37 results about "Retina cell" patented technology

Disclosed are immortalized human embryonic retina cells, having a nucleic acid sequence encoding an adenoviral E1A protein integrated into the genome of the cells, and further comprising a nucleic acid sequence encoding an enzyme involved in post-translational modification of proteins, such as a sialyltransferase, wherein said nucleic acid sequence encoding the enzyme involved in post-translational modification of proteins is under control of a heterologous promoter. Methods for producing recombinant proteins from such cells and obtaining such recombinant proteins having increased sialylation are provided as are novel compositions of isoforms of erythropoietin .

A retina implant including a chip adapted to be implanted into the interior of eye in subretinal contact with the retina. The chip has a plurality of pixel elements on a side thereof facing the lens for receiving an image projected into the retina and a plurality of electrodes for stimulating retina cells. The implants further includes a receiver coil for inductively coupling thereinto electromagnetic energy. The receiver coil coupled to a means for converting an alternating voltage induced into the receiver coil in a direct voltage suited for supplying the chip. The receiver coil is configured as a component separate from the chip, and for being positioned on the eye ball outside the sclera. The chip is connected to the receiver coil via a connecting lead which, in the implanted condition interconnects the interior and the exterior of the eye ball.

Methods and apparatuses for configuring an implantable device to interface with retina cells are described. The device may comprise an array of pixel units capable of stimulating the retina cells are described. The pixel units may operate in a mode of operation selected from a plurality of modes including a normal mode and a calibration mode. A control circuitry of the device may be configured to switch the mode of operation for the pixel units. In one embodiment, the pixel units may be configured to receive light for stimulating the retina cells during the normal mode to enable perception of the light. During the calibration mode, the pixel units may be configured to adjust amount of stimulation to the retina cells.

The invention discloses a traditional Chinese medicine for treating amblyopia eye diseases and relates to a preparation prepared from the traditional Chinese medicines as raw materials. The traditional Chinese medicine is prepared from semen cassiae, radix paeoniae alba, salvia miltiorrhiza, medlar, tuckahoe, dendrobe, kudzuvine root, tuber of dwarf lilyturf, tribulus terrestris, adenophora tetraphylla, yam, forsythia core, motherwort fruit, lophatherum gracile, antelope horn powder, glabrousleaf pittosporum seed and fructus psoraleae. The clinical use result of the traditional Chinese medicine shows that the prescription has the functions of enhancing the capability of supplying blood to caridiac muscle, promoting the blood circulation and improving the development process of eye parts of patients and promoting the repair of optic nerve and retina cells as well as the efficacies of nourishing the kidney, nourishing the liver and improving acuity of vision; the prescription can be used for treating amblyopia, hyperopia, yellow spot and other diseases caused by various reasons; and the traditional Chinese medicine has unique formula and curative effect, especially has remarkable effects for infants and juvenile patients and can ensure that the symptoms of the patients are eliminated and the visions of the patients are recovered.

This invention relates to the expression method of adeno-associated virus-mediated gene in retinal cells. This invention can significantly improve the transfer efficiency and gene expression level of adeno-associated virus-mediated gene in retinal cells by using a combination of different types of adeno-associated virus, and has no toxic or side effect. Experimental results show that at a certain dosage range, replication-competent adenovirus and replication-defective adenovirus can significantly accelerate AAV2-mediated gene expression, and no cell lesion is observed. This invention can be used for gene treatment of ocular fundus diseases, such as retinosis, maculopathy, diabetic retinopathy, uveitis, choroidal neovascularization, optic nerve degeneration and damage.

The present invention discloses a retina cell microscopic imaging system which can conduct stratified scanning and comprises an illuminating system and a microscopic imaging optical unit. The inside of an optical path between the illuminating system and a human eye (601) is provided with a stratified scanning optical unit which comprises a first object lens (501) and a second object lens (502). The first object lens (501) and/or the second object lens (502) can move critically along the axial direction. The parallel incident illumination beams of the illuminating system are focused on certain film inside a human eye retina (603) through the second object lens (502) and the first object lens (501) sequentially. During the stratified scanning, a focusing face formed on the retina (603) moves correspondingly at each cell layer inside the retina (603) along with the movement of the first object lens (501) and the second object lens (502). A small depth of focus imaging optical unit is used as the microscopic imaging optical unit. The retina cell microscopic imaging system of the present invention has simple structure and can effectively conduct stratified observation towards each film forming the retina.

The invention discloses a blended blueberry juice and a preparation method of the blended blueberry juice. The blended blueberry juice is prepared from the following raw materials in parts by weight: 30 to 40 parts of highbush blueberries, 20 to 25 parts of juicy peaches, 1 to 6 parts of pectin, 12 to 15 parts of black currant, 6 to 8 parts of granulated sugar, 1 to 3 parts of pectinase, 1 to 4 parts of cellulase, 2 to 4 parts of hemicellulase, 1 to 3 parts of protease, 12 to 15 parts of lonicera edulis, 22 to 24 parts of grape seeds, 1 to 4 parts of propolis and 3 to 5 parts of vitamin E. According to the blended blueberry juice disclosed by the invention, a large amount of anthocyanin active ingredients in blueberries are reserved, and the blended blueberry juice contains rich nutritional ingredients and has the functions of activating retinas, promoting the regeneration of rhodopsin in retina cells, preventing myopia, increasing the eyesight and removing eye fatigue.

The invention discloses a method for synthesizing human eye vision system perception effect in a dark environment, which provides an intuitive control technology of human vision system perception effect in a night environment, in particular a dark environment for users. By the method, a user can designate an arbitrary target lighting environment by inputting lighting intensity and frequency spectrum, and the human eye vision system perception effect of a scene shown in a source image in the target lighting environment can be automatically synthesized. In the method, color frequency spectrum is reestablished according to the source image, and response of the retina cell under the source lighting environment is calculated; the adapting situation of the retina cell in the target light environment is simulated according to measurement data, and response of the adapted retina cell is calculated; and finally, the image is non-uniformly blurred by using a two-sided filter to make an acutance loss effect in the target lighting environment. Application of the method is not used in a night environment only, also can be used for synthesizing the human eye vision system perception effect in other lighting environments.

The invention provides a laminin membrane for assisting iPS-RPE transplantation and an iPS-RPE cell patch prepared from the membrane. The laminin membrane can promote migration, differentiation and regeneration of injured and degenerated retina cell on a provided collagen scaffold to form the same tissues of the retina cell and simultaneously can interfere with non-sequential fibroblast proliferation so as to avoid scar formation. According to the invention, mechanical properties of an autoserum laminin biomaterial can be enhanced, subretinal transplantation can be realized, defects of poor mechanical property, high immunogenicity, difficulty in degradation and low survival rate after stem cell transplantation in the prior art are overcome, diseased tissue is effectively repaired, and a new treatment method and thinking is provided to minimize pains of patients.

The invention constructs a human embryo retina transformed cell line SL-2 by transforming adenovirus gene fragments into human embryo retina cells. The cell line can be used for producing biological products such as adenovirus and the like, and has obvious advantages. The cell line can also be used for producing influenza virus, herpes simplex virus, measles virus, rotavirus and other viruses, polypeptides and other biological products.

The invention discloses sea-buckthorn black fruit mountain ash berry eye-protection milk tablets and a preparing method thereof. The sea-buckthorn black fruit mountain ash berry eye-protection milk tablets comprise dry powder of a sea-buckthorn extract, dry powder of a black fruit mountain ash berry extract, defatted milk, citric acid and xylitol, and the eye-protection milk tablets are prepared through a series of steps. The prepared sea-buckthorn black fruit mountain ash berry eye-protection milk tablets are convenient to carry and eat and have a strong eye protection function, the harm of blue light to the eyes can be effectively avoided, regeneration of rhodopsin in retina cells can be promoted, severe myopia and retinal detachment can be prevented, and the vision can be enhanced and protected; meanwhile, cell and organ damage of free radicals in the human body can be resisted, and cardiovascular sclerosis, coronary heart diseases, phymatosis and other symptoms triggered by the body are effectively prevented.