion-proof coating

The invention discloses a preparation method of a flame-retardant high-performance flexible explosion-proof coating, which comprises a step 1, preparing a component A: modifying isocyanate, polyether resin and phthalic anhydride polymer polyol in an inert environment, namely dehydrating the isocyanate, the polyether resin and the phthalic anhydride polymer polyol at 100-110 DEG C under the vacuum of -0.1 MPa for 2-3 hours, relieving the vacuum, cooling to below 60 DEG C, adding isocyanate, reacting at 85-95 DEG C for 1.5-2 hours, measuring the -NCO value after the reaction is finished, discharging, and filtering to obtain the flame-retardant modified component A. An epoxy group and an isocyanate group are introduced into the coating prepared by the preparation method disclosed by the invention. The heat resistance of the coating is further improved on the basis that the epoxy has the advantages of good processing property, excellent mechanical property, interface property and the like. Polyether amine reacts with epoxy and isocyanate, polyether and the reactive flame retardant react with isocyanate to form a multi-dimensional network structure in a system, so that the excellent flame-retardant and explosion-proof performance of the coating is ensured.
Owner:师海峰

A kind of multifunctional cationic polymer gene carrier and its preparation method and application

InactiveCN103396557BHas a targeted effectEnhanced proton buffering capacityGenetic material ingredientsPharmaceutical non-active ingredientsCytotoxicityPlasmid dna
The invention relates to a multifunctional cationic polymer gene vector and a preparation method and application thereof. A multifunctional cationic polymer is synthesized by oxidizing low molecular weight chitosan used as a framework material with potassium periodate and subjecting the oxidized low molecular weight chitosan and polyethyleneimine coupled with a sartan-class drug to reduction and ammonification. To overcome technical problems, the invention provides the novel cationic polymer with targeting performance of the acceptor of the tumor cell AT1, multiple proton buffering capability and adjuvant therapy effects on tumors and provides a preparation method with the advantages of mild conditions, low cost, applicability and reliability for the cationic polymer. A compound formed by the cationic polymer provided by the invention and plasmid DNA has the advantages of low cytotoxicity, good targeting performance, high transfection efficiency, substantial in-vitro antineoplastic effects, etc.; the polymer can be used for preparation of a non-virus gene transfer system capable of simultaneously transferring a gene drug and a chemical drug for cooperated treatment of a tumor.
Owner:CHINA PHARM UNIV

Flame-retardant nanocomposite

The invention provides a flame-retardant nanocomposite made of the following raw materials in parts by weight: 40 to 50 parts of resin, 15 to 20 parts of a flame retardant, 1 to 3 parts of an antioxidant, 1 to 3 parts of a toughening agent, 10 to 20 parts of ceramic fiber, 20 to 30 parts of barium sulfate, 5 to 8 parts of nanometer titanium dioxide, 5 to 8 parts of nano silica, 5 to 8 parts of glass fiber and an appropriate amount of deionized water. According to the invention, the flame retardant effect is realized by reasonably allocating the existing flame retardant and auxiliary materials thereof, producing a cracked carbon layer by an organosilicone flame retardant and improving the oxidation resistance of the carbon layer.
Owner:ANHUI RUIYAN NEW MATERIAL TECH RES INST

Insecticide combination containing pymetrozine and high-efficacy lambda-cyhalothrin

The invention discloses an insecticide combination containing pymetrozine and high-efficacy lambda-cyhalothrin, which is mainly characterized in that the insecticide combination contains active ingredients, i.e. the pymetrozine and the high-efficacy lambda-cyhalothrin, the remaining ingredients are assistants, the weight ratio of the pymetrozine to the high-efficacy lambda-cyhalothrin is 9:1 to 1:9, and the combination is made into microcapsule suspension, microcapsule suspension - suspension or oil suspension. The insecticide combination has the advantages that the insecticide combination can prevent and control various injurious insects, the synergistic effect is obvious, the insecticidal spectrum is expanded and the activities to the injurious insects on rice, vegetables, cotton and fruit trees are high; the insecticide combination has a slow release effect, the pesticide dosage is reduced, the insecticide combination is safe to human beings and livestock, the pesticide damage does not exist and the environmental compatibility is good; and the preparation adhesive force is reinforced, the insecticide combination is resistant to rainwater washing, the efficacy duration is long, and the like.
Owner:张少武

A kind of pesticide composition containing fenconazole

The invention discloses a pesticide composition containing triticonazole. The composition is mainly characterized in that effective active components contain the triticonazole and an effective component B; the effective component B is selected from thiamethoxam, thiacloprid, imidacloprid and clothianidin, wherein the weight ratio of the triticonazole to the effective component B ranges from (1:90) to (30:1); the composition is prepared into a suspended seed coating. The composition disclosed by the invention can prevent and treat various underground insects and bacteria and has the obvious synergistic effect; an insecticidal spectrum is enlarged; the pesticide composition has high activity to the insects and the bacteria on wheat, corns, cotton, cucumbers and paddy rice; and diseases of the corns, the paddy rice and the cotton contain corn head smut, wheat smut, wheat powdery mildew, wheat tilletia and wheat net blotch. The pesticide composition has the slow release effect; the dosage of pesticides can be reduced; the pesticide composition is safe to people and livestock, has no phytotoxicity and is good in environmental compatibility.
Owner:陕西亿田丰作物科技有限公司

Electrical cooling, arc extinguishing and fire extinguishing reagent and preparation method thereof

ActiveCN114796966AReduce pollutionSolve the problem of prone to reflashingBattery isolationFire extinguisherToxic gasPhosphate
The invention discloses an electrical cooling, arc-extinguishing and fire-extinguishing reagent and a preparation method thereof, and the electrical cooling, arc-extinguishing and fire-extinguishing reagent comprises the following substances in parts by mass: 50-70 parts of perfluorohexanone, 30-50 parts of an organic silicon flame retardant, 20-40 parts of 5, 5-dimethyl-2-chloro-1, 3, 2-dioxo-phosphorus hetero-caprolactone phosphate, 5-12 parts of metal hydroxide, 20-30 parts of graphite powder and 3-5 parts of a dispersing agent. According to the fire extinguishing agent disclosed by the invention, the perfluorohexanone is adopted as a fire extinguishing agent, and the organic silicon flame retardant, the 5, 5-dimethyl-2-chloro-1, 3, 2-dioxo-phosphorus hetero-caprolactone phosphate, the inorganic flame retardant metal hydroxide and the graphite powder with a porous structure are supplemented, so that the problem that after-combustion is easy to occur when the perfluorohexanone fire extinguishing agent is independently applied is solved; and the porous structure of the graphite powder can adsorb HF toxic gas generated in the fire extinguishing process of the perfluorohexanone, so that air pollution is reduced.
Owner:重庆华航重科电气设备有限公司

Preparation method of nitrophenylacetonitrile compound

The invention discloses a preparation method of a nitrophenylacetonitrile compound. The nitrophenylacetonitrile compound is shown as a structural formula (1), wherein R1 refers to hydrogen, alkyl with 1-6 carbon atoms or halogenated alkyl with 1-3 carbon atoms; and R2 refers to hydrogen or alkoxyl with 1-6 carbon atoms. The method comprises the following step of: reacting the compound shown as a structural formula (2) with ferrous iron cyanide salt in a solvent under the action of cuprous chloride and / or cuprous bromide serving as a catalyst under a heating condition, wherein the definitions of R1 and R2 in the formula (2) are the same as those of R1 and R2 in the formula (2). Due to the adoption of the method for preparing nitrophenylacetonitrile by taking an o-nitrochlorobenzene compound as an initiator, the toxicity of a cyanidation reaction and the cost of a reactant can be lowered; meanwhile, cuprous chloride and cuprous bromide are used in a matching way, so that an unexpected effect is achieved, the product yield can be increased, and industrial mass production is facilitated; and moreover, three wastes do not contain virulent substances, and post-treatment is easy.
Owner:NUTRICHEM LAB CO LTD
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