A liposome dispersion loaded with AIE molecules and its preparation method and application
A technology of dispersion liquid and liposome, which is applied in the direction of non-active ingredient medical preparation, medical preparation containing active ingredient, liposome delivery, etc., to achieve good biocompatibility, uniform dispersion, and simple preparation method Effect
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Embodiment 1
[0054] Prepare liposome dispersion liquid 1 through the following steps:
[0055] Step (1): Disperse 5 mg of bispyrene molecules in a solvent obtained by mixing acetone and water at a volume ratio of 1:16. Use a magnetic stirrer to mix and stir for 20 minutes at a speed of 800 revolutions / min. The pyrene molecules are evenly dispersed to obtain a dispersion of bispyrene molecules with a concentration of 0.3 mg / mL;
[0056] Step (2), take the bispyrene molecular dispersion obtained in step (1) and add it to a solution in which 550 mg of dimyristoylphosphatidylcholine is dissolved in a solvent with a volume ratio of 1:1 of anhydrous methanol and chloroform , Ultrasonic treatment for 40min to make it evenly mixed, then put the mixed liquid into the rotary evaporator, adjust the rotary evaporator to work at a speed of 50 rpm for 45 minutes, so that all the solvents in it volatilize and form uniform and transparent on the rotating plane of the rotary evaporator The film is a phospholip...
Embodiment 2
[0059] Prepare liposome dispersion 2 through the following steps:
[0060] The difference from Example 1 is that the dimyristoylphosphatidylcholine used in each step is replaced with a mixture of phospholipid polyethylene glycol folic acid with a number average molecular weight of 3230 and dimyristylphosphatidylcholine.
[0061] In Example 2, liposome dispersion liquid 2 was obtained.
Embodiment 3
[0063] Prepare liposome dispersion 3 through the following steps:
[0064] The difference from Example 1 is that the solvent in step (1) is replaced with tetrahydrofuran, the rotating speed of the magnetic stirrer is adjusted to 100 revolutions / min, and the time of ultrasonic treatment is adjusted to 10 min.
[0065] In Example 3, liposome dispersion 3 was obtained.
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