143 results about "Multi-component reaction" patented technology

Mixing and dispensing apparatus and methods for use with, e.g., a multi-component reactive material process is disclosed. In one embodiment, the apparatus comprises a series of positive displacement pumps adapted for stacked or “piggy-back” mating to a common motive source. At least one of the pumps is supplied by a sealed and collapsible reservoir bag and flexible tubing, thereby allowing removal (and optionally disposal) of one or more complete material pathways within the system. Such a configuration allows for, inter alia, rapid colorant changing with minimal material waste, obviates the use of hazardous solvents, and increases process efficiency and worker productivity. This arrangement also obviates complex metering apparatus common to prior art systems, thereby allowing it to be as small and power/cost efficient as possible.

A new class of imidazolines as 4-position acids or esters with very potent anti-inflammatory as well as antimicrobial activity is described. The synthesis of these imidazolines includes a multicomponent reaction applicable to a combinatorial synthetic approach. The combination of these two key characteristics provides an effective therapeutic drug in the treatment of septic shock as well as many other inflammatory (arthritis and asthma) and infectious disorders. The use of this novel class of non-steroidal agents as anti-inflammatory agents (for the treatment of asthma, etc.), antibacterial agents, and antiseptic agents is described. The compounds are also useful in the treatment of tumors (such as cancers). The imidazolines are potent inhibitors of the transcription factor NF-kappaB as well as potent activity against the Gram (+) bacterium. The compositions are also useful for treating autoimmune diseases and for inhibiting rejection of organ and tissue transplants.

A system for controlling dispensation of multiple component reactant mixtures. A mixing chamber is positioned adjacent to a part. A metering ram is actuated to pressurize at least two reactant components. The metering ram is stopped if a measured pressure value exceeds a predetermined pressure value. At least one flow meter measures a volume of a reactant component passing through the system.

A mod of combustion and a multi-component reactor to accomplish this mode of combustion are disclosed which produces fullerenes and fullerenic material by combustion. This mode consists of de-coupling an oxidation region of a flame from a post-flame region, thus giving greater control over operating parameters, such as equivalence ratio, temperature, and pressure ; allows conditions of the operating parameters of the combustion reaction to be attained which would not be easily attained by conventional methods; and offers the ability to more easily stabilize the combustion reactions to allow for higher throughputs of fuel and oxidant. Several embodiments of a primary zone of a multicomponent reactor are also disclosed. Said primary zone serves as the oxidation region, operates on the principle of providing recycle to the reacting combustion mixture, and which may be operated as approximately a well-mixed reactor. A secondary zone is also disclosed which provides further residence time for reaction and the ability to control operating parameters, operates on the principle of minimizing recycle of the reacting combustion mixture. The secondary zone may be operated as approximately a plug-flow reactor. The primary and secondary zones may be operated in conjunction or either one alone.

The present invention relates to a multifunctional reusable catalyst and to a process for the preparation thereof on a single matrix of the support to perform multicomponent reaction in a single pot. The multifunctional catalysts of the invention are useful for the synthesis of chiral vicinal diols by tandem and/or simultaneous reactions involving Heck coupling, N-oxidation and AD reaction of olefins in presence of cinchona alkaloid compounds both as an native one and immobilized one in the said matrix support. This invention also relates to a process for preparing vicinal diols by asymmetric dihydroxylation of olefins in presence of cinchona alkaloid compounds employing reusable multifunctional catalysts as heterogeneous catalysts in place of soluble osmium catalysts.

The invention relates to synthesis and uses of beta-1-imidazole-2,3,4,6-tetrasulfo-D-glucopyranose hydrosulfate and belongs to hydrosulfate chemical synthesis by multi-component reactions and uses of the hydrosulfate. The synthesis includes: subjecting glucose 1 that is adopted as a raw material to acetylation to obtain a compound 2; performing bromination by adopting the compound 2 as a raw material to obtain a compound 3; reacting the compound 3 with 1-methylimidazole to obtain a compound 4; hydrolyzing the compound 4 under alkaline conditions to obtain a target compound 5; and reacting the compound 5 with chlorosulfonic acid to obtain a target product 6 that is the beta-1-imidazole-2,3,4,6-tetrasulfo-D-glucopyranose hydrosulfate. A five-component reaction of 2 equivalents of an aromatic aldehyde, 2 equivalents of an arylamine and 1 equivalent of ethyl acetoacetate is performed by adopting the target product 6 as a catalyst at 40 DEG C under mild conditions to synthesize an ethyl 4-phenylamino-1-phenyl-1,2,5,6-tetrahydro-2,6-diphenylpyridine-3-carboxylate derivative. The synthesis and the uses are characterized in that: (1) the product 10 is obtained rapidly with a high yield; (2) reaction conditions are mild, operation is simple, reaction time is short, the yield is high and after-treatment is simple and convenient; and (3) the synthesis is green, economical and efficient.

The invention provides a 1,3-cyclodiketone enol ether compound, a 1-asymmetirc donor-receptor cyclopropane as well as synthesis methods thereof. By use of a reaction method for selectively using oxygen atoms of 1,3-cyclodiketone as nucleophilic sits to perform nucleophilic attack on 1-symmetric donor-receptor cyclopropane, a 1,3-cyclodiketone enol ether compound is obtained; a novel 1-asymmetirc donor-receptor cyclopropane 5 is obtained through intracellular conversion of the compound 3. The 1-asymmetirc donor-receptor cyclopropane 5 is obtained efficiently through desymmetrization of 1-asymmetirc donor-receptor cyclopropane through the simple two-step reaction. Meanwhile, the 1-asymmetirc donor-receptor cyclopropane 5 contains a cycloketene structure which is a very good intermediate module for constructing complex compounds in Domino and multi-component reactions.