40 results about "Thiosulfonic Acids" patented technology

Provided is an inkjet recording medium in which hydrated alumina and a sulfinic acid compound or thiosulfonic acid compound coexist in a pigment in an ink receiving layer, and which can prevent white-background yellowing during storage in a resin file holder or the like and ensure printing quality at the same time. The ink receiving layer of the inkjet recording medium contains the sulfinic acid compound or thiosulfonic acid compound, which functions to prevent yellowing, in a salt form or in a free form so as to be diffusible.

This invention pertains generally to the field of chemical synthesis and purification, and more specifically to methods of synthesizing and purifying certain 3,7 diamino-phenothiazin-5-ium compounds (referred to herein as “diaminophenothiazinium compounds”) including Methylthioninium Chloride (MTC) (also known as Methylene Blue). In one embodiment, the method comprises the steps of, in order: nitrosylation (NOS); nitrosyl reduction (NR); thiosulfonic acid formation (TSAF); oxidative coupling (OC); Cr(VI) reduction (CR); isolation and purification of zwitterionic intermediate (IAPOZI); ring closure (RC); chloride salt formation (CSF); one of: sulphide treatment (ST); dimethyldithiocarbamate treatment (DT); carbonate treatment (CT); ethylenediaminetetraacetic acid treatment (EDTAT); organic extraction (OE); and recrystallisation (RX). The present invention also pertains to the resulting (high purity) compounds, compositions comprising them (e.g., tablets, capsules), and their use in methods of inactivating pathogens, and methods of medical treatment and diagnosis, etc., for example, for tauopathies, Alzheimer's disease (AD), skin cancer, melanoma, viral diseases, bacterial diseases, or protozoal diseases. Wherein: each of R1 and R9 is independently selected from: —H; C1-4 alkenyl; and halogenated C1-4alkyl; each of R3NA and R3NB is independently selected from: C1-4 alkyl; C2-4alkenyl; and halogenated C4-1 alkyl; each of R7NA and R7NB is independently selected from: C1-4 alkyl; C2-4alkenyl; and halogenated C1-4 alkyl; and X is one or more anionic counter ions to achieve electrical neutrality.

The invention discloses an isoquinoline compound as well as a preparation method and application thereof, and relates to the technical field of chemical synthesis. The isoquinoline compound is an indolo [2, 1-a] isoquinoline compound or a benzimidazo [2, 1-a] isoquinoline-6 (5H) ketone compound, and the preparation method comprises the following steps: dissolving a 1-(2, 3-diphenyl-1H-indole-1-yl)-2-methyl propenyl-1-ketone compound or a 1-methyl acryloyl-2-aryl-benzimidazole compound and an S-phenyl phenyl thiosulfonate compound in an organic solvent, adding tert-butyl benzoate oxide and a catalytic amount of copper bromide, and reacting at 110 DEG C to obtain the isoquinoline compound. The synthesis process does not need diazo compounds, has the characteristics of cheap and easily available raw materials, mild reaction conditions, simplicity and convenience in operation, high regioselectivity and high yield, and is beneficial to industrial production.

This invention pertains generally to the field of chemical synthesis and purification, and more specifically to methods of synthesizing and purifying certain 3,7 diamino-phenothiazin-5-ium compounds (referred to herein as “diaminophenothiazinium compounds”) including Methylthioninium Chloride (MTC) (also known as Methylene Blue). In one embodiment, the method comprises the steps of, in order: nitrosylation (NOS); nitrosyl reduction (NR); thiosulfonic acid formation (TSAF); oxidative coupling (OC); Cr(VI) reduction (CR); isolation and purification of zwitterionic intermediate (IAPOZI); ring closure (RC); chloride salt formation (CSF); one of: sulphide treatment (ST); dimethyldithiocarbamate treatment (DT); carbonate treatment (CT); ethylenediaminetetraacetic acid treatment (EDTAT); organic extraction (OE); and recrystallisation (RX). The present invention also pertains to the resulting (high purity) compounds, compositions comprising them (e.g., tablets, capsules), and their use in methods of inactivating pathogens, and methods of medical treatment and diagnosis, etc., for example, for tauopathies, Alzheimer's disease (AD), skin cancer, melanoma, viral diseases, bacterial diseases, or protozoal diseases. Wherein: each of R1 and R9 is independently selected from: —H; C1-4 alkenyl; and halogenated C1-4alkyl; each of R3NA and R3NB is independently selected from: C1-4 alkyl; C2-4alkenyl; and halogenated C4-1 alkyl; each of R7NA and R7NB is independently selected from: C1-4 alkyl; C2-4alkenyl; and halogenated C1-4 alkyl; and X is one or more anionic counter ions to achieve electrical neutrality.

This invention pertains generally to the field of chemical synthesis and purification, and more specifically to methods of synthesizing and purifying certain 3,7 diamino-phenothiazin-5-ium compounds (referred to herein as “diaminophenothiaziniumcompounds”) including Methylhioninium Chloride (MTC) (also known as Methylene Blue). In one embodiment, the method comprises the steps of, in order: nitrosylation (NOS); nitrosyl reduction (NR); thiosulfonic acid formation (TSAF); oxidative coupling (OC); Cr(VI) reduction (CR); isolation and purification of zwitterionic intermediate (IAPOZI); ring closure (RC); chloride salt-formation (CSF); one of: sulphide treatment (ST); dimethyldithiocarbamate treatment (DT); carbonate treatment (CT); ethylenediaminetetraacetic acid treatment (EDTAT); organic extraction (OE); and recrystallisation (RX). The present invention also pertains to the resulting (high purity) compounds, compositions comprising them (e.g., tablets, capsules), and their use in methods of inactivating pathogens, and methods of medical treatment and diagnosis, etc., for example, for tauopathies, Alzheimer's disease (AD), skin cancer, melanoma, viral diseases, bacterial diseases, or protozoal diseases.

The invention discloses an efficient pesticide for preventing and treating crop pests. The efficient pesticide is prepared from the following raw materials in parts by weight: 3-8 parts of dinitrobenzene, 4-6 parts of mineral oil, 5-9 parts of zosterin, 6-10 parts of epoxy resin, 4-8 parts of hexahydrophthalic anhydride, 1-5 parts of light calcium carbonate, 2-6 parts of chlorpyrifos, 0.5-2 parts of a stabilizing agent, 1.5-4 parts of a synergistic agent, 2-5 parts of acetyl methyl ammonium phosphate, 8-10 parts of ethion and 1-3 parts of sodium thiosulfonate. The efficient pesticide disclosed by the invention has the beneficial effects that the efficient pesticide for preventing and treating crop pests adopts a low-toxicity pesticide, and is low in toxicity and residue and can be used for effectively protecting the environment and crop quality under the condition of meeting the requirements of killing diseases and insect pests.

The invention belongs to the field of organic synthetic chemistry, and particularly discloses a preparation method of a thiosulfonate compound. The specific preparation process comprises the following steps: taking aryl diazonium salt, sodium pyrosulfite and thiophenol / mercaptan as raw materials, taking organic dye as a photocatalyst, adding an organic solvent, and reacting for 12 hours at room temperature under the irradiation of an LED visible light lamp and nitrogen protection to generate thiosulfonate; and after the reaction is finished, adding distilled water into the reaction system, extracting the reaction liquid with ethyl acetate, concentrating the extraction liquid to obtain a crude product, and carrying out silica gel column chromatography separation on the crude product to obtain thiosulfonate. According to the method, simple and easily available sodium pyrosulfite is used as a sulfone source, cheap organic dye is used as a photocatalyst, clean light energy is used as a reaction energy source, a high-energy-consumption heating device and a metal catalyst or strong acid are not used, the reaction condition is mild, the operation is simple and convenient, and a green synthesis strategy is provided for thiosulfonate.

The invention discloses an abalone blood cell anticoagulant protective agent and a preparation method thereof, and relates to an anticoagulant protective agent. The invention provides an abalone blood cell anticoagulant protective agent for maintaining the activity of isolated abalone blood cells within longer time and a preparation method thereof. The abalone blood cell anticoagulant protective agent comprises the following raw materials by mass percentage: 1.95 to 2.08 percent of glucose, 0.78 to 0.8 percent of sodium citrate (2H2O), 0.063 to 0.107 percent of citric acid, 0.37 to 0.57 percent of sodium chloride, 0.21 to 0.24 percent of hydroxyethyl piperazinyl ethyl thiosulfonic acid, and 100 percent of double distilled water, wherein the pH value is between 6.0 and 6.4. The abalone blood cell anticoagulant protective agent is obtained by dissolving the glucose, the sodium citrate (2H2O), the sodium chloride and the hydroxyethyl piperazinyl ethyl thiosulfonic acid into the double distilled water, stirring and dissolving the mixture, using the citric acid to adjust the pH value to be between 6.0 and 6.4, and performing high-temperature sterilization.

The invention discloses a compound containing monofluorochloromethylthiosulfonate represented by formula 1, a preparation method and application thereof. The preparation method of the compound shown in formula 1 includes the following steps: reacting with sodium phenylsulfinate in chlorine gas solution. The compound shown in formula 1 of the present invention can be used as a fluorochloromethylthiolation reagent, and its application yield is high, thereby providing an important methodological research tool for the fields of medicine, pesticides and materials.

Described are methods of synthesizing and purifying certain 3,7-diamino-phenothiazin-5-ium compounds (referred to herein as “diaminophenothiazinium compounds”) including Methylhioninium Chloride (MTC) (also known as Methylene Blue). In one embodiment, the method comprises the steps of, in order: a thiosulfonic acid formation (TSAF); an oxidative coupling (OC); and a ring closure (RC). Also described are resulting compounds and compositions comprising them (e.g., tablets, capsules) for use in methods of medical treatment and diagnosis, etc., for example, for tauopathies, or Alzheimer's disease (AD).

A process for synthesizing 2-amino-5-dimethlyaminophenyl thiosulfonic acid comprises the step of oxidizing N,N'-dimethyl-rho-phenylene-diamine in the presence of a source of thiosulfate ions, while maintaining the temperature of the reaction mixture not higher than about 10° C. This compound is useful as an intermediate in the synthesis of toluidine blue O. A process for manufacturing toluidine blue O with improved yield, includes the step of preparing the intermediate 2-amino-5-diethylaminopropyl thiosulfonic acid according to the above described procedure.

The invention discloses a pesticide composition containing a thiosulfonic acid ester fungicide. The pesticide composition contains 10-60% of thiosulfonic acid ester, powders of 1-40 parts of methoxy-crylic acid fungicide, a soluble concentrate, a microemulsion, an emulsion in water, a suspending agent or missible oil. The pesticide composition is a compound composition of the thiosulfonic acid ester fungicide and the methoxy-crylic acid fungicide, high synergetic effect can be generated, and the capabilities of sterilization, disease prevention and healing can be reinforced, so that the crop can be prevented from falling ill in the growth process, and the yield and the quality are improved; the pesticide composition has a broad-spectrum sterilization capability, can prevent the diseases caused by various germs, and particularly plays the role of forcefully killing the moulds; and according to the pesticide composition, the use dose is reduced relatively, and the using cost is lowered relatively; the pesticide composition is processed to be a water-based environment-friendly agent, such as the emulsion in water, the microemulsion, a suspending agent and a suspension emulsion, the use dosage of the organic solvent is reduced, and the safety of the pesticide composition is improved.

The invention relates to the field of agricultural fertilizers, in particular to a compound fertilizer for preventing and treating dead vegetables and a preparation method thereof. Mix 500,000 parts of sodium humate, 100,000 parts of urea, 200,000 parts of avermectin powder, and 100,000 parts of lemon pomace in a weight ratio, grind them to more than 80 meshes, enter the stirring tank, and adjust the pH value to 7.6; add 1,000,000 parts of fertilizer during the stirring process 2000 parts of Bacillus licheniformis, 2000 parts of Bacillus subtilis, 1000 parts of sodium naphthalene acetate, 800 parts of gertyl milk powder, 200 parts of gibberellic acid, 1000 parts of iron powder, 1000 parts of zinc powder, 1000 parts of copper powder, 1000 parts of boron powder, 20 parts of N-(2-benzoimidazolyl)-methyl carbamate, 15 parts of 3-hydroxy-5-methylisoxazole, 10 parts of tolclofos-methyl, ethanethiosulfonate 20 parts of ethyl acetate. The effect is obvious, and the problem of dead vegetables can be effectively prevented and treated.

The invention discloses an isoquinoline compound, a preparation method and application thereof, and relates to the technical field of chemical synthesis. The isoquinoline compound is an indolo[2,1-a]isoquinoline compound or a benzimidazolo[2,1-a]isoquinolin-6(5H)ketone compound, and the preparation method is as follows: 1‑(2,3‑diphenyl‑1H‑indol‑1‑yl)‑2‑methacryl‑1‑ketone compound or 1‑methacryl‑2‑aryl‑benzimidazole The compounds and S-phenylbenzenethiosulfonate compounds are dissolved in an organic solvent, tert-butyl benzoate and a catalytic amount of copper bromide are added to react at 110°C to obtain isoquinoline compounds. The synthesis process of the invention does not require the participation of diazonium compounds, has the characteristics of cheap and easy-to-obtain raw materials, mild reaction conditions, simple operation, high regioselectivity and high yield, and is beneficial to industrial production.

The invention relates to a synthetic method for preparing thiosulfonates on the basis of a sulfinic acid sodium salt disproportionated reaction. The preparation method comprises the steps that sulfinic acid sodium salts serve as the raw materials, boron trifluoride diethyl etherate serves as accelerant, dichloromethane serves as solvent, and by means of a disproportionation coupled reaction, a thiosulfinate compound with good biological activity is synthesized; two different sulfinic acid sodium salts serve as the raw materials, and by means of a crossed disproportionation coupled reaction method, an asymmetric thiosulfinate compound can be synthesized. By means of a one-pot method and a two-step method, and by means of a thiosulfonates intermediate prepared on site, a sulfones compound and a sulfonamides compound can be synthesized by directly starting from sulfinic acid sodium salts. Accordingly, a synthetic route for preparing thiosulfonates on the basis of the sulfinic acid sodiumsalt disproportionated reaction is provided for the first time, operation is easy, raw materials are easy to obtain, the condition is mild, no metal catalyst is needed, no additional oxidant or reductant is needed, and the prepared thiosulfonates can have the good biological activity, and can also serve as the intermediate of the reaction to be applied to organic synthesis.