Application of dendrobium nobile water extract in treating type 2 diabetes mellitus

A type 2 diabetes, dendrobium extract technology, applied in the treatment of type 2 diabetes, the field of dendrobium water extract, can solve the undiscovered problems such as the application and research of the Huoshan Dendrobium extract type 2 diabetes, and achieve the protection of pancreatic islet β Effects on cell function, reduction of biosynthesis, and enhancement of sensitivity

Inactive Publication Date: 2020-10-16
安徽同济生生物科技有限公司
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  • Abstract
  • Description
  • Claims
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Problems solved by technology

According to our literature research, the application and research of Dendrobium Huoshanense or its extracts in the treatment of type 2 diabetes have not been found

Method used

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  • Application of dendrobium nobile water extract in treating type 2 diabetes mellitus
  • Application of dendrobium nobile water extract in treating type 2 diabetes mellitus
  • Application of dendrobium nobile water extract in treating type 2 diabetes mellitus

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Experimental program
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Effect test

Embodiment 1

[0029] Prepare dry dendrobium water extract, fresh dendrobium water extract and dendrobium alcohol extract respectively, specifically as follows:

[0030] (1) Preparation of dry Dendrobium water extract: Weigh 20g of Dendrobium Huoshanense dry powder, extract with 400ml of distilled water in a 55°C water bath, filter and collect the filtrate, repeat the extraction 3 times, each time for 1 hour, and combine the extracts 3 times. The combined extracts were concentrated under reduced pressure at 55°C to 1 / 6-1 / 8 of the volume of the original liquid, and then freeze-dried to constant weight to obtain a dry Dendrobium water extract with a mass volume concentration of 100 mg / ml.

[0031] (2) Preparation of fresh Dendrobium water extract: Weigh 100g of freshly picked Dendrobium Huoshanense, remove the roots and leaves and keep the stems, after crushing, add 500ml distilled water to immerse the medicinal materials of Dendrobium Huoshanense, extract in a water bath at 80 °C, filter and ...

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Abstract

The invention belongs to the technical field of pharmacy, and relates to an application of a dendrobium nobile water extract in treating type 2 diabetes mellitus, in particular to regulation of insulin resistance and triglyceride synthesis of a dry dendrobium water extract and a fresh dendrobium water extract in a high-sugar state. Experimental results prove that the dendrobium nobile water extract prepared by the invention can obviously inhibit the expression level of mRNA of fatty acid binding protein, improve the peripheral insulin resistance, protect the pancreatic beta cell function, increase insulin sensitivity, obviously inhibit the expression level of diacylglycerol acyltransferase mRNA, reduce the TG biosynthesis, improve the sensitivity of the body to insulin and leptin, increasethe mRNA expression level of sterol regulatory element-binding protein 1, and effectively regulate the triglyceride biosynthesis so as to achieve inhibition of type 2 diabetes mellitus from multipleaspects. Therefore, the dendrobium nobile water extract disclosed by the invention can be used for treating type 2 diabetes mellitus and has a good development prospect in the aspect of treating type2 diabetes mellitus.

Description

technical field [0001] The invention relates to the technical field of pharmacy, in particular to the application of dendrobium water extract in treating type 2 diabetes. Background technique [0002] Diabetes mellitus is caused by genetic factors, immune dysfunction, microbial infection and its toxins, free radical toxins, mental factors and other pathogenic factors acting on the body to cause hypofunction of pancreatic islets and insulin resistance (Insulin Resistance, IR), etc. A series of metabolic disorder syndromes such as sugar, protein, fat, water and electrolytes. Common diabetes mainly includes type 1 diabetes and type 2 diabetes. Among them, type 1 diabetes mostly occurs in adolescents, who rely on exogenous insulin supplementation to maintain life due to lack of insulin secretion. Type 2 diabetes is more common in middle-aged and elderly people. The secretion of insulin is not low or even high. The clinical manifestation is that the body is not sensitive enough...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8984A61P3/10A61P5/50A61K135/00
CPCA61K36/8984A61K2236/331A61P3/10A61P5/50
Inventor 余茂耘韩际宏段亚君梁英权杨潇潇陈元利张丰陈贵兰
Owner 安徽同济生生物科技有限公司
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