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Conductive degradable multifunctional tissue engineering scaffold and preparation method thereof

A technology of tissue engineering scaffold and dopamine, which is applied in the field of biomedical materials, can solve the problems of polypyrrole non-degradable, etc., and achieve good biological safety, improved safety, and good dispersion

Active Publication Date: 2021-09-24
HUAZHONG UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Another example, Chinese patent CN201610166842 discloses a method for preparing a nano-polypyrrole chitin nerve guide, although it also discloses a preparation method for a conductive nerve guide, but there is still the problem that polypyrrole is not degradable

Method used

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  • Conductive degradable multifunctional tissue engineering scaffold and preparation method thereof
  • Conductive degradable multifunctional tissue engineering scaffold and preparation method thereof
  • Conductive degradable multifunctional tissue engineering scaffold and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0055] Example 1 Preparation of Conductive and Degradable Multifunctional Tissue Engineering Scaffold

[0056] 1. Preparation of two-dimensional phosphorus-based nanosheets (BP)

[0057] Weigh 10 mg block crystal BP (when the block raw material is too large, conventional treatment such as grinding can be used to control the quality), sandwich it on the electrode holder as the cathode, and the platinum sheet as the anode, dissolve 0.01mol / L in 15mL propylene carbonate Tetra-n-butylammonium bisulfate (TBA·HSO 4 ) as an electrolyte solution, apply a voltage of -5V to the electrochemical workstation to peel off the phosphorus-based block for 30min, then perform ultrasonic treatment in a water bath for 1h, then perform centrifugation at 1500rpm for 20min and take the supernatant to obtain a suspension of two-dimensional BP nanosheets; the two-dimensional The suspension of BP nanosheets was centrifuged at 5000rpm for 20min and the precipitate was taken to obtain two-dimensional BP ...

Embodiment 2

[0063] Example 2 Preparation of Conductive and Degradable Multifunctional Tissue Engineering Scaffold

[0064] 1. Preparation of two-dimensional phosphorus-based nanosheets (BP)

[0065] Weigh 10 mg block crystal BP, clamp it on the electrode holder as the cathode, platinum sheet as the anode, dissolve 0.01mol / L TBA·HSO in 15mL propylene carbonate 4 As an electrolyte solution, a -5V voltage was applied to the electrochemical workstation to peel off the phosphorus-based block for 30min, then ultrasonically treated in an ice-water bath for 1.5h, and then centrifuged at 2000rpm for 15min and the supernatant was taken to obtain a suspension of two-dimensional BP nanosheets; The suspension of dimensional BP nanosheets was centrifuged at 7000rpm for 15 minutes and the precipitate was taken to obtain two-dimensional BP nanosheets;

[0066] Ultrasonic dispersion of two-dimensional BP nanosheets in a small amount of absolute ethanol, the amount of absolute ethanol can cover the precip...

Embodiment 3

[0071] Example 3 Preparation of Conductive and Degradable Multifunctional Tissue Engineering Scaffold

[0072] 1. Preparation of two-dimensional phosphorus-based nanosheets (BP)

[0073] Weigh 10 mg block crystal BP, clamp it on the electrode holder as the cathode, platinum sheet as the anode, dissolve 0.01mol / L TBA·HSO in 15mL propylene carbonate 4 As an electrolyte solution, a voltage of -5V was applied to the electrochemical workstation to peel off the phosphorus-based block for 30min, then ultrasonically treated in an ice-water bath for 2h, and then centrifuged at 3000rpm for 10min and the supernatant was taken to obtain a suspension of two-dimensional BP nanosheets; the two-dimensional The suspension of BP nanosheets was centrifuged at 8000rpm for 10min and the precipitate was taken to obtain two-dimensional BP nanosheets;

[0074] Ultrasonic dispersion of two-dimensional BP nanosheets in a small amount of absolute ethanol, the amount of absolute ethanol can cover the pr...

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Abstract

The invention belongs to the technical field of biomedical materials, and discloses a conductive degradable multifunctional tissue engineering scaffold and a preparation method thereof. A precursor for forming the conductive degradable tissue engineering scaffold comprises a two-dimensional phosphorus-based nano material, a biopolymer material and a cross-linking agent, wherein the biopolymer material and the cross-linking agent are used for forming a framework of a hydrogel scaffold, and the two-dimensional phosphorus-based nano material is used for being loaded in or on the surface of the hydrogel scaffold to improve the conductivity of the scaffold. The key components of the scaffold and the precursor thereof are improved, and the two-dimensional phosphorus-based nano material is introduced to be matched with the biopolymer material (such as a natural polymer material naturally existing in nature) to participate in formation of the conductive degradable multifunctional tissue engineering scaffold and the precursor thereof, and the obtained tissue engineering scaffold has conductive and degradable functions, can guide nerve regeneration, and greatly promotes functional recovery of nerve injury areas.

Description

technical field [0001] The invention belongs to the technical field of biomedical materials, and more specifically relates to a conductive and degradable multifunctional tissue engineering scaffold and a preparation method thereof. Background technique [0002] With the development of the economic level of countries in the world, the incidence of spinal cord injury is increasing year by year. Spinal cord injury is the most serious complication of spinal cord injury, often leading to severe dysfunction of the limbs below the level of injury. Spinal cord injury will not only bring serious physical and psychological harm to the patients themselves, but also cause a huge economic burden to the whole society. Due to the social and economic losses caused by spinal cord injury, the prevention, treatment and rehabilitation of spinal cord injury has become a major topic in today's medical field. [0003] Implantable scaffolds are an effective strategy to provide cell support. The ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/20A61L27/22A61L27/12A61L27/50A61L27/52A61L27/58C08B37/08C01B25/02C01B25/08C01B33/00
CPCA61L27/20A61L27/222A61L27/12A61L27/52A61L27/50A61L27/58C08B37/0072C01B25/02C01B25/08C01B33/00A61L2430/32A61L2400/12C08L5/08C08L5/04C08L89/00
Inventor 罗志强徐超
Owner HUAZHONG UNIV OF SCI & TECH
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