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44 results about "Phosphatidal Compounds" patented technology
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Phospholipid compound of hydrophilic drugs as well as pharmaceutical composition and application of phospholipid compound
The invention discloses a phospholipid compound of hydrophilic drugs as well as a pharmaceutical composition and application of the phospholipid compound. The pharmaceutical composition of the phospholipid compound of the hydrophilic drugs or a combined pharmaceutical composition of the phospholipid compound of the hydrophilic drugs and a pharmacologically acceptable carrier; and the pharmaceutical composition is in the form of a liquid preparation, a solid preparation, a semisolid preparation, a capsule, granules, a gel or an injection. The pharmaceutical composition is in the form of liposome nanoparticles prepared from the phospholipid compound of the hydrophilic drugs or the phospholipid compound of the hydrophilic drugs and adjuvants, and the pharmaceutical composition is 10-1000nm in grain size. The phospholipid compound of the hydrophilic drugs and the liposome nanoparticles thereof can serve as a liquid preparation, a solid preparation, a semisolid preparation, a sterilized preparation and a sterile preparation; and the phospholipid compound of the hydrophilic drugs and the liposome nanoparticles thereof are low in toxicity, and are applicable to the efficient treatment of various tumors and the like.
Owner:SOUTHEAST UNIV
Aqueous systems containing phospholipid, surfactant and phosphate ester for water-insoluble materials
The present invention is drawn to a aqueous composition containing: (a) at least one phospholipid compound; (b) at least one nonionic surfactant; (c) at least one phosphate ester chosen from alkoxylated alkyl phosphate esters and alkyl phosphate esters; and (d) at least one water-insoluble material, and wherein the composition is both homogeneous, and clear to substantially clear in appearance.
Owner:LOREAL SA
Taxol phospholipids compound, medicine composition and application thereof
InactiveCN104225615AOrganic active ingredientsGroup 5/15 element organic compoundsMedicinePhospholipid
The invention discloses a taxol phospholipids compound, a medicine composition and application thereof. The medicine composition comprises the taxol phospholipids compound or a combined medicine composition which is combined by the taxol phospholipids compound and a carrier which can be accepted in pharmacology, namely a liquid preparation, a solid preparation, a semi-solid preparation, a capsule, a granule, a gel and an injection. The medicine composition is the taxol phospholipids compound or a liposomal nano particle which is prepared by the taxol phospholipids compound and an assistant, and the diameter of the particle is 10 to 1000 nanometer. The taxol phospholipids compound and the liposomal nano particle can be used as liquid preparations, solid preparations, semi-solid preparations, sterilization preparations and sterile preparations, the toxicity is low, so that the taxol phospholipids compound and the liposomal nano particle can be applied to the efficient treatment of various tumors.
Owner:SOUTHEAST UNIV
Paclitaxel phospholipid compound and drug combination and application thereof
PendingCN105233298AOrganic active ingredientsGroup 5/15 element organic compoundsNanoparticlePhospholipid
The invention discloses a paclitaxel phospholipid compound and a drug combination and application thereof. The drug combination comprises the paclitaxel phospholipid compound or a medicinal combination of the paclitaxel phospholipid compound and a pharmacodynamically-acceptable carrier, and can be a liquid preparation, a solid preparation, a semisolid preparation, capsules, granules, gel and an injection. The drug combination is liposome nanoparticles prepared from the paclitaxel phospholipid compound or the paclitaxel phospholipid compound and an auxiliary, and grain diameter of the liposome nanoparticles is 10-1000 nanometers. The paclitaxel phospholipid compound and the liposome nanoparticles utilize quickly-breakable spacer arms in molecular structure to quickly release paclitaxel drug, can be used as liquid preparations, solid preparations, semisolid preparations, sterilizing preparations and sterile preparations, are low in toxicity and can be used for efficient treatment of various tumors.
Owner:SOUTHEAST UNIV
Camptothecin phospholipid compound, and medicinal composition and application thereof
The invention discloses a camptothecin phospholipid compound, and a preparation method, a medicinal composition and a use thereof. The medicinal composition is a camptothecin phospholipid compound or a combined medicinal composition composed of the camptothecin phospholipid compound and a pharmacodynamically acceptable carrier, and can be a liquid preparation, a solid preparation, a semisolid preparation, a capsule, a granule, a gel or an injection. The medicinal composition is camptothecin phospholipid compound or a liposome nanoparticle prepared by using the camptothecin phospholipid compound and an assistant, and the particle size of the nanoparticle is 10-1000nm. The camptothecin phospholipid compound and its liposome nanoparticle can be used as a liquid preparation, a solid preparation, a semisolid preparation, a sterilized preparation or an aseptic preparation, have low toxicity, and can be used for efficient treatment of various tumors.
Owner:SOUTHEAST UNIV
Preparation for cell imaging and preparation method and applications thereof
InactiveCN107987825AEasy to prepareGood biocompatibilityFluorescence/phosphorescenceLuminescent compositionsMicrospherePhospholipid
The invention relates to a preparation for cell imaging and a preparation method and applications thereof. The preparation comprises phospholipid microspheres with dissolved AIE molecules and a solvent for dispersing phospholipid microspheres. The AIE molecules are fat soluble molecules with an AIE effect. The preparation method of the preparation is very simple. The prepared preparation has goodbiocompatibility and is uniformly dispersed. The particle size is in a range of 100-300 nm and is adjustable. In cells, the structure of phospholipid microspheres is degraded by a surfactant, and thedegradation time is 5-36 hours. Dissolved AIE molecules are released and aggregated. After laser radiation, fluorescence is generated, thus cell imaging and cell labeling are realized; at the same time, two-photon imaging can be realized through long wavelength laser excitation; the images are clear, furthermore, the interference of other fluorescent substances in cytoplasm is avoided, and by using the EPR effect of tumor tissues, the provided preparation can specifically identify and label the tumor cells.
Owner:THE NAT CENT FOR NANOSCI & TECH NCNST OF CHINA
Novel anti-browning and fresh-keeping method for lotus roots
ActiveCN107960455APrevent browningReduce contact timeFood ingredient as antioxidantFruits/vegetable preservation by irradiation/electric treatmentCell membranePhospholipid
The invention discloses a novel anti-browning and fresh-keeping method for lotus roots. The method comprises plasma preparation, treatment, preparation of a preservative and post-treatment. Active substances and groups in the low temperature plasma can undergo a reaction with an amino acid group of polyphenol oxidase on the lotus root surface so that the loss of enzyme activity is caused, oxidative deterioration of the phenols caused by the polyphenol oxidase is inhibited and lotus root browning is prevented. The preservative can effectively act the cytoplasmic membrane of microbial cells so that the synthesis of the microbial plasma membrane and phospholipid compounds is inhibited, cell membrane contents are leaked, even cell lysis is caused and microorganisms are killed and fresh-keepingand anticorrosion effects are obtained. The method is easy to operate, can be used for large-scale operation and has remarkable anti-browning and fresh-keeping effects. The preservative is a water-soluble material easy to elute, can be degraded and absorbed by the human body and is an efficient and safe novel anti-browning and fresh-keeping method for lotus roots.
Owner:ZHEJIANG OCEAN UNIV
Camptothecin phospholipid compound, drug composition and application thereof
ActiveCN105131039AGood antitumor activityImprove solubilityOrganic active ingredientsGroup 5/15 element organic compoundsPhospholipidPharmacodynamic Study
Owner:SOUTHEAST UNIV
Exosome drug delivery system and preparation method and application thereof
ActiveCN113292608AProtect completenessHigh drug loadingInorganic active ingredientsOrganic chemistry methodsPhospholipidDrug loading dose
The invention discloses an exosome drug delivery system as well as a preparation method and application thereof, provides an active drug loading system for loading a cis-platinum prodrug on an exosome by utilizing a phospholipid compound, and solves the problems of membrane rupture, low drug loading capacity and the like caused by an exosome drug loading strategy. According to the invention, the cis-platinum prodrug is prepared in advance and is prepared into the liposome, and then the liposome is mixed with the exosome to realize active drug loading, so that the fusion effect of the phospholipid compound and the exosome membrane is utilized, the completeness of the exosome membrane is protected, and the drug loading capacity of the exosome to the anti-cancer drug is improved.
Owner:天津外泌体科技有限公司
Metal organic framework catalyst as well as preparation method and application thereof
ActiveCN113788955AReduce contentImprove adsorption and contact abilityOrganic-compounds/hydrides/coordination-complexes catalystsEnergy based wastewater treatmentCarboxyl radicalPtru catalyst
The invention discloses a metal organic framework catalyst as well as a preparation method and application thereof. The preparation method comprises the following steps: 1) synthesizing a ligand, namely tetrakis(4-carboxyl)terphenyl methane; 2) synthesizing the metal organic framework catalyst constructed by an organic ligand and a metal cluster; and 3) calculating the efficiency of the catalytic phospholipid compound and exploring related mechanisms. According to the invention, an inorganic-organic hybridization strategy is adopted, and a high-pore catalyst is synthesized based on the advantages of a metal organic framework material. An adopted organic hybridization strategy can reduce the content of metal and improve the biological compatibility of catalysis; and a high-pore structure can improve the adsorption contact capacity of the catalyst and guest molecules and improve the catalytic efficiency, so performance optimization is achieved.
Owner:XIEHE HOSPITAL ATTACHED TO TONGJI MEDICAL COLLEGE HUAZHONG SCI & TECH UNIV
Medical phospholipid compound and medical composition and application thereof
InactiveCN110025789AQuick releaseFat solubleOrganic active ingredientsPharmaceutical non-active ingredientsChemical compositionCounterion
The invention discloses a medical phospholipid compound and a medical composition and application thereof. The phospholipid compound is a compound as shown in the following general formula (1) or pharmaceutically acceptable salt prepared from the compound as shown in the general formula (1) and counterions; and in the formula (1), m is a positive integer from 2-10, n is a positive integer from 5-10, X is a medicine, and L is 2-aminoethyl cations and 2-trimethylamine ethyl cations. The medical composition comprises the medical phospholipid compound, or the medical phospholipid compound and a pharmaceutically acceptable carrier. The application of the medical phospholipid compound to preparation of antitumor medicines lies in that the medical phospholipid compound or the pharmaceutically acceptable salt thereof, and the pharmaceutically acceptable carrier are prepared into a medicament. The medical phospholipid compound and liposome nanometer particles thereof can be used as a liquid preparation, a solid preparation, a semisolid preparation, a sterilizing preparation and a sterile preparation, and liposomes can be formed under a water-phase system.
Owner:SOUTHEAST UNIV
Phospholipid compound and preparation method thereof
InactiveCN110256485ARapid Fracture DegradationGroup 5/15 element organic compoundsPhosphatide foodstuff compositionsCarbonyldiimidazoleDisulfide bond
The invention discloses a phospholipid compound and a preparation method thereof. The structural general formula of the phospholipid compound is shown in the specification. In the formula, m is a positive integer from 2 to 10, and n is a positive integer from 7 to 15. The compound contains a disulfide bond easy to break and can be quickly broken and degraded in a reducing medium. The method comprises the following steps: (1) dissolving triphenylmethyl protected mercapto n-alkanoic acid into dimethyl sulfoxide, adding N,N'-carbonyl diimidazole, 1,8-diazabicyclo[5.4.0]undecane-7-ene and choline glycerophosphate, and carrying out a reaction to obtain bis-triphenylmethyl mercapto n-alkanoic acid choline glycerophosphate; 2) dissolving the bis-triphenylmethyl mercapto n-alkanoic acid choline glycerophosphate in dichloromethane, adding trifluoroacetic acid and triethylsilane, and carrying out a reaction to obtain bis-mercapto-alkanoic acid choline glycerophosphate; and 3) dissolving the bis-mercapto-alkanoic acid choline glycerophosphate in dichloromethane, adding n-alkyl dithiopyridine, and carrying out a reaction to obtain the bis-n-alkyl dithio-n-alkanoic acid choline glycerophosphate.
Owner:SOUTHEAST UNIV
A kind of exosome drug delivery system and its preparation method and application
ActiveCN113292608BProtect completenessHigh drug loadingInorganic active ingredientsOrganic chemistry methodsPhospholipidDrug loading dose
The invention discloses an exosome drug delivery system and its preparation method and application, and provides an active drug loading system that uses phospholipid compounds to load cisplatin prodrugs on exosomes, so as to solve the problem of membrane rupture caused by exosome drug loading strategy and low drug loading; the present invention prepares cisplatin prodrugs in advance, prepares them into liposomes, and then mixes them in exosomes to realize active drug loading, utilizing the fusion of phospholipid compounds and exosome membranes It protects the integrity of the exosome membrane and increases the drug loading capacity of the exosome anticancer drugs.
Owner:天津外泌体科技有限公司
Compositions containing quaternary ammonium polymers
The invention relates to compositions containing at least one alcohol-insoluble quaternary ammonium polymer, at least one amphoteric surfactant, at least one nonionic surfactant and, optionally, at least one phospholipid compound as well as to methods of using and preparing such compositions.
Owner:LOREAL SA
Phospholipid compound containing unsaturated fatty acid derivative having cyclopropane ring
ActiveUS20150376213A1Easy transferOrganic active ingredientsNervous disorderOctanoic AcidsPhosphatidylethanolamine
The invention provides a phospholipid compound containing unsaturated fatty acid having a cyclopropane ring such as 8-[2-(2-pentyl-cyclopropylmethyl)-cyclopropyl]-octanoic acid (DCP-LA) and 8-(2-octylcyclopropyl)octanoic acid (DCP-OA) and the like, particularly 1,2-o-bis-[8-{2-(2-pentyl-cyclopropylmethyl)-cyclopropyl}-octanoyl]-sn-glycero-3-phosphatidylethanolamine (diDCP-LA-PE), which has a cognitive function improving effect and an anti-diabetes action, and which is useful as a medicine such as a therapeutic drug for dementia, a therapeutic drug for diabetes and the like.
Owner:NISHIZAKI BIOINFORMATION RES INST
Composite nanometer particle as well as preparation method and application thereof
ActiveCN108079299AUniform particle sizeEvenly dispersedPowder deliveryPhotodynamic therapyAdditive ingredientPyrene
The invention provides a composite nanometer particle as well as a preparation method and application thereof. The composite nanometer particle is prepared from the following ingredients including di-pyrene molecules, a photosensitizer, a phospholipid compound and a compound with oxygen carrying capability. The composite nanometer particle provided by the invention has the advantages that the particle diameter is uniform; the dispersion is uniform; the particle diameter is about 200nm; the particle diameter is adjustable; in addition, di-pyrene molecules and the photosensitizer are used for forming two-photon absorption materials. Compared with the photosensitizer in the prior art, the composite nanometer particle has the advantages that the absorption cross section is large; photon can bemore effectively absorbed; the deeper detection depth can be reached; meanwhile, the damage to the normal tissue is reduced; through the FRET (fluorescence resonance energy transfer) effect, the energy can be transferred to the photosensitizer; the cells can be more effectively killed and injured; higher application values are realized in the photodynamic treatment.
Owner:北京柏欧利诺生物科技有限公司
Podophyllotoxin phospholipid compound as well as pharmaceutical composition and application of podophyllotoxin phospholipid compound
InactiveCN105037429AGood antitumor activityLow toxicityOrganic active ingredientsGroup 5/15 element organic compoundsAdjuvantNanoparticle
The invention discloses a podophyllotoxin phospholipid compound as well as a pharmaceutical composition and application of the podophyllotoxin phospholipid compound. The pharmaceutical composition comprises a podophyllotoxin phospholipid compound or a combined pharmaceutical composition of the podophyllotoxin phospholipid compound and a pharmacologically-acceptable carrier and is a liquid preparation, a solid preparation, a semi-solid preparation, a capsule, granules, gel and an injection. The pharmaceutical composition is a liposome nanoparticle (with the particle size of 10-1000nm) prepared from the podophyllotoxin phospholipid compound or the podophyllotoxin phospholipid compound and an adjuvant. The podophyllotoxin phospholipid compound and the liposome nanoparticle thereof can be used as liquid preparations, solid preparations, semi-solid preparations, disinfection preparations and sterile preparations, are low in toxicity and can be used for efficiently treating tumors.
Owner:SOUTHEAST UNIV
Dithiophospholipid compound and preparation method thereof
PendingCN113072578AReasonable structural designCan control targeted releasePharmaceutical non-active ingredientsPhosphorus organic compoundsDisulfide bondingWater methanol
The invention discloses a dithiophospholipid compound and a preparation method thereof. The preparation method comprises the following steps: weighing cystamine hydrochloride and triethylamine absolute methanol, adding di-tert-butyl dicarbonate, and reacting to obtain single protection cystamine; weighing fatty acid, 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride and N-hydroxythiosuccinimide, dissolving in dichloromethane, adding mono-protected cystamine, mixing, dissolving reactants in dichloromethane, and adding trifluoroacetic acid to obtain a solid; dissolving the solid in dichloromethane, adding triethylamine and succinic anhydride, and reacting to obtain an intermediate product; and weighing the intermediate product according to the ratio, dissolving dicyclohexylcarbodiimide and 4-dimethylaminopyridine in dimethyl sulfoxide, activating, adding choline glycerophosphate, and reacting to obtain the target product. The structure of the dithiophospholipid compound provided by the invention contains a disulfide bond which is easily reduced by glutathione, so that phospholipid is broken in the presence of GSH, and the dithiophospholipid compound has a GSH response breaking function.
Owner:ANHUI UNIVERSITY OF TECHNOLOGY
Special fat powder for freshwater fish as well as preparation method and application thereof
ActiveCN112075549APromote growthPromote growth and developmentAccessory food factorsNutritionZoology
The invention relates to a special fat powder for freshwater fish as well as a preparation method and application thereof. The special fat powder for the freshwater fish comprises freshwater fish structural ester, a phospholipid compound, carotenoid, eucalyptus essential oil, carnitine, an emulsifier and a wall material, wherein the freshwater fish structural ester comprises saturated fatty acid,monounsaturated fatty acid and polyunsaturated fatty acid. The special fat powder for the freshwater fish promotes the growth and development of the freshwater fish in a nutrient intake manner, improves the culture yield as well as the culture quality, saves resources and improves the economic benefits; in addition, fat stored in bodies of the freshwater fish is reduced, particularly the fat stored in liver pancreas, and some fat-soluble toxic substances stored in visceral organs due to oxidative rancidity of grease are reduced; and the intestinal health of the fish is regulated, the immunityof the freshwater fish is improved, and the survival rate is increased.
Owner:湖北优百特生物工程有限公司
Phosphorus-containing PBS flame-retardant material and phosphorus-containing polyurethane and preparation method
The invention belongs to the field of biodegradable flame-retardant material preparation, and particularly relates to a phosphorus-containing PBS flame-retardant material and phosphorus-containing polyurethane and a preparation method. The phosphorus-containing PBS flame-retardant material is prepared by using hydroxyl-terminated polybutylene succinate HO-PBS-OH as a substrate and a bifunctional phospholipid compound as a chain expanding agent. The phosphorus-containing polyurethane (PPU) is formed by adding an isocyanate functional reaction compound into the obtained PPBS and commercial PBS resin to prepare a high-performance biodegradable material having both flame-retardant effect and toughening effect. Number-average molecular weight Mn of a prepared phosphorus-containing polyurethane flame-retardant material reaches higher than 8000, limit oxygen index can reach higher than 30, and elongation at break reaches higher than 150%.
Owner:TIANJIN UNIVERSITY OF SCIENCE AND TECHNOLOGY
New margarine and producing method therefor
InactiveCN107047806AEdible oils/fats with fatty acid estersEdible oils/fats production/working-upPhospholipidOxygen
The invention provides new margarine and a producing method therefor. Inulin belongs to a soluble dietary fiber that helps to reduce blood lipid of the human body, regulate gastrointestinal transfer time, and promote absorption of mineral elements, especially the absorption of calcium element. Lecithin is an important phospholipid compound which is a natural surfactant and an important nutrient. Inulin contains hydroxy that can form an intermolecular hydrogen bond together with water or carbonyl groups of lecithin or an electronegative phosphorus-oxygen bond, and through self-assembly, a network structure or a zonal structure is formed, so as to obtain the margarine. The margarine is produced from the inulin and lecithin, free of trans fatty acids, and can completely or partly take place of commercially available margarine in the aspect of sensory characteristics.
Owner:WUHAN POLYTECHNIC UNIVERSITY
Simultaneous multicompound analysis method and simultaneous multicompound analysis program using mass spectrometry
ActiveUS20170299557A1Labor savingShorten the timeStability-of-path spectrometersComponent separationLiquid chromatography mass spectroscopyMass Spectrometry-Mass Spectrometry
The operation efficiency and accuracy of the simultaneous analysis of phospholipids, including fatty acid compositions are increased. After a first-time LC / MS / MS analysis for determining the phospholipid classes of the phospholipid contained in a sample is performed (S2-S3), a second-time LC / MS / MS analysis for determining fatty acid compositions is performed only for the detected phospholipids (S4-S8). By associating a method list in which an MRM transition for phospholipid class determination is recorded for each compound of phospholipid classes with a method list in which an MRM transition for fatty acid composition determination is recorded for each phospholipid compound, it is possible to promptly select MRM transitions for fatty acid composition determination that correspond to compounds of the detected phospholipid classes, and to easily create an analysis method for the second-time analysis.
Owner:SHIMADZU CORP +1
Phospholipids for the Treatment of Infection by Togaviruses, Herpes Viruses and Coronaviruses
Owner:FLEMING RONALD A +7
A kind of anti-browning fresh-keeping method of lotus root
ActiveCN107960455BPrevent browningSafe anti-browning preservation methodFood ingredient as antioxidantFruits/vegetable preservation by irradiation/electric treatmentCell membranePhospholipid
Owner:ZHEJIANG OCEAN UNIV
A kind of lipid compound siRNA transfection reagent
Owner:常州百代生物科技股份有限公司
Method for preparing phosphatidic acid phospholipid compound by two-step method
InactiveCN106883263AReduce usageEasy to use and efficientGroup 5/15 element organic compoundsDiethyl phosphate1-Propanol
The invention provides a method for preparing a phosphatidic acid phospholipid compound by a two-step method. The method comprises the following two steps: step 1, preparing 3-amino-1-propanol and diethyl phosphate into (O,O)-diethylphosphorylation-3-amino-1-propanol under the action of NaClO; step 2, preparing phosphatidic acid and diethylphosphorylation-3-amino-1-propanol into a target product under the action of DCC, namely the phosphatidic acid phospholipid compound. The method provided by the invention has the advantages of being simple in preparation process, mild in reaction conditions and low in synthesis cost, and the use of harmful CCl4, triethylamine and other organic reagents is avoided; meanwhile, a technical route for reaction can be suitable for preparation of kilogram-scale pilot test, which is the efficient, convenient and rapid method for preparing the phosphatidic acid phospholipid compound.
Owner:THIRD INST OF OCEANOGRAPHY STATE OCEANIC ADMINISTATION
A kind of phospholipid compound of hydrophilic drug, its pharmaceutical composition and application
The invention discloses a phospholipid compound of hydrophilic drugs as well as a pharmaceutical composition and application of the phospholipid compound. The pharmaceutical composition of the phospholipid compound of the hydrophilic drugs or a combined pharmaceutical composition of the phospholipid compound of the hydrophilic drugs and a pharmacologically acceptable carrier; and the pharmaceutical composition is in the form of a liquid preparation, a solid preparation, a semisolid preparation, a capsule, granules, a gel or an injection. The pharmaceutical composition is in the form of liposome nanoparticles prepared from the phospholipid compound of the hydrophilic drugs or the phospholipid compound of the hydrophilic drugs and adjuvants, and the pharmaceutical composition is 10-1000nm in grain size. The phospholipid compound of the hydrophilic drugs and the liposome nanoparticles thereof can serve as a liquid preparation, a solid preparation, a semisolid preparation, a sterilized preparation and a sterile preparation; and the phospholipid compound of the hydrophilic drugs and the liposome nanoparticles thereof are low in toxicity, and are applicable to the efficient treatment of various tumors and the like.
Owner:SOUTHEAST UNIV
A liposome dispersion loaded with AIE molecules and its preparation method and application
ActiveCN108042803BEasy to prepareGood biocompatibilityPhotodynamic therapyPharmaceutical non-active ingredientsPhospholipidLiposome
The invention relates to AIE molecules-loaded liposome dispersion liquid, and a preparation method and application thereof. The liposome dispersion liquid comprises a phospholipid compound microspherein which AIE molecules are dissolved, and a solvent for dispersing the phospholipid compound microsphere, and the AIE molecules are lipid-soluble molecules having the AIE effect. The preparation method of the liposome dispersion liquid is very simple, the prepared liposome dispersion liquid has good biocompatibility and uniform dispersibility, the particle size is between 100 and 300nm, specificrecognition of tumor cells can be achieved by utilizing the EPR effect of a tumor tissue, reactive oxygen can be produced after degradation in cells and illumination by light under specific wavelengths to kill the tumor cells, and the liposome dispersion liquid can be used for tumor treatment by adopting a PDT therapy method; compared with a traditional PDT therapy method, only partial illumination is needed, and there is no need to perform in a dark room, so that a patient can move freely to some extent.
Owner:北京柏欧利诺生物科技有限公司
Detection method and application for high-abundance and low-abundance class phospholipid compounds in cells
PendingCN112881567AAccurate detectionHigh sensitivityComponent separationChemical compoundPhosphatidal Compounds
The invention belongs to the technical field of biological sample materials and analysis, and discloses a detection method for high-abundance and low-abundance class phospholipid compounds in cells. According to the method, the UPLC-QqQ MS technology is adopted, and the phospholipid components in the cells are rapidly and effectively separated through UPLC; the glycerophosphatide components in cells are analyzed in a multi-reaction monitoring mode by adopting an ESI positive and negative ion scanning mode, and 218 phospholipid compounds are detected in total, including 44 PC and LPC; 37 kinds of PE and LPE; 38 kinds of PI and LPI; 24 kinds of PG; and 27 kinds of PA and LPA. The method has the characteristics of high specificity and high sensitivity, can be used as an effective means for separation and analysis of complex biological systems such as cells, serum and the like, and lays a foundation for research of phospholipid metabonomics.
Owner:上海鹿明生物科技有限公司
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