Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Metal organic framework catalyst as well as preparation method and application thereof

A metal-organic framework and catalyst technology, applied in organic compound/hydride/coordination complex catalysts, chemical instruments and methods, physical/chemical process catalysts, etc., can solve the problems of catalyst biocompatibility, low catalytic efficiency, etc. problems, to achieve the effect of improving adsorption contact ability, improving biocompatibility, and reducing metal content

Active Publication Date: 2021-12-14
XIEHE HOSPITAL ATTACHED TO TONGJI MEDICAL COLLEGE HUAZHONG SCI & TECH UNIV
View PDF6 Cites 4 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The purpose of the present invention is to provide a metal-organic framework catalyst and its preparation method and application, so as to solve the problems of unsatisfactory biocompatibility and low catalytic efficiency of current catalysts that catalyze the hydrolysis of phospholipid bonds

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Metal organic framework catalyst as well as preparation method and application thereof
  • Metal organic framework catalyst as well as preparation method and application thereof
  • Metal organic framework catalyst as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Synthesis of Aminotetraphenylmethane

[0037] Add 14.3g of triphenylmethanol, 7.7mL of aniline, 200mL of acetic acid and 28mL of concentrated hydrochloric acid into a 500mL flask, heat at 120°C for 8 hours, cool to room temperature, and neutralize with 6M sodium hydroxide to obtain aminotetraphenyl Methyl methane white powder. The pure product can be obtained by column chromatography with petroleum ether / dichloromethane=1:1 eluent.

Embodiment 2

[0039] Synthesis of Tetraphenylmethane

[0040] Add 850.9mg of tetraaminophenylmethane, 63.8mL of ethanol and 8.6mL of concentrated sulfuric acid into a 250mL flask, mix and cool to -10°C, add 1.4mL of isoamyl nitrite, stir for 30min, then add 6.5mL of 50% Hypophosphorous phosphoric acid, and then heat up to 80°C for 20 minutes to obtain yellow tetraphenylmethane.

Embodiment 3

[0042] Synthesis of Tetrabromophenylmethane

[0043] Add 5.0g of tetraphenylmethane into a 250mL flask, cool to 0°C, add 10mL of bromine water dropwise, then slowly warm up to room temperature and react for 20 minutes, then cool to -78°C, add 50mL of ethanol, warm up to room temperature, and add to the sodium sulfite solution and excess bromine water to obtain a dark yellow product.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a metal organic framework catalyst as well as a preparation method and application thereof. The preparation method comprises the following steps: 1) synthesizing a ligand, namely tetrakis(4-carboxyl)terphenyl methane; 2) synthesizing the metal organic framework catalyst constructed by an organic ligand and a metal cluster; and 3) calculating the efficiency of the catalytic phospholipid compound and exploring related mechanisms. According to the invention, an inorganic-organic hybridization strategy is adopted, and a high-pore catalyst is synthesized based on the advantages of a metal organic framework material. An adopted organic hybridization strategy can reduce the content of metal and improve the biological compatibility of catalysis; and a high-pore structure can improve the adsorption contact capacity of the catalyst and guest molecules and improve the catalytic efficiency, so performance optimization is achieved.

Description

technical field [0001] The invention relates to the technical field of catalyst material synthesis, in particular to a metal-organic framework catalyst, a preparation method, and an application. Background technique [0002] Phospholipid bonds are very common in living organisms, such as DNA, RNA, phospholipidated proteins, and ATP. Catalyzing the hydrolysis of phospholipid bonds can regulate the activity of proteins and the stability of DNA and RNA, further enabling the development of different therapeutic methods. Therefore, designing and synthesizing catalysts that catalyze phospholipid bonds is of great significance in the field of biomedicine. [0003] It has been reported that the catalysts capable of catalyzing the hydrolysis of phospholipid bonds are inorganic nanoparticles or small molecular compounds, such as: cerium oxide nanoparticles (M.H.Kuchma, C.B.Komanski, J.Colon, A.Teblum, A.E.Masunov, B.Alvarado, S.Babu, S.Seal, J.Summy, C.H.Baker, Nanomed.Nanotechnol.,...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): C08G83/00B01J31/22A61K31/80A61P43/00
CPCC08G83/008B01J31/2239A61K31/80A61P43/00B01J2531/48Y02P20/54Y02W10/37
Inventor 王征王琳刘志博张红艳汪洋
Owner XIEHE HOSPITAL ATTACHED TO TONGJI MEDICAL COLLEGE HUAZHONG SCI & TECH UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com