A method of cleaning a porous
polymeric membrane having a feed side and a permeate side including the steps of introducing a fluid containing a
cleaning agent to the permeate side of a membrane allowing the
cleaning agent to contact the permeate side of the membrane for a predetermined time, and contact the pores of the membrane, or introducing a fluid containing a
cleaning agent to the feed side of a membrane; applying a
transmembrane pressure to force the fluid containing the cleaning agent from the feed side to the permeate side of the membrane; allowing the cleaning agent to contact the permeate side of the membrane for a predetermined time, and contact the pores of the membrane. Preferably a
concentration gradient between the feed side fluid and the lumen side fluid containing the cleaning agent causes cleaning agent to diffuse into the feed side fluid. Pressure may be applied to the fluid containing a cleaning agent to dislodge, where present, dissolved and undissolved
solid from the membrane pores. The pressure may be applied in a pulsed fashion, and can be by way of
compressed air at a pressure not more than the membrane's
bubble point. The methods of the present invention may be preceded by, or followed with a backwash.