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53 results about "Triglyceride synthesis" patented technology

Through lipogenesis and subsequent triglyceride synthesis, the energy can be efficiently stored in the form of fats. Lipogenesis encompasses both the process of fatty acid synthesis and triglyceride synthesis (where fatty acids are esterified to glycerol).

Biomarkers of de novo lipogenesis and methods using the same

InactiveUS20160356798A1Assessing efficacyDisease diagnosisBiological testingDiseaseLipogenesis
Biomarkers relating to de novo lipogenesis are provided, as well as methods for using such biomarkers in an Index to assess DNL. In addition, methods for diagnosing, determining predisposition to, and monitoring progression / regression of diseases related to DNL are provided. Also provided are methods of monitoring the efficacy of treatments for diseases related to DNL as well as other methods based on biomarkers of DNL.
Owner:METABOLON

Novel stilbene compound oligomers in sword iris (Iris lacteal Pall .var .chinensis(Fisch .)Koidz .) seed kernels, and extraction method and usage thereof

The invention discloses novel stilbene compound oligomers in sword iris (Iris lacteal Pall .var .chinensis(Fisch .)Koidz .) seed kernels as well as an extraction method and usage thereof. The extraction method of the novel stilbene compound oligomers in the sword iris seed kernels comprises the following steps: performing amplified preparation on an alkali extracted and acid precipitated product of sword iris seed kernels; and then, carrying out two times of preparation by adopting an aqueous cetonitrile solution as mobile phase so as to obtain the novel stilbene compound oligomers S11 in thesword iris seed kernels, namely VitisinA-13b-o-glucoside. The invention further provides application of the new compound S11 in preparation of medicines used for preventing and / or treating lipid metabolism disorder. And moreover, inhibition of cell lipogenic differentiation and lipogenesis by the novel stilbene compound oligomers S11 is verified by studying activity of the novel stilbene compoundoligomers S11; so that, the novel stilbene compound oligomers S11 can be used for preparing medicines which are capable of preventing or treating metabolic disorders, such as obesity, hyperlipidemia and the like.
Owner:CHINA ACAD OF SCI NORTHWEST HIGHLAND BIOLOGY INST

Methods of treating fatty liver disease with helminth-derived glycan-containing compounds

InactiveUS20140315781A1Reduces hepatic inflammationInhibit fat accumulationBiocideSugar derivativesAntigenFatty liver
The present invention provides a compound comprising a helminth-derived glycan and / or glycoconjugate thereof (e.g., a compound comprising a Lewisx antigen (e.g., LNFPIII), a non-Lewisx antigen (e.g., LNnT, LDN, and LDN derivatives), or a mixture of Lewisx and non-Lewisx antigens (e.g., SEA)), useful as a therapeutic compound for treating or preventing diseases associated with fat accumulation in the liver. The compounds of the invention are useful for treating or preventing the development of a fatty liver disease in a subject that has the disease or is at risk of developing the disease, and inhibiting lipogenesis in hepatocytes. The invention also provides methods of regulating the Erk-c-fos / AP-1-FXRα signalling pathway by administering a compound comprising a helminth-derived glycan and / or glycoconjugate thereof to a subject with a fatty liver disease, or contacting a hepatocyte with a compound comprising a helminth-derived glycan and / or glycoconjugate thereof.
Owner:PRESIDENT & FELLOWS OF HARVARD COLLEGE

Anti-saccharification moisturizing cream and preparation method thereof

The invention discloses an anti-saccharification moisturizing cream and a preparation method thereof. The cream is prepared from an olive oat emulsifier, cetearyl alcohol, isooctadecyl isooctadecanoate, caprylic acid / capric acid triglyceride, synthetic squalane, polydimethylsiloxane, 2,6-di-tert-butyl-4-methylphenol, disodium EDTA, glycerol, propylene glycol, xanthan gum, carbomer 940, triethanolamine, Inonotus obliquus water extract, Inonotus obliquus alcohol extract, phellinus igniarius alcohol extract, a polysaccharide skin tightening agent, sodium hyaluronate, nicotinamide, panthenol, PCG, water and the like. The product of the invention is an oil-in-water emulsifying system, the novel mild olive oat emulsifier is selected, the Inonotus obliquus water extract and the Inonotus obliquusalcohol extract are used as main anti-saccharification components, and active components such as the phellinus igniarius alcohol extract and the polysaccharide skin tightening agent are compounded, so that the anti-saccharification effect of the product is improved, the effects of moisturizing skins, resisting oxidation, resisting inflammation and the like are enhanced, and the product can make the skin smooth, tender and tight after long-term use and can delay aging. The product of the invention can also be used by people with mild, no irritation and sensitive skin.
Owner:ANHUI UNIVERSITY

Composition Comprising the Alcohol Compound Isolated from the Extract of Cucurbitaceae Family Plant Having Anti-Adipogenic and Anti-Obesity Activity

InactiveUS20080280976A1Lose weightPotent anti-obesityBiocideMetabolism disorderDiseaseAlcohol
The present invention is related to an alcohol compound isolated from the extract of Cucurbitaceae family plant having anti-adipogenic and anti-obesity activity, and a composition comprising the same. The compound showed potent reducing activity of body weight, decreasing effect on the blood triglyceride and cholesterol level, activating activity of PPAR α and preventing activity from the adipogenesis of precursor fat cells with no toxicity, therefore, those extract can be useful in treating or preventing obesity and adipogenesis-involved diseases as a medicine or health care food.
Owner:HELIXIR

Application of fresh dendrobe aqueous extract in preparation of drugs for treating metabolic diseases

The invention belongs to the technical field of pharmacy, and relates to application of a fresh dendrobe aqueous extract in preparation of drugs for treating metabolic diseases. The invention particularly relates to adjustment of fatty acid and triglyceride synthesis by a fresh dendrobe aqueous extract. Experimental results prove that the fresh dendrobe aqueous extract prepared by the invention can obviously inhibit the mRNA expression level of sterol regulatory element binding protein 1, diacylglycerol acyltransferase and microsome triacylglycerol transporter, and effectively regulate the biosynthesis of triglyceride; and the fresh dendrobe aqueous extract can obviously inhibit the mRNA expression levels of acetyl-CoA carboxylase, fatty acid synthase and stearoyl-CoA desaturase, and effectively regulate fatty acid synthesis; and the fresh dendrobe aqueous extract can inhibit the mRNA expression level of the FABP4, improve the peripheral insulin resistance, protect pancreatic beta cellfunctions, and improve the sensitivity of insulin, thereby inhibiting the metabolic diseases related to the FABP4; and therefore, the fresh dendrobe aqueous extract prepared by the method can be usedas the drug for treating the metabolic diseases.
Owner:安徽同济生生物科技有限公司 +1

Skin-soothing cream with functions of soothing and repairing sensitive skin

The invention discloses a skin-soothing cream capable of soothing and repairing sensitive skin, and relates to the technical field of skin-care products. The skin-soothing cream is prepared from the following compound components in percentage by weight: 30 to 50 percent of butyrospermum parkii butter, 20 to 40 percent of triglyceride, 5 to 13 percent of synthetic bee wax, 2 to 6 percent of micro-crystalline wax, 0.1 to 5 percent of simmondsia chinensis seed oil, 0.1 to 5 percent of tocopheryl acetate, 1.2 percent of alkanet root extract/glyceryl acetate, 0.5 percent of bisabolol, 0.001 to 0.5 percent of pelargonium graveolens oil, 0.01 to 5 percent of squalane, 0.01 to 5 percent of Europe juniper fruit oil, 0.01 to 5 percent of argania spinosa kernel oil, 0.01 to 5 percent of camellia oleosa seed oil, 0.01 to 5 percent of sweet almond oil, 0.01 to 5 percent of sunflower seed oil, 0.01 to 5 percent of pentaphyllum camarum seed oil/rosa canina fruit extract, 0.01 to 5 percent of baobab seed oil and 0.001 to 0.5 percent of plum-leaf crab seed oil. According to the skin-soothing cream capable of soothing and repairing the sensitive skin, oil is used for nourishing the skin, the content of unsaturated fatty acid in the skin is increased, and the barrier function of the skin is improved.
Owner:广州阳菲生物科技有限公司

Composition comprising a combination of at least one proteolytic enzyme and at least one lipolytic enzyme, for use in preventing triglyceride synthesis

InactiveCN102811731APrevent or treat obesityPrevent or treat atherosclerosisPeptide/protein ingredientsMetabolism disorderSubtilisinIntestinal structure
The present invention relates to a composition comprising a combination of at least one proteolytic enzyme, such as subtilisin, and at least one lipolytic enzyme, for use in preventing triglyceride synthesis, advantageously by degrading 2-monoacylglycerol in the intestine. The subject matter of the invention is also such a composition for use as a medicament, as a cosmetic agent, as a medical device, as a food composition, as a food supplement or else as a nutriceutical, in particular for use in preventing or treating obesity, atherosclerosis or type II diabetes, or else for use in preventing or reducing excess weight.
Owner:IMARKO RES
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