The invention discloses a pesticide composition with carboxin. The pesticide composition is mainly characterized by comprising the carboxin and an effective ingredient B; the carboxin is an effective active ingredient, the effective ingredient B is selectively thiamethoxam, thiacloprid, imidacloprid and clothianidin, a weight ratio of the carboxin to the effective ingredient B is 1:80-40:1, and the pesticide composition can be prepared to obtain a suspending seed coating agent. The pesticide composition has the advantages that diversified underground insects and germs can be prevented and treated by the pesticide composition, obvious synergistic effects can be realized, prevention and treatment spectra can be expanded, and the pesticide composition is high in activity for injurious insects and germs on wheat, corns, sorghum and cotton; diseases of the wheat, the corns, the sorghum and the cotton include corn head smut, bunt smut, wheat rust, rice smut, sorghum loose smut, head smut, cotton rhizoctonia and cotton verticillium wilt; relief effects can be realized by the pesticide composition, the use of pesticides can be reduced, and the pesticide composition is safe for human and animals, free of pesticide hazards and good in environmental compatibility.