31 results about "Hyperglycemic Mouse" patented technology

The invention relates to madder extract and a preparation method and an application thereof, wherein the madder extract is prepared from the following steps: pulverizing the rhizome of the madder, and using ethanol for percolation extraction at room temperature; recovering the ethanol and obtaining extract; dissolving the extract into water, and heating and completely dissolving the extract; and then, extracting the extract by using ethyl acetate, and concentrating the extract to obtain the madder ethyl acetate extract. The experiment indicates that the madder ethyl acetate extract and the compound alizarin can effectively reduce the blood glucose value, the GSP value, the TG value and the content of MDA in the tissue homogenate of the mouse with hyperglycemia caused by alloxan, and can obviously increase the SOD activity value of the hepatocyte of the mouse and increase the content of the hepatic glycogen of the tissue. The results prove that the madder ethyl acetate extract and the alizarin have good effect on reducing the content of the blood glucose.

The invention relates to a process flow to produce a sesquiterpene inside a golden fungus fermentation liquid and the virtue of the sesquiterpene produced by the golden fungus to reduce the blood sugar, belonging to the biological fermentation and medicine field. The process flow is characterized in that the process flow applicant finds the fermentation liquid and the sesquiterpene produced by the production process are applied on a high blood sugar mouse through an oral administration route, the mouse significantly reduces the blood sugar and the fructosamine, which approves that the golden fungus fermentation liquid and the sesquiterpene are possessed of preparing a health care drink and medicine to reduce the blood sugar; the fermentation liquid color is orange to yellow-brown; the inhibitive rate to the ex vivo non-enzymic glycosylation is up to 72% to 90% with the fermentation liquid and 5mg / ml sesquiterpene. The process flow to produce a sesquiterpene inside a golden fungus fermentation liquid and the virtue of the sesquiterpene produced by the golden fungus to reduce the blood sugar has the advantages of not only creating a fire-new channel to further develop the golden fungus but also providing an ideal Chinese herbal medicine to reduce blood sugar.

The invention belongs to the technical field of microbes, and in particular relates to a strain of Lactobacillus paracasei with functions of lowering blood sugar, protecting oral cavity and antidepressant and application thereof. The Lactobacillus paracasei nbk-LC16 provided by the invention has strong acid and bile salt resistance, good tolerance in artificial gastric juice and artificial intestinal juice, and can effectively reduce blood sugar and inhibit mutans streptococcus. To study its effect on hyperglycemia mice, after intragastric administration of Lactobacillus paracasei nbk‑LC16 8W, compared with model group mice, the weight of hyperglycemia mice increased significantly, liver index and spleen index decreased significantly, and FBG and PBG significantly decreased. Decreased, HbA1c and insulin levels decreased significantly, liver glycogen content increased. The test results show that Lactobacillus paracasei nbk‑LC16 can regulate blood sugar by regulating insulin levels and HbA1c, and promoting the conversion of blood sugar into liver glycogen. Study its inhibitory effect on Streptococcus mutans, the results of in vitro test and oral cavity test show that it can effectively inhibit Streptococcus mutans, help to protect the health of oral cavity and teeth; at the same time, it has antidepressant effect.

The invention discloses a nano inclusion compound capable of reducing blood glucose and a preparation method of the nano inclusion compound and belongs to the technical field of functional food. The nano inclusion compound is prepared from a boletus frondosus dicks extract, dietary fiber and protein peptide by acid dissolution and addition of alkali liquor for neutralization. Raw materials of thenano inclusion compound are safe and reasonable in compatibility. Besides, the preparation method and process of the inclusion compound are simple to operate and good in repeatability, and obtained granules or tablets have attractive appearance, high wear resistance and good formability. Experiments prove that the inclusion compound has effects of gastric acid resistance and slow release, in a hyperglycemia mouse model, after 2 weeks of intragastric administration, the fasting blood-glucose decrease rate of the model is 39.5%, the functions of pancreatic beta cells can be effectively improved,and blood glucose can be reduced. The formula has excellent taste, can be used as a raw material of solid drinks or functional food and is widely applicable to diabetics.

The present invention relates to a madder extract and its preparation method and application, wherein the madder extract is prepared by the following method: crushing the rhizome of madder, extracting by percolating with ethanol at room temperature; recovering the ethanol to obtain an extract; extracting the extract Dissolved in water, heated to dissolve completely; then extracted with ethyl acetate, concentrated to obtain Rubia ethyl acetate extract. Experiments show that the extract of Rubia ethyl acetate and the compound alizarin can effectively reduce the blood glucose level, GSP value, TG value and MDA content in tissue homogenate of mice with hyperglycemia induced by alloxan, and can significantly increase the SOD activity value of hepatocytes and increase tissue liver glycogen content. It is proved that Rubia ethyl acetate extract and alizarin have good hypoglycemic effect.

An application of a Hangzhou chrysanthemum extract product in preparation of healthcare foods and medicines for preventing and treating hyperglycemia is disclosed. The Hangzhou chrysanthemum extract product is prepared into a medicine for animals and is administrated to mice by perfusion. Influences of the medicine prepared from the Hangzhou chrysanthemum extract product on blood glucose of normal mice, influences of the medicine on the glucose tolerance of normal mice, and influences of different concentrations of the medicine on glucose of mice with hyperglycemia induced by alloxan are measured. Results show that: long-term taking of the Hangzhou chrysanthemum extract product can reduce the blood glucose concentration of the normal mice, and reduce the blood glucose concentration of the mice with hyperglycemia induced by glucose and the alloxan. The Hangzhou chrysanthemum extract product can be used for healthcare foods and medicines for preventing and treating the hyperglycemia.

The invention discloses a preparation method and an application of stereum hirsutum mycelium polysaccharide, relates to the field of biological fermentation and medicines, and particularly relates to a production technology process for extracting mycelium polysaccharide by obtaining mycelium through liquid culture of stereum hirsutum, and blood sugar and blood fat reduction effects of the polysaccharide. Repeated experimental study proves that the mycelium polysaccharide produced by applying the production process can obviously reduce the levels of blood sugar and blood fat in hyperglycemic mice through intraperitoneal injection or oral administration, thus proving that the stereum hirsutum mycelium polysaccharide can be applied to the preparation of medicines for reducing blood sugar and blood fat. The preparation method opens the bran-new approach for further development and utilization of stereum hirsutum and can be used for providing a novel ideal traditional Chinese medicine for the reduction of blood sugar and blood fat.

The invention relates to a traditional Chinese medicine composition for treating diabetes, which is prepared from the following raw material components in weight ratio: 5-10 parts of Jerusalem artichoke, 5-8 parts of Panax notoginseng, 3-8 parts of Radix Paeoniae Alba, and 5-8 parts of gypsum , Astragalus 3-5 parts, Bitter Melon 2-3 parts, Trichosanthes root 2-3 parts, Anemarrhena 2-3 parts, Rehmannia glutinosa 2-3 parts, Dendrobium 2-3 parts, Scutellaria baicalensis 2-3 parts, Scutellaria 2-3 parts 3 servings, made into capsules or tablets by conventional preparation process. The traditional Chinese medicine composition of the invention has significant effects on improving the immunity of the human body, coordinating the functions of viscera, fundamentally improving the physiological functions of diabetic patients, and restoring the normal function of pancreatic beta cells. In animal experiments, it can significantly reduce adrenaline hyperglycemia in alloxan model hyperglycemia mice, and has a repairing effect on pancreatic tissue damage caused by alloxan; in clinical trials, it can treat diabetes and its complications. Reach the effect of treating both symptoms and root causes.

The invention relates to a catalpol-containing medicine composition for reducing blood glucose and a preparation method and application thereof. After the catalpol is singly used, or the catalpol is compounded with other active components, such as one or multiple of sulfonylurea, metformin, alpha-glycosidase inhibitors, insulin sensitization agents, glenn urea medicines or traditional Chinese medicine compositions, the excellent effect of reducing blood glucose, triglyceride, cholesterol and glycated hemoglobin in hyperglycemia mice or rats is realized; the catalpol-containing medicine composition can be widely applied to prevent and treat the diabetes, especially type 2 diabetes.

The invention relates to a sustained-release blood-glucose-reduction medicinal composition as well as a preparation method and application thereof. The sustained-release blood-glucose-reduction medicinal composition comprisesis prepared from catalpol and a sustained-release carrier, and is preferably comprisesprepared from other active ingredients such as one or a combination of more of sulfonylureas, biguanides, analpha-glucosidase inhibitor, an euglycemic agent, glimepirideglinide medicine or traditional Chinese medicine composition. By adopting the sustained-release blood-glucose-reductionmedicinal composition, an effect for significantly reducing the blood glucose, triglyceride, cholesterol and glycosylated hemoglobin of high-blood-glucose mice or rat can be achieved, and the effect for preventing and treating type-II diabetes can be achieved.

The invention discloses stereum hirsutum fermentation liquor and sesquiterpene which are produced by fermenting stereum hirsutum liquor, as well as applications thereof, and particularly relates to a production technology process of sesquiterpene cultured and obtained by the stereum hirsutum liquor, and the hypoglycemic efficiency of sesquiterpene. Repeated tests and study show that a culture solution produced by the production technology contains sesquiterpene, a mouse with hyperglycemia takes the culture solution orally, and then blood sugar and fructosamine of the mouse can be reduced remarkably, therefore, the stereum hirsutum culture solution is confirmed to have the application for preparing healthy drinks and medicines capable of reducing the blood sugar. The culture solution is liquor with the color ranging from aurantium to tawny, and the sesquiterpene content in the culture solution is 0.4 mg / mL-4.0 mg / mL. According to the invention, not only is a new way explored for the deep development and utilization of the stereum hirsutum, but also an ideal traditional Chinese medicine is provided for controlling the blood sugar.