The invention discloses a lyophobic matrix sustained-release tablet for pH independence drugs and a preparation method thereof. The sustained-release tablet is prepared from the following raw materials: a main
drug, a
wax matrix material, a local pH regulating agent, an
adhesive, a filler, a lubricating agent and a
glidant, wherein the local pH regulating agent is selected from
calcium hydrogen phosphate dihydrate,
disodium hydrogen phosphate or
calcium silicate. The preparation method of the lyophobic matrix sustained-release tablet comprises the following steps: heating and melting the
wax matrix material; uniformly mixing the main
drug, the local pH regulating agent, the
adhesive and the filler; melting and
pelletizing the matrix material and the uniformly
mixed materials; screening when the mixture is hot, granulating the mixture, performing standing to cool the mixture, adding the lubricating agent and the
glidant into the mixture, and performing
tableting to obtain the lyophobicmatrix sustained-release tablets. According to the lyophobic matrix sustained-release tablet, the local pH regulating agent is added into the existing prescription of
diclofenac sodium sustained-release tablets, the pH value of a micro-environment can be maintained to promote
solubility of drugs, and release
in vitro of pH independence drugs can be improved.