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39 results about "Antiretroviral therapy" patented technology

Antiretroviral Therapy (ART) Synonym(s): Combination Therapy, Combined Antiretroviral Therapy (cART), Highly Active Antiretroviral Therapy (HAART) The daily use of a combination of HIV medicines (called an HIV regimen) to treat HIV infection. A person's initial HIV regimen generally includes three antiretroviral (ARV) drugs from at least two different HIV drug classes.

Method of treating cancer using dithiocarbamate derivatives

InactiveUS20050096304A1Readily available easily used treatmentInhibitionHeavy metal active ingredientsBiocideAdjuvantAnticarcinogen
The invention encompasses neutral dithiocarbamate metal compounds and methods of treating cancer using such compounds, along with methods for sensitizing AIDS / HIV patients to anti-retroviral therapy by blocking the P-glycoprotein membrane toxin extrusion pump using such compounds. Compounds inhibit the growth of cancer cells of a variety of cell types. A method is presented for using the neutral compounds disclosed herein, amongst other uses disclosed herein, to reduce tumor growth, and to potentiate the effect of other anticancer agents. The invention also encompasses pharmaceutical compositions comprising the neutral compounds and a pharmaceutically acceptable excipient, diluent, solubilizer, solvent, adjuvant or carrier, or a mixture thereof.
Owner:AAIPHARMA SERVCIES CORP

Treatment of AIDS

The invention includes methods of treating HIV infection in a patient where the method includes administration of an antibody to TNF-alpha and an antibody to interferon-gamma to the patient and administering antiretroviral therapy to a patient. The invention further includes methods of treating HIV infection in a patient where the method comprises administration of an antibody to TNF-alpha and an antibody to alpha interferon to the patient and administering antiretroviral therapy to a patient. The invention further includes a method of treating HIV infection in a patient where the method includes administering an antibody to alpha interferon and antiretroviral therapy to a patient. The invention further includes a method of treating an HIV infection in a patient where the method comprises administering a chimeric TNF-alpha receptor and anti-retroviral therapy to a patient.
Owner:ADVANCED BIOTHERAPY

Combating side-effects

The invention relates to the use of active ingredients, which increase the concentration of pyrimidine-based elements for nucleic acid biosynthesis in the body, in particular to the use of pyrimidine nucleosides and / or prodrugs produced therefrom, for reducing the side-effects of inhibitors of nucleic acid biosynthesis or their precursors, in particular by activating the biosynthesis of mitochondrial DNA (mtDNA). The invention also relates to the use of said active ingredients, in particular pyrimidine nucleosides and / or prodrugs for producing pharmaceutical preparations for reducing the aforementioned side-effects and to combinations or products for administering active ingredients of this type, in particular pyrimidine nucleosides and / or prodrugs produced therefrom, comprising inhibitors of nucleic acid biosynthesis or their precursors. The invention further relates to methods for treating the side-effects of inhibitors of nucleic acid biosynthesis or their precursors using the aforementioned active ingredients, in particular pyrimidine nucleosides and / or prodrugs produced therefrom, or the aforementioned combinations or products and to corresponding pharmaceutical preparations. Side-effects of HAART (Highly Active Anti-Retroviral Therapy) and side-effects of other anti-viral nucleoside analogous agents, which inhibit the mitochondrial γ-polymerases, can in particular be prophylactically and / or therapeutically treated in this manner.
Owner:PHARMA NORD

Medicine composition for preventing and treating AIDS and its prepn process and use

The present invention discloses one kind of medicine composition for preventing and treating AIDS and its preparation process and use. The medicine composition consists of active ingredient and auxiliary ingredient, and may be prepared into granule, tablet, capsule, oral liquid or injection. It has the functions of inhibiting the copying of HIV, promoting immunologic reconstruction of the AIDS patient, delaying disease and clinical complication, and synergizing and attenuating in high efficiency retrovirus resisting therapy. The present invention has wide application foreground.
Owner:广州中医药大学热带医学研究所

Means and methods for monitoring protease inhibitor antiretroviral therapy and guiding therapeutic decisions in the treatment of HIV/AIDS

InactiveUS20060035249A1Identification and of fitnessCompound screeningApoptosis detectionAcquired immunodeficiencyGenotype
This invention relates to antiviral drug susceptibility and resistance tests to be used in identifying effective drug regimens for the treatment of human immunodeficiency virus (HIV) infection and acquired immunodeficiency syndrome (AIDS), particularly treatment regimens including a protease inhibitor. The invention further relates to the means and methods of monitoring the clinical progression of HIV infection and its response to antiretroviral therapy using phenotypic or genotypic susceptibility assays.
Owner:VIROLOGIC INCORPORATED

Traditional Chinese medicine capsule for treating bone marrow suppression caused by highly active antiretroviral therapy (HAART) for AIDS (acquired immure deficiency syndrome)

The invention relates to traditional Chinese medicine capsule for treating bone marrow suppression caused by an highly active antiretroviral therapy (HAART) for AIDS (acquired immure deficiency syndrome), which effectively solves the treatment medication problem of the bone marrow suppression caused by the HAART for the AIDS, wherein the capsule is prepared by ginseng, angelica, fructus ligustri lucidi, caulis spatholobi, radix astragali, herba epimedii, pericarpium citri reticulatae and oldenlandia diffusa, wherein the angelica and the pericarpium citri reticulatae are crushed, added with the water and distilled to respectively collect essential oil and distilled water solution; the dregs of the angelica and the pericarpium citri reticulatae are mixed with the fructus ligustri lucidi, the caulis spatholobi, the radix astragali, the herba epimedii and the oldenlandia diffusa, and the mixture is added with water to decoct twice; during the decocting process, the decocting liquid is combined with the distilled water solution of the angelica and the pericarpium citri reticulatae; the mixture is filtered, condensed and added with the ginseng powder for evenly mixing; then the mixture is dried, crushed into fine powder and sieved; the essential oil of the angelica and the pericarpium citri reticulatae is injected and mixed uniformly, and the capsule is filled. The traditional Chinese medicine capsule in the invention have scientific prescription and good edible effect, can effectively solve the treatment medication problem of the bone marrow suppression caused by the HAART for the AIDS, and are innovation of the traditional Chinese medicine.
Owner:HENAN UNIV OF CHINESE MEDICINE

Methods for reversing HIV latency using baf complex modulating compounds

PendingUS20210315876A1Prevent nucleosomal positioningRelieving transcriptional repressionOrganic active ingredientsOrganic chemistryMechanism of actionAntiretroviral therapy
This disclosure provides methods of using BAF complex modulating compounds as inhibitors of BAF-mediated transcription in target cells. The BAF complex modulating compounds include 12-membered macrolactam compounds that can target a BAF-specific subunit (e.g., ARID1A) to prevent nucleosomal positioning, relieving transcriptional repression of HIV-1. The subject methods can provide for reversal of latency of HIV-1 in cells in vitro or in vivo. Use of the macrolactam BAF complex modulating compounds represent a method of HIV latency reversal with a unique mechanism of action, which can be optionally combined with other Latency Reversal Agents to improve reservoir targeting. The subject methods can be utilized in conjunction with any convenient methods of treating HIV or HIV latency, including methods related to immune system activation, antiretroviral therapies and / or anti-HIV agents.
Owner:PURDUE RES FOUND INC +2
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