120 results about "Multiple dosing" patented technology

An automated drug dispensing system includes a cabinet adapted to store a variety of prepackaged pharmaceuticals in a plurality of bins for filling patient prescriptions. Each bin stores a particular variety of packaged multiple-dose pharmaceutical. Each variety of pharmaceutical is associated with a particular code. A controller receives request signals and in response generates dispense signals. Each bin includes a dispenser coupled to the controller for dispensing the packaged pharmaceuticals therefrom in response to a dispense signal sent from the controller. After a package is dispensed, a code reader determines the code of the dispensed package and verifies whether the code on the dispensed package matches the code of the requested package.

A dispenser for holding multiple doses of fluids or other substances, and for dispensing the substances, has a vial, a flexible bladder received within the vial, and a variable volume storage chamber formed between the bladder and vial. A filling valve is coupled in fluid communication with the storage chamber and defines (1) a normally closed, fluid-tight position hermetically sealing the storage chamber from the ambient atmosphere, and (2) an open position allowing the passage of fluid through the valve both to evacuate the storage chamber and to introduce fluid through the valve to fill the storage chamber. A pump is coupled in fluid communication with the storage chamber for pumping fluids out of the storage chamber. A dispensing valve is coupled in fluid communication with the pump and defines (1) a normally closed, fluid-tight position preventing the passage of fluid out of the dispenser, and (2) an open position for dispensing pumped fluid therethrough. The sealed, empty dispenser is sterilized, such as by applying gamma radiation thereto. Then, the sterilized, sealed, empty dispenser is filled with fluid by engaging the filling valve with an evacuating / dispensing member to evacuate the storage chamber, and by introducing fluid from the filling member through the open filling valve and into the storage chamber. The filling member is withdrawn from the valve, and a spring moves the valve to a closed position to hermetically seal the fluid within the dispenser.

A reusable continuously sealing one-way valve assembly and delivery system flows a sterile flowable substance from a source to an outlet orifice and prevents any backflow of contaminants through the continuously sealing one way valve assembly when the flowable substance ceases to flow. The valve assembly includes an elastomeric membrane which aids in preventing any backflow of contaminants when dispensing of the flowable substance is stopped. Multiple dosing of preservative-free flowable substance is provided.

A reusable continuously sealing metered dosing one-way valve assembly and delivery system flows a premeasured amount of a sterile flowable substance from a source which is coupled to an actuator assembly to an outlet orifice and prevents any backflow of contaminants through the continuously sealing one way valve assembly when the flowable substance ceases to flow. The valve assembly includes an elastomeric membrane which aids in preventing any backflow of contaminants when dispensing of the flowable substance is stopped. Multiple dosing of preservative-free flowable substance is provided.

Medicine injection apparatuses having multiple chambers. The chambers may be in lateral relationship. A torsional part is adapted to turn and be repositioned angularly relative to a main body to allow different chambers to be used to receive an injection assembly. The medicine injector can be constructed to administer multiple doses. The apparatuses may also have a storage chamber for storing the injection assembly after use. Plural drivers may be used to administer multiple doses, such as at the different angular positions of the torsional part. The apparatuses may allow multiple automatic injections from different angular positions and storage of an injector after use. Needle fright is reduced by minimizing exposure of an injection needle prior to injection.

This invention relates to a drive mechanism for a drug delivery device, drug delivery devices comprising the drive mechanism of the invention and a method of assembling such drug delivery devices, which allow the user to select multiple doses of an injectable drug and to dispense the set dose of the drug.

Disclosed is a pocketable container in the form of a resealable polymeric packet designed to hold and disperse multiple doses of a useful fluid. Resealing is achieved by means of a simple yet reliable fold closure technique making possible a cost effective tool for carrying about small quantities of useful liquids, specifically hand sanitizing fluids for control of sickness and infectious disease in a human population.

A dispenser has a body with a variable-volume storage chamber for storing substance, and a dispensing portion defining a dosage chamber in fluid communication with the storage chamber. A first valve includes a valve seat and a flexible valve cover seated thereon defining a normally-closed fluid-tight seam therebetween. The valve cover relative to moves from the valve seat to allow substance through the seam and out of the dispenser. A second valve allows substance from the storage chamber into the dosage chamber and substantially prevents flow from the dosage chamber into the storage chamber. An actuator is manually movable between (i) a first non-actuated position, and (ii) a second actuated position extending into the dosage chamber for compressing a dose of substance therein, dispensing substance through the first valve. The elasticity of the actuator causes it to return to the first non-actuated position upon manually releasing the actuator.

The present disclosure provides for methods of treating a patient with a CYP3A4 substrate drug contraindicated for concomitant administration with a strong CYP3A4 inhibitor, wherein the patient is treated with multiple doses of posaconazole, stops posaconazole treatment, and then is treated with the CYP3A4 substrate drug. In some embodiments, treatment with the CYP3A4 substrate drug is delayed for about 2-21 after stopping posaconazole. In some embodiments, the patient is treated with or prescribed a reduced dose of the CYP3A4 substrate drug for about 2-21 after stopping posaconazole.

A dispensing device, a storage device and a method for dispensing a medical formulation are proposed. Multiple doses of the formulation are stored in a carrier having multiple inserts, each insert containing a single dose. Preferably, each insert has at least one duct or nozzle for dispensing the respective dose. Each insert is located in a separate and sealed cavity in the carrier. The cavities can be individually opened for dispensing the respective dose from the respective insert.

The invention relates to a device for the time-controlled dispensing of pharmaceutical compositions to a patient. The device is intended to allow multiple doses of pharmaceutical compositions to be delivered to a patient over a predetermined or programmable dosing schedule.