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Acne-removing repair cream containing cell growth factors and preparation method thereof

A growth factor and repairing cream technology, applied in medical preparations containing active ingredients, preparations for skin care, pharmaceutical formulas, etc., can solve the problems of difficult to completely remove scars, large side effects of products, long period of acne removal, etc. Wound healing, easy absorption, reducing scar shrinkage effect

Inactive Publication Date: 2018-07-10
GUANGDONG COOWAY BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] There are many existing methods for removing acne, such as using antibiotics, hormones and other western medicines for treatment, the short-term effect is remarkable, but the side effects of the product are large, and it is easy to produce drug dependence; using plant components such as aloe vera and chamomile to regulate skin oil and other methods for removing acne, Although it is relatively safe and can play a fundamental role in removing acne, the acne removal cycle is very long, and it is difficult to completely remove the depressed or hypertrophic scars left by pustules, nodules, abscesses, and cysts after healing, which will affect the appearance.

Method used

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  • Acne-removing repair cream containing cell growth factors and preparation method thereof
  • Acne-removing repair cream containing cell growth factors and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Example 1 Preparation of deep-sea fish skin collagen enzymatic hydrolyzate

[0034] Including the following steps:

[0035] Take the deep-sea fish skin collagen powder, add water according to the solid-liquid ratio of 35g / L, add 0.03% by weight of the deep-sea fish skin collagen powder hydrolyzed cod skin protein, stir for 20 minutes, add 6% of the total weight of the solution compound protease, at temperature Enzymolysis at 50°C and pH value of 6.5 for 8 hours, inactivation of enzyme at 100°C for 10 minutes after the end of the enzymolysis, filtration, concentration of the filtrate under reduced pressure, and drying to obtain enzymatic hydrolyzate of deep-sea fish skin collagen; wherein, the complex protease It is composed of collagenase and bromelain in a weight ratio of 8:1.

Embodiment 2

[0036] Example 2 The preparation of cut melon extract extract

[0037] Including the following steps:

[0038] Take fresh chopped melons, wash and dry the surface moisture, chop and homogenize, add water 12 times the weight of chopped melons, sapinberry saponin with 0.03% of the weight of chopped melons and helicase with 0.8‰ weight of chopped melons, and stir 20min, enzymatic hydrolysis at pH 6.5 and temperature 50°C for 4h, ultrasonic extraction 2 times after enzymolysis, 20min each time, filtration, combined filtrate, filtrate inactivated at 100°C for 8min, filtration, filtrate concentrated under reduced pressure to 30% of the original volume, add ethanol until the alcohol content is 78%, let it stand for 12 hours at a temperature of 10°C, filter, concentrate the filtrate under reduced pressure, and dry to obtain the cut melon extract.

Embodiment 3～5

[0039] The preparation of embodiment 3~5 cell growth factor composite liposome

[0040] In this example, the cell growth factor complex liposome includes the following components in parts by weight: 0.005 parts of recombinant human acidic fibroblast growth factor, 0.0015 parts of heparin sodium, 6 parts of deep-sea fish skin collagen enzymatic hydrolyzate, dentate 5 parts of snake grape leaf extract, 110 parts of hydrogenated lecithin, 3 parts of sodium cholate and 27 parts of cholesterol.

[0041] The preparation method comprises the following steps:

[0042] 1) Take hydrogenated lecithin, sodium cholate and cholesterol, add them into absolute ethanol at a solid-to-liquid ratio of 4 mg / mL, stir and dissolve to obtain solution I;

[0043] 2) Take recombinant human acidic fibroblast growth factor, heparin sodium, enzymatic hydrolyzate of deep-sea fish skin collagen and grape leaf extract, add PBS with a pH of 6.5 at a solid-liquid ratio of 7 mg / mL, stir and dissolve to obtain ...

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Abstract

Belonging to the technical field of cosmetics, the invention relates to an acne-removing repair cream containing cell growth factors. The acne-removing repair cream containing cell growth factors comprises the following components: a cell growth factor compound liposome, macadamia oil, phytic acid, a peach leaf extract, a Kangua extract, ceteareth-25, ceteareth-6, cetearyl alcohol, sodium stearoylglutamate, caprylic / capric triglyceride, carboxymethyl chitosan, xanthan gum, polyglutamic acid, propylene glycol, PEG-40 hydrogenated castor oil, tocopheryl acetate, bisabolol, a preservative, essence and deionized water. Through the synergistic effect of all the components, the acne-removing repair cream containing cell growth factors provided by the invention can effectively maintain the activity of cell growth factors and improve the bioavailability of cell growth factors, has significant acne removing and inhibition effects, and has obvious prevention and repair effects on dark acne marks, sunken or hyperplastic scars left after healing of acnes.

Description

technical field [0001] The invention belongs to the technical field of cosmetics, and relates to an acne-removing and repairing ointment containing cell growth factors and a preparation method thereof. Background technique [0002] Acne is a chronic inflammatory disease involving the pilosebaceous glands. It occurs in fatty areas such as the cheeks, forehead, chin, and naso-buccal grooves, followed by the chest, back, and shoulders. It is debilitating to a certain extent. The occurrence of acne is mainly closely related to many factors such as excessive sebum secretion, pilosebaceous gland duct blockage, bacterial infection and inflammatory response. Acne is characterized by acne, papules, pustules, nodules, cysts, and scars. According to the severity of the disease, age, and physical condition, it can be divided into acne vulgaris, acne conglomerates, acne fulminans, and drug-induced acne. [0003] Acne vulgaris is the most common type of acne, commonly known as whelk, and...

Claims

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Application Information

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IPC IPC(8): A61K8/9789A61K8/34A61K8/37A61K8/44A61K8/55A61K8/64A61K8/67A61K8/73A61K8/86A61K8/88A61K8/92A61Q19/00A61Q19/02A61P17/10
CPCA61K8/64A61K8/34A61K8/345A61K8/375A61K8/44A61K8/55A61K8/678A61K8/73A61K8/736A61K8/86A61K8/88A61K8/922A61K8/97A61K2800/56A61K2800/5922A61K2800/805A61K2800/82A61Q19/00A61Q19/02
Inventor 陈松彬倪彦艳刘杰森陈健欢郑涌镟
Owner GUANGDONG COOWAY BIOTECH CO LTD
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