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A composition comprising the extract of cucurbitaceae family plant or the purified extract isolated therefrom having anti-adipogenic and anti-obesity activity

A plant extract and extract technology are applied in the directions of medical preparations containing active ingredients, drug combinations, plant/algae/fungus/moss ingredients, etc., to achieve effective anti-adipogenic activity and effective anti-obesity effects.

Inactive Publication Date: 2007-01-24
海利克斯公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] However, in any of the above-cited documents, there is no report or disclosure in the prophylactic or therapeutic activity of the extracts belonging to Cucurbitaceae plants to show effective anti-obesity effects, and the entire contents of the cited documents are hereby incorporated by reference.

Method used

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  • A composition comprising the extract of cucurbitaceae family plant or the purified extract isolated therefrom having anti-adipogenic and anti-obesity activity
  • A composition comprising the extract of cucurbitaceae family plant or the purified extract isolated therefrom having anti-adipogenic and anti-obesity activity
  • A composition comprising the extract of cucurbitaceae family plant or the purified extract isolated therefrom having anti-adipogenic and anti-obesity activity

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0077] [Example 1] Preparation of Cucurbitaceae Plant Hot Water Extract

[0078] 2 kg of dried pumpkin stems (Cucurbita moschataDUCH), watermelon stems (Citrullus vulgaris SCHRAD) and loofah stems (Luffa cylindrical L.ROEM) purchased in the Korean market were cut, mixed with 20 L of methanol, and extracted at 90 °C with a reflux extractor Extract for 1 hour. The above extraction procedure was repeated three times, the supernatant was collected, filtered with filter paper, and concentrated under reduced pressure to obtain 300 g, 350 g, and 240 g of dried pumpkin, watermelon, and loofah hot water extracts, respectively. Each of the obtained extracts was dissolved in distilled water to a concentration of 100 mg / ml, and used as test samples in the following Test Examples.

Embodiment 2

[0079] [embodiment 2] the preparation of the extract that is soluble in hexane

[0080] 200 g of the dried hot water-soluble pumpkin extract prepared in Example 1 was suspended in 1 L of distilled water, and 1 L of hexane was added thereto. The above solution was separated into a hexane layer and a water layer, which was repeated three times, and then the collected hexane layer was filtered and evaporated to dryness with a rotary vacuum evaporator, thereby obtaining 180 mg of a hexane-soluble extract. 1 L of the remaining aqueous layer was used in the following steps.

Embodiment 3

[0081] [Example 3] Preparation of chloroform-soluble extract

[0082] 1 L of chloroform was added to the above 1 L of the remaining aqueous layer, and then the resulting solution was separated into a chloroform layer and an aqueous layer, and this was repeated three times. The collected chloroform layer was filtered and evaporated to dryness with a rotary vacuum evaporator to obtain 770 mg of a chloroform-soluble extract. The remaining aqueous layer was used in the following steps.

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Abstract

The present invention relates to Cucurbitaceae plant extracts or purified extracts isolated therefrom having anti-adipogenic and anti-obesity activities, and compositions comprising them. Cucurbitaceae plant extract of the present invention exhibits effective body weight-lowering activity, lowering blood triglyceride and cholesterol content, activating PPARα and δ activity, reducing stearoyl-CoA dehydrogenase gene expression activity and preventing preadipocytes Adipogenesis activity, and no toxicity, therefore, those extracts can be used as medicine or health food for the treatment or prevention of obesity and diseases involving adipogenesis.

Description

technical field [0001] The present invention relates to compositions comprising extracts of Cucurbitaceae plants or purified extracts isolated therefrom having anti-adipogenic and anti-obesity activities. Background technique [0002] Adipogenesis, a process that differentiates preadipocytes into mature adipocytes and accumulates fat in cytoplasmic organelles called lipid droplets, is well known as a risk factor for several adult diseases such as obesity, Diabetes, sebaceous disease and coronary heart disease. Preadipocytes, such as fibroblasts, differentiate into mature adipocytes leading to the formation of lipid droplets within them. The differentiation mechanism has been studied by using specific cell lines, such as 3T3-L1. Adipocyte differentiation is a complex process accompanied by coordinated changes in morphology, hormone sensitivity, and gene expression. These changes are regulated by several transcription factors, such as C / EBPs (CAA T enhancer-binding proteins...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/42A61K36/00A61P3/04
CPCA61K36/42A61P3/04A61P3/06A61P9/00A61P9/10A61P3/10
Inventor 阵美琳柳载夏崔县净郑亨镇朴庆哲金善荣
Owner 海利克斯公司
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