149 results about "Tubulin polymerization" patented technology

The invention relates to a composition for preparing a gel polymer electrolyte, comprising: (1) a prepolymer; (2) a lithium salt; (3) an organic solvent; (4) a cross-linking agent; (5) an initiator; (6) optionally a monomer; and (7) optionally an additive; wherein the prepolymer comprises polyamides, polyimides and their combination. The invention also relates to a gel polymer electrolyte obtained by polymerization, especially in-situ polymerization of the composition and lithium-ion batteries employing the gelpolymer electrolyte, and a method of preparing the ge polymer electrolyte.

The invention provides a catalyst component for olefin polymerization, the catalyst component comprises an adduct shown as the general formula (I) of MgX2.m(R'OH).nE.qH2O, at least one titanium compound shown as the general formula (II) of Ti(OR)4-kXk, and at least two electron donor compounds of a and b, wherein the electron donor compound a is a diol ester compound, b is a diether compound, andthe molar ratio of a to b is 0.5-50. A catalyst shows ultra-high polymerization activity when the catalyst is used for olefin polymerization, in particular to propylene polymerization, and the obtained polymer simultaneously has wider molecular weight distribution and higher isotacticity.

Chrome compounds have been discovered which demonstrate impressive cytotoxicity as well as a remarkable ability to inhibit tubulin polymerization. Such compounds as well as related derivatives are excellent clinical candidates for the treatment of cancer in humans. In addition, certain of these ligands, as pro-drugs, may well prove to be tumor selective vascular targeting chemotherapeutic agents or to have vascular targeting activity resulting in the selective prevention and / or destruction of nonmalignant proliferating vasculature.

Analogs of combretastatin have been discovered which demonstrate impressive cytotoxicity as well as a remarkable ability to inhibit tubulin polymerization. Such compounds are excellent clinical candidates for the treatment of cancer in humans. In addition, certain of these ligands, as pro-drugs, may well prove to be tumor selective vascular targeting chemotherapeutic agents or to have vascular targeting activity resulting in the selective prevention and / or destruction of nonmalignant proliferating vasculature.

The invention relates to the inhibition of tubulin polymerization. The invention provides compounds and methods for inhibiting tubulin polymerization. The invention also provides compositions and methods for treating cell proliferative diseases and conditions.

The present invention relates to ethyl(2-methyl-3{(E)-[(naphtho[2,1-b]furan-2-ylcarbonyl)hydrazono]methyl}-1H-indole-1-yl)acetate, the novel mitosis inhibitor. The said ethyl(2-methyl-3{(E)-[(naphtho[2,1-b]furan-2-ylcarbonyl)hydrazono]methyl}-1H-indole-1-yl)acetate not only induces apoptosis by inhibiting tubulin polymerization in the course of mitosis but also displays an excellent anticancer effect in the multi-drug resistant cancer cells, so that it can be effectively used for the treatment of cell proliferative disease including various cancers.

The invention provides a catalyst component used for vinyl polymerization. The catalyst component comprises the following components: a magnesium composite, a titanium compound and an organosilicon compound, wherein the magnesium composite is a product prepared by dissolving alkoxy magnesium in a solvent system containing an organic epoxy compound, boron trihalide and at least one kind of organicalcohol; the titanium compound has the general formula of Ti(OR)aXb, wherein R refers to aliphatic hydrocarbon group or aryl group with 1 to 14 carbon atoms, X refers to halogen, a is 0, 1 or 2, b isan integer from 1 to 4, and a+b=3 or 4; and the organosilicon compound has at least one structural formula of a structural formula a, a structural formula b and a structural formula C.

Disclosed are nitrogen substitutive 3-oxygen substitutive-6-tetrahydroquinoxaline substitutive structure compound and preparation method and medical application thereof. The general structure of the compound is as shown in the formula (I). The compound has tubulin polymerization inhibition activities, and is good in tumor disease resistance and proliferative disease apart from tumors.

The present invention relates to the technical field of catalysts for ethylene polymerization, and provides a catalyst component for ethylene polymerization, and a preparation method thereof, and a catalyst for ethylene polymerization. The catalyst component comprises the reaction product of the following components: (1) a magnesium compound, (2) an organophosphorus compound, (3) an alcohol compound, (4) an organic epoxy compound, (5) an oxygen-containing organotitanium compound, and (6) a halogenated aromatic ester compound, wherein the halogenated aromatic ester compound has a general formula of R<1>C6H4COO(CH2)nCHmX3-m, R<1> is selected from hydrogen, halogen, C1-C20 alkyl, C1-C20 substituted alkyl, C3-C20 cycloalkyl and C6-C20 aromatic group, X is halogen, n and m are integers, n is more than or equal to 0 and is less than or equal to 10, and m is more than or equal to 0 and is less than 3. According to the present invention, the obtained catalyst component has characteristics of increased particle size and significantly-narrowed particle size distribution, and the obtained polymer has high bulk density and good hydrogen sensitivity.

Heterogeneous catalytic component obtainable by reacting a porous inorganic support with a metallocene compound characterized in that the metallocene compound is defined by the following general formulas: (LRk)z[LRk-f(RIOH)f]xMXy I wherein: L, equal to or different from each other, is selected from the group comprising: cyclopentadienyl, indenyl, tetrahydroindenyl, fluorenyl, octahydrofluorenyl or benzoindenyl; each R is independently selected from hydrogen, C1-C20 alkyl, C3-C20 cycloalkyl, C6-C20 aryl, C3-C20 alkenyl, C7-C20 arylalkyl, C7-C20 alkylaryl, C8-C20 arylalkenyl, linear or branched, optionally substituted by 1 to 10 halogen atoms, or a group SiRII3; each RI equal to or different from each other is a divalent aliphatic or aromatic hydrocarbon group containing from 1 to 20 carbon atoms, optionally containing from 1 to 5 heteroatoms of groups 14 to 16 of the periodic table of the elements and boron; each Q is independently selected from B, C, Si, Ge, Sn; M is a metal of group 3, 4 or 10 of the Periodic Table, Lanthanide or Actinide; each X is independently selected from: hydrogen, chlorine, bromine, ORII, NRII2, C1-C20 alkyl or C6-C20 aryl; each RII is independently selected from C1-C20 alkyl, C3-C20 cycloalkyl, C6-C20 aryl, C3-C20 alkenyl, C7-C20 arylalkyl, C7-C20 arylalkenyl or alkylaryl, linear or branched; RII is methyl, ethyl, isopropyl; L' is N or O; when L is cyclopentadienyl k is equal to 5, when L is indenyl k is equal to 7, when L is fluorenyl or benzoindenyl k is equal to 9, when L is tetrahydroindenyl k is equal to 11 and when L is octahydrofluorenyl, k is equal to 17; z is equal to 0, 1 or 2; x is equal to 1, 2 or 3; y is equal to 1, 2 or 3; x+y+z is equal to the valence of M; m is an integer which can assume the values 1, 2, 3 or 4; a and b are integers whose value ranges from 0 to k-1; f is an integer whose value ranges from 1 to k; g is 0 or 1; c and e are equal to 0 or 1; a+b+c is