51 results about "Hyperplastic scar" patented technology

The invention discloses chitosan-silicone dressing as well as a preparation method and application thereof. The chitosan-silicone dressing comprises chitosan, silicone, an organosilicone antibacterial agent and matrix. The chitosan silicone dressing is reasonable in formula, convenient to prepare, capable of effectively inhibiting various hyperplastic scars caused by burn injury, trauma, surgery, infection and the like and various wounds caused by protecting burn injury, trauma, surgery, inflection and the like, controlling wound infection, keeping wounds moist and promoting the heating of wounds; and the chitosan silicone dressing has the bacteria inhibition capability being higher than or equal to 99% for Staphylococcus aureus and Escherichia coli.

The invention discloses silicone dressing, and a preparation method and the use thereof. The silicone dressing is prepared from silicone, an organosilicon antibacterial agent, and matrix. The silicone dressing is reasonable in formula and convenient to prepare, can effectively restrain various hyperplastic scars caused by the reasons of burn, trauma, surgery, infection and the like, protects various wound surfaces caused by the reasons of burn, trauma, surgery, infection and the like, controls wound surface infection, keeps the wound surface wet, and promotes the wound surface to heal. The effective rate achieves over 95% by validation of more than 100 clinical cases; and the bacteriostatic ability of the product on staphylococcus aureus and escherichia coli can be over 99%.

The invention relates to the field of medical / cosmetic apparatuses, and in particular relates to scar-repairing silica gel containing human-like collagen, wherein the rapid transdermal absorption of the human-like collagen can be promoted. The scar-repairing silica gel can be used for repairing hyperplastic scars or keloids caused by burns, scalds, trauma, operations and the like in the medical / cosmetic field. The scar-repairing silica gel contains the human-like collagen, silica, cyclopentasiloxane, dimethiconol, water and polydimethylsiloxane.

Provided are a wound dressing and a preparation method thereof.The wound dressing is composed of a silicone membrane layer and an electrospun nanofiber layer.The preparation method comprises the steps that silicone, liquid paraffin, normal hexane and span-80 are mixed to be uniform, the mixed solution is cast in a polytetrafluoroethylene mold through a membrane casting method, after a membrane is formed through drying, a silicone membrane is soaked in ethyl alcohol, the composition of paraffin is removed, and the silicone membrane with a pore structure is obtained; eletrospinning is conducted on the silicone membrane to form a layer of biodegradable polymer nanofibers through an eletrospinning method, after drying is conducted, radiation sterilization is conducted, and a finished product is obtained.The wound dressing prepared through the method has good moisture retention and air permeability, the wound can be kept moist, hypertrophic scars are prevented, body tissue generation can be promoted by means of the unique support function of the nanofiber layer, and wound healing is accelerated.

The invention belongs to the field of gene engineering and relates to a targeted hIL-10 recombinant protein called as CBD-IL-10 for short and the application of the CBD-IL-10. The recombinant protein is a recombinant protein expressed by a CBD polypeptide combined by human interlenkin10, hIL-10 and collagen specificity after the fusion in a gene level, and a new protein is generated after recombination. The protein has the anti-virus and anti-tumor activities as well as the immune function same as the hIL-10; and more importantly, the CBD-IL-10 can be combined with the collagen specificity in a targeted way during the wound healing process and can prevent and inhibit the formation of scars in the application of the drug for treating the hyperplastic scar and keloid.

The chromaticity analysis method of hyperplastic scar of human body relates to a chromaticity detection method of image, and includes the following steps: using photoelectric test technology to obtain human scar tissue and colour image of normal skin, after A / D conversion, utilizing computer system and using module with artificial neural network function in the computer program to make chromaticity correction and chromaticity analysis, finally extracting characteristic chromaticity parameter so as to can objectively and accurately define scar healing time. Said invention is applicable to traumatic scars resulted from various scalds and burns, utilizes chromaticity analysis to provide scientific basis for evaluating therapeutic effect of scar and making therapeutic scheme.

The invention relates to application of captopril to the preparation of medicaments for treating and / or inhibiting scar hyperplastic diseases. Particularly, the hyperplastic diseases comprise hyperplastic scar, cheloid, urethral scar stricture and silicon gel breast augmentation prosthesis postoperative capsular contracture. When the diseases are treated, the captopril is used as an active ingredient, clinically-used emulsifiable paste, gel, injection and the like in different formulations are prepared by the conventional preparation process. The study indicates that the captopril can reduce the capacity of synthesizing pathologic scar fibroblast collagen and secreting the collagen, weaken the multiplication capacity of fibroblasts and reduce the expression of transforming growth factor-beta 1 (TGF-beta 1), and has a good treatment or prevention effect on pathologic scars. Simultaneously, the captopril acts on scar tissue directly, has the advantages of small dose, high curative effect, small side effect, mature raw material process, readily available materials, low cost and the like, and is expected to become a main medicament for treating and preventing the scars clinically.

The invention discloses a film for hyperplastic scar repair and a preparation method thereof. The film comprises a back lining layer, a viscous polymer layer and an isolation layer which are sequentially bonded, wherein the viscous polymer layer comprises a viscous polymer, a liposome permeation promoter and a scar removal active component and can keep good adhesiveness and cohesiveness in the case of moisture or sweat; meanwhile, with good hydrophilcity and lipophicity, the viscous polymer layer is more favorable for the medicine to penetrate through skin to promote medicine absorption, and a higher medicine-through-skin rate can be obtained. The film for hyperplastic scar repair, disclosed by the invention, takes effect quickly, the course of treatment is short, and the hyperplastic scar does not recur easily. The preparation method is simple, and the process cost is low.

The invention provides skin cream used for hyperplastic scar repair. The skin cream comprises the following components in parts by weight: 0.1-2 parts of onion bulb extract, 0.01-0.5 part of centella extract, 0.1-2 parts of beta-glucan, 1-5 parts of catechin, 0.0002-0.002 part of recombinant human interleukin-12, 1-5 parts of squalane, 1-3 parts of wheatgerm oil, 2-4 parts of cetearyl glucoside, 1-5 parts of isopropyl myristate, 1-5 parts of ethylhexyl palmitate, 0.5-2 parts of octyl methoxycinnamate, 1-5 parts of glycerol, 0.5-2 parts of cetostearyl alcohol, 0.5-2 parts of propylene glycol and 70-85 parts of water. The skin cream belongs to the technical field of cosmetics, is good in safety, is free of side effect, is quick in effect taking, has good repair effect on hyperplastic scars, is good in whitening effect, is easily accepted by a patient, and has a wide market prospect.

The invention discloses a microacupuncture needle paster for improving skin hyperplastic scars. The microacupuncture needle paster comprises a microacupuncture needle array loaded with active constitutents, a fixed connecting layer and a hydrogel layer, wherein the microacupuncture needle array is located on the first surface of the fixed connecting layer; the hydrogel layer is arranged on the second surface of the fixed connecting layer; the fixed connecting layer is located between the microacupuncture needle array and the hydrogel layer; a plurality of infiltration channels are formed in the fixed connecting layer, penetrate through the fixed connecting layer, and communicate with the microacupuncture needle array and the hydrogel layer; the fixed connecting layer comprises a silicone gel matrix and strengthening fibers; the strengthening fibers are connected with the silicone gel matrix and are used for supporting the silicone gel matrix; and the infiltration channels are formed inthe silicone gel matrix. According to the microacupuncture needle paster for improving the skin hyperplastic scars disclosed by the invention, the wound ulceration period can be accelerated and improved, the risk of forming hyperplastic scars during wound healing can be reduced, and local state blemish in skin after the hyperplastic scars are formed can also be improved.

Belonging to the technical field of cosmetics, the invention relates to an acne-removing repair cream containing cell growth factors. The acne-removing repair cream containing cell growth factors comprises the following components: a cell growth factor compound liposome, macadamia oil, phytic acid, a peach leaf extract, a Kangua extract, ceteareth-25, ceteareth-6, cetearyl alcohol, sodium stearoylglutamate, caprylic / capric triglyceride, carboxymethyl chitosan, xanthan gum, polyglutamic acid, propylene glycol, PEG-40 hydrogenated castor oil, tocopheryl acetate, bisabolol, a preservative, essence and deionized water. Through the synergistic effect of all the components, the acne-removing repair cream containing cell growth factors provided by the invention can effectively maintain the activity of cell growth factors and improve the bioavailability of cell growth factors, has significant acne removing and inhibition effects, and has obvious prevention and repair effects on dark acne marks, sunken or hyperplastic scars left after healing of acnes.

The invention belongs to the technical field of traditional Chinese medicines, and specifically discloses an external traditional Chinese medicine for burns and scalds as well as a preparation method thereof. The external traditional Chinese medicine for burns and scalds is prepared from the following raw material medicines in proportion by weight: 15-25g of garden burnet, 10-18g of scutellaria baicalensis, 12-16g of radix angelicae, 16-22g of asarum, 11-17g of rhizoma corydalis, 25-35g of catalpa bungei flower, 8-16g of polygonum cuspidatum, 5-15g of borneol, 12-24g of medicinal cyathula root, 3-12g of rheum officinale, 18-25g of honeysuckle, 10-20g of fructus forsythiae, 6-13g of safflower carthamus, 8-15g of lithospermum, 6-18g of myrrh, 12-18g of rhizoma smilacis glabrae, 15-25g of willow branches, 7-13g of tung tree flower, 9-12g of cacumen biotae leaves and 18-24g of viola. The external traditional Chinese medicine for burns and scalds provided by the invention is reasonable in formula and exact in curative effect; long-term clinic treatment effects prove that the external traditional Chinese medicine has a great curative effect on I-degree, II-degree and III-degree burns and scalds, and can further suppress the hyperplasia of wound surfaces and avoid the residues of hyperplastic scars.

The invention discloses a mechanical device for generating animal hyperplastic scars. The mechanical device comprises a skin testing mechanical support and a scar making support, wherein the skin testing mechanical support is used for measuring skin bearing tension, and the scar making support is used for building the hyperplastic scars according to the tested tension. The scar making support comprises two symmetric skin supports, two force application connecting blocks and a rotating screw, a fixing hole combined with skin is formed in each skin support, one force application connecting block is connected with the corresponding skin support through a fixing hoop combination, threaded holes in opposite thread directions are formed in the two force application connecting blocks, the rotating screw is sequentially connected with the two force application connecting blocks in a threaded manner, sliding rods are arranged on two sides of the rotating screw, and the force application connecting blocks can slide along the sliding rods. The mechanical device can continuously apply a certain mechanical stress to a laboratory rodent healing wound, and natural tension of human skin is simulated.

The invention discloses a gel for promoting wound healing. The gel is mainly prepared from the following raw materials in parts by mass: 4-9 parts of flos buddlejae, 7-12 parts of ixeris sonchifolia hance, 8-16 parts of shepherdspurse herb, 8-14 parts of diverse wormwood herb, 5-10 parts of rhizoma nelumbinis, 10-18 parts of radix saposhnikoviae, 9-15 parts of myrrh, 6-12 parts of incised notopterygium, 5-11 parts of gypsum, 7-13 parts of Chinese asystasiella herb, 10-15 parts of herb of hairyfruit violet, 20-40 parts of carbomer, 14-18 parts of a substrate, 0.02-0.04 parts of a fibroblast growth factor, 2-4 parts of vitamin E, 1.0-1.4 parts of ethyl p-hydroxybenzoate as well as proper amounts of glycerol and triethanolamine. The gel prepared by the invention has functions of healing sore and relieving swelling, stopping bleeding and relieving pain, promoting wound healing and the like; the gel is good in biocompatibility, good in absorptivity, non-irritant to skin and good in antibacterial performance, and the gel is non-adhesive to a wound surface and is capable of relieving hyperplastic scars.

The invention discloses silicone scar gel, comprising silicone and a solvent, wherein the silicone accounts for 30-80%; the solvent and the silicone are dissolved together, volatilizing speed is greater than 50, and nontoxicity is shown. The silicone oil and the volatile solvent are combined to prepare silicone gel that is convenient to use and high in film-forming speed, can combine with the skintightly and can significantly improve hyperplastic scars; the volatile solvent in the gel can bring away local heat of a body during vocalization; the heat symptom due to proliferation sin is relieved. In addition, organosilicone can inhibit sebum and provide cooling. The optimal formulation can gain high volatizing speed and enables the skin to feel cool and smooth; the silicone scar gel can beuse with other improving products and skin-care matters to prepare diverse gels.

The invention discloses a medicament for treating scarf hyperplasia with shorter course of treatment and better curative effect, which is prepared from pure natural animal and plant raw material through conventional process.

The invention discloses a traditional Chinese medicinal composition for eliminating a hyperplastic scar. The traditional Chinese medicinal composition for eliminating the hyperplastic scar is prepared from the following main raw materials in parts by weight: 5-9 parts of ormosia henryi, 10-15 parts of myrrh, 10-15 parts of folium artemisiae argyi, 3-6 parts of coptis chinensis, 8-12 parts of fructus cnidii, 7-10 parts of chaulmoogra, 5-10 parts of momordica cochinchinensis, 9-12 parts of franzenbach rhubarb root and rhizome, 5-10 parts of (old) onion stem, 7-15 parts of rhizoma smilacis glabrae, 8-12 parts of platycodon grandiflorum, 9-16 parts of carrot seeds, 0.3-0.6 part of rose geranium essential oil and 0.6-1.2 parts of permanent flower essential oil. The traditional Chinese medicinal composition for eliminating the hyperplastic scar is applied externally, a medicine can be directly acted to a scar part, a raised scar can be flattened and softened, new and old scars can be effectively faded, and curative effect on the hyperplastic scar is obvious.

The invention discloses a biological dressing with a scar prevention function and a preparation method thereof.The biological dressing comprises a component A and a component B. The component A and the component B have the scar removal and itching relieving functions, the dosage form of the biological dressing comprises gel or cream, the component A comprises a mussel extract and an onion extract, the mussel extract contains an L Dopa group, the onion extract contains an L Dopa group, and the onion extract contains an L Dopa group. L Dopa is combined with an epidermal nerve ending receptor to seal epidermal nerve endings to achieve the itching relieving effect, meanwhile, lysine is contained, mussel mucoprotein becomes a very few basic protein, molecules carry a large number of positive charges in the physiological environment, sick cells are recovered in time, the itching relieving effect is achieved, nerve endings can be passivated through electrostatic interaction, and the effect of relieving itching is achieved. The itching relieving effect is achieved. The biological dressing disclosed by the invention not only can prevent the formation of scars, but also can relieve skin itch, and can improve the appearance, erythema and height of hyperplastic scars of patients when being used for the hyperplastic scars.

The invention provides a medical suturing drawing buckle, and relates to the technical field of medical care articles for use. The medical suturing drawing buckle comprises drawing buckle bodies, a release paper bottom board and medical adhesive tapes, wherein each drawing buckle body contains a fixing sheet, lock catch, a tensioning band and a locking device, each lock catch is arranged at the front end of the corresponding fixing sheet, the left side of each lock catch extends outwards to form a corresponding tensioning band, and a guide groove for allowing each tensioning band to insert anda locking device are arranged on the right side of each lock catch; and the medical adhesive tapes are symmetrically arranged on the release paper bottom board, each fixing sheet is arranged on the corresponding medical adhesive tape, the tensioning bands on the two fixing sheets which are symmetrically arranged are respectively inserted into the guide groove in the lock catch in the opposite direction and are fixed through the corresponding locking devices. The medical suturing drawing buckle disclosed by the invention is simple in structure, reasonable in design, and simple and convenient to operate; through cooperation of dual tensioning bands, ectropion suturing of skin can be easily realized, so that the infection possibility is reduced, and scar minimization is realized; wound closure requirements can be met to the maximum extent; and through suturing force on the two sides of an incision, the production of hyperplastic scar tissue can be effectively reduced, no invasion and notrace are visually and really achieved, and after healing, taking out stitches is not needed.

The invention discloses a silicone scar spray. The silicone scar spray comprises silicone and a solvent as components, wherein the silicone accounts for 5-70%, and the solvent is soluble in the silicone and is volatile and non-toxic. Through combination of the silicone and the volatile solvent, a silicone spray which is convenient to use and rapid in film formation, can be tightly combined with skin and can significantly improve hypertrophic scars is prepared; the defects that the conventional cream or gel dosage form is greasy, difficult to smear and inconvenient to use are overcome; throughcoordination with other substances which can improve the efficacy and the skin feel of a product, diverse sprays can be prepared.

The present invention relates to a compound selected among the synthetic polysulphated oligosaccharides having 1 to 4 ose units and the salts and complexes thereof to be used for the treatment of wounds resulting in pathological scars selected among hypertrophic, retractile or atrophic scars. Said use is preferred in particular in patients that have a predisposition to developing hypertrophic, retractile or atrophic scars. According to a second aspect, the invention also relates to said compound for the use thereof in order to inhibit the differentiation of fibroblasts into myofibroblasts during the cicatrisation of wounds resulting in pathological scars selected among hypertrophic, retractile or atrophic scars.

The invention provides application of oxymatrine in promoting scar repair, application of oxymatrine in drugs for the treatment of scars, application of oxymatrine in drugs for treatment of hyperplastic scars and application of oxymatrine in inhibiting autophagy of scar fibroblasts. Active ingredients in the drugs for the treatment of the scars are oxymatrine. Ingredients in the drugs for treatment of the hyperplastic scars include oxymatrine and auxiliary materials, and active ingredients are oxymatrine. A signal pathway of the oxymatrine for inhibiting the autophagy of the scar fibroblasts is AMPK / mTOR / p62 / LC3-II.

The invention relates to the field of medical / cosmetic apparatuses, and in particular relates to scar-repairing silica gel containing human-like collagen, wherein the rapid transdermal absorption of the human-like collagen can be promoted. The scar-repairing silica gel can be used for repairing hyperplastic scars or keloids caused by burns, scalds, trauma, operations and the like in the medical / cosmetic field. The scar-repairing silica gel contains the human-like collagen, silica, cyclopentasiloxane, dimethiconol, water and polydimethylsiloxane.

The invention discloses a 3D printing burn pressure mask based on a silicone coating, which is worn on the face of a burn patient to perform pressurization treatment on hyperplastic scars on the faceof the burn patient, and is characterized in that a printing material of the mask is photosensitive resin; and the surface, facing the face of the patient, of the mask is covered with the silicone coating and provided with concave parts which correspond the hyperplastic scars in shape and of which the depths are smaller than those of the hyperplastic scars protruding the face. The invention further relates to a manufacturing method of the mask. According to the invention, wearing is simulated through pressure analysis software and a computer, so that accurate pressure is applied to the scars;and according to the mask manufactured through the silicone coating technology, the dual effects that the novel mask treats the scars by combining pressure with silicone to are achieved.

The invention belongs to the field of medical technology, and discloses a silica gel scar patch and a preparation method. The silica gel scar patch consists of medical polyurethane and silica gel andis formed by coating the medical polyurethane with the silica gel. The silica gel scar patch is widely used for repairing postoperative hyperplastic scars in surgical departments such as an obstetricsand gynecology department, a burns department, a plastic surgery department and a general surgery department, and is used for treating keloids. The used silica gel does not adhere to hair, is not residual, and adheres comfortably and gently; the silica gel scar patch can adhere repeatedly and can be cleaned; when the silica gel scar patch is torn off, new epithelium and surrounding skin of the mucosa of a wound are not injured, and a patient cannot feel pain; the silica gel scar patch is light and convenient, is convenient to use, soft in texture and good in compliance, and is suitable for various parts of the body of the patient; the silica gel scar patch has a good buffering effect and a heat-insulation property, and the patient feels comfortable; healed hyperplastic scars and keloids can be treated; the silica gel scar patch can cover the hyperplastic scars and the keloids, the area of scars caused by burn, trauma and surgical operation can be reduced, and the color of the scars becomes shallow; and pigment becomes shallow, and itching and pain are relieved.

The invention relates to a scar removing composition, which comprises the following components in percentage by weight: 2 to 8% of hexa-peptide, 2 to 8% of five mineral peptide, 1 to 4% of thioctic acid, 0.05 to 1% of plumbagin, 1 to 4% of inositol, 2 to 6% of composite nano liposome with biological activity, and 70 to 80% of antiseptic with m / v of 0.01-1.0% and auxiliary materials. The provided scar removing composition can prominently enhance the activity of matrix metalloproteinase, the degradation of accumulated I type collagen is promoted; the expression of fibronectin is obviously reduced; the density of fibroblast is reduced, the generation of scars is decelerated, the proliferative index of scar is decreased; the scar removing effect is good, at the same time, the clinical data shows that the scar removing composition also has a good effect for patients of hyper-plastic scars, and the cure rate can reach 96.7%.

The invention discloses an antibacterial and anti-inflammatory membrane, which is mainly prepared from the following raw materials in parts by mass: 7-11 parts of fructus gardeniae, 6-10 parts of coix seeds, 11-15 parts of radix rubiae, 13-17 parts of rhizoma bletillae, 9-17 parts of concha arcae, 8-12 parts of dried orange peel, 7-10 parts of fistular onion stalk, 9-13 parts of herba violae, 6-12 parts of rhizoma cimicifugae, 13-16 parts of longstalk condorvine herb, 11-14 parts of cortex moutan, 40-60 parts of carboxymethyl chitosan, 10-20 parts of hyaluronic acid, 4-8 parts of lysozyme, 1-5 parts of polyvinyl alcohol, 1-4 parts of polyhexamethylene biguanidine hydrochloride and 2-5 parts of menthol. The membrane prepared by the invention has good absorptivity, and the membrane is well bonded to a wound surface and non-adhesive to wound; and the membrane is loaded with active ingredients of traditional Chinese medicines, so that the membrane, besides excellent antibacterial and anti-inflammatory effects, also has functions of stopping bleeding and removing stasis, cooling blood and relieving swelling, and the like; and the membrane is good in biocompatibility to the wound surface, conducive to wound healing and is capable of inhibiting hyperplastic scars.

The invention provides a traditional Chinese medicine formula for treating hyperplastic scars. The traditional Chinese medicine formula is composed of the following components in percentage by weight: 10 to 25% of lavender essence, 12% to 15% of jasmine essence, 5 to 15% of mint leaf, 10 to 15% of garlic, and the balance being water, and the traditional Chinese medicine is prepared by decocting the raw materials mentioned above. The traditional Chinese medicine formula has the advantages that the lavender in the formula has a function of soothing the skin, and has a very good healthcare effect on human body through combining other ingredients in the preparation.

The invention relates to a traditional Chinese medicine mixture for treating scar hyperplasia. The traditional Chinese medicine mixture is prepared from, by weight, 10-20 parts of radix angelicae sinensis, 5-10 parts of radix salviae miltiorrhizae, 5-10 parts of rhizoma sparganii, 5-10 parts of rhizoma curcumae, 5-10 parts of spina gleditsiae, 3-5 parts of radix angelicae, 25-50 parts of sweet almond oil and 5-10 parts of beeswax. The traditional Chinese medicine mixture is prepared by steps: (1) soaking radix angelicae sinensis, radix salviae miltiorrhizae, rhizoma sparganii, rhizoma curcumaeand spina gleditsiae into sweet almond oil; (2) decocting over slow fire until liquid turns into yellow, cooling, and continuing decoction until the liquid is crineous; (3)adding radix angelicae intothe crineous mixture, stirring, discharging, and filtering to take the liquid; (4) adding high-purity beeswax into the filtered liquid, and well cooling at a certain position until the liquid turns into paste; (5) placing the paste at a low-temperature position for a while to obtain the traditional Chinese medicine mixture for treating scar hyperplasia. The traditional Chinese medicine mixture issimple in preparation process and effective in treatment of scar hyperplasia and can be widely applied to the technical field of scar treatment.