50 results about "Resistant virus" patented technology

The present invention provides small molecule compounds of bisheterocycle in tandem having the structural formula of P1-P2, and the use thereof as well as a composition containing the compounds, each of P1 and P2 is an unsaturated 5-member heterocyclic ring having one or two heteroatoms. This compound may effectively inhibit the replication of influenza virus, the DNA replication of hepatitis B virus (HBV), and the formation of HBsAg and HBeAg. These compounds can be used for the preparation of a medicament for viral diseases, and may overcome the limitations of the known nucleosides drugs, including cytotoxicity, the requirement of other drugs having different structures for against the drug-resistant virus variants induced by long-term therapy. The structure of the compounds according to the invention is relatively simple and easy to be prepared.

A novel single-cell-level phenotypic assay is described, which can simultaneously analyze HIV-1 drug susceptibility and intrinsic replication capacity. This allows quantitative dissection of the functions of antiretroviral drugs into suppression of viral replication and selection of resistant viruses with diminished replication capacities. The disclosed assay provides a tool for the rational evaluation of treatment decisions for patients failing antiretroviral therapy and is expected to be an important part in clinical management of HIV.

The construction of a chimeric Pestivirus by the identification of selected regions in the 3′NTR of the viral RNA genome is described where additional RNA sequences can be stably inserted. These sequence insertions in the viral RNA genome were stable in replication and capable of forming infectious, RNase resistant virus particles. This chimeric Pestivirus with a 3′NTR insertion can be utilized as a quality control material in analytical assays for RNA targets, including external, internal controls, quantitative standards in PCR and NAT nucleic acid assays.

The invention relates to a breeding method of a good-taste and transport-and-storage-resistant pink tomato. The breeding method of the good-taste and transport-and-storage-resistant pink tomato comprises the following steps of taking Chunxuehong tomato as the female parent to perform 7 generations of individual selection and mixed seed reservation; taking Difenni tomato as the male parent to perform 4 generations of individual selection through a continuous selfing and molecular marker-assisted selection method to obtain 4th-generation strains, then combining tomato yellow leaf curl disease-resistant virus and performing 2 generations of individual selection to obtain 6th-generation strains, performing 2 generations of individual selection, removing abnormal plants and performing mixed seed reservation; crossing the female parent and the male parent to obtain seeds of the good-taste and transport-and-storage-resistant pink tomato. The bred good-taste and transport-and-storage-resistantpink tomato has the advantages of being good in taste, high in sugar degree, regular in fruit shape, good in color, resistant to transport and storage, robust in plant growth, high in comprehensive disease resistance and the like.

A therapeutic face mask apparatus for wearers with resistant respiratory viruses, is connected to a heat gun that provides adjustable heated and humidified air for inhalation. The heat gun heats ambient air that is breathed in through the face mask during normal breathing, which is worn over the nose and mouth of a person. A temperature gauge monitors temperature for future adjustment of the amount of heat generating current to raise the heat to a predetermined temperature to deactivate resistant viruses in compromised upper and / or lower respiratory systems of the wearer. The air in the chamber is heated for inhalation by a resistive element in the heat gun. The temperature of the resistive material (and by extension the warm air generated), is regulated / adjusted by increasing or decreasing the current output settings on the power source, so that heated and pressured air is produced.