99 results about "Neurologic injury" patented technology

A disk replacement endoprosthesis and a procedure for implantation of the endoprosthesis to treat pain, nerve root compression, and neural injury caused by degeneration or injury to vertebral disks. The endoprosthesis may include an intervertebral wedge or other body having a lead-in distractor. A fastening plate may be attached to the intervertebral wedge by a joint such that the first fastening plate may move from a first configuration in which the first fastening plate is in-line with the intervertebral wedge to facilitate insertion of the endoprosthesis to a second configuration in which the first fastening plate is in contact with an anterior surface of the inferior vertebral body for attachment thereto.

Provided are activated collagen scaffold materials as well as their special fused active restoration factors useful for promoting tissue repair, such as bone damage repair or nerve injury repair. The special fused active restoration factors are fusion proteins comprising a collagen-binding domain (CBD) at N- / C-terminus of cytokines, wherein the collagen-binding domain is a polypeptide consisting of 7-27 amino acid residues with a conservative sequence shown in SEQ IN NO:1 at N-terminus.

The present invention provides amine derivatives represented by formula I, its isomers, racemes or optical isomers, pharmaceutical salts thereof, its amides or esters, pharmaceutical compositions containing said compounds and the preparation methods thereof. The invention also relates to the use of the above mentioned compounds in the preparation of drugs for the prophylaxis or treatment of cardiovascular diseases, diabetes, bronchial and urinary smooth muscle spasm as well as ischemic and anoxic nerve injury. The above compounds can be used to treat hypertension, angina diaphragmatic, myocardial infarction, congestive heart failure, arrhythmia, diabetes, spasmodic bronchial diseases, spasmodic bladder or ureter diseases, and depression.

Methods of enabling locomotor control, postural control, voluntary control of body movements (e.g., in non-weight bearing conditions), and / or autonomic functions in a human subject having spinal cord injury, brain injury, or neurological neuromotor disease. In certain embodiments, the methods involve stimulating the spinal cord of the subject using an epidurally placed electrode array, subjecting the subject to physical training thereby generating proprioceptive and / or supraspinal signals, and optionally administering pharmacological agents to the subject. The combination of stimulation, physical training, and optional pharmacological agents modulate in real time electrophysiological properties of spinal circuits in the subject so they are activated by supraspinal information and / or proprioceptive information derived from the region of the subject where locomotor activity is to be facilitated.

The present invention relates to novel non-sedating barbituric acid derivatives, pharmaceutical compositions containing them and methods of neuroprotection in cases of cerebral ischemia, head trauma and other acute neurologic injuries, and prevention of resulting neuronal damage. The invention also relates to the use of non-sedating barbituric acid derivatives given in a manner and dosage effective to produce blood levels and brain levels of these drugs and / or their active metabolites sufficient to provide a therapeutic effect.

Methods, uses, agents and compositions useful for the prevention, treatment and / or diagnosis of neuroinflammatory conditions such as multiple sclerosis and spinal cord injury based on the modulation of nerve injury-induced protein-1 (Ninjurin-1) are disclosed.

The present invention relates to novel non-sedating barbituric acid derivatives, pharmaceutical compositions containing them and methods of neuroprotection in cases of cerebral ischemia, head trauma and other acute neurologic injuries, and prevention of resulting neuronal damage. The invention also relates to the use of non-sedating barbituric acid derivatives given in a manner and dosage effective to produce blood levels and brain levels of these drugs and / or their active metabolites sufficient to provide a therapeutic effect.

The invention belongs to the field of medical biological materials capable of being implanted in human bodies, and relates to tissue engineering nerve graft for repairing injured nerves and a method for preparing the tissue engineering nerve graft. The tissue engineering nerve graft and the method have the advantages that micro-pattern techniques and freeze-dry molding processes are combined with one another, accordingly, an artificial nerve conduit favorable for adhesion and growth of nerve cells can be provided, orientation stripe structures are arranged on the inner walls of the conduit, the walls of the conduit are of loose porous structures, and suture or adhesion of the side walls of the conduit can be omitted during usage; the method for preparing the nerve conduit is simple and feasible and is applicable to mass production.

A method for treating neural damage with a composition prepared from roots of bupleurum and scutellaria.

The invention relates to a fibroin three-dimensional bracket for nervus centralis remediation, and belongs to the field of biological medicinal materials. The fibroin three-dimensional bracket comprises fibroin protein fiber with grooves, fibroin protein / hyaluronic acid plural gel and fibroin membrane conduits. By adopting the fibroin three-dimensional bracket, defects that a conventional bracket is low in mechanical property, low in biodegradability and the like are overcome. By adopting the fibroin three-dimensional bracket, physiological states of an extracellular matrix can be simulated, adhesion, migration, amplification and differentiation of cells can be facilitated, and furthermore orientated growth of axon to fracture parts can be guided; due to connection of the bracket, glial scars can be inhibited, and thus remediation of a nervus centralis system can be facilitated; and the bracket can be applied to basic research on neural injury remediation, can be also applied to bridging remediation of human body spinal cord injury or deficiency, and has good biomedical prospects.

The invention relates to the technical field of tissue engineering, in particular to a tissue engineering material for nerve injury repair as well as a preparation method and application of the tissueengineering material. The tissue engineering material for nerve injury repair is a linear ordered collagen stent of crosslinked N-cadherin. The tissue engineering material prepared by crosslinkingtheN-cadherin in the linear ordered collagen stent can efficiently induce neural stem cells to migrate towards an injury region, enrich neutral stem cells in the injury region, effectively inhibit deposition of inhibitors such as chondroitin sulfate proteolgycan and promote differentiation of the neutral stem cells towards neurons so as to promote recovery of electrophysiological and motion functions; and meanwhile, the N-cadherin crosslinked linear ordered collagen stent also has stable and ordered topological structures and excellent mechanical properties and thus can be used for repairing nerve injuries such as spinal cord injury.

The present invention provides methods and compositions for promoting recovery of function from neurologic injury, such as ischemic injury caused by acute stroke.

The invention relates to a high-emulation tissue-engineered nerve repair material which is characterized by being prepared from mixing one, two or three of type I collagen, chitosan and gelatin. The material is prepared from the following raw materials in parts by weight: 1-10 parts of the type I collagen and 1 part of the chitosan. The material can be used for the basic research on nerve injury repair and the bridge repair of clinic human spinal cord and peripheral nerve injury or defect, is beneficial to the growth of nerve regenerated fiber and can also be used for the repair of spinal cord and peripheral nerve injury.

The invention relates to a nerve repair drug-carrying system with bioelectrical stimulation and angiogenesis promoting effects and a preparation method thereof. Gelatin, chitosan, polylactic acid andother natural polymer components in the nerve repair drug-carrying system ensure good biocompatibility and no toxicity, polylactic acid can also meet the good mechanical property requirement of a catheter, catheter collapse in the nerve growth process is avoided, and excellent flexibility enables the nerve repair drug-carrying system not to hinder nerve regeneration. Due to the introduction of a conductive copolymer GO, the catheter has weak conductivity, meets the requirement of physiological current of a human body, and is beneficial to accelerating nerve repair; and by introducing a VEGF growth factor, an extracellular matrix microenvironment in a human body can be simulated to the maximum extent, nerve repair is promoted from the microvascular regeneration acceleration direction, and finally the nerve injury repair quality is improved.

The invention belongs to the field of medicinal chemistry, and relates to a preparation method and application of pongamol. The preparation method comprises the following steps: with 1,3-cyclohexanedione (6) as a starting raw material, carrying out a cyclization reaction to obtain 6,7-dihydro-4-(5H)-benzofuranone (7); carrying out acylation reaction on the compound (7) to obtain 5-acetyl-6,7-dihydro-4-(5H)-benzofuranone (8); carrying out dehydrogenation reaction on the compound (8) to obtain 1-(4-hydroxy-5-benzofuryl) ethyl ketone (3); carrying out methylation reaction on the compound (3) to obtain 1-(4-methoxy-5-benzofuryl) ethyl ketone (4); and condensing the compound (4) with benzoyl chloride to obtain the pongamol. According to the preparation method, the selected reagents are cheap and easy to obtain, the post-treatment method is simple, the reaction conditions are mild, and the product yield is high. Pharmacological activity experiments show that the synthesized compound has nerve injury resistance and anti-inflammatory activity, which means that the compound has a good application prospect in the field of treatment of nerve injury and inflammation related diseases.

The invention relates to an O-aryl glycoside derivative, a preparation method and application thereof in preparation of drugs or pharmaceutical compositions. The O-aryl glycoside derivative (I), its isomer, prodrug, solvate or pharmaceutically acceptable salt has a structure shown as the specification. The O-aryl glycoside derivative provided by the invention has good efficacy of treating ischemicnerve injury, especially has no strict time window limit in treatment of ischemic nerve injury after stroke molding, and can achieve continuous multiple dosing within 7 days to generate better efficacy.

The invention discloses a bitter gourd exosome, and an extraction method and application of same. Extraction comprises the following steps: taking fresh wild bitter gourds of Yunnan, removing seeds, and cleaning and drying the bitter gourds; obtaining bitter gourd juice by squeezing, centrifuging the bitter gourd juice continuously, taking the supernatant after centrifugation and discarding the sediment; conducting ultra-centrifugation of the obtained supernatant, discarding the supernatant, taking the sediment and suspending the sediment in a phosphoric acid buffer salt solution of 1-2mL; andfiltering the suspension with a 0.22 mum filtering film, centrifuging the filtrate in an ultra-centrifugation refrigeration machine for centrifugation again, discarding the supernatant, taking the sediment and suspending the sediment in the phosphoric acid buffer salt solution of 1-2mL. The extracted bitter gourd exosome can be used for preparing medicines of ischemic cerebral apoplexy. The extraction method disclosed by the invention is convenient and effective, the extraction purity is high, and the extracted bitter gourd exosome can protect nerve injuries after cerebral apoplexy.

The object of the present invention is to provide a therapeutic agent for nerve damage caused by spinal cord injury, nerve trauma, etc., which contains low molecular weight sugars as active ingredients. The low molecular weight sugars include at least glucuronic acid and / or N-acetylglucosamine. As constituent sugars or pharmaceutically acceptable salts thereof. Preferably, the nerve damage treatment agent contains low molecular weight hyaluronic acid (further preferably hyaluronic acid disaccharide to hyaluronic acid 2500 sugar, further preferably hyaluronic acid disaccharide to hyaluronic acid 50 sugar, particularly preferably hyaluronic acid tetrasaccharide ) or a pharmaceutically acceptable salt thereof as the active ingredient.

The invention belongs to the technical field of biomedical materials, and discloses a conductive degradable multifunctional tissue engineering scaffold and a preparation method thereof. A precursor for forming the conductive degradable tissue engineering scaffold comprises a two-dimensional phosphorus-based nano material, a biopolymer material and a cross-linking agent, wherein the biopolymer material and the cross-linking agent are used for forming a framework of a hydrogel scaffold, and the two-dimensional phosphorus-based nano material is used for being loaded in or on the surface of the hydrogel scaffold to improve the conductivity of the scaffold. The key components of the scaffold and the precursor thereof are improved, and the two-dimensional phosphorus-based nano material is introduced to be matched with the biopolymer material (such as a natural polymer material naturally existing in nature) to participate in formation of the conductive degradable multifunctional tissue engineering scaffold and the precursor thereof, and the obtained tissue engineering scaffold has conductive and degradable functions, can guide nerve regeneration, and greatly promotes functional recovery of nerve injury areas.

The invention relates to a method of treating optic nerve damage, ophthalmic ischemia or ophthalmic reperfusion injury including the step of administering an effective amount of a peptide comprising the sequence: GlyArgArgAlaAlaProGlyArgAibGlyGly (SEQ ID NO:1) or the sequence GlyArgArgAlaAlaProGlyArgAibGlyGly-HN2 (SEQ ID NO:2) to a subject in need thereof.

The invention belongs to the technical field of high polymer materials. The invention provides supramolecular hydrogel as well as a preparation method and application thereof. The preparation method of the supramolecular hydrogel comprises the following steps: mixing gelatin and pyrrole, and then adding an oxidizing agent for polymerization to obtain a mixed solution; and adding tannic acid to the mixed solution for crosslinking, and the supramolecular hydrogel is obtained. Pyrrole is polymerized under the action of an oxidizing agent to obtain polypyrrole, and tannic acid contains rich phenolic hydroxyl groups. The preparation method is easy to operate and short in gelling time, and the prepared supramolecular hydrogel has good plasticity and electroactivity and can be self-healed at room temperature without being stimulated by external conditions. The supramolecular hydrogel has a three-dimensional porous structure, is beneficial to transmission of nutrient substances and electrons, has mechanical properties matched with nervous tissues, can be clinically applied to tissue engineering nerve conduits and damaged nerve repair, and has a great application prospect in the aspect of nerve injury repair.

The present invention provides systems and methods for detection and diagnosis of concussion and / or acute neurologic injury comprising a portable headwear-based electrode array and computerized control system to automatically and accurately detect cortical spreading depression and acute neurological injury-based peri-infarct depolarization (CSD / PID). The portable headwear-based electrode system is applied to a patient or athlete, and is capable of performing an assessment automatically and with minimal user input. The user display indicates the presence of CSD / PID, gauges its severity and location, and stores the information for future use by medical professionals. The systems and methods of the invention use an instrumented DC-coupled electrode / amplifier array which performs real-time data analysis using unique algorithms to produce a voltage intensity-map revealing the temporally propagating wave depressed voltage across the scalp that originates from a CSD / PID on the brain surface.

The present invention provides central nervous system neural progenitor cells which can induce neurons with synapse forming ability, oligodendrocytes, astrocytes and the like when transplanted into an injured or disabled spinal cord, a method for preparing said central nervous system neural progenitor cells, a method for screening promoters or inhibitors of synapse formation using said central nervous system neural system neural progenitor cells, a therapeutic drug to improve neural injuries or neural functions using said central nervous system neural progenitor cells, and the like. The central nervous system neural progenitor cells comprising neural stem cells derived from the spinal cord and cultured in the presence of cytokine, is transplanted into the injury site at a certain period after the spinal injury. The transplantation can induce neurons with synapse forming ability, oligodentrocyte, and astrocytes in the injury site, resulting in forming synapses between induced neurons and host neurons, and thus the injured spinal cord function is improved.

The invention discloses a tissue engineering nerve complex as well as a preparation method and application thereof, and belongs to the field of biomedical materials. The tissue engineering nerve complex comprises a nerve conduit, a fiber scaffold and an injectable shear thinning biological material, wherein the nerve conduit is filled with the fiber scaffold and the injectable shear thinning biological material; the injectable shear thinning biological material (VEGF-iSTB) is prepared from gelatin, nano silicate SNPs, a vascular endothelial growth factor and water. The tissue engineering nerve complex containing VEGF-iSTB is prepared by utilizing a VEGF-iSTB slow release system and is transplanted to the subcutaneous part of a host, so that the pre-vascularized tissue engineering nerve complex is constructed; then, the pre-vascularized tissue engineering nerve complex is used for transplanting and repairing long-distance defects of sciatic nerves of rats, fusion with a host vascular system after transplantation can be achieved, and then the nerve injury repairing effect is improved.

According to the invention, human induced pluripotent stem cells are differentiated into NSCs in vitro, human umbilical cords are separated and cultured into MSC auxiliary materials, the materials are used according to the proportion of 1: 1, PBS is used as a solvent, an obtained cell biological product is jointly transplanted to the spinal cord of a mouse with acute spinal cord injury (at the thoracic marrow T10 stage) in situ, nerve injury repair is effectively promoted, and the motor function is improved. The product for treating animal acute spinal cord injury can be differentiated into neurons and glial cells in the host body, reduce the glial scar area, reduce fibrosis and reduce the inflammation level, so that the animal motor function, especially limb coordination, is improved, and the product fully plays a role in subsequent treatment of the spinal cord injury and promotion of tissue repair.

The invention discloses circular RNA circ-01477 and an application thereof to preparation of drugs for promoting nerve regeneration and repairing nerve injuries. Research results indicate that by means of down-regulation or suppression of organism circ-01477 expression, proliferation and migration of astrocytes are suppressed, and repair of central nerve injuries is facilitated.

The invention relates to the technical field of nerve vertigo and discloses a cranial nerve injury patient vertigo protection mechanism. The mechanism comprises a shell, wherein an air bag is fixedly connected to the inner side of the shell, a connecting block is fixedly connected to the inner wall of the shell, an electrode column is fixedly connected to the inner wall of the connecting block, and a leather ring is fixedly connected to the outer side of the electrode column; an electric heating wire is fixedly connected to the inner side of the leather ring, a round hole is formed in an inner wall of the connecting block, an electromagnet is fixedly connected to the inner wall of the shell, and a limiting block is elastically connected to the position, close to the outer side of the electromagnet, of the inner wall of the shell. According to the vertigo protection mechanism for the cranial nerve injury patient, through explosion of sodium azide in the leather ring, when the cranial nerve patient is in a standing state, if vertigo occurs, the cranial nerve patient topples over, a head of the cranial nerve patient is prevented from colliding with the ground, damage to the head is avoided, and damage to the cranial nerve patient is relieved; and potential safety hazards in rehabilitation of cranial nerve patients are eliminated.

The invention discloses a tetrodotoxin compound preparation which comprises the following components: tetrodotoxin, lidocaine, puerarin and an excipient. The invention also discloses use of the tetrodotoxin compound preparation in the preparation of a medicament for treating neuropathic pain, wherein the neuropathic pain is diabetic peripheral neuropathic pain or neuropathic injury pain. The novel tetrodotoxin compound preparation provided by the invention is used for treating diabetic peripheral neuropathic pain and neuropathic injury pain, and has advantages of small toxic side effect, good analgesic effect and the like.

A portable traction frame self-carrying a loading device includes a main traction frame combination, an attachment frame combination and the loading device; the distance between the main traction frame combination and the attachment frame combination can be adjusted to suit patients with different heights; the loading device applies traction force through a coil spring internally arranged, even when a patient moves, the traction force also keeps stable and the pain caused by the change of the traction force to patients is avoided. The main traction frame combination is also equipped with a sole baffle plate which can solve foot sagging of patients with nerve injury; the attachment frame combination is also equipped with a height regulating frame, and the height regulating frame can adjustthe angle between a crus attachment frame and a thigh attachment frame to adapt to patients with different heights and make the patients more comfortable. The main traction frame combination is also equipped with a fixed belt with hook and loop fasteners, and the fixed belt can fix the device conveniently on a sickbed.