44 results about "Phosphatidal Compounds" patented technology

Provided are compounds, methods and pharmaceutical compositions for treating a host, especially a human, infected with a togavirus, herpes virus and / or coronavirus, and in particular SARS-CoV, cytomegalovirus or varicella-zoster virus. The method in one embodiment comprises administering to that host an effective amount of an anti-togavirus, anti-herpes virus and / or anti-coronavirus phospholipid or a pharmaceutically acceptable salt or prodrug thereof. The phospholipid compound is, e.g., a 3-alkylamido-2-alkoxypropylphosphocholine compound or salt thereof. The compound may be administered alone or in combination and / or alternation with one or more other anti-viral agents.

The invention discloses a novel anti-browning and fresh-keeping method for lotus roots. The method comprises plasma preparation, treatment, preparation of a preservative and post-treatment. Active substances and groups in the low temperature plasma can undergo a reaction with an amino acid group of polyphenol oxidase on the lotus root surface so that the loss of enzyme activity is caused, oxidative deterioration of the phenols caused by the polyphenol oxidase is inhibited and lotus root browning is prevented. The preservative can effectively act the cytoplasmic membrane of microbial cells so that the synthesis of the microbial plasma membrane and phospholipid compounds is inhibited, cell membrane contents are leaked, even cell lysis is caused and microorganisms are killed and fresh-keepingand anticorrosion effects are obtained. The method is easy to operate, can be used for large-scale operation and has remarkable anti-browning and fresh-keeping effects. The preservative is a water-soluble material easy to elute, can be degraded and absorbed by the human body and is an efficient and safe novel anti-browning and fresh-keeping method for lotus roots.

The invention discloses a lipid compound siRNA (small interfering ribonucleic acid) transfection reagent, belonging to the technical field of siRNA transfection reagents. The lipid compound siRNA transfection reagent comprises lipopolyamine, phospholipid compounds and cationic lipid compounds. Compared with the existing siRNA transfection reagent, the siRNA transfection reagent disclosed by the invention has the advantages of low cytotoxicity, high transfection efficiency and more obvious gene suppression effect, and is especially suitable for research of cell gene functions and development of siRNA drugs.

The invention relates to AIE molecules-loaded liposome dispersion liquid, and a preparation method and application thereof. The liposome dispersion liquid comprises a phospholipid compound microspherein which AIE molecules are dissolved, and a solvent for dispersing the phospholipid compound microsphere, and the AIE molecules are lipid-soluble molecules having the AIE effect. The preparation method of the liposome dispersion liquid is very simple, the prepared liposome dispersion liquid has good biocompatibility and uniform dispersibility, the particle size is between 100 and 300nm, specificrecognition of tumor cells can be achieved by utilizing the EPR effect of a tumor tissue, reactive oxygen can be produced after degradation in cells and illumination by light under specific wavelengths to kill the tumor cells, and the liposome dispersion liquid can be used for tumor treatment by adopting a PDT therapy method; compared with a traditional PDT therapy method, only partial illumination is needed, and there is no need to perform in a dark room, so that a patient can move freely to some extent.

Disclosed are a taxol phospholipid compound, a pharmaceutical composition and a use thereof. In the invention, the pharmaceutical composition comprises a composition of the taxol phospholipid compound and a pharmacodynamically acceptable carrier, and is a liquid preparation, a solid preparation, a semi-solid preparation, a capsule, a granule, a gel or an injection. The pharmaceutical composition is a liposome nanoparticle prepared by using the taxol phospholipid compound and an adjuvant, and the particle size of the nanoparticle is 10-1000 nm.