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1899results about "Fluid pressure measurement using electrokinetic cells" patented technology
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Electrophoretic medium with improved stability
ActiveUS7236290B1Electrolysis componentsStatic indicating devicesElectrophoresisFree radicals scavenger
An electrophoretic medium comprises a liquid and at least one particle disposed within the liquid and capable of moving therethrough on application of an electric field to the medium. The medium further comprises a free radical scavenger selected from the group consisting of (a) stable free radicals; and (b) polymeric free radical scavengers comprising a plurality of free radical scavenging groups attached to a polymeric chain. The medium is desirably encapsulated.
Owner:E INK CORPORATION
Electro-optic displays
The invention provides an electrophoretic medium comprising at least two types of particles having substantially the same electrophoretic mobility but differing colors. The invention also provides article of manufacture comprising a layer of a solid electro-optic medium, a first adhesive layer on one surface of the electro-optic medium, a release sheet covering the first adhesive layer, and a second adhesive layer on an opposed second surface of the electro-optic medium.
Owner:E INK CORPORATION
Integrated system with modular microfluidic components
ActiveUS20050161669A1Reduce wearEasy to useElectrolysis componentsSemiconductor/solid-state device detailsModularityEngineering
Owner:SILICON VALLEY SCI
Method and Apparatus Using Electric Field for Improved Biological Assays
ActiveUS20090032401A1Avoid corrosionIncrease electric fieldElectrostatic separatorsSludge treatmentPresent methodEngineering
Disclosed are a method and apparatus that use an electric field for improved biological assays. The electric field is applied across a device having wells, which receive reactants, which carry a charge. The device thus uses a controllable voltage source between the first and second electrodes, which is controllable to provide a positive charge and a negative charge to a given electrode. By controlled use of the electric field charged species in a fluid in a fluid channel are directed into or out of the well by an electric field between the electrodes. The present method involves the transport of fluids, as in a microfluidic device, and the electric field-induced movement of reactive species according to various assay procedures, such as DNA sequencing, synthesis or the like.
Owner:THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIV
Gene silencing
InactiveUS6753139B1Reduce non-sequence specific bindingShorten the lengthBiocideElectrolysis componentsBiological bodyTranscriptional gene silencing
Owner:PLANT BIOSCI LTD
Microfluidic devices with thick-film electrochemical detection
InactiveUS6878255B1Reduce usageCost advantageSludge treatmentVolume/mass flow measurementAnalyteMicrofluidic channel
An apparatus for conducting a microfluidic process and analysis, including at least one elongated microfluidic channel, fluidic transport means for transport of fluids through the microfluidic channel, and at least one thick-film electrode in fluidic connection with the outlet end of the microfluidic channel. The present invention includes an integrated on-chip combination reaction, separation and thick-film electrochemical detection microsystem, for use in detection of a wide range of analytes, and methods for the use thereof.
Owner:ARROWHEAD CENT
Method and apparatus for the manipulation of particles by means of dielectrophoresis
InactiveUS6942776B2Increase rangeAvoid the needElectrostatic separatorsSludge treatmentPlanar substrateEngineering
An apparatus and method for establishing closed dielectrophoretic potential cages and precise displacement thereof comprising a first array of selectively addressable electrodes, lying on a substantially planar substrate and facing toward a second array comprising one electrode. The arrays define the upper and lower bounds of a micro-chamber where particles are placed in liquid suspension. By applying in-phase and counter-phase periodic signals to electrodes, one or more independent potential cages are established which cause particles to be attracted to or repelled from cages according to signal frequency and the dielectric characteristics of the particles and suspending medium. By properly applying voltage signal patterns into arrays, cages may trap one or more particles, thus permitting them to levitate steadily and / or move. In the preferred embodiment, where one array is integrated on a semiconductor substrate, displacement of particles can be monitored by embedded sensors.
Owner:SILICON BIOSYSTEMS SPA +1
Water desalination process and apparatus
ActiveUS20060060532A1Electrolysis componentsGeneral water supply conservationSolubilityWater desalination
A process and system for purifying water is disclosed. For example, in one embodiment, the process may be used to remove a divalent salt, such as calcium sulfate, from a water source in order to prevent the divalent salt from precipitating during the process. The water source, for instance, may be fed to an ion separating device, such as an electrodialysis device. In the electrodialysis device, an ion exchange takes place between the divalent salt and another salt, such as a monovalent salt to produce two concentrated salt streams that contain salts having greater solubility in water than the divalent salt. In one embodiment, the two salt streams that are produced may then be combined to precipitate the divalent salt in a controlled manner. During the process, various other components contained within the water feed stream may also be removed from the stream and converted into useful products. In one particular embodiment, the process is configured to receive a byproduct stream from a reverse osmosis process.
Owner:SOUTH CAROLINA THE UNIV OF
Dynamic coating with linear polymer mixture for electrophoresis
InactiveUS6787016B2Sludge treatmentVolume/mass flow measurementCapillary electrophoresisAqueous buffer
Compositions and methods are provided for performing capillary electrophoresis using a composition comprising in combination in an aqueous buffered medium a coating polymer and a sieving polymer, where the sieving polymer is more hydrophilic than the coating polymer and is present in greater amount. Of particular interest are uncrosslinked acrylamide polymer mixtures for coating plastic channels and providing sieving for performing DNA separations in microfluidic devices. Polyacrylamide or N,N-dimethyl acrylamide is used with a N,N-dialkyl acrylamide copolymer, either separately or together for sieving and coating, serving as the medium in capillary electrophoresis DNA separations.
Owner:MONOGRAM BIOSCIENCES
Electrochemical methods and devices for use in the determination of hematocrit corrected analyte concentrations
InactiveUS20050176153A1Electrolysis componentsVolume/mass flow measurementElectrical batteryBlood cell
Owner:LIFESCAN INC
Processes for the production of electrophoretic displays
ActiveUS20040226820A1Electrolysis componentsVolume/mass flow measurementElectrophoresisPotential difference
A coating of an encapsulated electrophoretic medium is formed on a substrate (106) by dispersing in a fluid (104) a plurality of electrophoretic capsules (102), contacting at least a portion of a substrate (106) with the fluid (104); and applying a potential difference between at least a part of the portion of the substrate (106) contacting the fluid (104) and a counter-electrode (110) in electrical contact with the fluid (104), thereby causing capsules (102) to be deposited upon at least part of the portion of the substrate (106) contacting the fluid (102). Patterned coatings of capsules containing different colors may be deposited in registration with electrodes using multiple capsule deposition steps. Alternatively, a patterned coating may be deposited upon a substrate containing a conductive layer by varying the conductivity of the conductive layer by radiation exposure or by coating portions of the conductive layer with an insulating layer, typically a photoresist.
Owner:E INK CORPORATION
Analyte injection system
InactiveUS20050133370A1Increase in sizeShort amount of timeSludge treatmentVolume/mass flow measurementGlutaric acidAntibody conjugate
This invention provides methods and devices for spatially separating at least first and second components in a sample which in one exemplary embodiment comprises introducing the first and second components into a first microfluidic channel of a microfluidic device in a carrier fluid comprising a spacer electrolyte solution and stacking the first and second components by isotachophoresis between a leading electrolyte solution and a trailing electrolyte solution, wherein the spacer electrolyte solution comprises ions which have an intermediate mobility in an electric field between the mobility of the ions present in the leading and trailing electrolyte solutions and wherein the spacer electrolyte solution comprises at least one of the following spacer ions MOPS, MES, Nonanoic acid, D-Glucuronic acid, Acetylsalicyclic acid, 4-Ethoxybenzoic acid, Glutaric acid, 3-Phenylpropionic acid, Phenoxyacetic acid, Cysteine, hippuric acid, p-hydroxyphenylacetic acid, isopropylmalonic acid, itaconic acid, citraconic acid, 3,5-dimethylbenzoic acid, 2,3-dimethylbenzoic acid, p-hydroxycinnamic acid, and 5-br-2,4-dihydroxybenzoic acid, and wherein the first component comprises a DNA-antibody conjugate and the second component comprises a complex of the DNA-antibody conjugate and an analyte.
Owner:WAKO PURE CHEMICAL INDUSTRIES +1
Ultra high throughput microfluidic analytical systems and methods
InactiveUS20050135655A1Efficient and cost-effectiveMaterial analysis by electric/magnetic meansLaboratory glasswaresExcitation beamControl system
Analytical systems and methods that use a modular interface structure for providing an interface between a sample substrate and an analytical unit, where the analytical unit typically has a particular interface arrangement for implementing various analytical and control functions. Using a number of variants for each module of the modular interface structure advantageously provides cost effective and efficient ways to perform numerous tests using a particular substrate or class of substrates with a particular analytical and control systems interface arrangement. Improved optical illumination and detection system for simultaneously analyzing reactions or conditions in multiple parallel microchannels are also provided. Increased throughput and improved emissions detection is provided by the present invention by simultaneously illuminating multiple parallel microchannels at a non-normal incidence using an excitation beam including multiple excitation frequencies, and simultaneously detecting emissions from the substances in the microchannels in a direction normal to the substrate using a detection module with multiple detectors.
Owner:CAPLIPER LIFE SCI INC
Single nucleotide detection using degradation of a fluorescent sequence
Methods and compositions are provided for detecting single nucleotide polymorphisms using a pair of oligonucleotides, a primer and a snp detection sequence, where the snp detection sequence hybridizes to the target DNA downstream from the primer and in the direction of primer extension. The snp detection sequence is characterized by having a nucleotide complementary to the snp and adjacent nucleotide complementary to adjacent nucleotides in the target and an electophoretic tag bonded to the 5'-nucleotide. The pair of oligonucleotides is combined with the target DNA under primer extension conditions, where the polymerase has 5'-3' exonuclease activity. When the snp is present, the electophoretic tag is released from the snp detection sequence, and can be detected by electrophoresis as indicative of the presence of the snp in the target DNA.
Owner:MONOGRAM BIOSCIENCES
Analyte injection system
InactiveUS20050121324A1Improve analysis resultsHigh resolutionSludge treatmentVolume/mass flow measurementAnalyteIsotachophoresis
This invention provides methods and systems for injection of analytes into a separation channel for resolution and detection. Samples can be preconditioned and concentrated by isotachophoresis (ITP) before the injection is triggered by a detected voltage event. Separation of analytes from other sample constituents can be enhanced using skewing channel ITP.
Owner:CAPLIPER LIFE SCI INC
Microfluidic method and device for transferring mass between two immiscible phases
InactiveUS20060231398A1Mass productionLow costSludge treatmentVolume/mass flow measurementElectricityElectrophoresis
A method of transferring mass of at least one solute between a liquid first phase and a fluid second phase that is immiscible with the first phase, the method comprising moving at least one droplet of said liquid first phase in a microfluidic device by using electric-type forces (electrowetting or dielectrophoresis) within a space that is filled with said fluid second phase. Said droplet is preferably moved by said electric-type forces along a path between a point for injecting said droplet into said microfluidic device, and an extraction and / or analysis zone, said path being defined in such a manner that said droplet sweeps through a significant fraction of said space filled with said fluid second phase. The method may include a step of transferring said droplet using said electric-type forces to a chemical analysis device integrated in said microfluidic device, and a step of chemically analyzing said droplet. The invention also provides a device for implementing such a method.
Owner:COMMISSARIAT A LENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES
Electrophoretic dispersion, electrophoretic display device, method of manufacturing electrophoretic display device, and electronic system
ActiveUS6947203B2Reduces and prevents aggregationImprove the display effectElectrolysis componentsStatic indicating devicesInorganic particleElectronic systems
Owner:E INK CORPORATION
Droplet Actuator Configurations and Methods
InactiveUS20100307917A1Easy to useFacilitates of propertyElectrostatic separatorsSludge treatmentEngineeringActuator
Droplet actuators for conducting droplet operations, such as droplet transport and droplet dispensing, are provided. In one embodiment, the droplet actuator may include a substrate including, droplet operations electrodes arranged for conducting droplet operations on a surface of the substrate; and reference electrodes associated with the droplet operations electrodes and extending above the surface of the substrate. Other embodiments of droplet actuators and methods of loading and using such droplet actuators are also provided.
Owner:ADVANCED LIQUID LOGIC
Methods for prevention of surface adsorption of biological materials to capillary walls in microchannels
InactiveUS7252928B1Inhibit bindingPrevent and reduce adsorptionNanotechElectrolysis componentsSilica particleLipid formation
Methods for reducing surface adsorption of biological materials to the walls of microfluidic conduits in microscale devices are provided. In an example of the methods, one or more colloidal-size particles, such as colloidal silica particles, are flowed in a fluid within the microfluidic conduit in the presence of one or more adherent biological materials (such as one or more proteins, cells, carbohydrates, nucleic acids, lipids and the like) to adsorb to the materials and prevent them from binding to the capillary walls of the microfluidic conduit. Other adsorption inhibition agents such as detergents and nonaqueous solvents can be used alone or in combination with colloidal particles to reduce surface adsorption in microfluidic conduits.
Owner:CAPLIPER LIFE SCI INC
Microfluidic surfaces
ActiveUS20020125135A1Easy to createStrong interactionSludge treatmentVolume/mass flow measurementPlanar substrateNon ionic
A microfluidic device comprising a set of one or more, preferably more than 5, covered microchannel structures manufactured in the surface of a planar substrate. The device is characterized in that a part surface of at least one of the microchannel structures has a coat exposing a non-ionic hydrophilic polymer. The non-ionic hydrophilic polymer is preferably attached covalently directly to the part surface or to a polymer skeleton that is attached to the surface.
Owner:GYROS
Electrophoretic media and processes for the production thereof
InactiveUS20100148385A1Improve stabilityEasy to adaptElectrolysis componentsVolume/mass flow measurementElectrophoresisEthylene Homopolymers
A first electrophoretic medium comprises an electrically charged particle suspended in a suspending fluid, the particle having a polymeric shell having repeating units derived from at least one monomer the homopolymer of which is incompatible with the suspending fluid. A second, similar electrophoretic medium comprises a suspending fluid, and first and second types of electrically charged particle suspended in the suspending fluid, the two types of particle having differing optical characteristics but both having polymeric shells. The polymeric shells are arranged such that homoaggregation of the two types of particles is thermodynamically favored over heteroaggregation.
Owner:E INK CORPORATION
Methods and devices for characterizing duplex nucleic acid molecules
Methods and devices are provided for characterizing a duplex nucleic acid, e.g., a duplex DNA molecule. In the subject methods, a fluid conducting medium that includes a duplex nucleic acid molecule is contacted with a nanopore under the influence of an applied electric field and the resulting changes in current through the nanopore caused by the duplex nucleic acid molecule are monitored. The observed changes in current through the nanopore are then employed as a set of data values to characterize the duplex nucleic acid, where the set of data values may be employed in raw form or manipulated, e.g., into a current blockade profile. Also provided are nanopore devices for practicing the subject methods, where the subject nanopore devices are characterized by the presence of an algorithm which directs a processing means to employ monitored changes in current through a nanopore to characterize a duplex nucleic acid molecule responsible for the current changes. The subject methods and devices find use in a variety of applications, including, among other applications, the identification of an analyte duplex DNA molecule in a sample, the specific base sequence at a single nulceotide polymorphism (SNP), and the sequencing of duplex DNA molecules.
Owner:RGT UNIV OF CALIFORNIA
Methods of Dispensing and Withdrawing Liquid in an Electrowetting Device
ActiveUS20120132528A1Improve throughputHeating or cooling apparatusElectrolysis componentsBiomedical engineeringLiquid drop
The invention provides a method for dispensing liquid, comprising the steps of: (a) positioning a droplet to be dispensed in a gap of an electrowetting device using an electrowetting array; and (b) dispensing the droplet through a hole in a housing or substrate of the electrowetting device. The invention further provides a method for withdrawing liquid comprising the steps of: (a) positioning a droplet to be withdrawn from a gap of an electrowetting device using an electrowetting array; and (b) withdrawing the droplet through a hole in a housing or substrate of the electrowetting device.
Owner:ADVANCED LIQUID LOGIC +1
Multiplexed Detection Schemes for a Droplet Actuator
InactiveUS20100236928A1Easy to useFacilitates of propertySludge treatmentVolume/mass flow measurementMultiplexingEngineering
A droplet actualor having electrodes configured for ejecting droplet operations transporting droplets on a surface, and a sensor arranged in proximity to one or more of the electrodes establishing a detection window on the surface for detection of one or more properties of one or more droplets on the surface, wherein the electrodes establish at least two pathways for transport of droplets into the detection window. Also provided is, A method of detecting a property of a target droplet, including using droplet operations to modulate signals from a droplet set comprising the target droplet, detecting the modulated signals of the droplet set, demodulating the modulated signals to identify the signal produced by one or more individual droplets of the set Related methods and alternative embodiments are also provided.
Owner:ADVANCED LIQUID LOGIC
Methods and systems for reducing background signal in assays
ActiveUS7060171B1Electrolysis componentsVolume/mass flow measurementLocation detectionElectrophoresis
Methods and systems of monitoring reactions, e.g., assays, that filter out background signal from substrate, in detecting the product. The methods and systems controllably move detectable reaction product from a first location to a second location at which the product is detected while controllably moving potentially interfering substrate materials away from or not toward the second location. Controllable movement of the different species is accomplished through the controlled combination of bulk fluid flow and differential electrophoresis of substrate and product to move the product, but not the substrate past the detection region.
Owner:CAPLIPER LIFE SCI INC
Color display device
ActiveUS8964282B2Eliminate needHighly color stateElectrolysis componentsVolume/mass flow measurementDisplay deviceEngineering
Owner:E INK CORPORATION
Microfluidic test device
ActiveUS20050230252A1Accurately determineImmobilised enzymesSludge treatmentAnalyteBiological fluids
The present invention provides biosensor test devices for measuring the presence or amount of an analyte in a biological fluid. The devices have a base plate that has an electrode system embedded therein, and a hydrophilic porous material situated on the base plate. A hydrophobic protective layer is situated on the hydrophilic porous material, and a cover is placed on the hydrophobic protective layer to complete the device. Some embodiments also use an insulating layer, which can be situated between the base layer and the hydrophilic porous material. The cover of the device has an opening present therein, situated over the electrodes, so that the electrodes communicate with the exterior of the device through the groove. The insulating layer can also have a groove situated therein, which in one embodiment is placed to align with the groove in the cover. The invention also provides methods of manufacturing the devices, and methods of using them.
Owner:LEADWAY HK
Implement and device for analysis
ActiveUS7351375B2Reduce the impactAccurate measurementElectrolysis componentsVolume/mass flow measurementEngineeringElectrically conductive
The present invention relates to an analyzing implement (1) having a capillary for movement of a specimen liquid. The capillary has inner surfaces (21c, 32c) provided with a first and a second opposed electrodes opposed to each other. The implement (1) includes, for example, a substrate (20), a cover (40) and a spacer (30) between the substrate (20) and the cover (40). In this case, the capillary is provided by the substrate (20), the cover (40) and the spacer (30). Preferably, capillary forming surfaces (31c, 32c) of the spacer (30) are electrically conductive, in which case the surfaces (31c, 32c) provide the first and the second electrodes.
Owner:ARKRAY INC
Image display panel manufacturing method, image display device manufacturing method, and image disiplay device
InactiveUS20060231401A1Drawback can be obviatedQuick responseElectrolysis componentsVolume/mass flow measurementSpray nozzleEngineering
In the case of filling and setting the liquid powders or the particles in a plurality of cells formed by the partition walls on the substrate, the method includes the steps of: setting a nozzle at an upper portion of a container; setting the substrate, on which the partition walls are arranged, at a lower portion of the container; scattering the liquid powders or the particles dispersed in a gas from the nozzle arranged at the upper portion in the container; and filling the liquid powders or the particles in the cells on the substrate arranged at the lower portion in the container. After this filling, the method further includes: a filling step for filling a predetermined amount of the liquid powders or the particles in spaces constituting the image display cells isolated by the partition walls; a removing step for removing unnecessary liquid powders or unnecessary particles remaining on the partition walls in the filling step; a substrate stacking step for stacking the transparent substrate and the opposed substrate via the partition walls and applying a sealing agent at a peripheral portion of the substrate so as to make an atmosphere between the transparent substrate and the opposed substrate uniform; and an electrode adhering step for connecting a circuit for displaying the image to the electrode so as to form a module.
Owner:BRIDGESTONE CORP
Production of purified water and high value chemicals from salt water
ActiveUS7083730B2Effective recoveryElectrolysis componentsSolvent extractionReverse osmosisHigh pressure
Sodium chloride and purified water are recovered by treating salt water that contains sodium chloride with an integrated reverse osmosis and electrodialysis system, which includes an efficiency-enhancing feature that is one or more of the following: the use of univalent anion and univalent cation selective membranes in the electrodialysis unit; the addition of a nanofiltration unit to process the diluate from the electrodialysis unit; or operation of the electrodialysis unit at an elevated pressure. Magnesium and bromine can optionally be produced when the salt water contains these materials.
Owner:SOUTH CAROLINA UNIV OF
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